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The map label for this gene is tpx

Identifier: 147673729

GI number: 147673729

Start: 376496

End: 376990

Strand: Direct

Name: tpx

Synonym: VC0395_A0349

Alternate gene names: 147673729

Gene position: 376496-376990 (Clockwise)

Preceding gene: 147673162

Following gene: 147673583

Centisome position: 12.45

GC content: 38.38

Gene sequence:

>495_bases
ATGACTGTTACATTTCAAAATAATCCTGTTTCTATTTCTGGCTCTTTTCCTAAAGTAGGTGATCGTTTGCCTAGTTTTAC
TCTTTGTGGTGCTGATTTGAACGATCTTAACAATGAAGATTTTAAAGGAAAAAAGATTGTAATGAGCATTTTTCCCAGTA
TCGATACTCCGGTTTGTTCTAAAAGTGTGAAAGTTCTTCAAAATGCACTTATGACTCGCAGTGATACAGTGCTTCTCTGT
GTTTCAGCAGATCTGCCTTTTGCTATGTCTCGCTTTTGTACAGAGCATGCAGTAGCTAATGTCACGAATGCATCGTTTTT
TCGTGAGCCTGCTTTTACTGAACGCTTCGGTGTAAATCTAAATGAAGGTGCTTTACGTGGGCTTGCTGCTAGAGCAGTGA
TTGTTGCAGATGAGTTCGGTGTAATTACCCACAGTGAATTAGTCAATGAAATCACCAATGAACCAGATTACGATCGTATT
TTGATGTCACTATAA

Upstream 100 bases:

>100_bases
AACTTCTAAACGGATTTTTTTTATTTAATTTGGTTTGTTTTTAATAGTTTGTATAATAGCGGTGACACTAAAGTAGTGTT
TATATTTGAGGAATTAAATT

Downstream 100 bases:

>100_bases
TCAGTAATTAGGCCAATGCTATCTATCAATAGATAAAAAAGCGTTGGATGACTTTATAAAAGGCCCTAAGTTCCCAAGGC
TTAGAGCCTTTTATTTTTCA

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: Protein tagD

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MTVTFQNNPVSISGSFPKVGDRLPSFTLCGADLNDLNNEDFKGKKIVMSIFPSIDTPVCSKSVKVLQNALMTRSDTVLLC
VSADLPFAMSRFCTEHAVANVTNASFFREPAFTERFGVNLNEGALRGLAARAVIVADEFGVITHSELVNEITNEPDYDRI
LMSL

Sequences:

>Translated_164_residues
MTVTFQNNPVSISGSFPKVGDRLPSFTLCGADLNDLNNEDFKGKKIVMSIFPSIDTPVCSKSVKVLQNALMTRSDTVLLC
VSADLPFAMSRFCTEHAVANVTNASFFREPAFTERFGVNLNEGALRGLAARAVIVADEFGVITHSELVNEITNEPDYDRI
LMSL
>Mature_163_residues
TVTFQNNPVSISGSFPKVGDRLPSFTLCGADLNDLNNEDFKGKKIVMSIFPSIDTPVCSKSVKVLQNALMTRSDTVLLCV
SADLPFAMSRFCTEHAVANVTNASFFREPAFTERFGVNLNEGALRGLAARAVIVADEFGVITHSELVNEITNEPDYDRIL
MSL

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2). Could play a role in fimbria synthesis or assembly

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Escherichia coli, GI1787584, Length=165, Percent_Identity=49.6969696969697, Blast_Score=157, Evalue=3e-40,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPX_VIBC3 (A5F3A2)

Other databases:

- EMBL:   U02375
- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F3A2
- SMR:   A5F3A2
- STRING:   A5F3A2
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0349
- eggNOG:   COG2077
- HOGENOM:   HBG493509
- OMA:   NITSHGE
- ProtClustDB:   PRK00522
- BioCyc:   VCHO345073:VC0395_A0349-MONOMER
- HAMAP:   MF_00269
- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10681:SF3

Pfam domain/function: PF08534 Redoxin; SSF52833 Thiordxn-like_fd

EC number: 1.11.1.- [C]

Molecular weight: Translated: 17925; Mature: 17793

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS51352 THIOREDOXIN_2; PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTFQNNPVSISGSFPKVGDRLPSFTLCGADLNDLNNEDFKGKKIVMSIFPSIDTPVCS
CEEEECCCCEEEECCCCCHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHH
KSVKVLQNALMTRSDTVLLCVSADLPFAMSRFCTEHAVANVTNASFFREPAFTERFGVNL
HHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHCCCC
NEGALRGLAARAVIVADEFGVITHSELVNEITNEPDYDRILMSL
CHHHHHHHHHEEEEEECCCCCEEHHHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure 
TVTFQNNPVSISGSFPKVGDRLPSFTLCGADLNDLNNEDFKGKKIVMSIFPSIDTPVCS
EEEECCCCEEEECCCCCHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHH
KSVKVLQNALMTRSDTVLLCVSADLPFAMSRFCTEHAVANVTNASFFREPAFTERFGVNL
HHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHCCCC
NEGALRGLAARAVIVADEFGVITHSELVNEITNEPDYDRILMSL
CHHHHHHHHHEEEEEECCCCCEEHHHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7523254