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The map label for this gene is uppS [H]

Identifier: 146343873

GI number: 146343873

Start: 7438837

End: 7439577

Strand: Reverse

Name: uppS [H]

Synonym: BRADO7124

Alternate gene names: 146343873

Gene position: 7439577-7438837 (Counterclockwise)

Preceding gene: 146343874

Following gene: 146343872

Centisome position: 99.77

GC content: 68.56

Gene sequence:

>741_bases
ATGCAAAGTAGTCTGCAACCGAAATCGCCTGCTGTGGTCGACGGCCTTCATGTCGGCATCATCATGGACGGCAACGGCCG
CTGGGCGACGCGCAAGGGCATGTCGCGGCTGCGCGGCCACGAGGCGGGCGTCGAGGCGATCCGCCGCATCGTCGAGGCCG
CGCCGGATCAGGGCATCGGCACGCTGACGCTCTACGCGTTCTCCAGCGACAATTGGCGTCGGCCGCGTGCCGAGGTCGCC
GCCCTGATGGCGCTGCTCCGGGTCTATCTCGCCAGCGAGGTGGAATCGCTGGTGCGCAACGGCGTTCGCCTCAACGTGAT
CGGCCGCCGCGATCGGCTGCCGGGCGGCATCGCCGATGCGATCGCTCGCGCCGAGCAGGCGACGCGCGACGGCCGCACCT
TGCATCTGCGCATCGCCGTCGACTACTCGGCGCGCGACGCGATCCTCAATGCCGCGGCGAAGGCAGGCAGCATCGAGGGC
CTGACCCGTCAGACATTCTCCGATCTCGTGACCGGAGAGGCAGGCTTGCGCGACGTCGACCTGATCATCCGCACGTCCGG
CGAGCAGCGGCTGTCCGACTTCCTGTTGTGGGAAGGCGCTTATGCCGAGCTGCACTTCACGGATCGGATGTGGCCCGATT
TCGACGCGGCCGACCTTGCCGAAGCGCTGGCCTCGTTTCATGGCCGGGAGCGCCGCTTCGGTGGCCTTGAGGCCGTGCCG
CTCGCGCCGGCAACGTCCTGA

Upstream 100 bases:

>100_bases
GGCCGCGGCGGCCGGCAAGGACCCCACCCCATCCTCGGCCAGTCTCATCCACGGCCGCGCCTGACCGTTTCATCGCGTTT
TTTTGACCTGGAGCTTTGCA

Downstream 100 bases:

>100_bases
CAGTCGATCTCCCACTGACCGTGACCGCGCAATCTTTCCGCGCATCCGGGAATCATCTACCGCTCGTGTCACGAGCGCAG
AGATCTCATGATGAAGCACA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1 [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MQSSLQPKSPAVVDGLHVGIIMDGNGRWATRKGMSRLRGHEAGVEAIRRIVEAAPDQGIGTLTLYAFSSDNWRRPRAEVA
ALMALLRVYLASEVESLVRNGVRLNVIGRRDRLPGGIADAIARAEQATRDGRTLHLRIAVDYSARDAILNAAAKAGSIEG
LTRQTFSDLVTGEAGLRDVDLIIRTSGEQRLSDFLLWEGAYAELHFTDRMWPDFDAADLAEALASFHGRERRFGGLEAVP
LAPATS

Sequences:

>Translated_246_residues
MQSSLQPKSPAVVDGLHVGIIMDGNGRWATRKGMSRLRGHEAGVEAIRRIVEAAPDQGIGTLTLYAFSSDNWRRPRAEVA
ALMALLRVYLASEVESLVRNGVRLNVIGRRDRLPGGIADAIARAEQATRDGRTLHLRIAVDYSARDAILNAAAKAGSIEG
LTRQTFSDLVTGEAGLRDVDLIIRTSGEQRLSDFLLWEGAYAELHFTDRMWPDFDAADLAEALASFHGRERRFGGLEAVP
LAPATS
>Mature_246_residues
MQSSLQPKSPAVVDGLHVGIIMDGNGRWATRKGMSRLRGHEAGVEAIRRIVEAAPDQGIGTLTLYAFSSDNWRRPRAEVA
ALMALLRVYLASEVESLVRNGVRLNVIGRRDRLPGGIADAIARAEQATRDGRTLHLRIAVDYSARDAILNAAAKAGSIEG
LTRQTFSDLVTGEAGLRDVDLIIRTSGEQRLSDFLLWEGAYAELHFTDRMWPDFDAADLAEALASFHGRERRFGGLEAVP
LAPATS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=221, Percent_Identity=34.3891402714932, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI45580742, Length=221, Percent_Identity=34.3891402714932, Blast_Score=125, Evalue=2e-29,
Organism=Escherichia coli, GI1786371, Length=246, Percent_Identity=45.9349593495935, Blast_Score=194, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71993029, Length=223, Percent_Identity=29.5964125560538, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6319474, Length=222, Percent_Identity=35.5855855855856, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=213, Percent_Identity=30.0469483568075, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18857969, Length=250, Percent_Identity=31.6, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26787; Mature: 26787

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSSLQPKSPAVVDGLHVGIIMDGNGRWATRKGMSRLRGHEAGVEAIRRIVEAAPDQGIG
CCCCCCCCCCCEECCEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
TLTLYAFSSDNWRRPRAEVAALMALLRVYLASEVESLVRNGVRLNVIGRRDRLPGGIADA
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHH
IARAEQATRDGRTLHLRIAVDYSARDAILNAAAKAGSIEGLTRQTFSDLVTGEAGLRDVD
HHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEE
LIIRTSGEQRLSDFLLWEGAYAELHFTDRMWPDFDAADLAEALASFHGRERRFGGLEAVP
EEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHCCCCCEEC
LAPATS
CCCCCC
>Mature Secondary Structure
MQSSLQPKSPAVVDGLHVGIIMDGNGRWATRKGMSRLRGHEAGVEAIRRIVEAAPDQGIG
CCCCCCCCCCCEECCEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
TLTLYAFSSDNWRRPRAEVAALMALLRVYLASEVESLVRNGVRLNVIGRRDRLPGGIADA
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHH
IARAEQATRDGRTLHLRIAVDYSARDAILNAAAKAGSIEGLTRQTFSDLVTGEAGLRDVD
HHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEE
LIIRTSGEQRLSDFLLWEGAYAELHFTDRMWPDFDAADLAEALASFHGRERRFGGLEAVP
EEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHCCCCCEEC
LAPATS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]