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The map label for this gene is cysG [H]

Identifier: 148243802

GI number: 148243802

Start: 198808

End: 199593

Strand: Direct

Name: cysG [H]

Synonym: Acry_3285

Alternate gene names: 148243802

Gene position: 198808-199593 (Clockwise)

Preceding gene: 148243801

Following gene: 148243804

Centisome position: 97.65

GC content: 71.37

Gene sequence:

>786_bases
ATGACCTCGTTGCCGCCGAATAGCAAGGCGCATCCCGTCATCCTCGCCGGCACCGGGCCGGGCGATCCGGATCTTCTCAC
CCTGCGGGCCGTACGGGCGATCGGCGCCGCCGAAATCATCCTGCATGATGCGCTGGTCGATGCTCGCATCCTGGTCCTTG
CCGCCCCGGATGCCGTCCTCATCCATGTCGGCAAGCGGTGTGGCCGGCACGCGATGAGCCAGACAGAGATCAACCGCCGC
CTTGTCGAATGCGCGCGCACCGGCGCTCGGGTGCTACGGCTGAAGGGCGGAGATCCGATGATCTTCGGCCGGGCCGGCGA
GGAGATCGCGGCCTTGCGGGCCGCAGGCATTGCGGTCGAGGTGATCCCGGGGATCACAGCGGCCTCGGCGGCGGCGGCGT
CTGCCTGCGTCTCGCTGACCGCGCGGGGCAGGGCGCGCGCTGTCACCCTGGTCACCGGCCACACCGCCGATGGCGGGCTA
CCGCCTCAGGACTGGGCGGCACTGGCCCGGCTCGATTCGACCCTCGTCTTCTACATGGGCTCCCGCCACGCCCGAGCGAT
CGCCGACCGCCTGATCGAGGCCGGGCTCGATCCCGCCACGCCGGCGATGCTGCTGACCAATGTCAGCCGCCCGGGCGAGA
CGCGCCGGCTTGCCCGCCTCATCGACCTCGCAGACGGAATCGCCGCCGCCGATCTCGCGGCCCCGGCGCTGATCCTGATC
GGCGCCGCGCTCGACGCGGCGGTTCCGGTGGCGACTATTCAGGCGGACGCCCGCGAGCTGTCGTGA

Upstream 100 bases:

>100_bases
ATCCGCGCCGGCTGCCGGAGCGTCGAGGCGATCGGCGCGGCCACCGGCGCCGGCACCGGCTGCGGTTCATGCCACTCCGA
ACTGAAGGGATTTCTCCGCC

Downstream 100 bases:

>100_bases
GCCAGCCCCGCGCCTCGACATGGTCGGCGATCCGGCGAGCCGTTTCGGGCATCGACATCCCTTCGGCGCGCCATCGCTCG
CGAAGTACCGCGATTTCAGA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MTSLPPNSKAHPVILAGTGPGDPDLLTLRAVRAIGAAEIILHDALVDARILVLAAPDAVLIHVGKRCGRHAMSQTEINRR
LVECARTGARVLRLKGGDPMIFGRAGEEIAALRAAGIAVEVIPGITAASAAAASACVSLTARGRARAVTLVTGHTADGGL
PPQDWAALARLDSTLVFYMGSRHARAIADRLIEAGLDPATPAMLLTNVSRPGETRRLARLIDLADGIAAADLAAPALILI
GAALDAAVPVATIQADARELS

Sequences:

>Translated_261_residues
MTSLPPNSKAHPVILAGTGPGDPDLLTLRAVRAIGAAEIILHDALVDARILVLAAPDAVLIHVGKRCGRHAMSQTEINRR
LVECARTGARVLRLKGGDPMIFGRAGEEIAALRAAGIAVEVIPGITAASAAAASACVSLTARGRARAVTLVTGHTADGGL
PPQDWAALARLDSTLVFYMGSRHARAIADRLIEAGLDPATPAMLLTNVSRPGETRRLARLIDLADGIAAADLAAPALILI
GAALDAAVPVATIQADARELS
>Mature_260_residues
TSLPPNSKAHPVILAGTGPGDPDLLTLRAVRAIGAAEIILHDALVDARILVLAAPDAVLIHVGKRCGRHAMSQTEINRRL
VECARTGARVLRLKGGDPMIFGRAGEEIAALRAAGIAVEVIPGITAASAAAASACVSLTARGRARAVTLVTGHTADGGLP
PQDWAALARLDSTLVFYMGSRHARAIADRLIEAGLDPATPAMLLTNVSRPGETRRLARLIDLADGIAAADLAAPALILIG
AALDAAVPVATIQADARELS

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=232, Percent_Identity=44.3965517241379, Blast_Score=176, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322922, Length=245, Percent_Identity=32.6530612244898, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 26778; Mature: 26647

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLPPNSKAHPVILAGTGPGDPDLLTLRAVRAIGAAEIILHDALVDARILVLAAPDAVL
CCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEE
IHVGKRCGRHAMSQTEINRRLVECARTGARVLRLKGGDPMIFGRAGEEIAALRAAGIAVE
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHCCEEEE
VIPGITAASAAAASACVSLTARGRARAVTLVTGHTADGGLPPQDWAALARLDSTLVFYMG
ECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEEEC
SRHARAIADRLIEAGLDPATPAMLLTNVSRPGETRRLARLIDLADGIAAADLAAPALILI
CCHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GAALDAAVPVATIQADARELS
HHHHHHHCCHHEEECHHHHCC
>Mature Secondary Structure 
TSLPPNSKAHPVILAGTGPGDPDLLTLRAVRAIGAAEIILHDALVDARILVLAAPDAVL
CCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEE
IHVGKRCGRHAMSQTEINRRLVECARTGARVLRLKGGDPMIFGRAGEEIAALRAAGIAVE
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHCCEEEE
VIPGITAASAAAASACVSLTARGRARAVTLVTGHTADGGLPPQDWAALARLDSTLVFYMG
ECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEEEC
SRHARAIADRLIEAGLDPATPAMLLTNVSRPGETRRLARLIDLADGIAAADLAAPALILI
CCHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GAALDAAVPVATIQADARELS
HHHHHHHCCHHEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA