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The map label for this gene is clcA [H]

Identifier: 148359278

GI number: 148359278

Start: 2013293

End: 2014576

Strand: Reverse

Name: clcA [H]

Synonym: LPC_1174

Alternate gene names: 148359278

Gene position: 2014576-2013293 (Counterclockwise)

Preceding gene: 148359279

Following gene: 148359276

Centisome position: 56.33

GC content: 40.26

Gene sequence:

>1284_bases
ATGGGTAAAAAAATACTGATTTTATATTTTGTATCAGTTCTATTAGGGATATTAACAGGCGCAATTGCTTCATTATTCCA
ACTTACTATTCAACAGATGGATCATCTGCTGGAGCTATTATTTCATATGACAGAAAGTTATGGACTTCCTGTAGGAATCG
TTTCCGCTATGACATCGATGGTGATGTTATTTATTGCCTGGATGATGGTGAAGTACATCGCCCCAGAAGCGGCAGGAAGT
GGTGTGCAAGAAATTGAAGGTACCTTGCTTCATGTGAGACCAATATTTTGGAAGCGTCTGATACCAGTAAAATTTTTTGG
GGGTGTGTTATCCATATCGGCAAAAATGGTTATGGGAAGAGAAGGGCCTACTATTCAGATGGGTGGTAACCTTGGACAGA
TGCTTGGAGAGTTGTTTCGGCTTACACGCCGTCGCCGTGATACTTTAATAGCCGCTGGTTCTGCCGCTGGTTTGGCTGCA
GCATTTAATGCGCCTCTGGCTGGTGTACTGTTTGTCATGGAGGAAATGCGTAACCAGTTTAATTATTCATTTACCAATTT
TAAAATGGTCGTTATTTGTTGTGTTATGGCAACGATTGTTTTGCATCTTATTATTGGCTCACAACCGGCTATTCAAATGG
AGGTTTTTGAACTACCTACACTGGGCTCTTTGTGGCTGTTCTTTGTTTTTGGAATATTAATGGGGCTGGCTGGCTTATTA
TTCAATGTCACACTCATGAGAACTGTTGGATGGTTAGATAAACAAAACCCCAAAAACAAAAAATATTATATTTTAGCTGT
TGGATTTTTAGTCGGTTATCTGGCGTACTCCTATCCTGCTACTGTTGGGGGCGGTTATGTTATCATCAGTGAAGCACTGA
CTATGTCACCTGCATTTAGCGTGTTATGCAGTCTTATTGTAATCAGGTTTATCATGACTATGTTATCCTATTCAAGTGGC
GTGCCTGGTGGTATCTTTGCACCAATGCTGGCTTTGGGAACACTATTTGGATTAGGTTTTTTCCATTTATTTCAATGGTT
AAGTATGGATTTTTCAATAGAGCCTGGTATGTTTGCAGTCGCAGGTATGGGAGCGCTTTTCGCAGCTGCAGTAAGATCAC
CAATTACTGGCGTGGTATTGGTTGTTGAAATGACTAAAAATTACTCTCTAATTCTACCTCTTATAGTTTCCTGCATTACT
GCAACGATTGTGGTGCAATTAGCACGTAACGAGCCGATTTACACTCAATTATTAGAGCGAACTTTACGACTCAATGCAAA
ATGA

Upstream 100 bases:

>100_bases
CCTGTGCATGCGGTTCAATTTCATCCAGAGACAATTTTGTCTTTATCGGATCAAGTGGGTTTAAGAATAATCATCAATTT
GATGAACATGGTGAAGGACA

Downstream 100 bases:

>100_bases
GTCTAAATGTCTCAATATGTATTGATAGTTCAGCTATGGGGAATAAGGATAAAAGTAAGAAGAGCCCTTGATTTATCTAC
CAAAAACACGAACTCACTGG

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MGKKILILYFVSVLLGILTGAIASLFQLTIQQMDHLLELLFHMTESYGLPVGIVSAMTSMVMLFIAWMMVKYIAPEAAGS
GVQEIEGTLLHVRPIFWKRLIPVKFFGGVLSISAKMVMGREGPTIQMGGNLGQMLGELFRLTRRRRDTLIAAGSAAGLAA
AFNAPLAGVLFVMEEMRNQFNYSFTNFKMVVICCVMATIVLHLIIGSQPAIQMEVFELPTLGSLWLFFVFGILMGLAGLL
FNVTLMRTVGWLDKQNPKNKKYYILAVGFLVGYLAYSYPATVGGGYVIISEALTMSPAFSVLCSLIVIRFIMTMLSYSSG
VPGGIFAPMLALGTLFGLGFFHLFQWLSMDFSIEPGMFAVAGMGALFAAAVRSPITGVVLVVEMTKNYSLILPLIVSCIT
ATIVVQLARNEPIYTQLLERTLRLNAK

Sequences:

>Translated_427_residues
MGKKILILYFVSVLLGILTGAIASLFQLTIQQMDHLLELLFHMTESYGLPVGIVSAMTSMVMLFIAWMMVKYIAPEAAGS
GVQEIEGTLLHVRPIFWKRLIPVKFFGGVLSISAKMVMGREGPTIQMGGNLGQMLGELFRLTRRRRDTLIAAGSAAGLAA
AFNAPLAGVLFVMEEMRNQFNYSFTNFKMVVICCVMATIVLHLIIGSQPAIQMEVFELPTLGSLWLFFVFGILMGLAGLL
FNVTLMRTVGWLDKQNPKNKKYYILAVGFLVGYLAYSYPATVGGGYVIISEALTMSPAFSVLCSLIVIRFIMTMLSYSSG
VPGGIFAPMLALGTLFGLGFFHLFQWLSMDFSIEPGMFAVAGMGALFAAAVRSPITGVVLVVEMTKNYSLILPLIVSCIT
ATIVVQLARNEPIYTQLLERTLRLNAK
>Mature_426_residues
GKKILILYFVSVLLGILTGAIASLFQLTIQQMDHLLELLFHMTESYGLPVGIVSAMTSMVMLFIAWMMVKYIAPEAAGSG
VQEIEGTLLHVRPIFWKRLIPVKFFGGVLSISAKMVMGREGPTIQMGGNLGQMLGELFRLTRRRRDTLIAAGSAAGLAAA
FNAPLAGVLFVMEEMRNQFNYSFTNFKMVVICCVMATIVLHLIIGSQPAIQMEVFELPTLGSLWLFFVFGILMGLAGLLF
NVTLMRTVGWLDKQNPKNKKYYILAVGFLVGYLAYSYPATVGGGYVIISEALTMSPAFSVLCSLIVIRFIMTMLSYSSGV
PGGIFAPMLALGTLFGLGFFHLFQWLSMDFSIEPGMFAVAGMGALFAAAVRSPITGVVLVVEMTKNYSLILPLIVSCITA
TIVVQLARNEPIYTQLLERTLRLNAK

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557473, Length=428, Percent_Identity=25.4672897196262, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI189217923, Length=428, Percent_Identity=25.4672897196262, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI189217921, Length=428, Percent_Identity=25.4672897196262, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI55770838, Length=423, Percent_Identity=26.0047281323877, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI55770840, Length=423, Percent_Identity=26.0047281323877, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI153252026, Length=419, Percent_Identity=23.6276849642005, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786350, Length=425, Percent_Identity=42.1176470588235, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI87081943, Length=322, Percent_Identity=29.1925465838509, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71985148, Length=445, Percent_Identity=26.9662921348315, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71985141, Length=445, Percent_Identity=27.1910112359551, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532615, Length=398, Percent_Identity=24.3718592964824, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17559050, Length=495, Percent_Identity=24.6464646464646, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322500, Length=388, Percent_Identity=26.2886597938144, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24665008, Length=418, Percent_Identity=23.6842105263158, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 46735; Mature: 46604

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCC
>Mature Secondary Structure 
GKKILILYFVSVLLGILTGAIASLFQLTIQQMDHLLELLFHMTESYGLPVGIVSAMTSM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VMLFIAWMMVKYIAPEAAGSGVQEIEGTLLHVRPIFWKRLIPVKFFGGVLSISAKMVMGR
HHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EGPTIQMGGNLGQMLGELFRLTRRRRDTLIAAGSAAGLAAAFNAPLAGVLFVMEEMRNQF
CCCEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHH
NYSFTNFKMVVICCVMATIVLHLIIGSQPAIQMEVFELPTLGSLWLFFVFGILMGLAGLL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
FNVTLMRTVGWLDKQNPKNKKYYILAVGFLVGYLAYSYPATVGGGYVIISEALTMSPAFS
HHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCEEEEEHHHHCCHHHH
VLCSLIVIRFIMTMLSYSSGVPGGIFAPMLALGTLFGLGFFHLFQWLSMDFSIEPGMFAV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AGMGALFAAAVRSPITGVVLVVEMTKNYSLILPLIVSCITATIVVQLARNEPIYTQLLER
HHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
TLRLNAK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA