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The map label for this gene is yqeC [H]

Identifier: 146342643

GI number: 146342643

Start: 6016280

End: 6017329

Strand: Direct

Name: yqeC [H]

Synonym: BRADO5810

Alternate gene names: 146342643

Gene position: 6016280-6017329 (Clockwise)

Preceding gene: 146342642

Following gene: 146342644

Centisome position: 80.68

GC content: 66.29

Gene sequence:

>1050_bases
ATGCAGTTGGGAATGATCGGTCTCGGGCGGATGGGCGGCAACATCGTGCGCCGCCTGATGCGCGCGGGGCATTCGTGCGT
GGTCTATGATCGTGATGCGAAAGCGGTTGCCGCGCTGGTTTCCGAGGGAGCGACCGGCGCAGCGAGCCTCGAAGAGTTCG
TCGGCAAGCTCGCGACGCCTCGGCATGCCTGGATCATGCTGCCGGCCGGCAAGATCACCGAAGCGACCGTCGAGCAGCTC
ACCAAGCTGATGTCCAGCGATGATGTCATCATCGATGGCGGCAACAGCTTCTGGCAGGACGACGTCCGCCGCGGCCAGGC
GCTGCGCGAGCGCGGCCTGCATTATGTCGACGTCGGCACGTCCGGCGGCGTCTGGGGCCTCGACCGCGGCTATTGCATGA
TGATCGGCGGCGACAAGGAAGTCGTCGACCGGCTCGACCCGATCTTTTCGACGCTGGCGCCGGGCATCGGCGACATTCCG
CGCACGCCCGGCCGTGACGGCCGCGACCCGCGCGTCGAGCAGGGCTACATCCATGCCGGCCCGACCGGCGCCGGCCATTT
CGTCAAGATGATCCACAACGGCATCGAATATGGCTTGATGCAGGCCTATGCGGAGGGCTTCGACATTTTGCGGCATGCCA
ACAGCGACGCGCTTCCCGAGGCGCATCGCTTCGACTTCGATCTCGCGGATATCGCCGAAGTCTGGCGACGCGGCAGCGTC
ATCCCGTCCTGGCTGCTCGATCTCACCGCGAGCGCGCTGGCGCGCCAGCCGGGCCTGGAGAAATATTCAGGTTATGTCGA
GGATTCCGGCGAAGGACGCTGGACCGTCAATGCCGCGATCGACGAGGCCGTGCCGGCCGAGGTTCTGACAGCCGCGCTGT
TCGCGCGCTTCCGCTCGCGACAGGAGCACACCTTCGCGGAGAAGATCCTGTCGGCCATGCGCGAGGGATTCGGCGGCCAC
AAGGAGCCCGAGCAGCATCCCGATCCGGCGCGCCAGAGTGCGCCCGAGATGGTCAAGCCCAAGGACGATCATAAGGCGGA
CCGCGCGTGA

Upstream 100 bases:

>100_bases
CGCCGCGCCTTGCGCGTGCATCTCAAAGGCAATCTGAAGTCGGGCCTGAAGATGCTCGACAGTGCCATCACCGAAGCGCT
GAGCTAGGAAGGTCTCCTCG

Downstream 100 bases:

>100_bases
CCCCGCTGCATCCGCACCAGCCGCCGCATCAGAAACCCGACGCTTGCGCCTTCGTCATCTTCGGCGTGACCGGCGACCTC
ACGCATCGCCTGGTGCTGCC

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MQLGMIGLGRMGGNIVRRLMRAGHSCVVYDRDAKAVAALVSEGATGAASLEEFVGKLATPRHAWIMLPAGKITEATVEQL
TKLMSSDDVIIDGGNSFWQDDVRRGQALRERGLHYVDVGTSGGVWGLDRGYCMMIGGDKEVVDRLDPIFSTLAPGIGDIP
RTPGRDGRDPRVEQGYIHAGPTGAGHFVKMIHNGIEYGLMQAYAEGFDILRHANSDALPEAHRFDFDLADIAEVWRRGSV
IPSWLLDLTASALARQPGLEKYSGYVEDSGEGRWTVNAAIDEAVPAEVLTAALFARFRSRQEHTFAEKILSAMREGFGGH
KEPEQHPDPARQSAPEMVKPKDDHKADRA

Sequences:

>Translated_349_residues
MQLGMIGLGRMGGNIVRRLMRAGHSCVVYDRDAKAVAALVSEGATGAASLEEFVGKLATPRHAWIMLPAGKITEATVEQL
TKLMSSDDVIIDGGNSFWQDDVRRGQALRERGLHYVDVGTSGGVWGLDRGYCMMIGGDKEVVDRLDPIFSTLAPGIGDIP
RTPGRDGRDPRVEQGYIHAGPTGAGHFVKMIHNGIEYGLMQAYAEGFDILRHANSDALPEAHRFDFDLADIAEVWRRGSV
IPSWLLDLTASALARQPGLEKYSGYVEDSGEGRWTVNAAIDEAVPAEVLTAALFARFRSRQEHTFAEKILSAMREGFGGH
KEPEQHPDPARQSAPEMVKPKDDHKADRA
>Mature_349_residues
MQLGMIGLGRMGGNIVRRLMRAGHSCVVYDRDAKAVAALVSEGATGAASLEEFVGKLATPRHAWIMLPAGKITEATVEQL
TKLMSSDDVIIDGGNSFWQDDVRRGQALRERGLHYVDVGTSGGVWGLDRGYCMMIGGDKEVVDRLDPIFSTLAPGIGDIP
RTPGRDGRDPRVEQGYIHAGPTGAGHFVKMIHNGIEYGLMQAYAEGFDILRHANSDALPEAHRFDFDLADIAEVWRRGSV
IPSWLLDLTASALARQPGLEKYSGYVEDSGEGRWTVNAAIDEAVPAEVLTAALFARFRSRQEHTFAEKILSAMREGFGGH
KEPEQHPDPARQSAPEMVKPKDDHKADRA

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=307, Percent_Identity=32.8990228013029, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1788341, Length=321, Percent_Identity=31.1526479750779, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17542558, Length=349, Percent_Identity=29.7994269340974, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321695, Length=322, Percent_Identity=31.9875776397516, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6321977, Length=343, Percent_Identity=31.4868804664723, Blast_Score=149, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24639279, Length=319, Percent_Identity=33.2288401253918, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 38085; Mature: 38085

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLGMIGLGRMGGNIVRRLMRAGHSCVVYDRDAKAVAALVSEGATGAASLEEFVGKLATP
CCCCCCCCHHCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHCCC
RHAWIMLPAGKITEATVEQLTKLMSSDDVIIDGGNSFWQDDVRRGQALRERGLHYVDVGT
CCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEEECC
SGGVWGLDRGYCMMIGGDKEVVDRLDPIFSTLAPGIGDIPRTPGRDGRDPRVEQGYIHAG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECC
PTGAGHFVKMIHNGIEYGLMQAYAEGFDILRHANSDALPEAHRFDFDLADIAEVWRRGSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHCCCC
IPSWLLDLTASALARQPGLEKYSGYVEDSGEGRWTVNAAIDEAVPAEVLTAALFARFRSR
CHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHH
QEHTFAEKILSAMREGFGGHKEPEQHPDPARQSAPEMVKPKDDHKADRA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQLGMIGLGRMGGNIVRRLMRAGHSCVVYDRDAKAVAALVSEGATGAASLEEFVGKLATP
CCCCCCCCHHCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHCCC
RHAWIMLPAGKITEATVEQLTKLMSSDDVIIDGGNSFWQDDVRRGQALRERGLHYVDVGT
CCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEEECC
SGGVWGLDRGYCMMIGGDKEVVDRLDPIFSTLAPGIGDIPRTPGRDGRDPRVEQGYIHAG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECC
PTGAGHFVKMIHNGIEYGLMQAYAEGFDILRHANSDALPEAHRFDFDLADIAEVWRRGSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHCCCC
IPSWLLDLTASALARQPGLEKYSGYVEDSGEGRWTVNAAIDEAVPAEVLTAALFARFRSR
CHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHH
QEHTFAEKILSAMREGFGGHKEPEQHPDPARQSAPEMVKPKDDHKADRA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]