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The map label for this gene is guaB [H]

Identifier: 147673264

GI number: 147673264

Start: 310725

End: 312194

Strand: Direct

Name: guaB [H]

Synonym: VC0395_A0296

Alternate gene names: 147673264

Gene position: 310725-312194 (Clockwise)

Preceding gene: 147674233

Following gene: 147675501

Centisome position: 10.28

GC content: 49.8

Gene sequence:

>1470_bases
TTGCACATGCTACGAATCGCAAAAGAAGCTCTAACCTTTGACGATGTTTTACTCGTCCCTGCTCATTCCACCGTTCTTCC
AAACACTGCCGATCTTCGCACTCGGTTAACCAAAAATATTGCGCTGAACATCCCTATGGTTTCTGCGTCTATGGATACTG
TTACGGAAGCACGTCTTGCGATCGCTCTGGCTCAAGAAGGCGGCATTGGCTTTATTCACAAGAATATGTCGATTGAACAG
CAAGCGGCTCAAGTTCACCAAGTGAAAATCTTTGAAGCGGGTGTGGTGACTCACCCTGTCACTGTCCGTCCAGAACAAAC
CATTGCTGATGTTATGGAACTTACCCATTACCACGGTTTTGCGGGTTTCCCTGTTGTCACTGAAAACAATGAACTGGTTG
GTATAATCACTGGCCGTGACGTTCGCTTCGTTACTGATCTCACCAAATCTGTGGCTGCTGTGATGACGCCAAAAGAGCGC
CTCGCGACAGTCAAAGAAGGTGCAACGGGTGCAGAAGTGCAAGAAAAAATGCACAAAGCGCGTGTTGAAAAAATTCTGGT
GGTGAATGATGAGTTCCAACTCAAAGGCATGATCACCGCGAAAGATTTCCACAAAGCCGAAAGCAAGCCAAATGCGTGTA
AAGATGAGCAAGGCCGTCTGCGTGTTGGTGCCGCTGTCGGTGCAGCACCGGGTAACGAAGAGCGTGTTAAAGCTCTGGTT
GAAGCCGGGGTTGACGTTCTACTGATCGACTCTTCTCATGGCCACTCCGAAGGGGTTTTACAGCGTATTCGCGAAACTCG
CGCAGCTTATCCACACCTTGAAATCATTGGTGGTAACGTGGCGACAGCTGAAGGTGCACGCGCACTTATTGAAGCGGGCG
TAAGCGCAGTGAAAGTCGGTATCGGTCCTGGCTCAATCTGTACCACGCGCATTGTCACAGGCGTGGGCGTTCCACAAATT
ACTGCTATTGCTGATGCAGCGGGTGTGGCTAACGAGTACGGTATTCCTGTTATTGCTGATGGCGGTATTCGTTTCTCTGG
CGACATTTCGAAAGCGATTGCGGCGGGGGCTTCTTGCGTTATGGTTGGCTCAATGTTTGCTGGTACTGAAGAAGCCCCAG
GTGAAGTGATCCTTTACCAAGGCCGCTCTTACAAAGCCTACCGTGGAATGGGTTCACTGGGTGCGATGTCAAAAGGTTCA
TCAGATCGTTACTTCCAAACCGATAACGCGGCAGACAAGCTGGTTCCAGAAGGCATCGAAGGCCGTATCGCTTATAAAGG
CCATCTGAAAGAGATTATCCACCAACAAATGGGCGGCCTACGCTCTTGTATGGGGCTGACTGGCTCAGCCACAGTAGAAG
ATCTGCGTACTAAAGCTCAATTTGTACGCATTTCTGGTGCGGGTATGAAAGAGTCTCACGTACATGACGTGCAGATCACT
AAAGAAGCACCAAACTACCGTCTGGGTTAA

Upstream 100 bases:

>100_bases
GCCTCGGGCGTATAATCCGTCCGCAATATCAAATATAAATCCCTTTGTTACGCGAAACGATGAAGTGGATTTCCGTTGTT
AACACTCCTGTTGTGAGATA

Downstream 100 bases:

>100_bases
GCGTAAACGTTTGCTTAAATGCTTGATGAGTGAATGTGAGGCGAGTAGACTCGCCTCCGTTGAAGAATCCCCCGTATTAA
TTCTCGGCTGATAAGACTGC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MHMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTRLTKNIALNIPMVSASMDTVTEARLAIALAQEGGIGFIHKNMSIEQ
QAAQVHQVKIFEAGVVTHPVTVRPEQTIADVMELTHYHGFAGFPVVTENNELVGIITGRDVRFVTDLTKSVAAVMTPKER
LATVKEGATGAEVQEKMHKARVEKILVVNDEFQLKGMITAKDFHKAESKPNACKDEQGRLRVGAAVGAAPGNEERVKALV
EAGVDVLLIDSSHGHSEGVLQRIRETRAAYPHLEIIGGNVATAEGARALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQI
TAIADAAGVANEYGIPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSKGS
SDRYFQTDNAADKLVPEGIEGRIAYKGHLKEIIHQQMGGLRSCMGLTGSATVEDLRTKAQFVRISGAGMKESHVHDVQIT
KEAPNYRLG

Sequences:

>Translated_489_residues
MHMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTRLTKNIALNIPMVSASMDTVTEARLAIALAQEGGIGFIHKNMSIEQ
QAAQVHQVKIFEAGVVTHPVTVRPEQTIADVMELTHYHGFAGFPVVTENNELVGIITGRDVRFVTDLTKSVAAVMTPKER
LATVKEGATGAEVQEKMHKARVEKILVVNDEFQLKGMITAKDFHKAESKPNACKDEQGRLRVGAAVGAAPGNEERVKALV
EAGVDVLLIDSSHGHSEGVLQRIRETRAAYPHLEIIGGNVATAEGARALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQI
TAIADAAGVANEYGIPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSKGS
SDRYFQTDNAADKLVPEGIEGRIAYKGHLKEIIHQQMGGLRSCMGLTGSATVEDLRTKAQFVRISGAGMKESHVHDVQIT
KEAPNYRLG
>Mature_489_residues
MHMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTRLTKNIALNIPMVSASMDTVTEARLAIALAQEGGIGFIHKNMSIEQ
QAAQVHQVKIFEAGVVTHPVTVRPEQTIADVMELTHYHGFAGFPVVTENNELVGIITGRDVRFVTDLTKSVAAVMTPKER
LATVKEGATGAEVQEKMHKARVEKILVVNDEFQLKGMITAKDFHKAESKPNACKDEQGRLRVGAAVGAAPGNEERVKALV
EAGVDVLLIDSSHGHSEGVLQRIRETRAAYPHLEIIGGNVATAEGARALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQI
TAIADAAGVANEYGIPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSKGS
SDRYFQTDNAADKLVPEGIEGRIAYKGHLKEIIHQQMGGLRSCMGLTGSATVEDLRTKAQFVRISGAGMKESHVHDVQIT
KEAPNYRLG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=462, Percent_Identity=41.7748917748918, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI156616279, Length=462, Percent_Identity=41.7748917748918, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI34328930, Length=462, Percent_Identity=41.7748917748918, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI34328928, Length=462, Percent_Identity=41.7748917748918, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=42.1286031042129, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI217035148, Length=462, Percent_Identity=41.1255411255411, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI66933016, Length=457, Percent_Identity=41.1378555798687, Blast_Score=335, Evalue=8e-92,
Organism=Homo sapiens, GI217035150, Length=464, Percent_Identity=38.5775862068966, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI156104880, Length=273, Percent_Identity=35.1648351648352, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=35.3658536585366, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=35.3658536585366, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=35.3658536585366, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=35.3658536585366, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=81.5195071868583, Blast_Score=743, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=242, Percent_Identity=33.4710743801653, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=507, Percent_Identity=35.7001972386588, Blast_Score=281, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI71994389, Length=429, Percent_Identity=38.2284382284382, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=36.1344537815126, Blast_Score=156, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=461, Percent_Identity=40.7809110629067, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6322012, Length=461, Percent_Identity=40.1301518438178, Blast_Score=336, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=444, Percent_Identity=41.8918918918919, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=39.9408284023669, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=102, Percent_Identity=44.1176470588235, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=40.1656314699793, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=40.1656314699793, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=40.5895691609977, Blast_Score=298, Evalue=6e-81,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51943; Mature: 51943

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTRLTKNIALNIPMVSASMDTVTEARLA
CCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCEEEECEEEECCHHHHHHHHEE
IALAQEGGIGFIHKNMSIEQQAAQVHQVKIFEAGVVTHPVTVRPEQTIADVMELTHYHGF
EEEECCCCEEEEECCCCHHHHHHHHHEEEEEECCCEECCEEECCHHHHHHHHHHHHHCCC
AGFPVVTENNELVGIITGRDVRFVTDLTKSVAAVMTPKERLATVKEGATGAEVQEKMHKA
CCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHH
RVEKILVVNDEFQLKGMITAKDFHKAESKPNACKDEQGRLRVGAAVGAAPGNEERVKALV
HHCEEEEECCCEEEEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHH
EAGVDVLLIDSSHGHSEGVLQRIRETRAAYPHLEIIGGNVATAEGARALIEAGVSAVKVG
HCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCHHHHHHHHCCCCEEEEE
IGPGSICTTRIVTGVGVPQITAIADAAGVANEYGIPVIADGGIRFSGDISKAIAAGASCV
CCCCCHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCCEEECCCEEECCCHHHHHHCCCCEE
MVGSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSKGSSDRYFQTDNAADKLVPEGIE
EEHHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCEEECCCCHHHCCCCCCC
GRIAYKGHLKEIIHQQMGGLRSCMGLTGSATVEDLRTKAQFVRISGAGMKESHVHDVQIT
CEEEEHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHEEEEEEECCCCCCCCCEEEEEE
KEAPNYRLG
CCCCCCCCC
>Mature Secondary Structure
MHMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTRLTKNIALNIPMVSASMDTVTEARLA
CCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCEEEECEEEECCHHHHHHHHEE
IALAQEGGIGFIHKNMSIEQQAAQVHQVKIFEAGVVTHPVTVRPEQTIADVMELTHYHGF
EEEECCCCEEEEECCCCHHHHHHHHHEEEEEECCCEECCEEECCHHHHHHHHHHHHHCCC
AGFPVVTENNELVGIITGRDVRFVTDLTKSVAAVMTPKERLATVKEGATGAEVQEKMHKA
CCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHH
RVEKILVVNDEFQLKGMITAKDFHKAESKPNACKDEQGRLRVGAAVGAAPGNEERVKALV
HHCEEEEECCCEEEEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHH
EAGVDVLLIDSSHGHSEGVLQRIRETRAAYPHLEIIGGNVATAEGARALIEAGVSAVKVG
HCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCHHHHHHHHCCCCEEEEE
IGPGSICTTRIVTGVGVPQITAIADAAGVANEYGIPVIADGGIRFSGDISKAIAAGASCV
CCCCCHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCCEEECCCEEECCCHHHHHHCCCCEE
MVGSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSKGSSDRYFQTDNAADKLVPEGIE
EEHHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCEEECCCCHHHCCCCCCC
GRIAYKGHLKEIIHQQMGGLRSCMGLTGSATVEDLRTKAQFVRISGAGMKESHVHDVQIT
CEEEEHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHEEEEEEECCCCCCCCCEEEEEE
KEAPNYRLG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]