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The map label for this gene is hlyA [H]

Identifier: 146343791

GI number: 146343791

Start: 7346274

End: 7347842

Strand: Reverse

Name: hlyA [H]

Synonym: BRADO7039

Alternate gene names: 146343791

Gene position: 7347842-7346274 (Counterclockwise)

Preceding gene: 146343792

Following gene: 146343790

Centisome position: 98.54

GC content: 60.42

Gene sequence:

>1569_bases
TTGTTTTTTCCGGCAGTGGTAGATCATTGCTCCCATTGCCGACTAATCAATTTGAAAGCGAACGTTGTGATGACGCCAAT
CATTTTGACGCAGTCAAGTCTGTTGGCGGCGCTCGCTCCGATCGATCCCGCTCTGCGCCAGCAGGTGATCGCCTATCTGA
TCGGGCGAACATCTTACACATCTCCCGACAATGGCCTGCCCATTCCCGCACAGTTGGGCGTCGCCATCTCCGTGCCGGAC
CCGTCCGCGAATGTTCTGATCGAGACCAATGCTGTTAATACCGTCAACGTGGATCCAAGCCTGAAGGTGATCGTTGCCAA
CGTCGCGTCCAACGTCGTCCTATCTGTCAACGGATTGTCGCCGGTGCTCGTCGCCACCGGCAATGGCGACAATCAGGTGT
TTGTCAACGACTCCGCGGCGGTGACCGTACTGACCGGGTCCGGCAATGACACGATCTACGCGGGTGCCGGCGCCGATACG
CTGTCGAGCGGAGCCGGCAACGACGTTCTGGTCGATCAGGTCTCAGGGGCGAGCCTTCTCGACGGTGGCTCCGGTTACGA
CCTGCTCTTCGGGTCGGGCGCCGACAAGCTGGCGGGCGGCGATGGCGACGATACGCTCTACGGCGGAACGGCATCCGATC
TGTTGGGTGGGAATGGCAACGACATCCTGATCTCAGGCAGCGACGCTGTCCATGCGAACGTGCTCGATGGTGGTGCTGAC
AGTGACCAGCTCTACGCCGGCGCTGGTCAGGATTCGCTTTATGGAGGGGCCGGCAGCGACATCTTGGTATTCGGCAGCGC
CGCGCAATATGCCGACGGCGATGACGACAATGACCTCGTCGTCGGCGGAGCCGGCAACGATGCCCTGCACGGCGGCAACG
GCAATGACGCGATCTACTCGAACTCCGTAGCCAGTCAAGGCGCGAAGCTCTACGGCGACTCGGGCAACGATTCTCTCTAC
GCAGGAGCAGGAGCCGATTCGCTCTGCGGCGGCGCCGATGCCGATCTCCTCATCGGCGGCGCGGCAACGGCTGTGCTCGA
CGGCGGTGGCGGTGACGACGTCGTTTACTCGAACAGCAATTCAAGCCAAGGCACCGTCGTCTATGGTGGCGGCGGCAATG
ACCAGCTCTATGCCGGATACGGCAACGACACGCTCTACGGCGGCAGCGGTCACGATCTTCTCAAGGCGGGCTATGGCAAC
GGCGTGACCGTGATGATCGGCGGAGACGATGGGAGTTCCTTCACCGACGATACCGGCGGCAATACCTCATCAATGGTCGG
CGGCGCTGGCCAGGACTTTTTCTATCTGAAGAATCTTTTCACCCCGGACACGATCGATGGCGGCGGTGGTGACTTGGACT
CCGTCACATTCTCTCTCTGCGACCTGTCGAGCGTCATGTCGATTACGCCCGGCGCCACGGCGGGGTCCTATGACGTCAAC
TTCGGCTATCACGTCTATCCGCGTTATCCAGAGGGGCCGCCGTCCTACGACGTTGTCACGCAGGTCGCACATGTGAGCAA
TATCGAGTACCTTATTTTCCGGGCTGGCAACTTTATCCATCTGACCTGA

Upstream 100 bases:

>100_bases
CCCCCAGCGCTCGGCGTCAATCGACGGATTTCCAGTCATCCGGTCTCATGCAAGTACGAATAAACCTTAAATTGCATGAT
AATTTCCGGACGCGACTGAG

Downstream 100 bases:

>100_bases
CCTGGTCGGAAAGACCGTCTTTACCTCGCCTGACAAGGGCGACCTCATTGCAGTTCGGATGTCAGGAGGCGTTGCGACGC
CCGACTCGACCGCCAACGTC

Product: hemolysin-type calcium-binding repeat-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MFFPAVVDHCSHCRLINLKANVVMTPIILTQSSLLAALAPIDPALRQQVIAYLIGRTSYTSPDNGLPIPAQLGVAISVPD
PSANVLIETNAVNTVNVDPSLKVIVANVASNVVLSVNGLSPVLVATGNGDNQVFVNDSAAVTVLTGSGNDTIYAGAGADT
LSSGAGNDVLVDQVSGASLLDGGSGYDLLFGSGADKLAGGDGDDTLYGGTASDLLGGNGNDILISGSDAVHANVLDGGAD
SDQLYAGAGQDSLYGGAGSDILVFGSAAQYADGDDDNDLVVGGAGNDALHGGNGNDAIYSNSVASQGAKLYGDSGNDSLY
AGAGADSLCGGADADLLIGGAATAVLDGGGGDDVVYSNSNSSQGTVVYGGGGNDQLYAGYGNDTLYGGSGHDLLKAGYGN
GVTVMIGGDDGSSFTDDTGGNTSSMVGGAGQDFFYLKNLFTPDTIDGGGGDLDSVTFSLCDLSSVMSITPGATAGSYDVN
FGYHVYPRYPEGPPSYDVVTQVAHVSNIEYLIFRAGNFIHLT

Sequences:

>Translated_522_residues
MFFPAVVDHCSHCRLINLKANVVMTPIILTQSSLLAALAPIDPALRQQVIAYLIGRTSYTSPDNGLPIPAQLGVAISVPD
PSANVLIETNAVNTVNVDPSLKVIVANVASNVVLSVNGLSPVLVATGNGDNQVFVNDSAAVTVLTGSGNDTIYAGAGADT
LSSGAGNDVLVDQVSGASLLDGGSGYDLLFGSGADKLAGGDGDDTLYGGTASDLLGGNGNDILISGSDAVHANVLDGGAD
SDQLYAGAGQDSLYGGAGSDILVFGSAAQYADGDDDNDLVVGGAGNDALHGGNGNDAIYSNSVASQGAKLYGDSGNDSLY
AGAGADSLCGGADADLLIGGAATAVLDGGGGDDVVYSNSNSSQGTVVYGGGGNDQLYAGYGNDTLYGGSGHDLLKAGYGN
GVTVMIGGDDGSSFTDDTGGNTSSMVGGAGQDFFYLKNLFTPDTIDGGGGDLDSVTFSLCDLSSVMSITPGATAGSYDVN
FGYHVYPRYPEGPPSYDVVTQVAHVSNIEYLIFRAGNFIHLT
>Mature_522_residues
MFFPAVVDHCSHCRLINLKANVVMTPIILTQSSLLAALAPIDPALRQQVIAYLIGRTSYTSPDNGLPIPAQLGVAISVPD
PSANVLIETNAVNTVNVDPSLKVIVANVASNVVLSVNGLSPVLVATGNGDNQVFVNDSAAVTVLTGSGNDTIYAGAGADT
LSSGAGNDVLVDQVSGASLLDGGSGYDLLFGSGADKLAGGDGDDTLYGGTASDLLGGNGNDILISGSDAVHANVLDGGAD
SDQLYAGAGQDSLYGGAGSDILVFGSAAQYADGDDDNDLVVGGAGNDALHGGNGNDAIYSNSVASQGAKLYGDSGNDSLY
AGAGADSLCGGADADLLIGGAATAVLDGGGGDDVVYSNSNSSQGTVVYGGGGNDQLYAGYGNDTLYGGSGHDLLKAGYGN
GVTVMIGGDDGSSFTDDTGGNTSSMVGGAGQDFFYLKNLFTPDTIDGGGGDLDSVTFSLCDLSSVMSITPGATAGSYDVN
FGYHVYPRYPEGPPSYDVVTQVAHVSNIEYLIFRAGNFIHLT

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 6 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR013550
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX; PF08339 RTX_C [H]

EC number: NA

Molecular weight: Translated: 52124; Mature: 52124

Theoretical pI: Translated: 3.61; Mature: 3.61

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFPAVVDHCSHCRLINLKANVVMTPIILTQSSLLAALAPIDPALRQQVIAYLIGRTSYT
CCCHHHHHHCCCCEEEEEECCEEEEEEEEECHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
SPDNGLPIPAQLGVAISVPDPSANVLIETNAVNTVNVDPSLKVIVANVASNVVLSVNGLS
CCCCCCCCCHHCCEEEECCCCCCCEEEEECCEEEEECCCCEEEEEEECCCCEEEEECCCC
PVLVATGNGDNQVFVNDSAAVTVLTGSGNDTIYAGAGADTLSSGAGNDVLVDQVSGASLL
EEEEEECCCCCEEEEECCCEEEEEECCCCCEEEECCCCCHHCCCCCCCEEEEECCCCEEE
DGGSGYDLLFGSGADKLAGGDGDDTLYGGTASDLLGGNGNDILISGSDAVHANVLDGGAD
CCCCCEEEEEECCCCCCCCCCCCCCEECCCHHHHCCCCCCEEEEECCCCEEEEEECCCCC
SDQLYAGAGQDSLYGGAGSDILVFGSAAQYADGDDDNDLVVGGAGNDALHGGNGNDAIYS
CCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEE
NSVASQGAKLYGDSGNDSLYAGAGADSLCGGADADLLIGGAATAVLDGGGGDDVVYSNSN
CCHHHCCCEEECCCCCCCEEECCCCCCCCCCCCCCEEEECEEEEEEECCCCCCEEEECCC
SSQGTVVYGGGGNDQLYAGYGNDTLYGGSGHDLLKAGYGNGVTVMIGGDDGSSFTDDTGG
CCCCEEEECCCCCCCEEEECCCCEEECCCCCHHHEECCCCCEEEEEECCCCCCCCCCCCC
NTSSMVGGAGQDFFYLKNLFTPDTIDGGGGDLDSVTFSLCDLSSVMSITPGATAGSYDVN
CCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHEEEHHHHHHHHEECCCCCCCCEECC
FGYHVYPRYPEGPPSYDVVTQVAHVSNIEYLIFRAGNFIHLT
CCEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCEEEEC
>Mature Secondary Structure
MFFPAVVDHCSHCRLINLKANVVMTPIILTQSSLLAALAPIDPALRQQVIAYLIGRTSYT
CCCHHHHHHCCCCEEEEEECCEEEEEEEEECHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
SPDNGLPIPAQLGVAISVPDPSANVLIETNAVNTVNVDPSLKVIVANVASNVVLSVNGLS
CCCCCCCCCHHCCEEEECCCCCCCEEEEECCEEEEECCCCEEEEEEECCCCEEEEECCCC
PVLVATGNGDNQVFVNDSAAVTVLTGSGNDTIYAGAGADTLSSGAGNDVLVDQVSGASLL
EEEEEECCCCCEEEEECCCEEEEEECCCCCEEEECCCCCHHCCCCCCCEEEEECCCCEEE
DGGSGYDLLFGSGADKLAGGDGDDTLYGGTASDLLGGNGNDILISGSDAVHANVLDGGAD
CCCCCEEEEEECCCCCCCCCCCCCCEECCCHHHHCCCCCCEEEEECCCCEEEEEECCCCC
SDQLYAGAGQDSLYGGAGSDILVFGSAAQYADGDDDNDLVVGGAGNDALHGGNGNDAIYS
CCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEE
NSVASQGAKLYGDSGNDSLYAGAGADSLCGGADADLLIGGAATAVLDGGGGDDVVYSNSN
CCHHHCCCEEECCCCCCCEEECCCCCCCCCCCCCCEEEECEEEEEEECCCCCCEEEECCC
SSQGTVVYGGGGNDQLYAGYGNDTLYGGSGHDLLKAGYGNGVTVMIGGDDGSSFTDDTGG
CCCCEEEECCCCCCCEEEECCCCEEECCCCCHHHEECCCCCEEEEEECCCCCCCCCCCCC
NTSSMVGGAGQDFFYLKNLFTPDTIDGGGGDLDSVTFSLCDLSSVMSITPGATAGSYDVN
CCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHEEEHHHHHHHHEECCCCCCCCEECC
FGYHVYPRYPEGPPSYDVVTQVAHVSNIEYLIFRAGNFIHLT
CCEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7801126; 8808931 [H]