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The map label for this gene is dsbC [H]

Identifier: 147674865

GI number: 147674865

Start: 2145844

End: 2146596

Strand: Reverse

Name: dsbC [H]

Synonym: VC0395_A1994

Alternate gene names: 147674865

Gene position: 2146596-2145844 (Counterclockwise)

Preceding gene: 147673043

Following gene: 147674577

Centisome position: 70.98

GC content: 50.6

Gene sequence:

>753_bases
ATGAGCGTACTGCGCCGACTAACATGGCTGGCATTTCCTTTACTGAGTATGGCATTCAACGTACAAGCGAACACTGCACC
AGCACAATTGAATAAAGCCGAGCTTGAGCAGCGCTTTGCCAAACTCGGATTGCAAGTGGAAGAGATAAAAACCTCTGATA
TCAATGGCTTGCTTGAAGTGCAAACGTCTGGTGGTGTGTTGTTCTCTTCGCCTGATGGTGAGCACTTTATCGCGGGTACT
CTGTATGCGCTGGATGGTAATGGCGGTTATGTTGATGTGCTGGCTAAACGCCAAGCGCCACTCAACGCCAAGAAAATTGC
CGCATTGCAAGACAGCATGATTGAGTTTAAAGCGCCCAATGAGAAATACGCGATCACCGTATTTACCGATATCACGTGTG
GTTACTGTGTGCGTCTGCACAGCCAGATCAAAGAGTACAATGATCTCGGCATTACGGTGCGTTATCTCGCCTACCCGCGT
CAGGGGCCGCAAGGTCAAGTCGCGGATCAAATGGCGGCCATCTGGTGTTCTAACGATCCGAAAGCGGCGATGCACGATGC
GAAAGTGAATCGTAAAACCATTACCGCCGATAAAGATATCGCCCAATGCCAAAAGACCATCGCGCAGCACTATATGCTGG
GTCACGAGCTCGGCATTAGCGGTACTCCAGCGATTTTCTTACCCAATGGTGAGATGGTTGGCGGCTATTTGCCTGCGCCG
CAATTGCTGCAACGCCTGCAAGCCACACAATAG

Upstream 100 bases:

>100_bases
GATTTATCGACCACACAAATTTATACTCATGTCGCCACTGAGCGGCTTAAACAACTCCACAACGAGCACCATCCAAGGGC
TTGAAAATAAGGTGATTTTC

Downstream 100 bases:

>100_bases
TTTTTCATTTTCGACTAATTAAGGAAACAGGCCAGAGGCAACTTTGGCCTGTCACAGCATGATAGAAATCCAGCGACGCC
CCGAACCTGATCTCTCACTT

Product: thiol:disulfide interchange protein DsbC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MSVLRRLTWLAFPLLSMAFNVQANTAPAQLNKAELEQRFAKLGLQVEEIKTSDINGLLEVQTSGGVLFSSPDGEHFIAGT
LYALDGNGGYVDVLAKRQAPLNAKKIAALQDSMIEFKAPNEKYAITVFTDITCGYCVRLHSQIKEYNDLGITVRYLAYPR
QGPQGQVADQMAAIWCSNDPKAAMHDAKVNRKTITADKDIAQCQKTIAQHYMLGHELGISGTPAIFLPNGEMVGGYLPAP
QLLQRLQATQ

Sequences:

>Translated_250_residues
MSVLRRLTWLAFPLLSMAFNVQANTAPAQLNKAELEQRFAKLGLQVEEIKTSDINGLLEVQTSGGVLFSSPDGEHFIAGT
LYALDGNGGYVDVLAKRQAPLNAKKIAALQDSMIEFKAPNEKYAITVFTDITCGYCVRLHSQIKEYNDLGITVRYLAYPR
QGPQGQVADQMAAIWCSNDPKAAMHDAKVNRKTITADKDIAQCQKTIAQHYMLGHELGISGTPAIFLPNGEMVGGYLPAP
QLLQRLQATQ
>Mature_249_residues
SVLRRLTWLAFPLLSMAFNVQANTAPAQLNKAELEQRFAKLGLQVEEIKTSDINGLLEVQTSGGVLFSSPDGEHFIAGTL
YALDGNGGYVDVLAKRQAPLNAKKIAALQDSMIEFKAPNEKYAITVFTDITCGYCVRLHSQIKEYNDLGITVRYLAYPRQ
GPQGQVADQMAAIWCSNDPKAAMHDAKVNRKTITADKDIAQCQKTIAQHYMLGHELGISGTPAIFLPNGEMVGGYLPAPQ
LLQRLQATQ

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=229, Percent_Identity=41.9213973799127, Blast_Score=186, Evalue=1e-48,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: 5.3.4.1

Molecular weight: Translated: 27383; Mature: 27252

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLRRLTWLAFPLLSMAFNVQANTAPAQLNKAELEQRFAKLGLQVEEIKTSDINGLLEV
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEEHCCCCCCCCEEEE
QTSGGVLFSSPDGEHFIAGTLYALDGNGGYVDVLAKRQAPLNAKKIAALQDSMIEFKAPN
ECCCCEEEECCCCCEEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHEEECCC
EKYAITVFTDITCGYCVRLHSQIKEYNDLGITVRYLAYPRQGPQGQVADQMAAIWCSNDP
CCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHEEEEECCCC
KAAMHDAKVNRKTITADKDIAQCQKTIAQHYMLGHELGISGTPAIFLPNGEMVGGYLPAP
CHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEECCCCCHH
QLLQRLQATQ
HHHHHHHCCC
>Mature Secondary Structure 
SVLRRLTWLAFPLLSMAFNVQANTAPAQLNKAELEQRFAKLGLQVEEIKTSDINGLLEV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEEHCCCCCCCCEEEE
QTSGGVLFSSPDGEHFIAGTLYALDGNGGYVDVLAKRQAPLNAKKIAALQDSMIEFKAPN
ECCCCEEEECCCCCEEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHEEECCC
EKYAITVFTDITCGYCVRLHSQIKEYNDLGITVRYLAYPRQGPQGQVADQMAAIWCSNDP
CCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHEEEEECCCC
KAAMHDAKVNRKTITADKDIAQCQKTIAQHYMLGHELGISGTPAIFLPNGEMVGGYLPAP
CHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEECCCCCHH
QLLQRLQATQ
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609; 9370270 [H]