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The map label for this gene is 146343878

Identifier: 146343878

GI number: 146343878

Start: 7442257

End: 7442667

Strand: Direct

Name: 146343878

Synonym: BRADO7129

Alternate gene names: NA

Gene position: 7442257-7442667 (Clockwise)

Preceding gene: 146343868

Following gene: 146343881

Centisome position: 99.81

GC content: 64.48

Gene sequence:

>411_bases
ATGCCGGTGAAGGTCCATGCACTCGATCACCTGGTCATCAACGTCGCCGACGTCGACCGAACGACAGCCTGGTACCAGAA
GGTTTTGGGCATGGATTTGCAGGTCACCGACCTCGGGCCAGGACGCGCCAGGCGCACGTCGCTCTTGTTCGGGACCCAGA
AGATCAACGTGCGACCGAAGGACGCGGACAAGGTCGACTGGTTCACCGCGGACCATGTCGGCGCGGGCAGCGACGATCTG
TGCTTCCTGACCAGCAGCACTCCGGATGAAGTGGTGGCCCACCTGCAAGCGCTCGGCATCGCCATCGAGGAAGGCCCGGT
CGACAAGCAGGGCGCCCGCGGCACCCTGCGCTCGGTGTATTGCCGCGATCCCGACGGCAGCCTGATCGAGATCTCGTCCT
ACCGGGAGTGA

Upstream 100 bases:

>100_bases
TTATGTATCGTTGAGCGCCCGTGAACGAAGCGCTGGTGTCGATTGTAGCCCAACCGCGCGATCGTCGCGAGGTCGATGTC
TTGATCAGGAGGAGAAGCTC

Downstream 100 bases:

>100_bases
GCGCGGGCTGTGCGCTACTTCGTGACGGCTTCGCCGCTTTGCTCCATCCGGGCGACGATCTCGCTGCGCGACCAGCCGGT
CAAGGCAGCCAGATCGGTCG

Product: putative glyoxalase I family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 136; Mature: 135

Protein sequence:

>136_residues
MPVKVHALDHLVINVADVDRTTAWYQKVLGMDLQVTDLGPGRARRTSLLFGTQKINVRPKDADKVDWFTADHVGAGSDDL
CFLTSSTPDEVVAHLQALGIAIEEGPVDKQGARGTLRSVYCRDPDGSLIEISSYRE

Sequences:

>Translated_136_residues
MPVKVHALDHLVINVADVDRTTAWYQKVLGMDLQVTDLGPGRARRTSLLFGTQKINVRPKDADKVDWFTADHVGAGSDDL
CFLTSSTPDEVVAHLQALGIAIEEGPVDKQGARGTLRSVYCRDPDGSLIEISSYRE
>Mature_135_residues
PVKVHALDHLVINVADVDRTTAWYQKVLGMDLQVTDLGPGRARRTSLLFGTQKINVRPKDADKVDWFTADHVGAGSDDLC
FLTSSTPDEVVAHLQALGIAIEEGPVDKQGARGTLRSVYCRDPDGSLIEISSYRE

Specific function: Is critically involved in promoting the replication of S.typhimurium cells inside host macrophages, suggesting a role in the establishment of bacterial colonization within macrophages. May be involved in the biosynthesis and modification of the peptidogly

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI254039722, Length=133, Percent_Identity=39.0977443609023, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: NA

Molecular weight: Translated: 14891; Mature: 14760

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKVHALDHLVINVADVDRTTAWYQKVLGMDLQVTDLGPGRARRTSLLFGTQKINVRPK
CCEEEEEECEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCEEEECCCC
DADKVDWFTADHVGAGSDDLCFLTSSTPDEVVAHLQALGIAIEEGPVDKQGARGTLRSVY
CCCCCEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHCEEEECCCCCCCCCCCCEEEEE
CRDPDGSLIEISSYRE
EECCCCCEEEECCCCC
>Mature Secondary Structure 
PVKVHALDHLVINVADVDRTTAWYQKVLGMDLQVTDLGPGRARRTSLLFGTQKINVRPK
CEEEEEECEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCEEEECCCC
DADKVDWFTADHVGAGSDDLCFLTSSTPDEVVAHLQALGIAIEEGPVDKQGARGTLRSVY
CCCCCEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHCEEEECCCCCCCCCCCCEEEEE
CRDPDGSLIEISSYRE
EECCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]