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The map label for this gene is srrB [H]

Identifier: 146343594

GI number: 146343594

Start: 7091513

End: 7093258

Strand: Direct

Name: srrB [H]

Synonym: BRADO6832

Alternate gene names: 146343594

Gene position: 7091513-7093258 (Clockwise)

Preceding gene: 146343593

Following gene: 146343595

Centisome position: 95.1

GC content: 64.72

Gene sequence:

>1746_bases
ATGGCCGAACAGGACGATGTCCTCCACCTGATCGACGACACCGGCTTCGCAGAGGACGCCCAATCGGCCCGGAAATGGAA
GATCGCCGTCATCGACGACGACCATGCCGTACACGATGGCACCCGATTTGCGCTGTCGGACTACAGCTTGAACGGCCAGG
GTCTCGAGATCCTCTCCGCCTACTCGGCGGCTGAGGGCCGCATCCTGATGCGCGAGCATGGCGACATCGCTGCAGTGCTG
CTCGATGTCATCATGGAGACCGATGTCGCCGGCCTGGAGCTCGTCGAATACATCCGCAACGAGATCAGGAACGAGACCGT
CCGCATCATCCTGCGCACCGGCCAGCCTGGCCAGGCGCCGGAGCGGCGGGTCATCGTCCAGTACGACATCAACGACTACA
AGGCCAAGACCGAGCTCACCGCCGACAAGCTGTTCACCTCGCTGACCGCGGCGCTGCGCAGCTATCAGCAGCTCGAGCGC
ATGGTGCAGACCCGCCGCGGCCTGGAGATCATCATCGACGCGGCCTCGACATTGTACGACTTCAAGTCGATGCAGCGGCT
CGCCGAAGGCGTGCTGACTCAGATCGCGTCGCTGCTGAACGTCGATTGCGCCGGCATTCTCGTGCTGCGCGACGACGGCA
GCCCGAGAGAGGATTTTTCCGTATTGGCCGGCTCCGGCTGCTACAGCCGCTTCTCCGGCGCCGTCACCTCGCGCTCGCTC
GACCCGGACCTGCGCGGCATGGTCGAGGCCGCCTTCAGGCAGCGGACGAACGAATTCGCCGACCACAAGACGGTGCTGTA
CCTGCGGACCGGCTCCGGCCGGGAGGTGGTGGTTCTGCTGCAGGCCGAGCGGCCCTTGTCCGAGACTGACCGCTCGCTGG
TCGAGATCTTCTCCAGCCGCCTGTCGATCGCCTTCGACAATGTGATCCTGTATCAGCAGCTGCATGAGGCCAACACCCAG
CTCGAGGACCGTGTCGCCCAGCGCACCCGCGCCCTGATGCAGGCCAACCGGCGGCTGTCGGCGCAGTGGCTGCGGCTGCA
GCGCGCCAACGGTTTCAAGAACGAAATTTTGGGCACCGTTGCCCACGATCTGAAGAATCCGCTCGGCGTGATCCTCGGAC
GTACCGAGATGCTGACGGAGCTGGTCGCCACAGGCGCATCGGCTGACGGCATCGCCAGCCAGATCGGCCACATCCGTGAT
GCGGCCAAACGGCTGACCTCGATGGTCGACCATCTGATCTCGGATGCGATGGCCGACGCATTCGACATCACGATCCGCCG
CGAGCCGGTCGATATCGCCGCTTTGATCCACGAGGTGGTCGAGGCCAACCAGCCGCTGGCGCTCAACAAGCAGCAGGTCA
TCGCGGTGTCGGCGCCGCCGCAGCTCTCGACGATGTGCGACATCGACCGCATCCGCGAGGCGATCGACAATCTGCTGAGC
AACGCCATCAAATACAGCCCGATCGGCGGGCGGATCAGCGTTGACGTCACCGACGATGGCGACAACACCATCATCGGCAT
CACCGACCAGGGCGCCGGACTGTCGCCGGAGGATCTCGGCCGGCTGTTCGGGCGGTTCCAGCGCCTCTCGGCCAAACCGA
CCGCGGGCGAGAGCTCGACGGGGCTCGGCCTGTCGATTGTCAAACGCATCGTCGACATGCATGGTGGCGAGGTGACGGCC
AAGAGCGATGGGCCGGGATCGGGGTCAACCTTCACCATCACACTGCCTGCGGCCGAGTTGTCATGA

Upstream 100 bases:

>100_bases
TGCTGGAATCCCGCGAGGGACAAGGCACGACTTTTCGGATAATCATGCCGCGGGTCGCCAAGGGCGACACCGAGACAGCA
ATGGGTGACGGAACGACGCA

Downstream 100 bases:

>100_bases
GTCAGAGCCAGCACATCATCATCGTCGACGATGAGGCACCCGCCCGCGAGATGGTGGGCGATTACCTCAAGATGCACGGT
TTCACGGTGACCTTGTGCGA

Product: two-component system regulator response regulator receiver/ histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MAEQDDVLHLIDDTGFAEDAQSARKWKIAVIDDDHAVHDGTRFALSDYSLNGQGLEILSAYSAAEGRILMREHGDIAAVL
LDVIMETDVAGLELVEYIRNEIRNETVRIILRTGQPGQAPERRVIVQYDINDYKAKTELTADKLFTSLTAALRSYQQLER
MVQTRRGLEIIIDAASTLYDFKSMQRLAEGVLTQIASLLNVDCAGILVLRDDGSPREDFSVLAGSGCYSRFSGAVTSRSL
DPDLRGMVEAAFRQRTNEFADHKTVLYLRTGSGREVVVLLQAERPLSETDRSLVEIFSSRLSIAFDNVILYQQLHEANTQ
LEDRVAQRTRALMQANRRLSAQWLRLQRANGFKNEILGTVAHDLKNPLGVILGRTEMLTELVATGASADGIASQIGHIRD
AAKRLTSMVDHLISDAMADAFDITIRREPVDIAALIHEVVEANQPLALNKQQVIAVSAPPQLSTMCDIDRIREAIDNLLS
NAIKYSPIGGRISVDVTDDGDNTIIGITDQGAGLSPEDLGRLFGRFQRLSAKPTAGESSTGLGLSIVKRIVDMHGGEVTA
KSDGPGSGSTFTITLPAAELS

Sequences:

>Translated_581_residues
MAEQDDVLHLIDDTGFAEDAQSARKWKIAVIDDDHAVHDGTRFALSDYSLNGQGLEILSAYSAAEGRILMREHGDIAAVL
LDVIMETDVAGLELVEYIRNEIRNETVRIILRTGQPGQAPERRVIVQYDINDYKAKTELTADKLFTSLTAALRSYQQLER
MVQTRRGLEIIIDAASTLYDFKSMQRLAEGVLTQIASLLNVDCAGILVLRDDGSPREDFSVLAGSGCYSRFSGAVTSRSL
DPDLRGMVEAAFRQRTNEFADHKTVLYLRTGSGREVVVLLQAERPLSETDRSLVEIFSSRLSIAFDNVILYQQLHEANTQ
LEDRVAQRTRALMQANRRLSAQWLRLQRANGFKNEILGTVAHDLKNPLGVILGRTEMLTELVATGASADGIASQIGHIRD
AAKRLTSMVDHLISDAMADAFDITIRREPVDIAALIHEVVEANQPLALNKQQVIAVSAPPQLSTMCDIDRIREAIDNLLS
NAIKYSPIGGRISVDVTDDGDNTIIGITDQGAGLSPEDLGRLFGRFQRLSAKPTAGESSTGLGLSIVKRIVDMHGGEVTA
KSDGPGSGSTFTITLPAAELS
>Mature_580_residues
AEQDDVLHLIDDTGFAEDAQSARKWKIAVIDDDHAVHDGTRFALSDYSLNGQGLEILSAYSAAEGRILMREHGDIAAVLL
DVIMETDVAGLELVEYIRNEIRNETVRIILRTGQPGQAPERRVIVQYDINDYKAKTELTADKLFTSLTAALRSYQQLERM
VQTRRGLEIIIDAASTLYDFKSMQRLAEGVLTQIASLLNVDCAGILVLRDDGSPREDFSVLAGSGCYSRFSGAVTSRSLD
PDLRGMVEAAFRQRTNEFADHKTVLYLRTGSGREVVVLLQAERPLSETDRSLVEIFSSRLSIAFDNVILYQQLHEANTQL
EDRVAQRTRALMQANRRLSAQWLRLQRANGFKNEILGTVAHDLKNPLGVILGRTEMLTELVATGASADGIASQIGHIRDA
AKRLTSMVDHLISDAMADAFDITIRREPVDIAALIHEVVEANQPLALNKQQVIAVSAPPQLSTMCDIDRIREAIDNLLSN
AIKYSPIGGRISVDVTDDGDNTIIGITDQGAGLSPEDLGRLFGRFQRLSAKPTAGESSTGLGLSIVKRIVDMHGGEVTAK
SDGPGSGSTFTITLPAAELS

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: COG3437

COG function: function code KT; Response regulator containing a CheY-like receiver domain and an HD-GYP domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=29.646017699115, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=27.1551724137931, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI48994928, Length=371, Percent_Identity=25.3369272237197, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=26.7241379310345, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87081816, Length=238, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=25.3218884120172, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788713, Length=322, Percent_Identity=23.9130434782609, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=244, Percent_Identity=28.2786885245902, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=29.3577981651376, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786783, Length=220, Percent_Identity=29.5454545454545, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790346, Length=242, Percent_Identity=28.099173553719, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=27.1186440677966, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=219, Percent_Identity=25.1141552511416, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082128, Length=263, Percent_Identity=26.615969581749, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789808, Length=201, Percent_Identity=28.3582089552239, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63523; Mature: 63392

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQDDVLHLIDDTGFAEDAQSARKWKIAVIDDDHAVHDGTRFALSDYSLNGQGLEILSA
CCCCCCEEEEECCCCCCHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHH
YSAAEGRILMREHGDIAAVLLDVIMETDVAGLELVEYIRNEIRNETVRIILRTGQPGQAP
HCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
ERRVIVQYDINDYKAKTELTADKLFTSLTAALRSYQQLERMVQTRRGLEIIIDAASTLYD
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
FKSMQRLAEGVLTQIASLLNVDCAGILVLRDDGSPREDFSVLAGSGCYSRFSGAVTSRSL
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCHHHHHCCCHHCCCC
DPDLRGMVEAAFRQRTNEFADHKTVLYLRTGSGREVVVLLQAERPLSETDRSLVEIFSSR
CHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHH
LSIAFDNVILYQQLHEANTQLEDRVAQRTRALMQANRRLSAQWLRLQRANGFKNEILGTV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AHDLKNPLGVILGRTEMLTELVATGASADGIASQIGHIRDAAKRLTSMVDHLISDAMADA
HHHHCCCHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDITIRREPVDIAALIHEVVEANQPLALNKQQVIAVSAPPQLSTMCDIDRIREAIDNLLS
HEEEEECCCHHHHHHHHHHHHCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
NAIKYSPIGGRISVDVTDDGDNTIIGITDQGAGLSPEDLGRLFGRFQRLSAKPTAGESST
HHEEECCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
GLGLSIVKRIVDMHGGEVTAKSDGPGSGSTFTITLPAAELS
CCHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
AEQDDVLHLIDDTGFAEDAQSARKWKIAVIDDDHAVHDGTRFALSDYSLNGQGLEILSA
CCCCCEEEEECCCCCCHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHH
YSAAEGRILMREHGDIAAVLLDVIMETDVAGLELVEYIRNEIRNETVRIILRTGQPGQAP
HCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
ERRVIVQYDINDYKAKTELTADKLFTSLTAALRSYQQLERMVQTRRGLEIIIDAASTLYD
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
FKSMQRLAEGVLTQIASLLNVDCAGILVLRDDGSPREDFSVLAGSGCYSRFSGAVTSRSL
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCHHHHHCCCHHCCCC
DPDLRGMVEAAFRQRTNEFADHKTVLYLRTGSGREVVVLLQAERPLSETDRSLVEIFSSR
CHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHH
LSIAFDNVILYQQLHEANTQLEDRVAQRTRALMQANRRLSAQWLRLQRANGFKNEILGTV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AHDLKNPLGVILGRTEMLTELVATGASADGIASQIGHIRDAAKRLTSMVDHLISDAMADA
HHHHCCCHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDITIRREPVDIAALIHEVVEANQPLALNKQQVIAVSAPPQLSTMCDIDRIREAIDNLLS
HEEEEECCCHHHHHHHHHHHHCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
NAIKYSPIGGRISVDVTDDGDNTIIGITDQGAGLSPEDLGRLFGRFQRLSAKPTAGESST
HHEEECCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
GLGLSIVKRIVDMHGGEVTAKSDGPGSGSTFTITLPAAELS
CCHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA