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The map label for this gene is fabI [H]

Identifier: 146343165

GI number: 146343165

Start: 6624363

End: 6625184

Strand: Direct

Name: fabI [H]

Synonym: BRADO6363

Alternate gene names: 146343165

Gene position: 6624363-6625184 (Clockwise)

Preceding gene: 146343164

Following gene: 146343166

Centisome position: 88.84

GC content: 67.76

Gene sequence:

>822_bases
ATGTCCGAGAGCGCTCACGATCCGCTGCCGACCGTCTGGAATCCGGACGACCGCATCGGCGACATGCTGAAGGGCCTGCG
CGGCCTCGTGGTCGGCGTCGCCAATGAGAGCTCGATCGCCTTCGGCTGCGCGGCCAAGCTGCGCGCCTTCGGCGCCGAGG
TGGCGCTCACCTATGCCGATGAGCGCACCCGCGATTTCGTCGCGCCGCTCGCCGCGCAGATCGGCGCCAGCCTGCTGCTG
CCGCTCAATGTCGAGCAGCCGGGCGAGCTCGATGCCGTGTTCGCGCGCCTCAGACAGGACTGGGGCCGGCTCGATTTCGT
CGTCCACTCCATCGCCTTCGCGCCGAAGGACGACTTGCACGGCCGCGTCATCGACTGCTCGGCCGACGGCTTTACCCGCG
CGATGCGCATCTCGGTCTATTCCTTCCTGGAGCTCTCGCGCGCCGCGGAGCAGCTGATGACCCAGGGCGGCACGCTGCTG
ACGATGAGCTATTACGGCGCCGACAAGGTCGTGAACAACTACAATATCATGGGCCTCGCAAAGGCGTCGCTCGAAGCGTC
CGTGCGCTATCTCGCGGCGGAGCTCGGCGGCAAGAACATCCGCGTCTATGCCGTGTCGCCCGGGCCGCTGAAGACCCGCG
CCGCCAGCGGCATCGCGCATTTCGACGAACTGGTCGAAGCCGCCGTCAACCGCAGTCCGGGACGACGCCTGGTCGACATC
GCCGAGATCGGCCGTGTCGTCGCGTTCCTGGTCGGCGGCGGCGCCTCCGGCATGACCGGCGACACGATCTATGTCGATGC
CGGGCTGCACAACATGGCGTGA

Upstream 100 bases:

>100_bases
CGAGGCGCTCGGCTTGCCGCCGCTGGCGTTGGCCGCGGTGTCGGCCGATCCGCTCAAGGAGAACGGCGCGATCCGCGACG
TCGCCTGACGGAAGAGGACG

Downstream 100 bases:

>100_bases
GAAAGTCGCTCGGACGGAACGCCGCGCGACCGTCTCCAACCGATCTCTCCGGTCCGGCTGCCGGTCATTCGATCGGCTTG
CGATTTCAGGTCTCCCGAAC

Product: enoyl-[acyl-carrier-protein] reductase (NADH)

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSESAHDPLPTVWNPDDRIGDMLKGLRGLVVGVANESSIAFGCAAKLRAFGAEVALTYADERTRDFVAPLAAQIGASLLL
PLNVEQPGELDAVFARLRQDWGRLDFVVHSIAFAPKDDLHGRVIDCSADGFTRAMRISVYSFLELSRAAEQLMTQGGTLL
TMSYYGADKVVNNYNIMGLAKASLEASVRYLAAELGGKNIRVYAVSPGPLKTRAASGIAHFDELVEAAVNRSPGRRLVDI
AEIGRVVAFLVGGGASGMTGDTIYVDAGLHNMA

Sequences:

>Translated_273_residues
MSESAHDPLPTVWNPDDRIGDMLKGLRGLVVGVANESSIAFGCAAKLRAFGAEVALTYADERTRDFVAPLAAQIGASLLL
PLNVEQPGELDAVFARLRQDWGRLDFVVHSIAFAPKDDLHGRVIDCSADGFTRAMRISVYSFLELSRAAEQLMTQGGTLL
TMSYYGADKVVNNYNIMGLAKASLEASVRYLAAELGGKNIRVYAVSPGPLKTRAASGIAHFDELVEAAVNRSPGRRLVDI
AEIGRVVAFLVGGGASGMTGDTIYVDAGLHNMA
>Mature_272_residues
SESAHDPLPTVWNPDDRIGDMLKGLRGLVVGVANESSIAFGCAAKLRAFGAEVALTYADERTRDFVAPLAAQIGASLLLP
LNVEQPGELDAVFARLRQDWGRLDFVVHSIAFAPKDDLHGRVIDCSADGFTRAMRISVYSFLELSRAAEQLMTQGGTLLT
MSYYGADKVVNNYNIMGLAKASLEASVRYLAAELGGKNIRVYAVSPGPLKTRAASGIAHFDELVEAAVNRSPGRRLVDIA
EIGRVVAFLVGGGASGMTGDTIYVDAGLHNMA

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787545, Length=249, Percent_Identity=41.7670682730924, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1787905, Length=262, Percent_Identity=26.3358778625954, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=27.3858921161826, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI23397609, Length=187, Percent_Identity=26.2032085561497, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 29115; Mature: 28983

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESAHDPLPTVWNPDDRIGDMLKGLRGLVVGVANESSIAFGCAAKLRAFGAEVALTYAD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCEEHHHHHHHHHCCCEEEEEECC
ERTRDFVAPLAAQIGASLLLPLNVEQPGELDAVFARLRQDWGRLDFVVHSIAFAPKDDLH
HHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GRVIDCSADGFTRAMRISVYSFLELSRAAEQLMTQGGTLLTMSYYGADKVVNNYNIMGLA
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCCEEEEE
KASLEASVRYLAAELGGKNIRVYAVSPGPLKTRAASGIAHFDELVEAAVNRSPGRRLVDI
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
AEIGRVVAFLVGGGASGMTGDTIYVDAGLHNMA
HHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
SESAHDPLPTVWNPDDRIGDMLKGLRGLVVGVANESSIAFGCAAKLRAFGAEVALTYAD
CCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCEEHHHHHHHHHCCCEEEEEECC
ERTRDFVAPLAAQIGASLLLPLNVEQPGELDAVFARLRQDWGRLDFVVHSIAFAPKDDLH
HHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GRVIDCSADGFTRAMRISVYSFLELSRAAEQLMTQGGTLLTMSYYGADKVVNNYNIMGLA
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCCEEEEE
KASLEASVRYLAAELGGKNIRVYAVSPGPLKTRAASGIAHFDELVEAAVNRSPGRRLVDI
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
AEIGRVVAFLVGGGASGMTGDTIYVDAGLHNMA
HHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]