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The map label for this gene is frpA [H]

Identifier: 146343792

GI number: 146343792

Start: 7348099

End: 7349739

Strand: Reverse

Name: frpA [H]

Synonym: BRADO7040

Alternate gene names: 146343792

Gene position: 7349739-7348099 (Counterclockwise)

Preceding gene: 146343793

Following gene: 146343791

Centisome position: 98.57

GC content: 61.55

Gene sequence:

>1641_bases
TTGGAGCAGGGGCGGATCTCGATGGCCACTTATAATCTCGACCAGACGGACCTTAAGGCGGCAATTTCTGCCAATTTCGA
CCCCACCGTTCAGCAACAGATCATTGACTATCTGATCGGAAAGACGGCCTACACCAATCCCGACAATGGCGATGCGATCC
CCGTTCAGGTCGGGACTGGCGTAGGGACGCCAGACCCGAACGCGAACGTTCTTATTGAGGTCAATGCCAACAACACCGTC
ACGACGGATCCGGCACTCAAGGCAATCATCGTCGACACGCCGAGCGACGCGACGCTCGTGGTCAATGGCAGTGACCCGGT
CCTGGTCGCAACGGGTGGTGGCGCCGATCAGATCTACATCAACGACACCGCGAACGTGACAGTTCTGACCGGCGCGGGCA
ATGACACGATCTATGCCGGTGCTGGTTCGGACTCGATCGAGAGTGGCTCCGGCAACGACGTGCTCGTCGATCAGGTGTCG
GGTACGAGCACGCTGAGCGCCGGCGCGGGCAACGACTATCTCTTCGGCTTCGGCGCCGATACTCTGTTCGGCGGATCGGG
CAATGACACCCTCTATGGCGGCACCAGCTCGGAGCTGCACGGCGGTGACGACAACGATGTGCTGATCTCCGGCAGCAACT
CCCACACCGCGAACCTGCTCTATGGTGACGGCGGCAACGACCAGCTGTTCGGCGGAGCGGGCAGCGACAGCCTTTATGGC
GGCGCTGGCGCAGACACGCTGACGGCCGGTATTGGTAATCAGCTGCTCGACGGTGGTGATGACAACGACATCATCCTCGG
CAACGTGGCCGGCTACGACTCGCTCTATGGCGGCAACGGCAACGATATCATCTACTCGAACTCTGCAGCCACCCACGCCA
GCCTGCTCTCGGGTGATGCCGGAAACGATTCGCTCTACGCCGGTGACGGCTCCGATCTGCTGTTCGGCGGCACGGGCAAT
GACCTTCTGGTCGGTGGCGCTCGGACGGCTGAGCTGCATGGCGGCGCTGACAACGACGCGCTGTACTCGTATAGCGACGC
TTCACATGGCACGCAGCTGTTCGGTGATGCGGGCAACGATTCCCTGTACGCCGGCAGCGGCGCCGATACACTTTATGGCG
GCGCTGGCAACGATCTGCTCGTGGGTGGCGCCAGCACGGTCGTGCTCAACGGCGGCGACGACAACGACACGGTCTACTCG
TTCAGCGACTCGTCGCATGCGACAAGCCTCTATGGTGGCGCGGGCAACGACACGCTGTATGGCGGATCCGGAAGCGATAC
GCTCTACGGCGGATCGGGCAACGACGTTCTGGTGGCCGGCTCGGGTACGCAGACGCTCATCGGTGGCAGCGACGGAAGCT
CGTTCATCGGCTCGAGCACTGGCACCGCGTCGATGGTTGGCGGCGCTGGTCAGGACTATTTCTATCTCAACAACGCTACC
AGCAACGATACGATCGATGGCGGCGGCGGCAATCTCGACTCTGTCACGTTCCTCGATCATTCTCAGGCCGACCTGAGCGG
CATCACGGCAAGCGCTACCACGCCTGGTGCCCTCGACGTGACCTTCAGCAACGGCCAGGTCGTTCAGGTCAGCAACATCG
AGTACCTGATCTTCAACGATGGCAACTACACCAAGCTCTGA

Upstream 100 bases:

>100_bases
GCGGCTAACAAGTTGTTAACGTGGCATGGTGTGTGTGCTATGCAGCAATCGCGTTGACGAATCAGTTGCTTAAGCGTGGG
CGGTCTTTTGACACTAGTTT

Downstream 100 bases:

>100_bases
TCGGCCGTCTTGATCTAGCAGTCGACATTGCCTTCATAACGCCGCCCGGCTCCGCCGAGGCGGCGTTATCGTTTGGTCAT
AAATAATCGTGCATCTCCTT

Product: hemolysin-type calcium-binding repeat-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MEQGRISMATYNLDQTDLKAAISANFDPTVQQQIIDYLIGKTAYTNPDNGDAIPVQVGTGVGTPDPNANVLIEVNANNTV
TTDPALKAIIVDTPSDATLVVNGSDPVLVATGGGADQIYINDTANVTVLTGAGNDTIYAGAGSDSIESGSGNDVLVDQVS
GTSTLSAGAGNDYLFGFGADTLFGGSGNDTLYGGTSSELHGGDDNDVLISGSNSHTANLLYGDGGNDQLFGGAGSDSLYG
GAGADTLTAGIGNQLLDGGDDNDIILGNVAGYDSLYGGNGNDIIYSNSAATHASLLSGDAGNDSLYAGDGSDLLFGGTGN
DLLVGGARTAELHGGADNDALYSYSDASHGTQLFGDAGNDSLYAGSGADTLYGGAGNDLLVGGASTVVLNGGDDNDTVYS
FSDSSHATSLYGGAGNDTLYGGSGSDTLYGGSGNDVLVAGSGTQTLIGGSDGSSFIGSSTGTASMVGGAGQDYFYLNNAT
SNDTIDGGGGNLDSVTFLDHSQADLSGITASATTPGALDVTFSNGQVVQVSNIEYLIFNDGNYTKL

Sequences:

>Translated_546_residues
MEQGRISMATYNLDQTDLKAAISANFDPTVQQQIIDYLIGKTAYTNPDNGDAIPVQVGTGVGTPDPNANVLIEVNANNTV
TTDPALKAIIVDTPSDATLVVNGSDPVLVATGGGADQIYINDTANVTVLTGAGNDTIYAGAGSDSIESGSGNDVLVDQVS
GTSTLSAGAGNDYLFGFGADTLFGGSGNDTLYGGTSSELHGGDDNDVLISGSNSHTANLLYGDGGNDQLFGGAGSDSLYG
GAGADTLTAGIGNQLLDGGDDNDIILGNVAGYDSLYGGNGNDIIYSNSAATHASLLSGDAGNDSLYAGDGSDLLFGGTGN
DLLVGGARTAELHGGADNDALYSYSDASHGTQLFGDAGNDSLYAGSGADTLYGGAGNDLLVGGASTVVLNGGDDNDTVYS
FSDSSHATSLYGGAGNDTLYGGSGSDTLYGGSGNDVLVAGSGTQTLIGGSDGSSFIGSSTGTASMVGGAGQDYFYLNNAT
SNDTIDGGGGNLDSVTFLDHSQADLSGITASATTPGALDVTFSNGQVVQVSNIEYLIFNDGNYTKL
>Mature_546_residues
MEQGRISMATYNLDQTDLKAAISANFDPTVQQQIIDYLIGKTAYTNPDNGDAIPVQVGTGVGTPDPNANVLIEVNANNTV
TTDPALKAIIVDTPSDATLVVNGSDPVLVATGGGADQIYINDTANVTVLTGAGNDTIYAGAGSDSIESGSGNDVLVDQVS
GTSTLSAGAGNDYLFGFGADTLFGGSGNDTLYGGTSSELHGGDDNDVLISGSNSHTANLLYGDGGNDQLFGGAGSDSLYG
GAGADTLTAGIGNQLLDGGDDNDIILGNVAGYDSLYGGNGNDIIYSNSAATHASLLSGDAGNDSLYAGDGSDLLFGGTGN
DLLVGGARTAELHGGADNDALYSYSDASHGTQLFGDAGNDSLYAGSGADTLYGGAGNDLLVGGASTVVLNGGDDNDTVYS
FSDSSHATSLYGGAGNDTLYGGSGSDTLYGGSGNDVLVAGSGTQTLIGGSDGSSFIGSSTGTASMVGGAGQDYFYLNNAT
SNDTIDGGGGNLDSVTFLDHSQADLSGITASATTPGALDVTFSNGQVVQVSNIEYLIFNDGNYTKL

Specific function: May participate in the pathogenesis of meningococcal disease [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 12 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010566
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF06594 HCBP_related; PF00353 HemolysinCabind [H]

EC number: NA

Molecular weight: Translated: 54201; Mature: 54201

Theoretical pI: Translated: 3.32; Mature: 3.32

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQGRISMATYNLDQTDLKAAISANFDPTVQQQIIDYLIGKTAYTNPDNGDAIPVQVGTG
CCCCEEEEEEECCCHHHHHEEEECCCCHHHHHHHHHHHHCCCEECCCCCCCEEEEEECCC
VGTPDPNANVLIEVNANNTVTTDPALKAIIVDTPSDATLVVNGSDPVLVATGGGADQIYI
CCCCCCCCCEEEEECCCCEEECCCCEEEEEEECCCCCEEEEECCCCEEEEECCCCCEEEE
NDTANVTVLTGAGNDTIYAGAGSDSIESGSGNDVLVDQVSGTSTLSAGAGNDYLFGFGAD
CCCCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCEEEEECCC
TLFGGSGNDTLYGGTSSELHGGDDNDVLISGSNSHTANLLYGDGGNDQLFGGAGSDSLYG
EEECCCCCCEEECCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCEECCCCCCCCCC
GAGADTLTAGIGNQLLDGGDDNDIILGNVAGYDSLYGGNGNDIIYSNSAATHASLLSGDA
CCCCCHHHHHCCHHHHCCCCCCCEEEEEECCCCCEECCCCCEEEEECCCCCCHHHHCCCC
GNDSLYAGDGSDLLFGGTGNDLLVGGARTAELHGGADNDALYSYSDASHGTQLFGDAGND
CCCCEEECCCCEEEEECCCCCEEEECCEEEEECCCCCCCCEEEECCCCCCCEEECCCCCC
SLYAGSGADTLYGGAGNDLLVGGASTVVLNGGDDNDTVYSFSDSSHATSLYGGAGNDTLY
CEEECCCCCEEECCCCCEEEEECCEEEEEECCCCCCEEEEECCCCCCEEEECCCCCCEEE
GGSGSDTLYGGSGNDVLVAGSGTQTLIGGSDGSSFIGSSTGTASMVGGAGQDYFYLNNAT
CCCCCCEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCEEECCCCCCCEEEEECCC
SNDTIDGGGGNLDSVTFLDHSQADLSGITASATTPGALDVTFSNGQVVQVSNIEYLIFND
CCCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCCEEEEEECCCCEEEEECEEEEEECC
GNYTKL
CCEECC
>Mature Secondary Structure
MEQGRISMATYNLDQTDLKAAISANFDPTVQQQIIDYLIGKTAYTNPDNGDAIPVQVGTG
CCCCEEEEEEECCCHHHHHEEEECCCCHHHHHHHHHHHHCCCEECCCCCCCEEEEEECCC
VGTPDPNANVLIEVNANNTVTTDPALKAIIVDTPSDATLVVNGSDPVLVATGGGADQIYI
CCCCCCCCCEEEEECCCCEEECCCCEEEEEEECCCCCEEEEECCCCEEEEECCCCCEEEE
NDTANVTVLTGAGNDTIYAGAGSDSIESGSGNDVLVDQVSGTSTLSAGAGNDYLFGFGAD
CCCCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCEEEEECCC
TLFGGSGNDTLYGGTSSELHGGDDNDVLISGSNSHTANLLYGDGGNDQLFGGAGSDSLYG
EEECCCCCCEEECCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCEECCCCCCCCCC
GAGADTLTAGIGNQLLDGGDDNDIILGNVAGYDSLYGGNGNDIIYSNSAATHASLLSGDA
CCCCCHHHHHCCHHHHCCCCCCCEEEEEECCCCCEECCCCCEEEEECCCCCCHHHHCCCC
GNDSLYAGDGSDLLFGGTGNDLLVGGARTAELHGGADNDALYSYSDASHGTQLFGDAGND
CCCCEEECCCCEEEEECCCCCEEEECCEEEEECCCCCCCCEEEECCCCCCCEEECCCCCC
SLYAGSGADTLYGGAGNDLLVGGASTVVLNGGDDNDTVYSFSDSSHATSLYGGAGNDTLY
CEEECCCCCEEECCCCCEEEEECCEEEEEECCCCCCEEEEECCCCCCEEEECCCCCCEEE
GGSGSDTLYGGSGNDVLVAGSGTQTLIGGSDGSSFIGSSTGTASMVGGAGQDYFYLNNAT
CCCCCCEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCEEECCCCCCCEEEEECCC
SNDTIDGGGGNLDSVTFLDHSQADLSGITASATTPGALDVTFSNGQVVQVSNIEYLIFND
CCCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCCEEEEEECCCCEEEEECEEEEEECC
GNYTKL
CCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]