Click here to switch to the map view.

The map label for this gene is tdcB [H]

Identifier: 146341955

GI number: 146341955

Start: 5290013

End: 5291002

Strand: Reverse

Name: tdcB [H]

Synonym: BRADO5091

Alternate gene names: 146341955

Gene position: 5291002-5290013 (Counterclockwise)

Preceding gene: 146341956

Following gene: 146341952

Centisome position: 70.96

GC content: 66.97

Gene sequence:

>990_bases
ATGACAGCTCATGCCCCGATCCCGCCCGTGACCGCCGCCGACATCGATGCGGCGGCCCGGGTTCTCGCGCCGGTGGCGGT
GCGGACCCCGCTGCTGCCAGCCCCGGTGCTCAACGAGCAGCTCAAGGCGAACGTGTTCGTGAAGCCCGAGGTGCTGCAAC
GCACCGGCTCGTTCAAGTTCCGCGGCGCCTACAACAAGCTGGCATCAATTCCCGAATCGTCGCGGGCGAATGGTGTCGTC
GCCTTTTCTTCGGGCAATCACGCCCAGGGCGTCGCGCATGCCGCAACGCTGCTCGGGATGCATGCGACCATCGTGATGCC
GTCCGATGCTCCGGTCGCCAAGCGCGAGCGCACCAAGGCCTTCGGGGCCGATGTCGTGCTGTATGATCGCGACCGTGAAG
ACCGAGAGGCGATTGCCCGCGAGATCGCCGGCAAGCGCGGCTCGACCGTGGTGCCGCCCTATGACGATCCCTATGTCATT
GCCGGGCAGGGCACCGTCGGCCGCGAGATCGCGGAAGATCTTGCGGTACTTGGCCTGTCGCCCGATGTCGTCATCGTTCC
CGCCTCGGGAGGCGGTTTGCTCGCAGGCGTGTCGACGGCGGTGAAGGCGCGCTATCCGCAAGCCCAGATGATCGTCGCCG
AGCCCAAGGGATACGATGACCACGCCCGCTCGCTGCGTGCTGGCCATCGCGAGGCGCACGACGCGAAGGGACGCACCATC
TGCGATGCGCTGATGGCGGCGATCCCCGGCGAGATCACCTTCGCCATCAACAGCAAGCTGTTGTCCGCTGCGGTCGAGGC
GTCGGATGAGGAGGTCGGCCGCGCGGTCGGCTTCGCCTTCCGTGAGCTGAAGCTCGTCGTCGAGCCCGGCGGCTCGGTCG
GGCTGGCGGCCTTGCTGGCGGGGCGGCTCGATGTTGCAGGCAAGACGGTGGTGATCGTTCTTTCCGGCGGCAATGTCGAT
GCCGATCTCTATGCCATGCTGATCGCCTGA

Upstream 100 bases:

>100_bases
AGCAGCCGGCGCCGGTTCCGCAACTGGCGGCCCGCGCGGCCTGAGAGCAAGCGAGCGGGCTCCCTTGCCTCGCAGCGACC
GGGCGCGGTAAATTGAGCAC

Downstream 100 bases:

>100_bases
CCTGGCCTCAGTGGAAGCCGAGGCCACCCCGCGAAAAACCTCCGCCTCCCGGACGCGGTCCGGATTGCGCGAAGTGCGGT
GCGCCGGGCCCGCGTGCCAC

Product: putative threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MTAHAPIPPVTAADIDAAARVLAPVAVRTPLLPAPVLNEQLKANVFVKPEVLQRTGSFKFRGAYNKLASIPESSRANGVV
AFSSGNHAQGVAHAATLLGMHATIVMPSDAPVAKRERTKAFGADVVLYDRDREDREAIAREIAGKRGSTVVPPYDDPYVI
AGQGTVGREIAEDLAVLGLSPDVVIVPASGGGLLAGVSTAVKARYPQAQMIVAEPKGYDDHARSLRAGHREAHDAKGRTI
CDALMAAIPGEITFAINSKLLSAAVEASDEEVGRAVGFAFRELKLVVEPGGSVGLAALLAGRLDVAGKTVVIVLSGGNVD
ADLYAMLIA

Sequences:

>Translated_329_residues
MTAHAPIPPVTAADIDAAARVLAPVAVRTPLLPAPVLNEQLKANVFVKPEVLQRTGSFKFRGAYNKLASIPESSRANGVV
AFSSGNHAQGVAHAATLLGMHATIVMPSDAPVAKRERTKAFGADVVLYDRDREDREAIAREIAGKRGSTVVPPYDDPYVI
AGQGTVGREIAEDLAVLGLSPDVVIVPASGGGLLAGVSTAVKARYPQAQMIVAEPKGYDDHARSLRAGHREAHDAKGRTI
CDALMAAIPGEITFAINSKLLSAAVEASDEEVGRAVGFAFRELKLVVEPGGSVGLAALLAGRLDVAGKTVVIVLSGGNVD
ADLYAMLIA
>Mature_328_residues
TAHAPIPPVTAADIDAAARVLAPVAVRTPLLPAPVLNEQLKANVFVKPEVLQRTGSFKFRGAYNKLASIPESSRANGVVA
FSSGNHAQGVAHAATLLGMHATIVMPSDAPVAKRERTKAFGADVVLYDRDREDREAIAREIAGKRGSTVVPPYDDPYVIA
GQGTVGREIAEDLAVLGLSPDVVIVPASGGGLLAGVSTAVKARYPQAQMIVAEPKGYDDHARSLRAGHREAHDAKGRTIC
DALMAAIPGEITFAINSKLLSAAVEASDEEVGRAVGFAFRELKLVVEPGGSVGLAALLAGRLDVAGKTVVIVLSGGNVDA
DLYAMLIA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=298, Percent_Identity=36.241610738255, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI19923959, Length=147, Percent_Identity=32.6530612244898, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1789505, Length=314, Percent_Identity=39.171974522293, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1790207, Length=294, Percent_Identity=34.3537414965986, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71991565, Length=316, Percent_Identity=32.9113924050633, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17537387, Length=309, Percent_Identity=34.6278317152104, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=28.1645569620253, Blast_Score=120, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6322631, Length=323, Percent_Identity=41.1764705882353, Blast_Score=222, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6320930, Length=292, Percent_Identity=36.986301369863, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319788, Length=285, Percent_Identity=25.6140350877193, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355833, Length=316, Percent_Identity=34.4936708860759, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24645328, Length=220, Percent_Identity=35, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34160; Mature: 34028

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAHAPIPPVTAADIDAAARVLAPVAVRTPLLPAPVLNEQLKANVFVKPEVLQRTGSFKF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEECHHHHHHCCCEEE
RGAYNKLASIPESSRANGVVAFSSGNHAQGVAHAATLLGMHATIVMPSDAPVAKRERTKA
ECHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCCCHHHHHHHH
FGADVVLYDRDREDREAIAREIAGKRGSTVVPPYDDPYVIAGQGTVGREIAEDLAVLGLS
CCCEEEEEECCCHHHHHHHHHHCCCCCCEECCCCCCCEEEECCCCHHHHHHHHHHHCCCC
PDVVIVPASGGGLLAGVSTAVKARYPQAQMIVAEPKGYDDHARSLRAGHREAHDAKGRTI
CCEEEEECCCCCEEHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCHHHCCCCHHH
CDALMAAIPGEITFAINSKLLSAAVEASDEEVGRAVGFAFRELKLVVEPGGSVGLAALLA
HHHHHHHCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHH
GRLDVAGKTVVIVLSGGNVDADLYAMLIA
HCCCCCCCEEEEEEECCCCCHHHHEEEEC
>Mature Secondary Structure 
TAHAPIPPVTAADIDAAARVLAPVAVRTPLLPAPVLNEQLKANVFVKPEVLQRTGSFKF
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEECHHHHHHCCCEEE
RGAYNKLASIPESSRANGVVAFSSGNHAQGVAHAATLLGMHATIVMPSDAPVAKRERTKA
ECHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCCCHHHHHHHH
FGADVVLYDRDREDREAIAREIAGKRGSTVVPPYDDPYVIAGQGTVGREIAEDLAVLGLS
CCCEEEEEECCCHHHHHHHHHHCCCCCCEECCCCCCCEEEECCCCHHHHHHHHHHHCCCC
PDVVIVPASGGGLLAGVSTAVKARYPQAQMIVAEPKGYDDHARSLRAGHREAHDAKGRTI
CCEEEEECCCCCEEHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCHHHCCCCHHH
CDALMAAIPGEITFAINSKLLSAAVEASDEEVGRAVGFAFRELKLVVEPGGSVGLAALLA
HHHHHHHCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHH
GRLDVAGKTVVIVLSGGNVDADLYAMLIA
HCCCCCCCEEEEEEECCCCCHHHHEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA