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The map label for this gene is lip2 [H]

Identifier: 146343668

GI number: 146343668

Start: 7180996

End: 7181955

Strand: Direct

Name: lip2 [H]

Synonym: BRADO6911

Alternate gene names: 146343668

Gene position: 7180996-7181955 (Clockwise)

Preceding gene: 146343666

Following gene: 146343669

Centisome position: 96.3

GC content: 66.46

Gene sequence:

>960_bases
ATGCCGCTCGACCCTCGTGCCCGGCGATTGCTGTCGATGGTGGCCGCGACCGGCTCGGAAGAGCGGGAGCGCCCGAGCGT
AGAGCACCGCCGGCAGTCGCTCGCGAAGCTGATGCAGTTCGCACGCAACGATGTCGGCGTGGTGACGACGCAGGACGCTC
ACTTGTTCGGGCCCGCGGGTCCGCTGCGCTACCGCCTGTACACGCCGACCGACGAGGCGGTCGAGACCGACGCGCGCCGT
TCCGGCTTCGTCTACTTTCATGGTGGCGGGCTCGTCGCGGGAAGCATCGAGACCCATGACCGCCTCGCTGCGGCGCTCGC
CGCTGCGAGCAAATGCCGTCTGCTCTCGATCGAATACCGGCTTGCGCCGGAACACACGTTTCCAGCAGCGTTCGACGACG
CGGTTGCCGCGGTCCAGTTCGCCGTCGATCACGCGAACGCGCTCGGCCTCGACCGCGACCGGATCGTGGTGGGAGGCGAT
TCCGCGGGCGCGACACTCGCTGCGGCCGTCTGCCGATATTTCGGCAGCACTGCAAGCTTCAGGATCGCGACGCAGTGCCT
GATCTGTCCCGTGCTGGACTTCTCGCGAGCCTGGCCATCGCGGGAGCTGTTCGGAAACGGTTATCTGGTCGATGCAGCCA
TCTGGCAGGCCGACCTCGCCGACTGCCTTCCAGAAGGAACAGACCTCCGCGATCCGCGGATCTCACCCTTGTGCGGCGCT
GACTTTTCCAACCTGCCACCCGCCGTCATCCACACCGCGGAGTTCGATCCGATGCGCGACGAAGGCAACGCCTATGCCGC
CAGGCTGAAGCAGGCCGGCGTCCCGGTGGCGCATGTCTGTCACGACGGCATGGTTCACAATTTCCATGCGCTCGGCGCGC
TGCTGCCGCAGGCCAAGCCGGCACTCGAGCTGATCGGGCGTCAGATCCAATCGCTGCTGCACGCCAGGGATTTGAGTTAA

Upstream 100 bases:

>100_bases
GGCGTGGAGATTTTAAGGATCTGCTTGCCGATGCGCTGCTCATGATCGATACACGCTTGGCTAGCACAATGCCGATCGCC
TTGGTTAACCTGGAACCCCC

Downstream 100 bases:

>100_bases
TTCGACGTTTGTCGGCGACATCTCGTTAGGGTTATTTCGTCGTTGTTGTCGCGAATTATGGACCGCTTTACGCCTACACT
CCTACAACATCGGTACTCGC

Product: putative lipase/esterase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MPLDPRARRLLSMVAATGSEERERPSVEHRRQSLAKLMQFARNDVGVVTTQDAHLFGPAGPLRYRLYTPTDEAVETDARR
SGFVYFHGGGLVAGSIETHDRLAAALAAASKCRLLSIEYRLAPEHTFPAAFDDAVAAVQFAVDHANALGLDRDRIVVGGD
SAGATLAAAVCRYFGSTASFRIATQCLICPVLDFSRAWPSRELFGNGYLVDAAIWQADLADCLPEGTDLRDPRISPLCGA
DFSNLPPAVIHTAEFDPMRDEGNAYAARLKQAGVPVAHVCHDGMVHNFHALGALLPQAKPALELIGRQIQSLLHARDLS

Sequences:

>Translated_319_residues
MPLDPRARRLLSMVAATGSEERERPSVEHRRQSLAKLMQFARNDVGVVTTQDAHLFGPAGPLRYRLYTPTDEAVETDARR
SGFVYFHGGGLVAGSIETHDRLAAALAAASKCRLLSIEYRLAPEHTFPAAFDDAVAAVQFAVDHANALGLDRDRIVVGGD
SAGATLAAAVCRYFGSTASFRIATQCLICPVLDFSRAWPSRELFGNGYLVDAAIWQADLADCLPEGTDLRDPRISPLCGA
DFSNLPPAVIHTAEFDPMRDEGNAYAARLKQAGVPVAHVCHDGMVHNFHALGALLPQAKPALELIGRQIQSLLHARDLS
>Mature_318_residues
PLDPRARRLLSMVAATGSEERERPSVEHRRQSLAKLMQFARNDVGVVTTQDAHLFGPAGPLRYRLYTPTDEAVETDARRS
GFVYFHGGGLVAGSIETHDRLAAALAAASKCRLLSIEYRLAPEHTFPAAFDDAVAAVQFAVDHANALGLDRDRIVVGGDS
AGATLAAAVCRYFGSTASFRIATQCLICPVLDFSRAWPSRELFGNGYLVDAAIWQADLADCLPEGTDLRDPRISPLCGAD
FSNLPPAVIHTAEFDPMRDEGNAYAARLKQAGVPVAHVCHDGMVHNFHALGALLPQAKPALELIGRQIQSLLHARDLS

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=309, Percent_Identity=28.8025889967638, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI157041239, Length=287, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI68051721, Length=271, Percent_Identity=30.9963099630996, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI61966717, Length=335, Percent_Identity=26.865671641791, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI21328446, Length=91, Percent_Identity=39.5604395604396, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786682, Length=249, Percent_Identity=28.9156626506024, Blast_Score=88, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71996133, Length=324, Percent_Identity=28.0864197530864, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17540028, Length=299, Percent_Identity=29.7658862876254, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17567059, Length=137, Percent_Identity=34.3065693430657, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI72001146, Length=132, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115533410, Length=141, Percent_Identity=30.4964539007092, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533412, Length=141, Percent_Identity=30.4964539007092, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24656084, Length=84, Percent_Identity=40.4761904761905, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24656076, Length=84, Percent_Identity=40.4761904761905, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20130169, Length=84, Percent_Identity=40.4761904761905, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 34447; Mature: 34316

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDPRARRLLSMVAATGSEERERPSVEHRRQSLAKLMQFARNDVGVVTTQDAHLFGPAG
CCCCHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEECCCC
PLRYRLYTPTDEAVETDARRSGFVYFHGGGLVAGSIETHDRLAAALAAASKCRLLSIEYR
CEEEEEECCCHHHHHHHHHHCCEEEEECCEEEECCCCHHHHHHHHHHHHHCCEEEEEEEE
LAPEHTFPAAFDDAVAAVQFAVDHANALGLDRDRIVVGGDSAGATLAAAVCRYFGSTASF
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCH
RIATQCLICPVLDFSRAWPSRELFGNGYLVDAAIWQADLADCLPEGTDLRDPRISPLCGA
HHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DFSNLPPAVIHTAEFDPMRDEGNAYAARLKQAGVPVAHVCHDGMVHNFHALGALLPQAKP
CCCCCCHHEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCCH
ALELIGRQIQSLLHARDLS
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLDPRARRLLSMVAATGSEERERPSVEHRRQSLAKLMQFARNDVGVVTTQDAHLFGPAG
CCCHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEECCCC
PLRYRLYTPTDEAVETDARRSGFVYFHGGGLVAGSIETHDRLAAALAAASKCRLLSIEYR
CEEEEEECCCHHHHHHHHHHCCEEEEECCEEEECCCCHHHHHHHHHHHHHCCEEEEEEEE
LAPEHTFPAAFDDAVAAVQFAVDHANALGLDRDRIVVGGDSAGATLAAAVCRYFGSTASF
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCH
RIATQCLICPVLDFSRAWPSRELFGNGYLVDAAIWQADLADCLPEGTDLRDPRISPLCGA
HHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DFSNLPPAVIHTAEFDPMRDEGNAYAARLKQAGVPVAHVCHDGMVHNFHALGALLPQAKP
CCCCCCHHEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCCH
ALELIGRQIQSLLHARDLS
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]