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The map label for this gene is lldD [H]

Identifier: 146342782

GI number: 146342782

Start: 6180694

End: 6181830

Strand: Direct

Name: lldD [H]

Synonym: BRADO5958

Alternate gene names: 146342782

Gene position: 6180694-6181830 (Clockwise)

Preceding gene: 146342777

Following gene: 146342789

Centisome position: 82.89

GC content: 64.56

Gene sequence:

>1137_bases
ATGAAACACGTCACCTGCATTGAAGATCTGCGCCTGCTGCACAAGCGCCGCGTCCCCAAGGCGTTCTTCGACTACGCCGA
CCGCGGCTCCTACGCCGAAGAAACCTTGCGCGCCAACCGCGACGACCTGCAGAAGATCAAGTTCCGGCAGCGCATTCTGG
TCGACGTCTCCAAGCGCGACCTGTCGACCACGATTCTCGGCGAGCCCTCGTCGATGCCGCTGGTCCTCGCGCCGGTGGGC
CTCCTGGGTATGCAGCATGGCGACGGCGAGATCCACGCCTGTCGCGCCGCGCAGGCCGCGGGAATTCCATTCACCCAGAG
CACGATGTCGATCTGCTCGATCGAGGACATCGCCTCCAGTGTCGAGAAGCCGTTCTGGTTCCAGCTTTACGTGATGAAGG
ACCGCGGATTCATCAAGGCGCTGATCGAGCGCGCCATCGCCGCGAAGTGCACCGCGCTCTGCCTGACCGTCGACCTGCAG
GTGATCGGCCAGCGCCACCAGGACATCAAGAACGGCATGAGCGTGCCGCCGGAATGGTCGCTGTCGAAACTGTTCGACTT
CGCCACCAAGCCCGCCTGGGTGCAGGGCGTGCTGCAGGGCAAGCGCCGCACCTTCGGCAACATTGCCGGCCATGTGAAGA
ACACTGAGGATCTCACCAAGCTCTCCGCCTGGACCGCGTCGCAGTTCGACACCTCGCTGAACTGGAAGGACGTCGACTGG
ATCCGCTCGATCTGGCCGGGCAAGCTGATCATCAAAGGCATCCATGACATCGAGGACGCCAAGCTTGCCGCCGCGACGGG
CGCACAGGCGATGGTCGTGTCCAACCATGGGGGCCGCCAGCTCGACGGCGCGCCGTCGTCGATCCACGTTCTGCCGGGCA
TTGCGGAAGCGGTCGGCGACAAGATCGAGATCATGTTCGATGGCGGCATCCGCTCCGGCCAGGACGTGATGCGCGCGCTG
GCGCTCGGCGCCAAATCCTGCATGATCGGCCGCGCCTATGCCTACGGCCTCGGCGCCGGTGGCCAGGTCGGCGTCGCCAA
GGCCATCGACATCATCCGCAACGAGCTGCTGACAACGATGGGCCTGTGCGGCGTCAACACCGTGGCGGAGATCGATCGCA
AGGTGCTGGCGGATTAA

Upstream 100 bases:

>100_bases
ATGCTGGGCGGCCGATGTCGGATTTGGCAGCCGCTCCAAAGATGCTAGAGGACAGTCAGTCAAAGAAACGAAACCGTCGG
TGGGGGAGCCGAAGACTGCG

Downstream 100 bases:

>100_bases
TTCGAGAGGCGGAGAGCAGAGAGCTCCGACTCATCAGTCGATGCGATCCGGACCGCCACTCCGCAAAGGCCGTTGTCCGG
ACAAATCGTGACGCGCGCCA

Product: putative L-lactate dehydrogenase (cytochrome)/FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKHVTCIEDLRLLHKRRVPKAFFDYADRGSYAEETLRANRDDLQKIKFRQRILVDVSKRDLSTTILGEPSSMPLVLAPVG
LLGMQHGDGEIHACRAAQAAGIPFTQSTMSICSIEDIASSVEKPFWFQLYVMKDRGFIKALIERAIAAKCTALCLTVDLQ
VIGQRHQDIKNGMSVPPEWSLSKLFDFATKPAWVQGVLQGKRRTFGNIAGHVKNTEDLTKLSAWTASQFDTSLNWKDVDW
IRSIWPGKLIIKGIHDIEDAKLAAATGAQAMVVSNHGGRQLDGAPSSIHVLPGIAEAVGDKIEIMFDGGIRSGQDVMRAL
ALGAKSCMIGRAYAYGLGAGGQVGVAKAIDIIRNELLTTMGLCGVNTVAEIDRKVLAD

Sequences:

>Translated_378_residues
MKHVTCIEDLRLLHKRRVPKAFFDYADRGSYAEETLRANRDDLQKIKFRQRILVDVSKRDLSTTILGEPSSMPLVLAPVG
LLGMQHGDGEIHACRAAQAAGIPFTQSTMSICSIEDIASSVEKPFWFQLYVMKDRGFIKALIERAIAAKCTALCLTVDLQ
VIGQRHQDIKNGMSVPPEWSLSKLFDFATKPAWVQGVLQGKRRTFGNIAGHVKNTEDLTKLSAWTASQFDTSLNWKDVDW
IRSIWPGKLIIKGIHDIEDAKLAAATGAQAMVVSNHGGRQLDGAPSSIHVLPGIAEAVGDKIEIMFDGGIRSGQDVMRAL
ALGAKSCMIGRAYAYGLGAGGQVGVAKAIDIIRNELLTTMGLCGVNTVAEIDRKVLAD
>Mature_378_residues
MKHVTCIEDLRLLHKRRVPKAFFDYADRGSYAEETLRANRDDLQKIKFRQRILVDVSKRDLSTTILGEPSSMPLVLAPVG
LLGMQHGDGEIHACRAAQAAGIPFTQSTMSICSIEDIASSVEKPFWFQLYVMKDRGFIKALIERAIAAKCTALCLTVDLQ
VIGQRHQDIKNGMSVPPEWSLSKLFDFATKPAWVQGVLQGKRRTFGNIAGHVKNTEDLTKLSAWTASQFDTSLNWKDVDW
IRSIWPGKLIIKGIHDIEDAKLAAATGAQAMVVSNHGGRQLDGAPSSIHVLPGIAEAVGDKIEIMFDGGIRSGQDVMRAL
ALGAKSCMIGRAYAYGLGAGGQVGVAKAIDIIRNELLTTMGLCGVNTVAEIDRKVLAD

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=377, Percent_Identity=35.5437665782493, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=37.4331550802139, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=37.4331550802139, Blast_Score=225, Evalue=5e-59,
Organism=Escherichia coli, GI1790033, Length=374, Percent_Identity=44.9197860962567, Blast_Score=340, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI193208036, Length=369, Percent_Identity=34.4173441734417, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI32566217, Length=309, Percent_Identity=33.6569579288026, Blast_Score=148, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6323587, Length=387, Percent_Identity=32.0413436692506, Blast_Score=179, Evalue=8e-46,
Organism=Drosophila melanogaster, GI78707188, Length=369, Percent_Identity=38.2113821138211, Blast_Score=248, Evalue=5e-66,
Organism=Drosophila melanogaster, GI281363140, Length=369, Percent_Identity=38.2113821138211, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI78707190, Length=369, Percent_Identity=38.2113821138211, Blast_Score=248, Evalue=7e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41225; Mature: 41225

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHVTCIEDLRLLHKRRVPKAFFDYADRGSYAEETLRANRDDLQKIKFRQRILVDVSKRD
CCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
LSTTILGEPSSMPLVLAPVGLLGMQHGDGEIHACRAAQAAGIPFTQSTMSICSIEDIASS
CCEEEECCCCCCCEEEECHHHHCCCCCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHH
VEKPFWFQLYVMKDRGFIKALIERAIAAKCTALCLTVDLQVIGQRHQDIKNGMSVPPEWS
HCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LSKLFDFATKPAWVQGVLQGKRRTFGNIAGHVKNTEDLTKLSAWTASQFDTSLNWKDVDW
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHH
IRSIWPGKLIIKGIHDIEDAKLAAATGAQAMVVSNHGGRQLDGAPSSIHVLPGIAEAVGD
HHHHCCCHHEEHHHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCEEECCCHHHHCCC
KIEIMFDGGIRSGQDVMRALALGAKSCMIGRAYAYGLGAGGQVGVAKAIDIIRNELLTTM
EEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
GLCGVNTVAEIDRKVLAD
HHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKHVTCIEDLRLLHKRRVPKAFFDYADRGSYAEETLRANRDDLQKIKFRQRILVDVSKRD
CCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
LSTTILGEPSSMPLVLAPVGLLGMQHGDGEIHACRAAQAAGIPFTQSTMSICSIEDIASS
CCEEEECCCCCCCEEEECHHHHCCCCCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHH
VEKPFWFQLYVMKDRGFIKALIERAIAAKCTALCLTVDLQVIGQRHQDIKNGMSVPPEWS
HCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LSKLFDFATKPAWVQGVLQGKRRTFGNIAGHVKNTEDLTKLSAWTASQFDTSLNWKDVDW
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHH
IRSIWPGKLIIKGIHDIEDAKLAAATGAQAMVVSNHGGRQLDGAPSSIHVLPGIAEAVGD
HHHHCCCHHEEHHHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCEEECCCHHHHCCC
KIEIMFDGGIRSGQDVMRALALGAKSCMIGRAYAYGLGAGGQVGVAKAIDIIRNELLTTM
EEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
GLCGVNTVAEIDRKVLAD
HHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA