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The map label for this gene is pyrP [H]

Identifier: 148267690

GI number: 148267690

Start: 1303106

End: 1304413

Strand: Direct

Name: pyrP [H]

Synonym: SaurJH9_1258

Alternate gene names: 148267690

Gene position: 1303106-1304413 (Clockwise)

Preceding gene: 148267689

Following gene: 148267691

Centisome position: 44.83

GC content: 34.94

Gene sequence:

>1308_bases
ATGCAAAATGATGAAATGTTTGAACGAACAGTAAAACCAGTACTAGATGTAAATGAAAAACCACAACCAGCGCAATGGGC
ATTTTTAAGCTTACAACATTTATTTGCGATGTTTGGCGCAACAGTACTAGTACCATTCTTAACAGGACTACCAATATCCG
CAGCGTTACTAGCTTCGGGAATCGGTACATTACTTTATATCTTAATAACGAAGGCGCAAATACCAGCATACTTGGGATCT
AGCTTTGCATTTATCACACCAATTATCACGGGATTAAGTACGCATAGCTTAGGAGACATGCTTGTAGCATTATTCATGAG
TGGTGTTATGTACGTCATCATCGGAATTCTAATCAAATTAAGTGGGACAGCATGGTTAATGAAATTATTACCACCAGTTG
TTGTTGGACCAGTCATCATGGTAATTGGTTTAAGCTTAGCGCCTACTGCAGTCAATATGGCAATGTATGAAAATCCTGGA
GATATGAAAGGTTACAATATCAGTTTCTTAATTGTTGCAATGATAACCTTGCTTGTAACAATAGTCGTTCAAGGATTTTT
TAAAGGATTCCTATCTTTAATTCCAGTACTTGTAGGTATTATCGTAGGTTATGTGGTAGCGATTTTTATGGGGATTGTGA
AATTTGATGCAATTATGTCAGCAAAATGGATAGATTTCCCTCATATTTATCTGCCATTTAAAGATTATGTACCTTCATTT
CACTTAGGACTTGTACTTGTAATGATTCCGATTGTGTTTGTAACAGTAAGTGAACATATTGGGCACCAAATGGTATTGAA
TAAAATCGTAGGTAGAAACTTCTTTGAAAAGCCAGGACTTGATAAATCAATCATTGGTGATGGTGTTTCTACAATGTTTG
CCAGTATTATTGGTGGACCACCAAGTACAACATACGGTGAAAATATCGGTGTATTAGCGATTACAAGAATATACAGTATT
TACGTCATTGGTGGTGCAGCAGTTATAGCAATTGTTTTAGCATTCATTGGTAAGTTCACTGCATTAATTTCTTCTATACC
TACACCAGTTATGGGAGGAGTATCTATATTACTTTTCGGTATTATTGCAGCAAGTGGCTTAAGAATGTTAGTTGAAAGCA
AAGTAGATTTTGCGAACAATCGAAATTTAGTTATAGCTTCTGTAATTTTAGTTGTAGGTATCGGTAATTTAGTATTTAAC
TTAAAAGAAATTGGTATCAACCTTCAAATTGAGGGGATGGCATTAGCTGCACTTTCAGGAATTATTTTGAACTTAATCTT
ACCTAAAGAGAAAAAACAAAACAATTAA

Upstream 100 bases:

>100_bases
TCTATGGACGAAAATGACTTGTAGCAACTTGTCACACTTTTTGTCTCTTTACATATACTGATGTAAAGAGATTTTTTTAT
TATCGGAGGAAATGAATATT

Downstream 100 bases:

>100_bases
GATTTACAAATTAAGGAGGGCGCTTTTATGAATCATTTATTATCAATGGAACATTTATCTACAGATCAAATATACAAACT
TATCCAAAAGGCAAGTCAAT

Product: uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MQNDEMFERTVKPVLDVNEKPQPAQWAFLSLQHLFAMFGATVLVPFLTGLPISAALLASGIGTLLYILITKAQIPAYLGS
SFAFITPIITGLSTHSLGDMLVALFMSGVMYVIIGILIKLSGTAWLMKLLPPVVVGPVIMVIGLSLAPTAVNMAMYENPG
DMKGYNISFLIVAMITLLVTIVVQGFFKGFLSLIPVLVGIIVGYVVAIFMGIVKFDAIMSAKWIDFPHIYLPFKDYVPSF
HLGLVLVMIPIVFVTVSEHIGHQMVLNKIVGRNFFEKPGLDKSIIGDGVSTMFASIIGGPPSTTYGENIGVLAITRIYSI
YVIGGAAVIAIVLAFIGKFTALISSIPTPVMGGVSILLFGIIAASGLRMLVESKVDFANNRNLVIASVILVVGIGNLVFN
LKEIGINLQIEGMALAALSGIILNLILPKEKKQNN

Sequences:

>Translated_435_residues
MQNDEMFERTVKPVLDVNEKPQPAQWAFLSLQHLFAMFGATVLVPFLTGLPISAALLASGIGTLLYILITKAQIPAYLGS
SFAFITPIITGLSTHSLGDMLVALFMSGVMYVIIGILIKLSGTAWLMKLLPPVVVGPVIMVIGLSLAPTAVNMAMYENPG
DMKGYNISFLIVAMITLLVTIVVQGFFKGFLSLIPVLVGIIVGYVVAIFMGIVKFDAIMSAKWIDFPHIYLPFKDYVPSF
HLGLVLVMIPIVFVTVSEHIGHQMVLNKIVGRNFFEKPGLDKSIIGDGVSTMFASIIGGPPSTTYGENIGVLAITRIYSI
YVIGGAAVIAIVLAFIGKFTALISSIPTPVMGGVSILLFGIIAASGLRMLVESKVDFANNRNLVIASVILVVGIGNLVFN
LKEIGINLQIEGMALAALSGIILNLILPKEKKQNN
>Mature_435_residues
MQNDEMFERTVKPVLDVNEKPQPAQWAFLSLQHLFAMFGATVLVPFLTGLPISAALLASGIGTLLYILITKAQIPAYLGS
SFAFITPIITGLSTHSLGDMLVALFMSGVMYVIIGILIKLSGTAWLMKLLPPVVVGPVIMVIGLSLAPTAVNMAMYENPG
DMKGYNISFLIVAMITLLVTIVVQGFFKGFLSLIPVLVGIIVGYVVAIFMGIVKFDAIMSAKWIDFPHIYLPFKDYVPSF
HLGLVLVMIPIVFVTVSEHIGHQMVLNKIVGRNFFEKPGLDKSIIGDGVSTMFASIIGGPPSTTYGENIGVLAITRIYSI
YVIGGAAVIAIVLAFIGKFTALISSIPTPVMGGVSILLFGIIAASGLRMLVESKVDFANNRNLVIASVILVVGIGNLVFN
LKEIGINLQIEGMALAALSGIILNLILPKEKKQNN

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=429, Percent_Identity=25.8741258741259, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI40316845, Length=429, Percent_Identity=25.8741258741259, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI44680143, Length=173, Percent_Identity=34.1040462427746, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI44680145, Length=173, Percent_Identity=34.1040462427746, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1788843, Length=418, Percent_Identity=44.4976076555024, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI87081818, Length=436, Percent_Identity=36.697247706422, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI87082181, Length=451, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1790087, Length=476, Percent_Identity=27.3109243697479, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87082178, Length=466, Percent_Identity=26.8240343347639, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17541904, Length=383, Percent_Identity=22.1932114882507, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17542262, Length=435, Percent_Identity=23.2183908045977, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=170, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71993493, Length=217, Percent_Identity=23.5023041474654, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21356175, Length=447, Percent_Identity=25.9507829977629, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46611; Mature: 46611

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCCCCC
>Mature Secondary Structure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HHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1709162; 8206849; 9384377 [H]