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The map label for this gene is pacS [H]

Identifier: 148358440

GI number: 148358440

Start: 321758

End: 324316

Strand: Reverse

Name: pacS [H]

Synonym: LPC_0306

Alternate gene names: 148358440

Gene position: 324316-321758 (Counterclockwise)

Preceding gene: 148358442

Following gene: 148358439

Centisome position: 9.07

GC content: 40.6

Gene sequence:

>2559_bases
ATGCTGTATAGTAATTATCGATTCTACCTTGCAAAAGATGCCCAACTTCTCAACCCGGAAGAATCCAGAGAAGCAATTGA
GCAGATTTTGGCTAAAACTAAAGAGTTGGAGTTAATAAGAGTAGCTGTCGATTTGACTAGTTCAAATAAAAGCATCTGCT
TATTGAGCGCATCCAAAGAGAGTCATGTCATAAAAACCAAAGTGACCCAGATTTTAAAGGAGCAAGGCCTTTCTATAATA
GACATGATGGAAGTAGAAGTACTCCAAGATATTGAAAAAATAGAGCATCACCATCCTACTCATAAGTCTAAGGACACACA
TCTTCATCCCATTAAAAAGCACCCAAAAAAAGCGAAACATGACCATTCTCATGGGCATGGGCACCACCATGGACATCATC
ATGAAAATCATTGGATCAAAGCGGCATTAGGTTTGATTTGGGGAATTGGATTACTTGTTCTTTCTATTGGGACTTTTAAT
ATTCCCCTGGTTGCTTACTATGTCATTACAGGACTTACCTCTTTGATGACTTTGTATTTGGGCCATACAGTTTATCAATC
AGCCTGGCAAGCATTGAAAGAAAAAAAATGGGACACCACTACCTTATACTCAATTAGCACTCTCACTATTCTTGCTGTTT
CTATTGCGAGCGTTTTTGTCCCTGGCCTACCCATGATGTTTGAGGCAGCCCCTCTGGTTTTAGGCTTTTGGCATTTAGGT
GAAGGAATTGAACATACTCTGGTCGGTAAAATCAATAAAAAATTGGATGTCCGGGATTGTGTACCACCATTAGTCCTGTT
AAAAGGTAATCCGGATAAAGAGATTTCAGTCAAGACATTAATTCCTAACGACATGATTATCGTTAAAAAAGGACAGGTCA
TTCCTGTTGATGGTGTCTTAACGCAAAAAGCGCTCCTTTATACCACAAGAATTGATGGCTCGCCCAAACTCAAAGAATTT
CACCCTGGCGATGTTGTAAAAGCTGGCATGCAATTGGCAGATCATATTCCTTCTCTGGAAATGCAGGTTACCAAAACTTA
TCAAAATTCTTATCTGTCATTGATTGCCGAAAACATTAATAAAGCGAATGATGAGAAAGCGCCTATCGAAATGTTTGCAA
ACAAGGTATTGAAATATTTTATCCCTGGTTTGATTGCGGTAGCGCTTCTATCGGGGATTGTCATCGGTTCGTTGTTTAAC
CCGGCACTGGCTATTCAATGCGTCGTGTCTGTTCTGGTAAGTGCCTGCCCGTGCGCTTTGAGTTTAATTACCCCAATGGC
AGTTAAAATCGGTATGAAAAAAGCCTCTGAAAACGGCATCCACTTTAACAACGGTAAAGCCTTGCAAGCAGCAGCCGACA
TCGATACCGTTGTTTTTGATTTAAATGGCACTCTGACTCAGGGCAAAATGGTGGTAAAATCATTGCATATTACCGATAAA
AAGTATTTGCGCCCTATTGCATTACTGGAAAGCCAGTCGGATCATCCGGTAGCGAAAATTATTAAATCTTACATAGAACA
GCAAGACACGGTTTCAACCGAACCATTAGAAATAGCCTCCATTGACAAAAGCCATCATTCTGGCATGAAAGGTATTATTA
ATGGTGAGGCCTTTATGATAGGGAATAAAGACATGCTTGCAGCCAATGGAATTACCTCTATCGACAAACCCTATGATAAT
CCTGAAAAAGGCTCTGTTTATATTGTGCGCGGGACAACGGTGATAGGACAAATTGCCTTAATTGATCCATTGCGAGAGGA
TGCCATTGCTACAGTGAAGCAATTGAAACGTCTTGGTAAATCCGTACATATTTGCACCGGGGCAGATCAGGCTACTGCAG
AAAAATATGCGGCATTATTAGGCATTCCCAAAGATAATATCTGTGCGAACACTGTGGGGGCTGTCACGCAAAAGGGGGAA
GTATCCAAAACCAGTTATATTCAACAATTAAAGCAAAAAGGCTTTAAAGTAGCTATGGTTGGTGATGCCGCTAATGACGC
TACCGCAATTGCCTATTCCGATATAGGCATTGCTGTTAAATCAAGTATCGGCGACTCCATAACCGAACAACATGCCGGCA
TAGTCGTACAACAAGGGTTATTATTTCCTATAGCAACAGCATTTGATGTAGCCCAAAAAACCAAACAAAATATTTTCCAA
AACCTGTTCGTGAGCCTAAGCTATAACTCAATAATTACGCTTGTGGCAGCGGGGTTGTTTGTGGCATTAGGTTTTGCACT
AAATCCTGTGCTGGGTGTCGCATTGATGGTACTTGAATCCACTATTGTTTTGACGAACTTATACCTTTTCAAGCAACAAG
ACATTGTATCCTCAACATCACCCAATGCTAATAATGCTGTAGAGGTCGAGCCCACTGTCAATACAACCTCAAAAGTCTTG
CATGCTTTAGGGCATCGTTCCCAGCCTCAAGAAAATTTAGCAATTGTGACAGAGTCTAAACTAGTCAATCCCAAAGTAAT
AAATTTGTTTGCGCCTAAAGAACTTTCTTCTAATAGACCTGATGTCACTCAACAAAAATTGGGGTGTGTAACCTGTTGA

Upstream 100 bases:

>100_bases
CAGCTGGATCTATTGTGCAGATCAAGTTTCAAAATAGGCATTTGCAGAAAATTAACCTTTCTCTATAGCAACCAGAAACC
CCTTTAAATAGAGGAAAGCC

Downstream 100 bases:

>100_bases
TCAAGTAATACTGAATTGCCTTGATTTTCTACTTCAAGGCAGTTGTTACGATAATCATCTTTTCGTTAATAACTGTTTTT
TGGACTATACTCATATCAAG

Product: heavy metal transporting P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 852; Mature: 852

Protein sequence:

>852_residues
MLYSNYRFYLAKDAQLLNPEESREAIEQILAKTKELELIRVAVDLTSSNKSICLLSASKESHVIKTKVTQILKEQGLSII
DMMEVEVLQDIEKIEHHHPTHKSKDTHLHPIKKHPKKAKHDHSHGHGHHHGHHHENHWIKAALGLIWGIGLLVLSIGTFN
IPLVAYYVITGLTSLMTLYLGHTVYQSAWQALKEKKWDTTTLYSISTLTILAVSIASVFVPGLPMMFEAAPLVLGFWHLG
EGIEHTLVGKINKKLDVRDCVPPLVLLKGNPDKEISVKTLIPNDMIIVKKGQVIPVDGVLTQKALLYTTRIDGSPKLKEF
HPGDVVKAGMQLADHIPSLEMQVTKTYQNSYLSLIAENINKANDEKAPIEMFANKVLKYFIPGLIAVALLSGIVIGSLFN
PALAIQCVVSVLVSACPCALSLITPMAVKIGMKKASENGIHFNNGKALQAAADIDTVVFDLNGTLTQGKMVVKSLHITDK
KYLRPIALLESQSDHPVAKIIKSYIEQQDTVSTEPLEIASIDKSHHSGMKGIINGEAFMIGNKDMLAANGITSIDKPYDN
PEKGSVYIVRGTTVIGQIALIDPLREDAIATVKQLKRLGKSVHICTGADQATAEKYAALLGIPKDNICANTVGAVTQKGE
VSKTSYIQQLKQKGFKVAMVGDAANDATAIAYSDIGIAVKSSIGDSITEQHAGIVVQQGLLFPIATAFDVAQKTKQNIFQ
NLFVSLSYNSIITLVAAGLFVALGFALNPVLGVALMVLESTIVLTNLYLFKQQDIVSSTSPNANNAVEVEPTVNTTSKVL
HALGHRSQPQENLAIVTESKLVNPKVINLFAPKELSSNRPDVTQQKLGCVTC

Sequences:

>Translated_852_residues
MLYSNYRFYLAKDAQLLNPEESREAIEQILAKTKELELIRVAVDLTSSNKSICLLSASKESHVIKTKVTQILKEQGLSII
DMMEVEVLQDIEKIEHHHPTHKSKDTHLHPIKKHPKKAKHDHSHGHGHHHGHHHENHWIKAALGLIWGIGLLVLSIGTFN
IPLVAYYVITGLTSLMTLYLGHTVYQSAWQALKEKKWDTTTLYSISTLTILAVSIASVFVPGLPMMFEAAPLVLGFWHLG
EGIEHTLVGKINKKLDVRDCVPPLVLLKGNPDKEISVKTLIPNDMIIVKKGQVIPVDGVLTQKALLYTTRIDGSPKLKEF
HPGDVVKAGMQLADHIPSLEMQVTKTYQNSYLSLIAENINKANDEKAPIEMFANKVLKYFIPGLIAVALLSGIVIGSLFN
PALAIQCVVSVLVSACPCALSLITPMAVKIGMKKASENGIHFNNGKALQAAADIDTVVFDLNGTLTQGKMVVKSLHITDK
KYLRPIALLESQSDHPVAKIIKSYIEQQDTVSTEPLEIASIDKSHHSGMKGIINGEAFMIGNKDMLAANGITSIDKPYDN
PEKGSVYIVRGTTVIGQIALIDPLREDAIATVKQLKRLGKSVHICTGADQATAEKYAALLGIPKDNICANTVGAVTQKGE
VSKTSYIQQLKQKGFKVAMVGDAANDATAIAYSDIGIAVKSSIGDSITEQHAGIVVQQGLLFPIATAFDVAQKTKQNIFQ
NLFVSLSYNSIITLVAAGLFVALGFALNPVLGVALMVLESTIVLTNLYLFKQQDIVSSTSPNANNAVEVEPTVNTTSKVL
HALGHRSQPQENLAIVTESKLVNPKVINLFAPKELSSNRPDVTQQKLGCVTC
>Mature_852_residues
MLYSNYRFYLAKDAQLLNPEESREAIEQILAKTKELELIRVAVDLTSSNKSICLLSASKESHVIKTKVTQILKEQGLSII
DMMEVEVLQDIEKIEHHHPTHKSKDTHLHPIKKHPKKAKHDHSHGHGHHHGHHHENHWIKAALGLIWGIGLLVLSIGTFN
IPLVAYYVITGLTSLMTLYLGHTVYQSAWQALKEKKWDTTTLYSISTLTILAVSIASVFVPGLPMMFEAAPLVLGFWHLG
EGIEHTLVGKINKKLDVRDCVPPLVLLKGNPDKEISVKTLIPNDMIIVKKGQVIPVDGVLTQKALLYTTRIDGSPKLKEF
HPGDVVKAGMQLADHIPSLEMQVTKTYQNSYLSLIAENINKANDEKAPIEMFANKVLKYFIPGLIAVALLSGIVIGSLFN
PALAIQCVVSVLVSACPCALSLITPMAVKIGMKKASENGIHFNNGKALQAAADIDTVVFDLNGTLTQGKMVVKSLHITDK
KYLRPIALLESQSDHPVAKIIKSYIEQQDTVSTEPLEIASIDKSHHSGMKGIINGEAFMIGNKDMLAANGITSIDKPYDN
PEKGSVYIVRGTTVIGQIALIDPLREDAIATVKQLKRLGKSVHICTGADQATAEKYAALLGIPKDNICANTVGAVTQKGE
VSKTSYIQQLKQKGFKVAMVGDAANDATAIAYSDIGIAVKSSIGDSITEQHAGIVVQQGLLFPIATAFDVAQKTKQNIFQ
NLFVSLSYNSIITLVAAGLFVALGFALNPVLGVALMVLESTIVLTNLYLFKQQDIVSSTSPNANNAVEVEPTVNTTSKVL
HALGHRSQPQENLAIVTESKLVNPKVINLFAPKELSSNRPDVTQQKLGCVTC

Specific function: May play a role in the osmotic adaptation [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=734, Percent_Identity=26.2942779291553, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI115529486, Length=680, Percent_Identity=26.1764705882353, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI55743073, Length=532, Percent_Identity=26.8796992481203, Blast_Score=150, Evalue=7e-36,
Organism=Escherichia coli, GI1786691, Length=670, Percent_Identity=30, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI1789879, Length=613, Percent_Identity=28.5481239804241, Blast_Score=151, Evalue=2e-37,
Organism=Escherichia coli, GI1786914, Length=440, Percent_Identity=25.6818181818182, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17556548, Length=680, Percent_Identity=25.8823529411765, Blast_Score=162, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320475, Length=640, Percent_Identity=28.90625, Blast_Score=201, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6319772, Length=647, Percent_Identity=25.6568778979907, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI221329854, Length=407, Percent_Identity=29.4840294840295, Blast_Score=110, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 92697; Mature: 92697

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYSNYRFYLAKDAQLLNPEESREAIEQILAKTKELELIRVAVDLTSSNKSICLLSASKE
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCEEEEEECCCC
SHVIKTKVTQILKEQGLSIIDMMEVEVLQDIEKIEHHHPTHKSKDTHLHPIKKHPKKAKH
CHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCHHCC
DHSHGHGHHHGHHHENHWIKAALGLIWGIGLLVLSIGTFNIPLVAYYVITGLTSLMTLYL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GHTVYQSAWQALKEKKWDTTTLYSISTLTILAVSIASVFVPGLPMMFEAAPLVLGFWHLG
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
EGIEHTLVGKINKKLDVRDCVPPLVLLKGNPDKEISVKTLIPNDMIIVKKGQVIPVDGVL
CCCCHHHHHHHCCCCCHHHCCCCEEEEECCCCCCEEEEEECCCCEEEEECCCEEECCCHH
TQKALLYTTRIDGSPKLKEFHPGDVVKAGMQLADHIPSLEMQVTKTYQNSYLSLIAENIN
HCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHH
KANDEKAPIEMFANKVLKYFIPGLIAVALLSGIVIGSLFNPALAIQCVVSVLVSACPCAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLITPMAVKIGMKKASENGIHFNNGKALQAAADIDTVVFDLNGTLTQGKMVVKSLHITDK
HHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCH
KYLRPIALLESQSDHPVAKIIKSYIEQQDTVSTEPLEIASIDKSHHSGMKGIINGEAFMI
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHCCCCCEEECCCEEEE
GNKDMLAANGITSIDKPYDNPEKGSVYIVRGTTVIGQIALIDPLREDAIATVKQLKRLGK
CCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEHHHHHCHHHHHHHHHHHHHHHHCC
SVHICTGADQATAEKYAALLGIPKDNICANTVGAVTQKGEVSKTSYIQQLKQKGFKVAMV
EEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEE
GDAANDATAIAYSDIGIAVKSSIGDSITEQHAGIVVQQGLLFPIATAFDVAQKTKQNIFQ
ECCCCCCEEEEEECCCEEEHHHCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHH
NLFVSLSYNSIITLVAAGLFVALGFALNPVLGVALMVLESTIVLTNLYLFKQQDIVSSTS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNANNAVEVEPTVNTTSKVLHALGHRSQPQENLAIVTESKLVNPKVINLFAPKELSSNRP
CCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEECCHHHCCCCC
DVTQQKLGCVTC
CHHHHHCCCCCC
>Mature Secondary Structure
MLYSNYRFYLAKDAQLLNPEESREAIEQILAKTKELELIRVAVDLTSSNKSICLLSASKE
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCEEEEEECCCC
SHVIKTKVTQILKEQGLSIIDMMEVEVLQDIEKIEHHHPTHKSKDTHLHPIKKHPKKAKH
CHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCHHCC
DHSHGHGHHHGHHHENHWIKAALGLIWGIGLLVLSIGTFNIPLVAYYVITGLTSLMTLYL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GHTVYQSAWQALKEKKWDTTTLYSISTLTILAVSIASVFVPGLPMMFEAAPLVLGFWHLG
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
EGIEHTLVGKINKKLDVRDCVPPLVLLKGNPDKEISVKTLIPNDMIIVKKGQVIPVDGVL
CCCCHHHHHHHCCCCCHHHCCCCEEEEECCCCCCEEEEEECCCCEEEEECCCEEECCCHH
TQKALLYTTRIDGSPKLKEFHPGDVVKAGMQLADHIPSLEMQVTKTYQNSYLSLIAENIN
HCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHH
KANDEKAPIEMFANKVLKYFIPGLIAVALLSGIVIGSLFNPALAIQCVVSVLVSACPCAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLITPMAVKIGMKKASENGIHFNNGKALQAAADIDTVVFDLNGTLTQGKMVVKSLHITDK
HHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCH
KYLRPIALLESQSDHPVAKIIKSYIEQQDTVSTEPLEIASIDKSHHSGMKGIINGEAFMI
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHCCCCCEEECCCEEEE
GNKDMLAANGITSIDKPYDNPEKGSVYIVRGTTVIGQIALIDPLREDAIATVKQLKRLGK
CCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEHHHHHCHHHHHHHHHHHHHHHHCC
SVHICTGADQATAEKYAALLGIPKDNICANTVGAVTQKGEVSKTSYIQQLKQKGFKVAMV
EEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEE
GDAANDATAIAYSDIGIAVKSSIGDSITEQHAGIVVQQGLLFPIATAFDVAQKTKQNIFQ
ECCCCCCEEEEEECCCEEEHHHCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHH
NLFVSLSYNSIITLVAAGLFVALGFALNPVLGVALMVLESTIVLTNLYLFKQQDIVSSTS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNANNAVEVEPTVNTTSKVLHALGHRSQPQENLAIVTESKLVNPKVINLFAPKELSSNRP
CCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEECCHHHCCCCC
DVTQQKLGCVTC
CHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]