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The map label for this gene is cpg2 [H]

Identifier: 146343221

GI number: 146343221

Start: 6683588

End: 6684844

Strand: Direct

Name: cpg2 [H]

Synonym: BRADO6431

Alternate gene names: 146343221

Gene position: 6683588-6684844 (Clockwise)

Preceding gene: 146343219

Following gene: 146343222

Centisome position: 89.63

GC content: 66.98

Gene sequence:

>1257_bases
ATGACGCCTTCGACCTCCCGCCTTGCCGCCCTCGTCCTGTTGGCAAGTTCAGCCACCGTCTCTGCCGCATACGCGGCGCC
CGACGACAAGATCAGAGCCGCCGCCGAGCAGGCCAAGCCGGCGGTGATCGACAGCTTGCGCGAGATGGTGCTGATCGAAT
CCGGATCGAGCGACGTCGAGGGCTTGAAGAAGATGGCCGACCTCACCGAAGCCCGGCTCAAGGCGCTCGGCGCGACCACG
GAGCGGCGCAAGACCACGCGGGGCGTCGGCGCCGACATGGTGATCGGCACTTTCGAGGGCACCGGCCGCCGCAAGCTGAT
GCTGATCGCGCATATGGACACGGTGTATCAGCCCGGCATTCTCAAGACCGAGCCCTATCATGTCGAAGGCGACCTGATCT
ACGGGCCGGGGATCGCCGACGACAAGGGCGGCATCGCGGTGATCCTGCACAGCCTGCAGATCCTGAAGGACATGGGCTGG
CGCGACTACGCCAGGCTGACCGTCGCCTTCAATCCAGACGAAGAGGTGGGCTCGATCGGCTCCGGCGAGTTCATCGCCGA
GCTCGCCGATCAGCACGACGTCGTGCTGTCCTGCGAGCCGACGGCGGCGAAGCCTGCCGCGCCGGTCGACAGCCTGCTGC
TCGGCGCCAGCGGCACGGCTACCGCCACGATGGAGGTGACCGGCCGCGCCGCGCATGCCGGCGCCGCCCCTGAGCGCGGC
CGCAACGCGCTGATCGAGCTGTCGCATCAATTGCTGCAGACCAGGGATATCGCCAAGTCGATCCCGGGCACGCAGCTGAA
CTGGACGACCGCGACCGCCGGCACCGTGCGCAACCAGATTCCCGAGAAGGCCAGCGCCGGCGGCGACGTGCGCCTCACGG
TGGCCGACGGCGTCGAGAAGCTGCAGGCCGCGCTGGACGAGACGATCAAGACTCATCTCGTGCCGGACACCGAGGTCAAG
GTCAGGATCGACAAGGGCCGTCCGCCCTTCATCGCCTCGGAGCGCGGCCGTGCGCTGGGCAAGGAGGCGCAGGCGATCTA
CGCCGAGATGGAACGGCCGCTCGCGCTGGTCGACATGACCGGCGGCGCCACCGATGCCGGCTTGGCCAATCGCAGCGGCA
AGGCCATCGTGGTCGAGAGTTTTGGTATCGCCGGCTTCAACTACCATGCGCACAACGAGTACATCGACGCGACCACCATC
GTCCCTCGCCTGTATTTGATGACCCGCATGCTGATCGAGCAGGGCAAGAAGATGTAG

Upstream 100 bases:

>100_bases
AATAGGCTTGGAGAATGTTGCGATCCACCCGGATTCTGCCAATGTCGACAGCCGCCGCCGGGCGAGGCCCGCCGCGAGCC
GCTGAATACAAGGACCCCGG

Downstream 100 bases:

>100_bases
CTTCGCGTCGGACGCAGCCCGGCGAAGACCGGGCGCCTCCAAGAGGAAACGAGCAAGAGAGGCCACCATGAAGCTGACGC
CGGAGCAGATCGCATTCTTC

Product: glutamate carboxypeptidase

Products: NA

Alternate protein names: CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTPSTSRLAALVLLASSATVSAAYAAPDDKIRAAAEQAKPAVIDSLREMVLIESGSSDVEGLKKMADLTEARLKALGATT
ERRKTTRGVGADMVIGTFEGTGRRKLMLIAHMDTVYQPGILKTEPYHVEGDLIYGPGIADDKGGIAVILHSLQILKDMGW
RDYARLTVAFNPDEEVGSIGSGEFIAELADQHDVVLSCEPTAAKPAAPVDSLLLGASGTATATMEVTGRAAHAGAAPERG
RNALIELSHQLLQTRDIAKSIPGTQLNWTTATAGTVRNQIPEKASAGGDVRLTVADGVEKLQAALDETIKTHLVPDTEVK
VRIDKGRPPFIASERGRALGKEAQAIYAEMERPLALVDMTGGATDAGLANRSGKAIVVESFGIAGFNYHAHNEYIDATTI
VPRLYLMTRMLIEQGKKM

Sequences:

>Translated_418_residues
MTPSTSRLAALVLLASSATVSAAYAAPDDKIRAAAEQAKPAVIDSLREMVLIESGSSDVEGLKKMADLTEARLKALGATT
ERRKTTRGVGADMVIGTFEGTGRRKLMLIAHMDTVYQPGILKTEPYHVEGDLIYGPGIADDKGGIAVILHSLQILKDMGW
RDYARLTVAFNPDEEVGSIGSGEFIAELADQHDVVLSCEPTAAKPAAPVDSLLLGASGTATATMEVTGRAAHAGAAPERG
RNALIELSHQLLQTRDIAKSIPGTQLNWTTATAGTVRNQIPEKASAGGDVRLTVADGVEKLQAALDETIKTHLVPDTEVK
VRIDKGRPPFIASERGRALGKEAQAIYAEMERPLALVDMTGGATDAGLANRSGKAIVVESFGIAGFNYHAHNEYIDATTI
VPRLYLMTRMLIEQGKKM
>Mature_417_residues
TPSTSRLAALVLLASSATVSAAYAAPDDKIRAAAEQAKPAVIDSLREMVLIESGSSDVEGLKKMADLTEARLKALGATTE
RRKTTRGVGADMVIGTFEGTGRRKLMLIAHMDTVYQPGILKTEPYHVEGDLIYGPGIADDKGGIAVILHSLQILKDMGWR
DYARLTVAFNPDEEVGSIGSGEFIAELADQHDVVLSCEPTAAKPAAPVDSLLLGASGTATATMEVTGRAAHAGAAPERGR
NALIELSHQLLQTRDIAKSIPGTQLNWTTATAGTVRNQIPEKASAGGDVRLTVADGVEKLQAALDETIKTHLVPDTEVKV
RIDKGRPPFIASERGRALGKEAQAIYAEMERPLALVDMTGGATDAGLANRSGKAIVVESFGIAGFNYHAHNEYIDATTIV
PRLYLMTRMLIEQGKKM

Specific function: Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity [H]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR017150
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.17.11 [H]

Molecular weight: Translated: 44389; Mature: 44258

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00758 ARGE_DAPE_CPG2_1 ; PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSTSRLAALVLLASSATVSAAYAAPDDKIRAAAEQAKPAVIDSLREMVLIESGSSDVE
CCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHEEEEECCCHHHH
GLKKMADLTEARLKALGATTERRKTTRGVGADMVIGTFEGTGRRKLMLIAHMDTVYQPGI
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEECCHHCCCCC
LKTEPYHVEGDLIYGPGIADDKGGIAVILHSLQILKDMGWRDYARLTVAFNPDEEVGSIG
CCCCCEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHCCCC
SGEFIAELADQHDVVLSCEPTAAKPAAPVDSLLLGASGTATATMEVTGRAAHAGAAPERG
CCHHHHHHHCCCCEEEEECCCCCCCCCCHHHHEECCCCCCEEEEEECCCCCCCCCCCCCC
RNALIELSHQLLQTRDIAKSIPGTQLNWTTATAGTVRNQIPEKASAGGDVRLTVADGVEK
CHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCHHCCCCCEEEEEHHHHHH
LQAALDETIKTHLVPDTEVKVRIDKGRPPFIASERGRALGKEAQAIYAEMERPLALVDMT
HHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEEC
GGATDAGLANRSGKAIVVESFGIAGFNYHAHNEYIDATTIVPRLYLMTRMLIEQGKKM
CCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TPSTSRLAALVLLASSATVSAAYAAPDDKIRAAAEQAKPAVIDSLREMVLIESGSSDVE
CCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHEEEEECCCHHHH
GLKKMADLTEARLKALGATTERRKTTRGVGADMVIGTFEGTGRRKLMLIAHMDTVYQPGI
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEECCHHCCCCC
LKTEPYHVEGDLIYGPGIADDKGGIAVILHSLQILKDMGWRDYARLTVAFNPDEEVGSIG
CCCCCEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHCCCC
SGEFIAELADQHDVVLSCEPTAAKPAAPVDSLLLGASGTATATMEVTGRAAHAGAAPERG
CCHHHHHHHCCCCEEEEECCCCCCCCCCHHHHEECCCCCCEEEEEECCCCCCCCCCCCCC
RNALIELSHQLLQTRDIAKSIPGTQLNWTTATAGTVRNQIPEKASAGGDVRLTVADGVEK
CHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCHHCCCCCEEEEEHHHHHH
LQAALDETIKTHLVPDTEVKVRIDKGRPPFIASERGRALGKEAQAIYAEMERPLALVDMT
HHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEEC
GGATDAGLANRSGKAIVVESFGIAGFNYHAHNEYIDATTIVPRLYLMTRMLIEQGKKM
CCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396165; 3838935; 9083113 [H]