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The map label for this gene is hldE [H]

Identifier: 146342026

GI number: 146342026

Start: 5374471

End: 5375973

Strand: Direct

Name: hldE [H]

Synonym: BRADO5164

Alternate gene names: 146342026

Gene position: 5374471-5375973 (Clockwise)

Preceding gene: 146342025

Following gene: 146342027

Centisome position: 72.08

GC content: 64.14

Gene sequence:

>1503_bases
TTGGACCATATAATTGCAGTTCCGGTCGATGCTGTCTGCGAGAAGATTCGCGCGTCCTGTGAATCCGGACAGACGATCGC
CTTCGTGTCGGGCAACTTCAACGTCGTGCACCCCGGACATTTACGGCTCTTGAAATTCGCGGCCGAGCAGGCCGACGTTC
TCATCGTCGGCGTCAATCCGGATTCGACGCCGGGCGTCACCCTCGCTCAGGACATGCGGCTGGAAAATGTGCGGTCGATC
TCCTTTGTGCATCATGCCGTGCGCCTGGAAGCTTCCGCATCCGACTTCATCTCGCACCTGAAACCGACCGTCGTCGTCAA
GGGCAAGGAGTTCGAGGACCGCGCCAACGCCGAGCAAGATGCTGTGGACGCATATGGCGGCCGCCTGATCTTTTCGTCCG
GTGAGTTGCGCTTCGCCTCTCTGTCGCTCTTGGAACGCGACGCGAACATCGACATCTCGACGGTCCGCAAGCCGCTGGAG
TTTCCCAAGCGCCACGGCTTCGAGATCTCGAATCTGAAGGACCTGCTCGGCAAGCTCTCGGGCATGCGGGTGGCCGTCAT
CGGCGACCTCATCGTCGACGAATATGTGACCTGCGATGCGGTCGGCATGTCCCAGGAGGATCCGACCATCGTCGTGACGC
CGCTCATGACCCGCACCTTCGTCGGCGGCGCCGGTGCGGTTGCGGCGCATGCGCACGGCCTCGGCGCCGACGTCAAGTTC
TTCACCCTGGTCGGCGACGACGAAGCCGCGCGGTTTGCGCGCAGCACGCTCGAGCAGCACGGCGTGAACTTCAACGCCTT
CACCGATCAGAGCCGTCCGACGACGCGCAAGCAGCGTTTTCGGGCGCTCAACAAGACGCTGCTGCGCGTCAATCATCTGC
GCCAGCATGCCTCCGACGCCGACCTTCAGCGGCAGATGCTGACCTCTGTCGAGCGCGCCTTGAAGACCTGCGATCTGCTG
CTGTTCTCCTGCTTCAACTATGGCTGTCTGCCGCAGGATCTGGTCGACGCAATCGCCGATCGCGCCCGTGCCCAGGGCGT
GATGATGGCGGCCGACAGCCAGGTGTCATCGCAGACCGGCGACGTCTCCCGCTTCAAGGGCATGACCTTGCTGACGCCAA
CCGAGCGCGAGGCGCGCGTCGCGCTGAACGACTTCATCTCCGGCCTCGCCGTCATCAGCGAGCGACTGGTCGAGCGCGCC
CGCACCAAGAACCTCGTGATCACGCTCGGCGCCGAGGGCGCGCTGATCAACACCATGGCCGAAGGCATCTTCACCTCCGA
CCGCTTGCCCGCGTTCAACCCGTCGCCCAAGGACGTCTCCGGCGCGGGCGACAGCTTTTTCATGGCCTGCTCGATGGGCC
TGCGCGCCGGCGCCGATATCTGGCAGGCGTCTTATCTCGGCTCGCTGGCCGCCGCCCTCCAGGTCTCCCGAGTCGGCAAC
CTGCCGCTGACGACCGCCGAACTGGTGCGCGAGATCGACGAGACGGGGTTCAGCCAGGAATAA

Upstream 100 bases:

>100_bases
CAACCGTTTGGACTATTGATCCGATTCTGCCAGGCCCCTGAGAAGGGGCCCTGCGCCAACGCGCAGATCGTCACCCACAG
CCGCCGCCGGAGACCGATTT

Downstream 100 bases:

>100_bases
ATCCCAGAGTAGGATGCCGTCATGCGTGCCCTTCTGCTCGCCGCTGGCATTGGAAGCCGGCTGCGCCCGCTGACCAATAC
GACGCCAAAATGCCTGGTGC

Product: putative bifunctional enzyme (sugar kinase/cytidylyltransferase)

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MDHIIAVPVDAVCEKIRASCESGQTIAFVSGNFNVVHPGHLRLLKFAAEQADVLIVGVNPDSTPGVTLAQDMRLENVRSI
SFVHHAVRLEASASDFISHLKPTVVVKGKEFEDRANAEQDAVDAYGGRLIFSSGELRFASLSLLERDANIDISTVRKPLE
FPKRHGFEISNLKDLLGKLSGMRVAVIGDLIVDEYVTCDAVGMSQEDPTIVVTPLMTRTFVGGAGAVAAHAHGLGADVKF
FTLVGDDEAARFARSTLEQHGVNFNAFTDQSRPTTRKQRFRALNKTLLRVNHLRQHASDADLQRQMLTSVERALKTCDLL
LFSCFNYGCLPQDLVDAIADRARAQGVMMAADSQVSSQTGDVSRFKGMTLLTPTEREARVALNDFISGLAVISERLVERA
RTKNLVITLGAEGALINTMAEGIFTSDRLPAFNPSPKDVSGAGDSFFMACSMGLRAGADIWQASYLGSLAAALQVSRVGN
LPLTTAELVREIDETGFSQE

Sequences:

>Translated_500_residues
MDHIIAVPVDAVCEKIRASCESGQTIAFVSGNFNVVHPGHLRLLKFAAEQADVLIVGVNPDSTPGVTLAQDMRLENVRSI
SFVHHAVRLEASASDFISHLKPTVVVKGKEFEDRANAEQDAVDAYGGRLIFSSGELRFASLSLLERDANIDISTVRKPLE
FPKRHGFEISNLKDLLGKLSGMRVAVIGDLIVDEYVTCDAVGMSQEDPTIVVTPLMTRTFVGGAGAVAAHAHGLGADVKF
FTLVGDDEAARFARSTLEQHGVNFNAFTDQSRPTTRKQRFRALNKTLLRVNHLRQHASDADLQRQMLTSVERALKTCDLL
LFSCFNYGCLPQDLVDAIADRARAQGVMMAADSQVSSQTGDVSRFKGMTLLTPTEREARVALNDFISGLAVISERLVERA
RTKNLVITLGAEGALINTMAEGIFTSDRLPAFNPSPKDVSGAGDSFFMACSMGLRAGADIWQASYLGSLAAALQVSRVGN
LPLTTAELVREIDETGFSQE
>Mature_500_residues
MDHIIAVPVDAVCEKIRASCESGQTIAFVSGNFNVVHPGHLRLLKFAAEQADVLIVGVNPDSTPGVTLAQDMRLENVRSI
SFVHHAVRLEASASDFISHLKPTVVVKGKEFEDRANAEQDAVDAYGGRLIFSSGELRFASLSLLERDANIDISTVRKPLE
FPKRHGFEISNLKDLLGKLSGMRVAVIGDLIVDEYVTCDAVGMSQEDPTIVVTPLMTRTFVGGAGAVAAHAHGLGADVKF
FTLVGDDEAARFARSTLEQHGVNFNAFTDQSRPTTRKQRFRALNKTLLRVNHLRQHASDADLQRQMLTSVERALKTCDLL
LFSCFNYGCLPQDLVDAIADRARAQGVMMAADSQVSSQTGDVSRFKGMTLLTPTEREARVALNDFISGLAVISERLVERA
RTKNLVITLGAEGALINTMAEGIFTSDRLPAFNPSPKDVSGAGDSFFMACSMGLRAGADIWQASYLGSLAAALQVSRVGN
LPLTTAELVREIDETGFSQE

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=325, Percent_Identity=27.3846153846154, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 54153; Mature: 54153

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHIIAVPVDAVCEKIRASCESGQTIAFVSGNFNVVHPGHLRLLKFAAEQADVLIVGVNP
CCCEEECCHHHHHHHHHHHHCCCCEEEEEECCEEEECCCHHHHHHHHHCCCCEEEEECCC
DSTPGVTLAQDMRLENVRSISFVHHAVRLEASASDFISHLKPTVVVKGKEFEDRANAEQD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCCHHCCCCHH
AVDAYGGRLIFSSGELRFASLSLLERDANIDISTVRKPLEFPKRHGFEISNLKDLLGKLS
HHHHCCCEEEEECCCEEEHHHHHHHHCCCCCHHHHHHHHHCHHHCCCCHHHHHHHHHHHC
GMRVAVIGDLIVDEYVTCDAVGMSQEDPTIVVTPLMTRTFVGGAGAVAAHAHGLGADVKF
CCEEEEHHHHHHHHHHEECCCCCCCCCCEEEEECHHHHHHCCCCCHHHHHHCCCCCCEEE
FTLVGDDEAARFARSTLEQHGVNFNAFTDQSRPTTRKQRFRALNKTLLRVNHLRQHASDA
EEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
DLQRQMLTSVERALKTCDLLLFSCFNYGCLPQDLVDAIADRARAQGVMMAADSQVSSQTG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECCHHCCCCC
DVSRFKGMTLLTPTEREARVALNDFISGLAVISERLVERARTKNLVITLGAEGALINTMA
CHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
EGIFTSDRLPAFNPSPKDVSGAGDSFFMACSMGLRAGADIWQASYLGSLAAALQVSRVGN
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LPLTTAELVREIDETGFSQE
CCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDHIIAVPVDAVCEKIRASCESGQTIAFVSGNFNVVHPGHLRLLKFAAEQADVLIVGVNP
CCCEEECCHHHHHHHHHHHHCCCCEEEEEECCEEEECCCHHHHHHHHHCCCCEEEEECCC
DSTPGVTLAQDMRLENVRSISFVHHAVRLEASASDFISHLKPTVVVKGKEFEDRANAEQD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCCHHCCCCHH
AVDAYGGRLIFSSGELRFASLSLLERDANIDISTVRKPLEFPKRHGFEISNLKDLLGKLS
HHHHCCCEEEEECCCEEEHHHHHHHHCCCCCHHHHHHHHHCHHHCCCCHHHHHHHHHHHC
GMRVAVIGDLIVDEYVTCDAVGMSQEDPTIVVTPLMTRTFVGGAGAVAAHAHGLGADVKF
CCEEEEHHHHHHHHHHEECCCCCCCCCCEEEEECHHHHHHCCCCCHHHHHHCCCCCCEEE
FTLVGDDEAARFARSTLEQHGVNFNAFTDQSRPTTRKQRFRALNKTLLRVNHLRQHASDA
EEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
DLQRQMLTSVERALKTCDLLLFSCFNYGCLPQDLVDAIADRARAQGVMMAADSQVSSQTG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECCHHCCCCC
DVSRFKGMTLLTPTEREARVALNDFISGLAVISERLVERARTKNLVITLGAEGALINTMA
CHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
EGIFTSDRLPAFNPSPKDVSGAGDSFFMACSMGLRAGADIWQASYLGSLAAALQVSRVGN
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LPLTTAELVREIDETGFSQE
CCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA