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The map label for this gene is zraS [H]

Identifier: 146343593

GI number: 146343593

Start: 7089609

End: 7091543

Strand: Direct

Name: zraS [H]

Synonym: BRADO6831

Alternate gene names: 146343593

Gene position: 7089609-7091543 (Clockwise)

Preceding gene: 146343590

Following gene: 146343594

Centisome position: 95.08

GC content: 65.94

Gene sequence:

>1935_bases
GTGCTCGCCGCGCTGATCTGGAACGGCGCCCGGGTGCTGGGCACGGCCTGGGACGACGTCCGCCAGGTGCGCGAGTCCGA
CAAGGTGCTGGCGCTGCTGGAGAGCGAGACCAGCCGGCTGCAGAACCTGATCCACCGCTACATCAATCAGCCGAGCCCGG
AGCTGTTCGCCGAGATCCTGCTGCTGCGCGAGGCCGTGCTCGGCACGCTGACGACGCGCGCCTCGACCGATCCCATGCTG
TCGGGATCGGTCGAGGATCTGGAGCGCGTCACCGTGCGCTTCCTCGACGGCTTCGGCGAGCTGCGCGGCCTGCAGGCGAC
GATCTCCAAGACCTATGAGGAGGAGGTGCTCGGCCCTGCCCGAGACATCGCCGGACTCTATTCGGCGATCGAAGGCGCGA
CCGGCCATCGCGACGCGGAGATCTGGCCGTCGCTCGGCAAATCGCGCGAGGCCTTCACGGCGATGCTGGTGGCCGCCAAC
TCCTACTATCTGTCGCTGACGCCGACCTCCGCGGATGACGCCCGCCGCAACATCGAGACGATCGAGAAGACCATCCCCGT
CATGTCGGGCCTCGCCGACAATGACCCGCAGCACCTCGCGCTGCAGCGGCTCTCGGCGCGCGCCGCCGCGCTACGCGCCG
GGTTTTCCAAGCTGACGGATCAATTGAGCAATCGCACCGAGCTGTTGCGCAACACCATCGACGCGAGCCAGGCGGAGACC
ATCGCCGTGATCGACGGGCTGTCGGTGAAGATGCGGCAGCACGAACAGAAGGCGCAGGCGACCTTCGACAAAACCCTGCG
CGACATCTCGCGCCGCGTGCTGTCGATTGCGGTCATTTTCCTCGGAATCATCCTGTCCGCCGGCGTGCTGATCGCACTGT
CGATCCGGCTGCCGCTGCAGCAGATCATGGCGTCCATGCGCGCCATCACGCTTGGCGACTACGATCGGCGGGTTCAGGGG
ACCGAGGCGCGGGACGAGGTCGGCGCGATGGCCCGCGCAGTGGAGGTGTTCCGTGAGAACGCCATCGCCAAGCGCAAAAC
CGAGGACGAACTGCGGACAGCCAAGGAGAAGGCCGAAAGCGCGCTGCTCGAGCTCAATGCCGCGCAGCGCAATCTGATCG
ACGCCGAGCGGCTCGCGGCGCTCGGCGGCCTGGTCGCCGGCGTGGCTCACGAGGTGAACAACCCGATCGGCATCAGCCTG
ACCGTCGCCTCGAGCTTCGCGCGCCGGGTCGAGATTTTCGAAGCTGCGCTGCGGTCGCCTGAAGGGGGCCTGCGACGGTC
GCAACTGGAGGAGTTCGTGCGCACCTCGCGCGACGCCTCCGAACAATTGGTCGCCAATCTGCAGCGCGCCGGCGAGCTGA
TCCAGTCGTTCAAGCAGGTCGCCGTCGACCGGTCGCACGCCGAACGGCGGACTTTCGTCTTGAGCGAGGCCACCGATCAG
ATCATCACCAGCCTGAAGCCGGTGCTCAAGCGCGCCCCGATCACGCTGTCCGTCGATGTGCCCGAGGGACTTTTCATCGA
CGGCTATCCCGGGTTCTATGGCCAGATCCTGACCAACCTTTTCCTCAACGCGGTCAACCATGCCTTTGCCGATGGCCGGT
CGGGGACCATCTCGATCGCGGCGCGTCCTCGCGGCGCGGATGACATCGAGATCATTTTCGCCGATAACGGTGCCGGCATG
ACCCCCGAGGTCCAGCGTCAGGCTTTCGACCCGTTCTTCACGACGCGCCGCAACGAGGGTGGGACCGGATTGGGCCTGCA
TATCGTCTACAATCTCGTGACTCAGCAGCTCGGCGGCCGCATGATGCTGGAATCCCGCGAGGGACAAGGCACGACTTTTC
GGATAATCATGCCGCGGGTCGCCAAGGGCGACACCGAGACAGCAATGGGTGACGGAACGACGCAATGGCCGAACAGGACG
ATGTCCTCCACCTGA

Upstream 100 bases:

>100_bases
GGCGGTTCTCGGGCGCGCTCGGATCGTGCGCGTGCTCCGGGCTGTGCCCATACGTTGGCGCATCCTCTCAATTGCCGCCC
TCAACTCCGCCGTGGTGATC

Downstream 100 bases:

>100_bases
TCGACGACACCGGCTTCGCAGAGGACGCCCAATCGGCCCGGAAATGGAAGATCGCCGTCATCGACGACGACCATGCCGTA
CACGATGGCACCCGATTTGC

Product: putative sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MLAALIWNGARVLGTAWDDVRQVRESDKVLALLESETSRLQNLIHRYINQPSPELFAEILLLREAVLGTLTTRASTDPML
SGSVEDLERVTVRFLDGFGELRGLQATISKTYEEEVLGPARDIAGLYSAIEGATGHRDAEIWPSLGKSREAFTAMLVAAN
SYYLSLTPTSADDARRNIETIEKTIPVMSGLADNDPQHLALQRLSARAAALRAGFSKLTDQLSNRTELLRNTIDASQAET
IAVIDGLSVKMRQHEQKAQATFDKTLRDISRRVLSIAVIFLGIILSAGVLIALSIRLPLQQIMASMRAITLGDYDRRVQG
TEARDEVGAMARAVEVFRENAIAKRKTEDELRTAKEKAESALLELNAAQRNLIDAERLAALGGLVAGVAHEVNNPIGISL
TVASSFARRVEIFEAALRSPEGGLRRSQLEEFVRTSRDASEQLVANLQRAGELIQSFKQVAVDRSHAERRTFVLSEATDQ
IITSLKPVLKRAPITLSVDVPEGLFIDGYPGFYGQILTNLFLNAVNHAFADGRSGTISIAARPRGADDIEIIFADNGAGM
TPEVQRQAFDPFFTTRRNEGGTGLGLHIVYNLVTQQLGGRMMLESREGQGTTFRIIMPRVAKGDTETAMGDGTTQWPNRT
MSST

Sequences:

>Translated_644_residues
MLAALIWNGARVLGTAWDDVRQVRESDKVLALLESETSRLQNLIHRYINQPSPELFAEILLLREAVLGTLTTRASTDPML
SGSVEDLERVTVRFLDGFGELRGLQATISKTYEEEVLGPARDIAGLYSAIEGATGHRDAEIWPSLGKSREAFTAMLVAAN
SYYLSLTPTSADDARRNIETIEKTIPVMSGLADNDPQHLALQRLSARAAALRAGFSKLTDQLSNRTELLRNTIDASQAET
IAVIDGLSVKMRQHEQKAQATFDKTLRDISRRVLSIAVIFLGIILSAGVLIALSIRLPLQQIMASMRAITLGDYDRRVQG
TEARDEVGAMARAVEVFRENAIAKRKTEDELRTAKEKAESALLELNAAQRNLIDAERLAALGGLVAGVAHEVNNPIGISL
TVASSFARRVEIFEAALRSPEGGLRRSQLEEFVRTSRDASEQLVANLQRAGELIQSFKQVAVDRSHAERRTFVLSEATDQ
IITSLKPVLKRAPITLSVDVPEGLFIDGYPGFYGQILTNLFLNAVNHAFADGRSGTISIAARPRGADDIEIIFADNGAGM
TPEVQRQAFDPFFTTRRNEGGTGLGLHIVYNLVTQQLGGRMMLESREGQGTTFRIIMPRVAKGDTETAMGDGTTQWPNRT
MSST
>Mature_644_residues
MLAALIWNGARVLGTAWDDVRQVRESDKVLALLESETSRLQNLIHRYINQPSPELFAEILLLREAVLGTLTTRASTDPML
SGSVEDLERVTVRFLDGFGELRGLQATISKTYEEEVLGPARDIAGLYSAIEGATGHRDAEIWPSLGKSREAFTAMLVAAN
SYYLSLTPTSADDARRNIETIEKTIPVMSGLADNDPQHLALQRLSARAAALRAGFSKLTDQLSNRTELLRNTIDASQAET
IAVIDGLSVKMRQHEQKAQATFDKTLRDISRRVLSIAVIFLGIILSAGVLIALSIRLPLQQIMASMRAITLGDYDRRVQG
TEARDEVGAMARAVEVFRENAIAKRKTEDELRTAKEKAESALLELNAAQRNLIDAERLAALGGLVAGVAHEVNNPIGISL
TVASSFARRVEIFEAALRSPEGGLRRSQLEEFVRTSRDASEQLVANLQRAGELIQSFKQVAVDRSHAERRTFVLSEATDQ
IITSLKPVLKRAPITLSVDVPEGLFIDGYPGFYGQILTNLFLNAVNHAFADGRSGTISIAARPRGADDIEIIFADNGAGM
TPEVQRQAFDPFFTTRRNEGGTGLGLHIVYNLVTQQLGGRMMLESREGQGTTFRIIMPRVAKGDTETAMGDGTTQWPNRT
MSST

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=245, Percent_Identity=32.6530612244898, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI87081816, Length=362, Percent_Identity=27.9005524861878, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1789149, Length=359, Percent_Identity=24.7910863509749, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 70496; Mature: 70496

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAALIWNGARVLGTAWDDVRQVRESDKVLALLESETSRLQNLIHRYINQPSPELFAEIL
CEEEEEECCCHHHHCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LLREAVLGTLTTRASTDPMLSGSVEDLERVTVRFLDGFGELRGLQATISKTYEEEVLGPA
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RDIAGLYSAIEGATGHRDAEIWPSLGKSREAFTAMLVAANSYYLSLTPTSADDARRNIET
HHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHEECCEEEEECCCCCHHHHHHHHH
IEKTIPVMSGLADNDPQHLALQRLSARAAALRAGFSKLTDQLSNRTELLRNTIDASQAET
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
IAVIDGLSVKMRQHEQKAQATFDKTLRDISRRVLSIAVIFLGIILSAGVLIALSIRLPLQ
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
QIMASMRAITLGDYDRRVQGTEARDEVGAMARAVEVFRENAIAKRKTEDELRTAKEKAES
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ALLELNAAQRNLIDAERLAALGGLVAGVAHEVNNPIGISLTVASSFARRVEIFEAALRSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCC
EGGLRRSQLEEFVRTSRDASEQLVANLQRAGELIQSFKQVAVDRSHAERRTFVLSEATDQ
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IITSLKPVLKRAPITLSVDVPEGLFIDGYPGFYGQILTNLFLNAVNHAFADGRSGTISIA
HHHHHHHHHHHCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
ARPRGADDIEIIFADNGAGMTPEVQRQAFDPFFTTRRNEGGTGLGLHIVYNLVTQQLGGR
ECCCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCE
MMLESREGQGTTFRIIMPRVAKGDTETAMGDGTTQWPNRTMSST
EEEECCCCCCCEEEEEECHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLAALIWNGARVLGTAWDDVRQVRESDKVLALLESETSRLQNLIHRYINQPSPELFAEIL
CEEEEEECCCHHHHCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LLREAVLGTLTTRASTDPMLSGSVEDLERVTVRFLDGFGELRGLQATISKTYEEEVLGPA
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RDIAGLYSAIEGATGHRDAEIWPSLGKSREAFTAMLVAANSYYLSLTPTSADDARRNIET
HHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHEECCEEEEECCCCCHHHHHHHHH
IEKTIPVMSGLADNDPQHLALQRLSARAAALRAGFSKLTDQLSNRTELLRNTIDASQAET
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
IAVIDGLSVKMRQHEQKAQATFDKTLRDISRRVLSIAVIFLGIILSAGVLIALSIRLPLQ
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
QIMASMRAITLGDYDRRVQGTEARDEVGAMARAVEVFRENAIAKRKTEDELRTAKEKAES
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ALLELNAAQRNLIDAERLAALGGLVAGVAHEVNNPIGISLTVASSFARRVEIFEAALRSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCC
EGGLRRSQLEEFVRTSRDASEQLVANLQRAGELIQSFKQVAVDRSHAERRTFVLSEATDQ
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IITSLKPVLKRAPITLSVDVPEGLFIDGYPGFYGQILTNLFLNAVNHAFADGRSGTISIA
HHHHHHHHHHHCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
ARPRGADDIEIIFADNGAGMTPEVQRQAFDPFFTTRRNEGGTGLGLHIVYNLVTQQLGGR
ECCCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCE
MMLESREGQGTTFRIIMPRVAKGDTETAMGDGTTQWPNRTMSST
EEEECCCCCCCEEEEEECHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]