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The map label for this gene is envZ [H]

Identifier: 146342520

GI number: 146342520

Start: 5880929

End: 5882314

Strand: Reverse

Name: envZ [H]

Synonym: BRADO5682

Alternate gene names: 146342520

Gene position: 5882314-5880929 (Counterclockwise)

Preceding gene: 146342521

Following gene: 146342517

Centisome position: 78.89

GC content: 70.06

Gene sequence:

>1386_bases
ATGAAGCCTGACAGCAAGACGTGCGGCAACACGTTGCCTCGCCTCGGCCTCACCACGCAGATCGTGACCTTGGCGTCGCT
GTCGGTGCTGTTCGGCATGGTGCTGATGATCGCGGCGGCGATCCTGTTCCTCGATCCGCCGGACGAGCAGGAATCACCGG
CCTATGGCGTCGCGCGCGTCGCCGAGGCGGTGCACTTCGTGCGCGCCGCCAGCGACTCCGCCGCGGTCGATAGCAGCCTG
TCGAGCCTGCGCAGCTCCGGCATCCAGGTCGAGCTCGTGCCGCTGGCCTCGCTCACGCTGCTGGCGAAGCCGGTGCAGAA
CGTGCCCTTCACCTCGAAGCTCGCCCGCCGCCAGCTCAGCGTGCTGCGCGACGTCAGCCTGCTGCACGGCGTGAGCTATG
GCGCGGCGCCGCCGACCCAGATCATCGTCCAGGTCGACGGCGAGCGCGCGCTGGTGTTCGACGACGTGCCGCGGCTGGAA
TTCTGGTCGATGGTGCTGAAGCCGACCGTCGTGTTCCTCTTCATCATCCTGATTCTCGGCGTGCTCCTGTCGTTCTACGC
AGCGCGCGCGATCATTCGGCCGCTGTCGGAGATGGCACGCGCGGCGGCCGCGTTCGGCCGCTCGCCGGGCGCGCAGGAGC
CGCTCGGCCGGCGCGGGCCAAGGGAGATCGTCCAGGTCGCCGACGCGCTGAACGACATGCAGGCGCGCATCCGTGCGCTG
CTCGACGACCGCACGCGGATGCTGGCAGCGATCAGCCATGATCTCCGCACGCCGCTGACCCGGCTTCGGCTGCGCTCGGA
GCGGATCGGGCAGGGCGACATGCGCAGCGCCATGCTGCGCGACATCGACCAGGTCAGCCGCATGCTCGACGAGACGCTCG
ACTATTTGCGCGACGACACCAAGGCCGAGCAGCCGGCGCGCATCGAACTGTCGAGCCTCTTGGAAACCATTTGCTGCGAC
TTCGCCGATGTCGGCCACGCGGTCAGCTATCGCGGCCCGCAGCGGCTGGTCTGCGAGGGCCGGCCGCGGGCGCTGTCGCG
CGCGGTGACCAACGTGGTCGAGAACGCCGTCAAGCACGGCACCGAGGTCGTCGTGAGCCTCGACAGCACGGCGGACGGCG
TGATCGCCATCGAGGTCGCCGATGACGGCCCGGGGATTCCCCAGGCGCTACAGGCGCGCGCGCTGGAGCCGTTCGTCAAG
CTCGACCAGGCGCGCGCCGCCGGCGGCTTTGGCCTCGGCCTGTCGATCGCCCAGGAGATCATGAAGAAGCACGAGGGCGG
CATCGCGCTGATGCCGAACACGCCGCGCGGCCTTCGCGTGCGGCTGTCATTGCCGCTGCGCGCGGCGCTGCCCGCCGCCG
CGCCGATCCCCGCCAAGGTGGCGTAA

Upstream 100 bases:

>100_bases
CGCATCCGCCAGAAGATCGAGCCCGGCGCCAGGAGCTGGAGCATGATCAAGACCGTGCGCCTCGGCGGCTACGTCTTCAC
GCCAAGAGTCGAGACCCTCG

Downstream 100 bases:

>100_bases
GCGAAAGACCCCGCCGGAGGGACTGGTCCCGGCGGGGTCTCGCATCGCTGACGACGGGGGCGGCGTCAGCTGATCCGCTT
CCAGGTCTGGCCGCCGCAGA

Product: putative two component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MKPDSKTCGNTLPRLGLTTQIVTLASLSVLFGMVLMIAAAILFLDPPDEQESPAYGVARVAEAVHFVRAASDSAAVDSSL
SSLRSSGIQVELVPLASLTLLAKPVQNVPFTSKLARRQLSVLRDVSLLHGVSYGAAPPTQIIVQVDGERALVFDDVPRLE
FWSMVLKPTVVFLFIILILGVLLSFYAARAIIRPLSEMARAAAAFGRSPGAQEPLGRRGPREIVQVADALNDMQARIRAL
LDDRTRMLAAISHDLRTPLTRLRLRSERIGQGDMRSAMLRDIDQVSRMLDETLDYLRDDTKAEQPARIELSSLLETICCD
FADVGHAVSYRGPQRLVCEGRPRALSRAVTNVVENAVKHGTEVVVSLDSTADGVIAIEVADDGPGIPQALQARALEPFVK
LDQARAAGGFGLGLSIAQEIMKKHEGGIALMPNTPRGLRVRLSLPLRAALPAAAPIPAKVA

Sequences:

>Translated_461_residues
MKPDSKTCGNTLPRLGLTTQIVTLASLSVLFGMVLMIAAAILFLDPPDEQESPAYGVARVAEAVHFVRAASDSAAVDSSL
SSLRSSGIQVELVPLASLTLLAKPVQNVPFTSKLARRQLSVLRDVSLLHGVSYGAAPPTQIIVQVDGERALVFDDVPRLE
FWSMVLKPTVVFLFIILILGVLLSFYAARAIIRPLSEMARAAAAFGRSPGAQEPLGRRGPREIVQVADALNDMQARIRAL
LDDRTRMLAAISHDLRTPLTRLRLRSERIGQGDMRSAMLRDIDQVSRMLDETLDYLRDDTKAEQPARIELSSLLETICCD
FADVGHAVSYRGPQRLVCEGRPRALSRAVTNVVENAVKHGTEVVVSLDSTADGVIAIEVADDGPGIPQALQARALEPFVK
LDQARAAGGFGLGLSIAQEIMKKHEGGIALMPNTPRGLRVRLSLPLRAALPAAAPIPAKVA
>Mature_461_residues
MKPDSKTCGNTLPRLGLTTQIVTLASLSVLFGMVLMIAAAILFLDPPDEQESPAYGVARVAEAVHFVRAASDSAAVDSSL
SSLRSSGIQVELVPLASLTLLAKPVQNVPFTSKLARRQLSVLRDVSLLHGVSYGAAPPTQIIVQVDGERALVFDDVPRLE
FWSMVLKPTVVFLFIILILGVLLSFYAARAIIRPLSEMARAAAAFGRSPGAQEPLGRRGPREIVQVADALNDMQARIRAL
LDDRTRMLAAISHDLRTPLTRLRLRSERIGQGDMRSAMLRDIDQVSRMLDETLDYLRDDTKAEQPARIELSSLLETICCD
FADVGHAVSYRGPQRLVCEGRPRALSRAVTNVVENAVKHGTEVVVSLDSTADGVIAIEVADDGPGIPQALQARALEPFVK
LDQARAAGGFGLGLSIAQEIMKKHEGGIALMPNTPRGLRVRLSLPLRAALPAAAPIPAKVA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=334, Percent_Identity=30.5389221556886, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=29.368029739777, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082128, Length=296, Percent_Identity=26.3513513513513, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=29.7872340425532, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790551, Length=266, Percent_Identity=26.6917293233083, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789403, Length=298, Percent_Identity=29.8657718120805, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787374, Length=316, Percent_Identity=25.9493670886076, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788713, Length=257, Percent_Identity=22.568093385214, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=26.1261261261261, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786783, Length=306, Percent_Identity=24.5098039215686, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788393, Length=246, Percent_Identity=26.4227642276423, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=28.2511210762332, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788549, Length=217, Percent_Identity=26.2672811059908, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081816, Length=239, Percent_Identity=27.6150627615063, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49624; Mature: 49624

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDSKTCGNTLPRLGLTTQIVTLASLSVLFGMVLMIAAAILFLDPPDEQESPAYGVARV
CCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
AEAVHFVRAASDSAAVDSSLSSLRSSGIQVELVPLASLTLLAKPVQNVPFTSKLARRQLS
HHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHH
VLRDVSLLHGVSYGAAPPTQIIVQVDGERALVFDDVPRLEFWSMVLKPTVVFLFIILILG
HHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
VLLSFYAARAIIRPLSEMARAAAAFGRSPGAQEPLGRRGPREIVQVADALNDMQARIRAL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LDDRTRMLAAISHDLRTPLTRLRLRSERIGQGDMRSAMLRDIDQVSRMLDETLDYLRDDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KAEQPARIELSSLLETICCDFADVGHAVSYRGPQRLVCEGRPRALSRAVTNVVENAVKHG
CCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCC
TEVVVSLDSTADGVIAIEVADDGPGIPQALQARALEPFVKLDQARAAGGFGLGLSIAQEI
CEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
MKKHEGGIALMPNTPRGLRVRLSLPLRAALPAAAPIPAKVA
HHHCCCCEEECCCCCCCEEEEEECCHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKPDSKTCGNTLPRLGLTTQIVTLASLSVLFGMVLMIAAAILFLDPPDEQESPAYGVARV
CCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
AEAVHFVRAASDSAAVDSSLSSLRSSGIQVELVPLASLTLLAKPVQNVPFTSKLARRQLS
HHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHH
VLRDVSLLHGVSYGAAPPTQIIVQVDGERALVFDDVPRLEFWSMVLKPTVVFLFIILILG
HHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
VLLSFYAARAIIRPLSEMARAAAAFGRSPGAQEPLGRRGPREIVQVADALNDMQARIRAL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LDDRTRMLAAISHDLRTPLTRLRLRSERIGQGDMRSAMLRDIDQVSRMLDETLDYLRDDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KAEQPARIELSSLLETICCDFADVGHAVSYRGPQRLVCEGRPRALSRAVTNVVENAVKHG
CCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCC
TEVVVSLDSTADGVIAIEVADDGPGIPQALQARALEPFVKLDQARAAGGFGLGLSIAQEI
CEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
MKKHEGGIALMPNTPRGLRVRLSLPLRAALPAAAPIPAKVA
HHHCCCCEEECCCCCCCEEEEEECCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]