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The map label for this gene is fadI [H]

Identifier: 148359134

GI number: 148359134

Start: 1831431

End: 1832750

Strand: Reverse

Name: fadI [H]

Synonym: LPC_1024

Alternate gene names: 148359134

Gene position: 1832750-1831431 (Counterclockwise)

Preceding gene: 148359135

Following gene: 148359133

Centisome position: 51.24

GC content: 44.62

Gene sequence:

>1320_bases
ATGAAACACCAGTCGAATTTAAGTGGTCGTAACGTTTATGTTGTCGATGGAAGTCGAACGCCTTTTCTTAAAGCAAAAGG
AGTAGGTCCATTCTGTGGTTCAGATTTGGCAGTTGCTGCAGGAACAACTTTGCTAAATCGCCAACCATTTTCTCCGGACG
AGCTTGATGAGGTCATTATTGGTAGCGCTATGCCAGGACCAGACGAGGCCAATATCGCTCGCGTGGTTGCTCTGCGTTTG
GGATGTGGTGATAAGGTGCCTGCATTTACTGTAATGAGAAATTGTGCGTCAGGCATGCAGGCATTGGATAATGCCGCAAT
ACAAATTGCTACAGGGCGCAGTAATTTGGTCCTCGCTGGTGGAACAGATGCCATGAGCCATGCACCGTTGTTATTTAATG
AAAAAATGGCTTCCTGGCTGGCAAACTGGTTTGCAGCTAAAAGTATGGGGCAAAAGCTGGCTTTAATTACAAAGTTTAAA
CCTTCTTATCTGGCACCGGTAATCGCTTTGCTCAGAGGCCTGACTGATCCGATAGTAGGATTGAATATGGGACAAACAGC
TGAGAAAGTAGCTTATCGATTTAACATCACAAGAGAGCAAATGGATGAATTCGCAGCTCAAAGCCATTTAAGAATAGCTC
AAGCTTATGCTGAAAATAGAATGTCTGAAGTTGCCCCAATTATAGATTACAAAGGTTGTATATATCCTCAAGATGATGGG
ATTAGGGCAGATTCTACGGTGGAAAAATTGTCAAAACTAAAACCATTTTTTGACAAAAAATATGGCATGGTCACCCCAGG
TAACAGTTCACAGATAACTGATGGAGCCTGTTTGTTGCTATTAGCCAGCGCTGAGGCTGTAAAAAAATATGCTTTACCGG
TATTAGGCCGAATAGTTGATTCACAATGGGCTGCTCTAGATCCCTCTCAAATGGGTTTGGGTCCTGTTCATGCGGCAACC
CCTATATTAGAAAGACATAACCTAAAGCCACAGGATTTGGATTGTTGGGAAATCAATGAAGCCTTTGCCGCTCAAGTCTT
AGGGTGTTTGGCTGCATGGGATGATGAAGAATACTGCAAAACACAGCTTGGCCTTAAGGGGGCAATTGGAGCGCCGTCGC
TGGAGCGGCTCAATCGGGATGGAGGAGCAATTGCGTTAGGTCATCCTATTGGTGCCAGTGGGGCTCGTATTGTGTTGCAC
GTTCTTAAATCTTTAGAGCAAAGAAATGAGTCGCGAGGTATGGCAGCAATTTGTATCGGAGGTGGTCAGGGAGGAGCTAT
GTATCTTGAACGAGTTACTGAGGTGAAAGGACATGAATAA

Upstream 100 bases:

>100_bases
AATCATCTTAAGATTTCCAAAATATCAAGAATACTGCTAATCTTTGAATCTGTTGATTTTAGTATAGATTCTTATGCAGA
GGCCCTAACAAGGAGGACTA

Downstream 100 bases:

>100_bases
TTATAAACATTGGGATTTACAACGAGACAAAGATGCCATTCTGTGGCTTGGATTAAATAGAAGAGATGCTGCTGTTAATA
GTATTAATGAAGAAGTCTTG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKHQSNLSGRNVYVVDGSRTPFLKAKGVGPFCGSDLAVAAGTTLLNRQPFSPDELDEVIIGSAMPGPDEANIARVVALRL
GCGDKVPAFTVMRNCASGMQALDNAAIQIATGRSNLVLAGGTDAMSHAPLLFNEKMASWLANWFAAKSMGQKLALITKFK
PSYLAPVIALLRGLTDPIVGLNMGQTAEKVAYRFNITREQMDEFAAQSHLRIAQAYAENRMSEVAPIIDYKGCIYPQDDG
IRADSTVEKLSKLKPFFDKKYGMVTPGNSSQITDGACLLLLASAEAVKKYALPVLGRIVDSQWAALDPSQMGLGPVHAAT
PILERHNLKPQDLDCWEINEAFAAQVLGCLAAWDDEEYCKTQLGLKGAIGAPSLERLNRDGGAIALGHPIGASGARIVLH
VLKSLEQRNESRGMAAICIGGGQGGAMYLERVTEVKGHE

Sequences:

>Translated_439_residues
MKHQSNLSGRNVYVVDGSRTPFLKAKGVGPFCGSDLAVAAGTTLLNRQPFSPDELDEVIIGSAMPGPDEANIARVVALRL
GCGDKVPAFTVMRNCASGMQALDNAAIQIATGRSNLVLAGGTDAMSHAPLLFNEKMASWLANWFAAKSMGQKLALITKFK
PSYLAPVIALLRGLTDPIVGLNMGQTAEKVAYRFNITREQMDEFAAQSHLRIAQAYAENRMSEVAPIIDYKGCIYPQDDG
IRADSTVEKLSKLKPFFDKKYGMVTPGNSSQITDGACLLLLASAEAVKKYALPVLGRIVDSQWAALDPSQMGLGPVHAAT
PILERHNLKPQDLDCWEINEAFAAQVLGCLAAWDDEEYCKTQLGLKGAIGAPSLERLNRDGGAIALGHPIGASGARIVLH
VLKSLEQRNESRGMAAICIGGGQGGAMYLERVTEVKGHE
>Mature_439_residues
MKHQSNLSGRNVYVVDGSRTPFLKAKGVGPFCGSDLAVAAGTTLLNRQPFSPDELDEVIIGSAMPGPDEANIARVVALRL
GCGDKVPAFTVMRNCASGMQALDNAAIQIATGRSNLVLAGGTDAMSHAPLLFNEKMASWLANWFAAKSMGQKLALITKFK
PSYLAPVIALLRGLTDPIVGLNMGQTAEKVAYRFNITREQMDEFAAQSHLRIAQAYAENRMSEVAPIIDYKGCIYPQDDG
IRADSTVEKLSKLKPFFDKKYGMVTPGNSSQITDGACLLLLASAEAVKKYALPVLGRIVDSQWAALDPSQMGLGPVHAAT
PILERHNLKPQDLDCWEINEAFAAQVLGCLAAWDDEEYCKTQLGLKGAIGAPSLERLNRDGGAIALGHPIGASGARIVLH
VLKSLEQRNESRGMAAICIGGGQGGAMYLERVTEVKGHE

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=37.1158392434988, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI167614485, Length=427, Percent_Identity=36.5339578454333, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI148539872, Length=432, Percent_Identity=33.5648148148148, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI4501853, Length=436, Percent_Identity=33.4862385321101, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4557237, Length=438, Percent_Identity=31.0502283105023, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI194353979, Length=254, Percent_Identity=28.3464566929134, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1788683, Length=429, Percent_Identity=34.7319347319347, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1787663, Length=431, Percent_Identity=37.3549883990719, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1788554, Length=434, Percent_Identity=35.0230414746544, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI48994986, Length=432, Percent_Identity=36.5740740740741, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI87082165, Length=430, Percent_Identity=32.5581395348837, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=432, Percent_Identity=36.8055555555556, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=33.0188679245283, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI25147385, Length=436, Percent_Identity=30.7339449541284, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17535921, Length=433, Percent_Identity=29.3302540415704, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=204, Percent_Identity=30.3921568627451, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6322031, Length=373, Percent_Identity=34.0482573726542, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=439, Percent_Identity=31.8906605922551, Blast_Score=162, Evalue=9e-41,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=35.1288056206089, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24655093, Length=428, Percent_Identity=34.5794392523364, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI17648125, Length=437, Percent_Identity=33.8672768878719, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24640423, Length=426, Percent_Identity=30.0469483568075, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 46978; Mature: 46978

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHQSNLSGRNVYVVDGSRTPFLKAKGVGPFCGSDLAVAAGTTLLNRQPFSPDELDEVII
CCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCHHHHHCCHHHCCCCCCHHHHHHHHC
GSAMPGPDEANIARVVALRLGCGDKVPAFTVMRNCASGMQALDNAAIQIATGRSNLVLAG
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEC
GTDAMSHAPLLFNEKMASWLANWFAAKSMGQKLALITKFKPSYLAPVIALLRGLTDPIVG
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCCCCCCCC
LNMGQTAEKVAYRFNITREQMDEFAAQSHLRIAQAYAENRMSEVAPIIDYKGCIYPQDDG
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IRADSTVEKLSKLKPFFDKKYGMVTPGNSSQITDGACLLLLASAEAVKKYALPVLGRIVD
CCCHHHHHHHHHHCHHHHCCCCEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
SQWAALDPSQMGLGPVHAATPILERHNLKPQDLDCWEINEAFAAQVLGCLAAWDDEEYCK
CCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
TQLGLKGAIGAPSLERLNRDGGAIALGHPIGASGARIVLHVLKSLEQRNESRGMAAICIG
HHCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEE
GGQGGAMYLERVTEVKGHE
CCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MKHQSNLSGRNVYVVDGSRTPFLKAKGVGPFCGSDLAVAAGTTLLNRQPFSPDELDEVII
CCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCHHHHHCCHHHCCCCCCHHHHHHHHC
GSAMPGPDEANIARVVALRLGCGDKVPAFTVMRNCASGMQALDNAAIQIATGRSNLVLAG
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEC
GTDAMSHAPLLFNEKMASWLANWFAAKSMGQKLALITKFKPSYLAPVIALLRGLTDPIVG
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCCCCCCCC
LNMGQTAEKVAYRFNITREQMDEFAAQSHLRIAQAYAENRMSEVAPIIDYKGCIYPQDDG
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IRADSTVEKLSKLKPFFDKKYGMVTPGNSSQITDGACLLLLASAEAVKKYALPVLGRIVD
CCCHHHHHHHHHHCHHHHCCCCEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
SQWAALDPSQMGLGPVHAATPILERHNLKPQDLDCWEINEAFAAQVLGCLAAWDDEEYCK
CCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
TQLGLKGAIGAPSLERLNRDGGAIALGHPIGASGARIVLHVLKSLEQRNESRGMAAICIG
HHCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEE
GGQGGAMYLERVTEVKGHE
CCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA