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The map label for this gene is lysP [H]

Identifier: 148268162

GI number: 148268162

Start: 1836860

End: 1838353

Strand: Reverse

Name: lysP [H]

Synonym: SaurJH9_1739

Alternate gene names: 148268162

Gene position: 1838353-1836860 (Counterclockwise)

Preceding gene: 148268163

Following gene: 148268161

Centisome position: 63.25

GC content: 34.34

Gene sequence:

>1494_bases
ATGTCAAAAGTTCAAAATGAAAGTAACAATGTTGTCAAAAGGGGACTTAAAGATCGTCATATTTCTATGATTGCGATTGG
GGGTTGTATTGGTACAGGTTTATTTGTAACTTCTGGTGGAGCAATTCATGATGCAGGTGCTTTGGGTGCATTAATAGGAT
ACGCAATTATCGGAATAATGGTATTTTTCTTAATGACGTCACTTGGTGAAATGGCTACGTATTTACCAGTATCAGGTTCA
TTTAGTACATATGCTACAAGATTTGTTGATCCATCTTTAGGGTTTGCGCTTGGTTGGAACTATTGGTTTAACTGGGTAGT
AACTGTAGCAGCAGATATTACGATTGCAGCACAAGTCATTCAATATTGGACACCATTGCAAGGCATACCCGCTTGGGCAT
GGAGTGCGTTGTTTTTAGTTATAATTTTTAGTCTGAATTCGTTATCAGTTCGCGTCTATGGTGAAAGTGAATACTGGTTG
GCATTGATAAAAGTGATTACAGTTATTGTTTTCATTGCAATTGGTTTATTAACGATTGTAGGAATCATGGGTGGTCATGT
TGTAGGATTTGAAATATTTAATAAAGGTGAAGGTCCTATTCTTGGTGGCAACTTAGGAGGAAGTTTGTTATCAATTCTAG
GTGTATTCTTAATCGCTGGTTTCTCATTCCAAGGTACTGAGTTAATTGGTATTACGGCTGGTGAATCAGAAAATCCTGAA
CGTGCTGTGCCGAAAGCAATTAAACAAGTATTCTGGAGAATTTTATTATTTTACATTTTAGCCATTTTTGTTATCGGTAT
GTTAATTCCTTATGATAGTAGTGCATTAATGGGTGGTAGTGATAATGTAGCAACGTCTCCATTCACATTAGTGTTTAAAA
ATGCTGGATTTGCGTTTGCAGCATCATTTATGAATGCAGTCATTTTAACGTCTGTGTTATCAGCAGGTAACTCAGGTATG
TATGCTTCAACCCGAATGCTATATTCAATGAGTAAAGATAAATTAGCGTTTGAAGCATTTGGTAAAACAAATAAAAACGG
TGTGCCATATATGTCGTTACTCGTTACAGCAATCATTGTAGTGATTATTTTCGTATTACAAAGCCTTACAAAAGGTGCAT
ACGAATATATCGTTGCAGCAAGTGGTTTAACTGGTTTTATTGCTTGGGTAGGTATAGCAGTAAGTCATTATCGATTTAGA
AGAGCATTTGATAAACAAAATTATGACAAATCTAAATTAAAATATACTGCTAAATTATTCCCATTCGGACCATTATTTGC
TGGCTTTTTATGTATTGTAGTAATTATTGGTCAAGATGTTGACTTTATTAAAACAGGAGATTTTAATTTTAGTCGCTTCT
TAATTACGTATATGGGAATTCCAGTATTTTTAGCATTCTTTATTTATCATAAGCTTCGATATAAAACGAAAAAAATTCCA
TTAGAACAAGTAGATTTACGTCAAGACGTGTCAATGGATGAAATAAAAGGTTAA

Upstream 100 bases:

>100_bases
CTTTTTTACTTTTAATATCACTATGTTCTGTAAAAAAGGGTATGAAAGTGAATAAAGGTTATTTATTTCTTGGCCTCTAA
AACATGGAAAGGGAGCTTAT

Downstream 100 bases:

>100_bases
AATAAAAATAATTACAGTTATAGTGTTGACTTAAATGTGAATTGTTGATATGATTAACAACGTTGAATACGAAACGAACC
AAGTAGAAGCACCCGCTTCT

Product: amino acid permease-associated region

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MSKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIMVFFLMTSLGEMATYLPVSGS
FSTYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVIQYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWL
ALIKVITVIVFIAIGLLTIVGIMGGHVVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPE
RAVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGSDNVATSPFTLVFKNAGFAFAASFMNAVILTSVLSAGNSGM
YASTRMLYSMSKDKLAFEAFGKTNKNGVPYMSLLVTAIIVVIIFVLQSLTKGAYEYIVAASGLTGFIAWVGIAVSHYRFR
RAFDKQNYDKSKLKYTAKLFPFGPLFAGFLCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIP
LEQVDLRQDVSMDEIKG

Sequences:

>Translated_497_residues
MSKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIMVFFLMTSLGEMATYLPVSGS
FSTYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVIQYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWL
ALIKVITVIVFIAIGLLTIVGIMGGHVVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPE
RAVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGSDNVATSPFTLVFKNAGFAFAASFMNAVILTSVLSAGNSGM
YASTRMLYSMSKDKLAFEAFGKTNKNGVPYMSLLVTAIIVVIIFVLQSLTKGAYEYIVAASGLTGFIAWVGIAVSHYRFR
RAFDKQNYDKSKLKYTAKLFPFGPLFAGFLCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIP
LEQVDLRQDVSMDEIKG
>Mature_496_residues
SKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIMVFFLMTSLGEMATYLPVSGSF
STYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVIQYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWLA
LIKVITVIVFIAIGLLTIVGIMGGHVVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPER
AVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGSDNVATSPFTLVFKNAGFAFAASFMNAVILTSVLSAGNSGMY
ASTRMLYSMSKDKLAFEAFGKTNKNGVPYMSLLVTAIIVVIIFVLQSLTKGAYEYIVAASGLTGFIAWVGIAVSHYRFRR
AFDKQNYDKSKLKYTAKLFPFGPLFAGFLCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIPL
EQVDLRQDVSMDEIKG

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=490, Percent_Identity=50.2040816326531, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI87081708, Length=446, Percent_Identity=37.8923766816144, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI1786789, Length=472, Percent_Identity=36.6525423728814, Blast_Score=273, Evalue=3e-74,
Organism=Escherichia coli, GI1786302, Length=483, Percent_Identity=35.8178053830228, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI48994972, Length=442, Percent_Identity=37.3303167420815, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789017, Length=450, Percent_Identity=34, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI87081915, Length=403, Percent_Identity=34.4913151364764, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1790653, Length=451, Percent_Identity=33.9246119733925, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI1786602, Length=409, Percent_Identity=34.9633251833741, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI87081869, Length=406, Percent_Identity=23.6453201970443, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=446, Percent_Identity=23.3183856502242, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=484, Percent_Identity=38.8429752066116, Blast_Score=344, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6320772, Length=495, Percent_Identity=39.1919191919192, Blast_Score=335, Evalue=8e-93,
Organism=Saccharomyces cerevisiae, GI6324990, Length=492, Percent_Identity=35.9756097560976, Blast_Score=312, Evalue=6e-86,
Organism=Saccharomyces cerevisiae, GI6324059, Length=496, Percent_Identity=37.9032258064516, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6322892, Length=496, Percent_Identity=36.491935483871, Blast_Score=295, Evalue=8e-81,
Organism=Saccharomyces cerevisiae, GI6324553, Length=501, Percent_Identity=34.5309381237525, Blast_Score=270, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6324924, Length=500, Percent_Identity=32.6, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6321629, Length=500, Percent_Identity=30.6, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6320717, Length=493, Percent_Identity=29.2089249492901, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6319824, Length=502, Percent_Identity=30.0796812749004, Blast_Score=243, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6319543, Length=496, Percent_Identity=30.4435483870968, Blast_Score=232, Evalue=9e-62,
Organism=Saccharomyces cerevisiae, GI6321053, Length=490, Percent_Identity=31.6326530612245, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6322967, Length=507, Percent_Identity=29.585798816568, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6319542, Length=488, Percent_Identity=28.8934426229508, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6320251, Length=491, Percent_Identity=28.3095723014257, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324981, Length=494, Percent_Identity=30.5668016194332, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6319608, Length=504, Percent_Identity=28.5714285714286, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320364, Length=550, Percent_Identity=27.4545454545455, Blast_Score=185, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54234; Mature: 54102

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIM
CCCCCCCCHHHHHCCCCCCCEEEEEECCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHH
VFFLMTSLGEMATYLPVSGSFSTYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVI
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWLALIKVITVIVFIAIGLLTIV
HHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
GIMGGHVVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPE
HHHCCCEEEEEEEECCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCH
RAVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGSDNVATSPFTLVFKNAGFAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
ASFMNAVILTSVLSAGNSGMYASTRMLYSMSKDKLAFEAFGKTNKNGVPYMSLLVTAIIV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHH
VIIFVLQSLTKGAYEYIVAASGLTGFIAWVGIAVSHYRFRRAFDKQNYDKSKLKYTAKLF
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
PFGPLFAGFLCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIP
CCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LEQVDLRQDVSMDEIKG
HHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
SKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIM
CCCCCCCHHHHHCCCCCCCEEEEEECCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHH
VFFLMTSLGEMATYLPVSGSFSTYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVI
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWLALIKVITVIVFIAIGLLTIV
HHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
GIMGGHVVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPE
HHHCCCEEEEEEEECCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCH
RAVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGSDNVATSPFTLVFKNAGFAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
ASFMNAVILTSVLSAGNSGMYASTRMLYSMSKDKLAFEAFGKTNKNGVPYMSLLVTAIIV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHH
VIIFVLQSLTKGAYEYIVAASGLTGFIAWVGIAVSHYRFRRAFDKQNYDKSKLKYTAKLF
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
PFGPLFAGFLCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIP
CCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LEQVDLRQDVSMDEIKG
HHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]