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The map label for this gene is dsbD [H]

Identifier: 148359218

GI number: 148359218

Start: 1940551

End: 1941876

Strand: Reverse

Name: dsbD [H]

Synonym: LPC_1112

Alternate gene names: 148359218

Gene position: 1941876-1940551 (Counterclockwise)

Preceding gene: 148359219

Following gene: 148359217

Centisome position: 54.3

GC content: 38.01

Gene sequence:

>1326_bases
ATGATTTTATTACTGATATTTTTTACTCAGGCGGCGTGGTCATATACTCCTGGCTTTGAAAGTTCTAACCCGGATACTGT
GATGCATTTTATTACAGGAAATAGTGCTTTTGTTTATTTGAGTGCTTTTTTCGGATTAGGTATTTTGTTGGCTTTTACGC
CCTGTGTTCTACCGATGGTTCCTATTTTATCAGGAATTATTGTAGGACAAAATTCTATTTCTACAGGAAAAGCCTTTAAA
TTATCACTGAGTTATGTGACTGGAATGGCTATCACCTATGCAGGAGCAGGGATGCTTGCCGGGTATATGGGAAGTACAAT
CCAGACTGTAATGCAACGTCCAGTAGTAATCACTTTATTCAGTGTTGTGTTTGTAGCCATGGCTCTTTCAATGTTTGGCT
TTTTTGAATTGAAGTTTCCTACAAGCCTTGGGAATCGGTTAAATAAAAACAATCAATTAGGGAAGCAGAGAAGTTATCTT
TCTGTTGGAATAATGGGAGTTTTATCCACTTTAATTGTTTCTCCTTGTGTTACCGCTCCTTTAATTGGTGTTTTAAGTTA
TATTGGTCAAAATGGCCAGGTCATAATGGGCGGATTGATTTTATTTGTTATGGCATTGGGGATGGGGGTTCCTCTGCTGA
TTGTTGGTGCGGGTTATGGTACTTTACTCCCAAAAGCAGGTTCCTGGATGCTTAAAATAAAACAATTGTTTGGTTTTATC
ATGTTGGGAATTGCCATATGGATGTTATCCCGGATTCTGAATCAGACCATTACGCACATTTTGTGGGCAGGATTACTCAT
GGTCGCCAGCATCAGTTTAGGTGCTTTAAAATCACAAAACAATTGGCGTGGTTATTTGGCTCAGGGATTGGGTATTCTTG
CTTTGATTTCAGGAGGTATTATTTTTTACAACACCGCAATACCTTCAGTAAAAATAAAACAAGCGTCTGTAGAAAATAGC
CCATTTATCAAGATTAATACCTTAAACGCTCTTCAACTGCAATTGGAGCAGGCTAAAAAAGTTAGAAAAGCAGTATTTCT
TGATTTCTCAGCGGATTGGTGCGGTGACTGTCAGGAAATGGATACCAAAGTATTCAATCAACCAGAAATTCAAAAAGCTA
TGTCTGATTGGGTTAGCATTAAAGTGGATATCAGTGATAAGAATGCAGAGGTTGATTCTATAAAAAAAGCTTTTGGTATT
TATGGAACGCCAACGATGATATTTTTTAATACATCGGGAGAGCCTATTACTCAAATGACTTCGGTTGGTTTGATTTCGCT
ATCAAAAATGCTTCAATTGCTCGAGCAAGCGCGCCATTTGAGTTGA

Upstream 100 bases:

>100_bases
AGAGGTCCAGTGTAGGTTACTTGTACTCTGATACAAGTATCTATCGTTGTTATTTATTACTTATTGGGACATTAAAATGA
GAAAAATAATTGATTCGTTC

Downstream 100 bases:

>100_bases
AATAATAGACAATTTGCTACCGAAATTTGTTCTTAATAATTTGGGTATGGTTAATATTTGATAAATAAATCAAATTCAAA
CTGTACCCAAAATATTGAAA

Product: thiol:disulfide interchange protein DsbD

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MILLLIFFTQAAWSYTPGFESSNPDTVMHFITGNSAFVYLSAFFGLGILLAFTPCVLPMVPILSGIIVGQNSISTGKAFK
LSLSYVTGMAITYAGAGMLAGYMGSTIQTVMQRPVVITLFSVVFVAMALSMFGFFELKFPTSLGNRLNKNNQLGKQRSYL
SVGIMGVLSTLIVSPCVTAPLIGVLSYIGQNGQVIMGGLILFVMALGMGVPLLIVGAGYGTLLPKAGSWMLKIKQLFGFI
MLGIAIWMLSRILNQTITHILWAGLLMVASISLGALKSQNNWRGYLAQGLGILALISGGIIFYNTAIPSVKIKQASVENS
PFIKINTLNALQLQLEQAKKVRKAVFLDFSADWCGDCQEMDTKVFNQPEIQKAMSDWVSIKVDISDKNAEVDSIKKAFGI
YGTPTMIFFNTSGEPITQMTSVGLISLSKMLQLLEQARHLS

Sequences:

>Translated_441_residues
MILLLIFFTQAAWSYTPGFESSNPDTVMHFITGNSAFVYLSAFFGLGILLAFTPCVLPMVPILSGIIVGQNSISTGKAFK
LSLSYVTGMAITYAGAGMLAGYMGSTIQTVMQRPVVITLFSVVFVAMALSMFGFFELKFPTSLGNRLNKNNQLGKQRSYL
SVGIMGVLSTLIVSPCVTAPLIGVLSYIGQNGQVIMGGLILFVMALGMGVPLLIVGAGYGTLLPKAGSWMLKIKQLFGFI
MLGIAIWMLSRILNQTITHILWAGLLMVASISLGALKSQNNWRGYLAQGLGILALISGGIIFYNTAIPSVKIKQASVENS
PFIKINTLNALQLQLEQAKKVRKAVFLDFSADWCGDCQEMDTKVFNQPEIQKAMSDWVSIKVDISDKNAEVDSIKKAFGI
YGTPTMIFFNTSGEPITQMTSVGLISLSKMLQLLEQARHLS
>Mature_441_residues
MILLLIFFTQAAWSYTPGFESSNPDTVMHFITGNSAFVYLSAFFGLGILLAFTPCVLPMVPILSGIIVGQNSISTGKAFK
LSLSYVTGMAITYAGAGMLAGYMGSTIQTVMQRPVVITLFSVVFVAMALSMFGFFELKFPTSLGNRLNKNNQLGKQRSYL
SVGIMGVLSTLIVSPCVTAPLIGVLSYIGQNGQVIMGGLILFVMALGMGVPLLIVGAGYGTLLPKAGSWMLKIKQLFGFI
MLGIAIWMLSRILNQTITHILWAGLLMVASISLGALKSQNNWRGYLAQGLGILALISGGIIFYNTAIPSVKIKQASVENS
PFIKINTLNALQLQLEQAKKVRKAVFLDFSADWCGDCQEMDTKVFNQPEIQKAMSDWVSIKVDISDKNAEVDSIKKAFGI
YGTPTMIFFNTSGEPITQMTSVGLISLSKMLQLLEQARHLS

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=386, Percent_Identity=35.4922279792746, Blast_Score=236, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 47749; Mature: 47749

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS01319 RBFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLLIFFTQAAWSYTPGFESSNPDTVMHFITGNSAFVYLSAFFGLGILLAFTPCVLPMV
CEEEEEEHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
PILSGIIVGQNSISTGKAFKLSLSYVTGMAITYAGAGMLAGYMGSTIQTVMQRPVVITLF
HHHHCEEECCCCCCCCCEEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHH
SVVFVAMALSMFGFFELKFPTSLGNRLNKNNQLGKQRSYLSVGIMGVLSTLIVSPCVTAP
HHHHHHHHHHHHHHEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGVLSYIGQNGQVIMGGLILFVMALGMGVPLLIVGAGYGTLLPKAGSWMLKIKQLFGFI
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCHHHHHHHHHHHHH
MLGIAIWMLSRILNQTITHILWAGLLMVASISLGALKSQNNWRGYLAQGLGILALISGGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCE
IFYNTAIPSVKIKQASVENSPFIKINTLNALQLQLEQAKKVRKAVFLDFSADWCGDCQEM
EEEECCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHH
DTKVFNQPEIQKAMSDWVSIKVDISDKNAEVDSIKKAFGIYGTPTMIFFNTSGEPITQMT
HHHHCCCHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHH
SVGLISLSKMLQLLEQARHLS
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MILLLIFFTQAAWSYTPGFESSNPDTVMHFITGNSAFVYLSAFFGLGILLAFTPCVLPMV
CEEEEEEHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
PILSGIIVGQNSISTGKAFKLSLSYVTGMAITYAGAGMLAGYMGSTIQTVMQRPVVITLF
HHHHCEEECCCCCCCCCEEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHH
SVVFVAMALSMFGFFELKFPTSLGNRLNKNNQLGKQRSYLSVGIMGVLSTLIVSPCVTAP
HHHHHHHHHHHHHHEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGVLSYIGQNGQVIMGGLILFVMALGMGVPLLIVGAGYGTLLPKAGSWMLKIKQLFGFI
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCHHHHHHHHHHHHH
MLGIAIWMLSRILNQTITHILWAGLLMVASISLGALKSQNNWRGYLAQGLGILALISGGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCE
IFYNTAIPSVKIKQASVENSPFIKINTLNALQLQLEQAKKVRKAVFLDFSADWCGDCQEM
EEEECCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHH
DTKVFNQPEIQKAMSDWVSIKVDISDKNAEVDSIKKAFGIYGTPTMIFFNTSGEPITQMT
HHHHCCCHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHH
SVGLISLSKMLQLLEQARHLS
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA