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The map label for this gene is acbB [H]

Identifier: 146342050

GI number: 146342050

Start: 5400301

End: 5401320

Strand: Direct

Name: acbB [H]

Synonym: BRADO5190

Alternate gene names: 146342050

Gene position: 5400301-5401320 (Clockwise)

Preceding gene: 146342049

Following gene: 146342051

Centisome position: 72.42

GC content: 58.92

Gene sequence:

>1020_bases
GTGAGCCGGCGGATTCTCGTGACCGGTGGCGCCGGTTTCATTGGCAGCCATCTCGTTGAACATCTATTGTCATCCGGCTA
CGTAGTGACCGTGCTCGACGATCTCTCCACGGGGAGCATCGATAACCTCGCAGAAGCAAATGAGACGGGACGTCTCCGGC
TGATCGAGGGCTCCGTGCTCGACGCTCAGGCCGTCGAGACAGCCATGCACCAATGCGACTACGTATTTCACCTCGCCGTG
CAATGCGTTCGAAAGTCGCTGGGAAAACCGATCGAAAACCACGAGATCAATGCGACCGGCACTCTCCGTATGCTTGAGGC
CGCCCGCAAGCACAATATCAAGCGGTTCGTCTACTGCTCATCGTCCGAGGTCTATGGCAGTGTATCAACCGGGCTTCTGG
ACGAAGATACGCTGTGCCGCCCCGTCACCGTTTATGGAGCGGCCAAGCTTGCTGGTGAACTTTATACCGACGCCTATCAC
CAGACCTACGGCTTGCCGACGGTCGTGGTAAGGCCCTTCAATGCGTATGGTCCACGCGCCCACGAGCGAGGCGACCTCGC
CGAAGTTATTCCGCGTTTCTTCATCCGTTGTCTGAATGGACTTCCACCCGTGATCTTTGGCGACGGGAGTAATGGCCGGG
ATTTCACCTACGTTACCGAGGTCGCCCGCGGACTCGCTCTGGCTTGCGATGCGGATGGTTTAGTCGGCTCCAAGGTGAAC
ATCGCCTATGGGCAAATGATCTCAATTGGTCAGGTGGCTGCCGAAGTCATCAAGGCCACCGGCCGAAATGATCTCGGTAT
CGAGCACATCTCAGGCCGACCGGGCGACGTGCGCGTACTGAGCGCCGACGTCAGTCGCGCACGTCGCCTGCTTGGCTACC
GGGCAGAGATCGACTTTGCGCATGGACTTCGACGCTACCTCGACTGGTTCCGCCTCAAGCATTCAGACCCGTCTCAACTG
ATCGAGCGGGACATCGTGAATTGGACCATGCCCACCGCACCCGACCAACCCGCGCCATGA

Upstream 100 bases:

>100_bases
CTCCTGAACGAGGGACGAAGATCGTACGTATTCTGGAGATGACACAGAAGATCCTGGACGGTGCGCCAACCGCGGGACGG
CAAGTCCGGGAGCCGCGATC

Downstream 100 bases:

>100_bases
CCCCCATACAGTTCGCGCTACCCTATTTCGGACCGGAGGAAGCCGCAGCGGCGGCCGCCGCCGTTCAAAGCGGCTGGGTG
GTCGGCGGGCCTCGGCTGAG

Product: putative NAD dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSRRILVTGGAGFIGSHLVEHLLSSGYVVTVLDDLSTGSIDNLAEANETGRLRLIEGSVLDAQAVETAMHQCDYVFHLAV
QCVRKSLGKPIENHEINATGTLRMLEAARKHNIKRFVYCSSSEVYGSVSTGLLDEDTLCRPVTVYGAAKLAGELYTDAYH
QTYGLPTVVVRPFNAYGPRAHERGDLAEVIPRFFIRCLNGLPPVIFGDGSNGRDFTYVTEVARGLALACDADGLVGSKVN
IAYGQMISIGQVAAEVIKATGRNDLGIEHISGRPGDVRVLSADVSRARRLLGYRAEIDFAHGLRRYLDWFRLKHSDPSQL
IERDIVNWTMPTAPDQPAP

Sequences:

>Translated_339_residues
MSRRILVTGGAGFIGSHLVEHLLSSGYVVTVLDDLSTGSIDNLAEANETGRLRLIEGSVLDAQAVETAMHQCDYVFHLAV
QCVRKSLGKPIENHEINATGTLRMLEAARKHNIKRFVYCSSSEVYGSVSTGLLDEDTLCRPVTVYGAAKLAGELYTDAYH
QTYGLPTVVVRPFNAYGPRAHERGDLAEVIPRFFIRCLNGLPPVIFGDGSNGRDFTYVTEVARGLALACDADGLVGSKVN
IAYGQMISIGQVAAEVIKATGRNDLGIEHISGRPGDVRVLSADVSRARRLLGYRAEIDFAHGLRRYLDWFRLKHSDPSQL
IERDIVNWTMPTAPDQPAP
>Mature_338_residues
SRRILVTGGAGFIGSHLVEHLLSSGYVVTVLDDLSTGSIDNLAEANETGRLRLIEGSVLDAQAVETAMHQCDYVFHLAVQ
CVRKSLGKPIENHEINATGTLRMLEAARKHNIKRFVYCSSSEVYGSVSTGLLDEDTLCRPVTVYGAAKLAGELYTDAYHQ
TYGLPTVVVRPFNAYGPRAHERGDLAEVIPRFFIRCLNGLPPVIFGDGSNGRDFTYVTEVARGLALACDADGLVGSKVNI
AYGQMISIGQVAAEVIKATGRNDLGIEHISGRPGDVRVLSADVSRARRLLGYRAEIDFAHGLRRYLDWFRLKHSDPSQLI
ERDIVNWTMPTAPDQPAP

Specific function: Probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4- hexulose via a three-step process involving oxidation, dehydration and re

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=324, Percent_Identity=28.7037037037037, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI42516563, Length=329, Percent_Identity=30.0911854103343, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI56237023, Length=355, Percent_Identity=30.9859154929577, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI56118217, Length=355, Percent_Identity=30.9859154929577, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI189083684, Length=355, Percent_Identity=30.9859154929577, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI193211614, Length=249, Percent_Identity=25.7028112449799, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI8393516, Length=249, Percent_Identity=25.7028112449799, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788353, Length=338, Percent_Identity=31.0650887573964, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI48994969, Length=346, Percent_Identity=30.635838150289, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1786974, Length=315, Percent_Identity=30.4761904761905, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788589, Length=343, Percent_Identity=23.9067055393586, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788366, Length=340, Percent_Identity=26.7647058823529, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790049, Length=222, Percent_Identity=30.1801801801802, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788365, Length=331, Percent_Identity=24.4712990936556, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17539532, Length=316, Percent_Identity=28.4810126582279, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71982035, Length=341, Percent_Identity=29.9120234604106, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71982038, Length=343, Percent_Identity=29.7376093294461, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17568069, Length=329, Percent_Identity=27.0516717325228, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI115532424, Length=323, Percent_Identity=28.4829721362229, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI133901786, Length=323, Percent_Identity=25.3869969040248, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17539422, Length=323, Percent_Identity=25.3869969040248, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=323, Percent_Identity=25.3869969040248, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI133901788, Length=323, Percent_Identity=25.3869969040248, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539424, Length=323, Percent_Identity=25.3869969040248, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=323, Percent_Identity=25.077399380805, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71987463, Length=219, Percent_Identity=28.310502283105, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=341, Percent_Identity=28.7390029325513, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21356223, Length=315, Percent_Identity=28.8888888888889, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI19923002, Length=346, Percent_Identity=26.878612716763, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24158427, Length=332, Percent_Identity=24.6987951807229, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 37040; Mature: 36908

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRILVTGGAGFIGSHLVEHLLSSGYVVTVLDDLSTGSIDNLAEANETGRLRLIEGSVL
CCCEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHCCCCCCEEEEECCCC
DAQAVETAMHQCDYVFHLAVQCVRKSLGKPIENHEINATGTLRMLEAARKHNIKRFVYCS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEC
SSEVYGSVSTGLLDEDTLCRPVTVYGAAKLAGELYTDAYHQTYGLPTVVVRPFNAYGPRA
CCCCCCCHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
HERGDLAEVIPRFFIRCLNGLPPVIFGDGSNGRDFTYVTEVARGLALACDADGLVGSKVN
CCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHCEEEEECCCCCCCCEEE
IAYGQMISIGQVAAEVIKATGRNDLGIEHISGRPGDVRVLSADVSRARRLLGYRAEIDFA
EHHCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCHH
HGLRRYLDWFRLKHSDPSQLIERDIVNWTMPTAPDQPAP
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SRRILVTGGAGFIGSHLVEHLLSSGYVVTVLDDLSTGSIDNLAEANETGRLRLIEGSVL
CCEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHCCCCCCEEEEECCCC
DAQAVETAMHQCDYVFHLAVQCVRKSLGKPIENHEINATGTLRMLEAARKHNIKRFVYCS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEC
SSEVYGSVSTGLLDEDTLCRPVTVYGAAKLAGELYTDAYHQTYGLPTVVVRPFNAYGPRA
CCCCCCCHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
HERGDLAEVIPRFFIRCLNGLPPVIFGDGSNGRDFTYVTEVARGLALACDADGLVGSKVN
CCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHCEEEEECCCCCCCCEEE
IAYGQMISIGQVAAEVIKATGRNDLGIEHISGRPGDVRVLSADVSRARRLLGYRAEIDFA
EHHCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCHH
HGLRRYLDWFRLKHSDPSQLIERDIVNWTMPTAPDQPAP
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10196166 [H]