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The map label for this gene is mltA

Identifier: 147673142

GI number: 147673142

Start: 2016229

End: 2017335

Strand: Reverse

Name: mltA

Synonym: VC0395_A1899

Alternate gene names: 147673142

Gene position: 2017335-2016229 (Counterclockwise)

Preceding gene: 147673802

Following gene: 147675632

Centisome position: 66.71

GC content: 49.86

Gene sequence:

>1107_bases
GTGAGTAAACGTCTTCTTTCTCTCGCCAGTTTGGCACTGCTGTTTGGTTGTGCTCAGCAACCTAACGATCGTGCTCAGCA
ATACCAACAACAAACTTTTCCACACATTTTGAATCGTGCCGATGTGGTTGAATCCAATAAGCCGCGTGACTATACCGAAT
TCAGTAAACAGAGTGAGTTGGTCGTGCAAGGCTCAGCCTCCATGGCCAAGATCTATCGACCGCTGTATGAACAATTGAAT
GAGTGGGTTCTGCAAAGCGGAGATCCTGCCACTTTAGCGCAATTTGGTATTCAAGCAGCGCAGTTAGGTGGCGGGGATAA
ACAAGGTAACGTATTGTTTACTGGCTATTTTTCACCTGTGATTGAGCTGCGTCATCAACCCGACAGCGTGTTTAAATATC
CGGTTTACGGCTTGCCAAAATGCAACAAAAACTGCCCCACTCGAGCGGAGATTTACCAAGGTGCGCTGGATGGTCAAGGT
TTAGAATTGGGCTATGCGGAGAACTTGATCGATCCTTTCATCATGGAAGTGCAGGGCAGTGGCTTTGTTCACTTTGGGGA
TGACGATACTTTGGAATACTTCGCTTACGCGGGTAAAAATAACAAGGCTTACGTCAGCATTGGTAAAGTGTTGATTGAAC
GCGGTTTGGTTGAGCGCGAGAAAATGTCGCTCAAAGCGATCAAAGATTGGGTGCTGGCCAACGATGAAGCCACCGTACGT
GAACTGCTTGAGGAAAACCCTTCCTTCGTATTTTTCAAACCCAGCGCCGCGGCACCTGTGAAGGGCAGCGCCGGGATTCC
TTTATTGCCGATGGCATCGGTTGCCGGGGACCGTTCAATTTTGCCTATGGGGACGCCAATTCTAGCGGAAGTCCCCCTGC
TGAATGCCGATGGCACTTGGTCTGGCGCACATCAACTGCGTTTGTTGATTGTGCTTGATACAGGCGGTGCCGTGAAACAA
AACCATCTCGACTTGTACCACGGTATGGGACCACGTGCAGGGTTAGAAGCGGGGCACTATAAGCACTTTGGCCGTGTGTG
GAAACTCGGGTTAGAAAACTCGCCTACCCAAGCACCATGGGCATTGCCGCCGGAAAAACAGCAATAG

Upstream 100 bases:

>100_bases
TCAGAAAAAGTAAAAAATAATCGCTATTAATCAAACGCCAATTGCACAGTTTCACTGACTTTGTCATGCTCTTGGCAAAC
ATAAACCATGGACCTCTTTT

Downstream 100 bases:

>100_bases
TTTTTCCTGATATTGTGCCGGTAGCAAACTGGACATTTTTGTGAAGAGTGCGTATAAATCGCACTCTTTATTTTTCAGCT
AGAGTGGAAATGTGGTTATG

Product: murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSKRLLSLASLALLFGCAQQPNDRAQQYQQQTFPHILNRADVVESNKPRDYTEFSKQSELVVQGSASMAKIYRPLYEQLN
EWVLQSGDPATLAQFGIQAAQLGGGDKQGNVLFTGYFSPVIELRHQPDSVFKYPVYGLPKCNKNCPTRAEIYQGALDGQG
LELGYAENLIDPFIMEVQGSGFVHFGDDDTLEYFAYAGKNNKAYVSIGKVLIERGLVEREKMSLKAIKDWVLANDEATVR
ELLEENPSFVFFKPSAAAPVKGSAGIPLLPMASVAGDRSILPMGTPILAEVPLLNADGTWSGAHQLRLLIVLDTGGAVKQ
NHLDLYHGMGPRAGLEAGHYKHFGRVWKLGLENSPTQAPWALPPEKQQ

Sequences:

>Translated_368_residues
MSKRLLSLASLALLFGCAQQPNDRAQQYQQQTFPHILNRADVVESNKPRDYTEFSKQSELVVQGSASMAKIYRPLYEQLN
EWVLQSGDPATLAQFGIQAAQLGGGDKQGNVLFTGYFSPVIELRHQPDSVFKYPVYGLPKCNKNCPTRAEIYQGALDGQG
LELGYAENLIDPFIMEVQGSGFVHFGDDDTLEYFAYAGKNNKAYVSIGKVLIERGLVEREKMSLKAIKDWVLANDEATVR
ELLEENPSFVFFKPSAAAPVKGSAGIPLLPMASVAGDRSILPMGTPILAEVPLLNADGTWSGAHQLRLLIVLDTGGAVKQ
NHLDLYHGMGPRAGLEAGHYKHFGRVWKLGLENSPTQAPWALPPEKQQ
>Mature_367_residues
SKRLLSLASLALLFGCAQQPNDRAQQYQQQTFPHILNRADVVESNKPRDYTEFSKQSELVVQGSASMAKIYRPLYEQLNE
WVLQSGDPATLAQFGIQAAQLGGGDKQGNVLFTGYFSPVIELRHQPDSVFKYPVYGLPKCNKNCPTRAEIYQGALDGQGL
ELGYAENLIDPFIMEVQGSGFVHFGDDDTLEYFAYAGKNNKAYVSIGKVLIERGLVEREKMSLKAIKDWVLANDEATVRE
LLEENPSFVFFKPSAAAPVKGSAGIPLLPMASVAGDRSILPMGTPILAEVPLLNADGTWSGAHQLRLLIVLDTGGAVKQN
HLDLYHGMGPRAGLEAGHYKHFGRVWKLGLENSPTQAPWALPPEKQQ

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=350, Percent_Identity=48.2857142857143, Blast_Score=338, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MLTA_VIBCH (Q9KPQ4)

Other databases:

- EMBL:   AE003852
- PIR:   A82093
- RefSeq:   NP_231943.1
- ProteinModelPortal:   Q9KPQ4
- SMR:   Q9KPQ4
- GeneID:   2613108
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC2312
- TIGR:   VC_2312
- HOGENOM:   HBG296995
- OMA:   NQGDFLT
- ProtClustDB:   PRK11162
- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300
- Gene3D:   G3DSA:2.40.40.10
- SMART:   SM00925

Pfam domain/function: PF06725 3D; PF03562 MltA

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40459; Mature: 40327

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRLLSLASLALLFGCAQQPNDRAQQYQQQTFPHILNRADVVESNKPRDYTEFSKQSEL
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCE
VVQGSASMAKIYRPLYEQLNEWVLQSGDPATLAQFGIQAAQLGGGDKQGNVLFTGYFSPV
EEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHCCCCCCCCCEEEEECHHHH
IELRHQPDSVFKYPVYGLPKCNKNCPTRAEIYQGALDGQGLELGYAENLIDPFIMEVQGS
HHHCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHCCCEEEEECCC
GFVHFGDDDTLEYFAYAGKNNKAYVSIGKVLIERGLVEREKMSLKAIKDWVLANDEATVR
CEEEECCCCCEEEEEEECCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHH
ELLEENPSFVFFKPSAAAPVKGSAGIPLLPMASVAGDRSILPMGTPILAEVPLLNADGTW
HHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHEECCEECCCCCC
SGAHQLRLLIVLDTGGAVKQNHLDLYHGMGPRAGLEAGHYKHFGRVWKLGLENSPTQAPW
CCCCEEEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCC
ALPPEKQQ
CCCCCCCC
>Mature Secondary Structure 
SKRLLSLASLALLFGCAQQPNDRAQQYQQQTFPHILNRADVVESNKPRDYTEFSKQSEL
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCE
VVQGSASMAKIYRPLYEQLNEWVLQSGDPATLAQFGIQAAQLGGGDKQGNVLFTGYFSPV
EEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHCCCCCCCCCEEEEECHHHH
IELRHQPDSVFKYPVYGLPKCNKNCPTRAEIYQGALDGQGLELGYAENLIDPFIMEVQGS
HHHCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHCCCEEEEECCC
GFVHFGDDDTLEYFAYAGKNNKAYVSIGKVLIERGLVEREKMSLKAIKDWVLANDEATVR
CEEEECCCCCEEEEEEECCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHH
ELLEENPSFVFFKPSAAAPVKGSAGIPLLPMASVAGDRSILPMGTPILAEVPLLNADGTW
HHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHEECCEECCCCCC
SGAHQLRLLIVLDTGGAVKQNHLDLYHGMGPRAGLEAGHYKHFGRVWKLGLENSPTQAPW
CCCCEEEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCC
ALPPEKQQ
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301