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The map label for this gene is acoR [H]

Identifier: 146341266

GI number: 146341266

Start: 4532758

End: 4534686

Strand: Direct

Name: acoR [H]

Synonym: BRADO4343

Alternate gene names: 146341266

Gene position: 4532758-4534686 (Clockwise)

Preceding gene: 146341265

Following gene: 146341277

Centisome position: 60.79

GC content: 69.26

Gene sequence:

>1929_bases
ATGGACCAACGGGACGTACGGGCCGCATGGCAAAGATTCGTCGAGCGCGGCACCTTGTCGGGTGACGTGAGATCAACGGT
GGCCGCTTCGTGGCGGCGTTCTCAGCAGCACCGCATCACCGTCGATCGCGCCAAGGCGCCGCTGGTCGCGGAGGACGAAT
TGGCCCGCCAGCGGGCCAAGCATGCCGCGCTTCGCCACGCCGCACGGAGCGCGCTGCAGAACTCGAAGACGTTCCTGAGA
GATGCAGGATCCATCATGATCCTCACCGATCCCACCGGCCTGATCATCGATACCCAGGGCGATGCCCGGGTGATCGATGC
CGGGCGTACCGTGCATCTGGAGCATGGCGGGCGCTGGAGCGAGGCCGACATCGGCACCAACGCGATCGGCGCGGCGCTGG
CTGACTCGTGCCCGGTGCAGATTCACGGCGCCGAGCATTTCTGCACCGAGGTGCAGCGCTGGACCTGTGCGGCCGTGCCG
GTCCACGATCCGAACGACGGCGAGCTGCTCGGCGTCGTCGACATCTCCGGCCCGGCCAGCACGTTCAATCCGCAGAGCCT
GGCGCTGGCGGTTGCGGTCGGCCATCACGTCGAAAGCGTGCTGGCGCAGCTGGCGCGCCAGGACAAGGAGCAGCTGCTGT
GCGATTTCATCGCCAAGCGCGCCTCCTGGGCCACCGAGGAATGCATCCTGCTCGATCGCCGCGGCGCCATCCTGCATGCG
ACCGAGCGCGGCCTGCGCGCGATGAAGGACAACGGTCTCAACACCGACGGCGATGCGCCGACGCGGTTCCTGAAGACGGT
GGCCTTTGAGGACTGGCCGGCGAAGCTCAGGGAGATCCTGCCCCATGCGAGCTTCGAGCTTGTAAAGAACGGCAACACGG
GCGTCGGCGCGATCGTCGTGATGCACGCCCGGCGGCGTGCCGCCGGGGAGCGCAGCGCGGCGGGCATGCGCGGGCGCGAT
GCTGCGCCGCCGCGCTCGGCGCAGGCGCCTCCGCCGGCGAGGTCAGCCGGCAACAAGACGCCGCGATTTGTCGCCGAGGA
CCCGAACGTGCTCGCGATCGTGCGGCGCGTCGAGGGCGCGGCGGCGCGCAAGATGCCGATCCTCATCCGCGGCGAGACCG
GCACCGGCAAAGAGCAGCTGGCACGCCACGCCCATGCCGCCAGCGGACGCGCCGGGGCGTTCATCGCGGTCAATTGTGCC
GCGCTCCCCGACAGCCTGATCGAGGCCGAGCTGTTCGGCTATGCCGATGGCGCGTTCACCGGCGCGCGGTCCGGCGGCGC
CATGGGCCTGGTGAAGGAGGCCGATGGCGGCACGCTGTTTCTCGACGAGATCGGCGACATGCCGGTGGCGCTGCAGGGCG
TGTTGCTGCGCCTGCTCGACGACTGGACGGTGCGCCCGGTCGGCGGCGCCGCCTTCAAGGTCGACGTCTTCCTGGTGTCG
GCGACCAACGCCGCGCTTGACAAGGCGATCGCCGAGGGACGCTTCCGGTCCGACCTGCTGTATCGGCTGAACACGCTCGA
GGTGCGGCTGCCGCGGCTGCGCGAGCGCAGCGATTTCGACGCCATTGCGCGCCAGCTGCTGCACAAGATCGATCCCGGCT
GCGCCATCACCGCCGAAGCGCTGGCCCGGCTGGCGCCGAACCACTGGCACGGCAACATTCGCGAGCTCGGCAACATGCTG
GCGCGGCTCACGCTCGGCGTGTCCAACGGGATCATCGATGAGGCTTGCGTGGACGCGATGCTCGGTCAAACGATCGGCCA
ACTGATTGCTCGGCCATCGCTGGACACGGAGGGGTCGCTGCACGATGTGCAGCGCGCCCGCATCCTCATGGTCTACGCGG
AGACCAACGGCAATGTCAGCGAGACCGCACGCCGGCTCGGCGTGTCCCGCAACACGATCTATCGCGCGCTCGGCCAGCCG
CGGCCGTAG

Upstream 100 bases:

>100_bases
ATTGCGGCTGATGCGTGGCCAGTCGGACACGATGTCCGCAGCAGGTGTTTGATCGCGAGGCGACGCTGGCAGCTTGCATC
GACACGTTGGAGGAACCGGA

Downstream 100 bases:

>100_bases
TCCGCGGCTGTGCTCGGCGTCGCCCGTCGCCGTGACGAGGCTCGAACGGAGAGACGCACGATCAGTCCGCCGCAGCCGGG
CGCGAACGCCCGGTCCGTCA

Product: putative sigma-54-dependent transcriptional regulator transcriptional activator of acetoin/glycerol metabolism

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MDQRDVRAAWQRFVERGTLSGDVRSTVAASWRRSQQHRITVDRAKAPLVAEDELARQRAKHAALRHAARSALQNSKTFLR
DAGSIMILTDPTGLIIDTQGDARVIDAGRTVHLEHGGRWSEADIGTNAIGAALADSCPVQIHGAEHFCTEVQRWTCAAVP
VHDPNDGELLGVVDISGPASTFNPQSLALAVAVGHHVESVLAQLARQDKEQLLCDFIAKRASWATEECILLDRRGAILHA
TERGLRAMKDNGLNTDGDAPTRFLKTVAFEDWPAKLREILPHASFELVKNGNTGVGAIVVMHARRRAAGERSAAGMRGRD
AAPPRSAQAPPPARSAGNKTPRFVAEDPNVLAIVRRVEGAAARKMPILIRGETGTGKEQLARHAHAASGRAGAFIAVNCA
ALPDSLIEAELFGYADGAFTGARSGGAMGLVKEADGGTLFLDEIGDMPVALQGVLLRLLDDWTVRPVGGAAFKVDVFLVS
ATNAALDKAIAEGRFRSDLLYRLNTLEVRLPRLRERSDFDAIARQLLHKIDPGCAITAEALARLAPNHWHGNIRELGNML
ARLTLGVSNGIIDEACVDAMLGQTIGQLIARPSLDTEGSLHDVQRARILMVYAETNGNVSETARRLGVSRNTIYRALGQP
RP

Sequences:

>Translated_642_residues
MDQRDVRAAWQRFVERGTLSGDVRSTVAASWRRSQQHRITVDRAKAPLVAEDELARQRAKHAALRHAARSALQNSKTFLR
DAGSIMILTDPTGLIIDTQGDARVIDAGRTVHLEHGGRWSEADIGTNAIGAALADSCPVQIHGAEHFCTEVQRWTCAAVP
VHDPNDGELLGVVDISGPASTFNPQSLALAVAVGHHVESVLAQLARQDKEQLLCDFIAKRASWATEECILLDRRGAILHA
TERGLRAMKDNGLNTDGDAPTRFLKTVAFEDWPAKLREILPHASFELVKNGNTGVGAIVVMHARRRAAGERSAAGMRGRD
AAPPRSAQAPPPARSAGNKTPRFVAEDPNVLAIVRRVEGAAARKMPILIRGETGTGKEQLARHAHAASGRAGAFIAVNCA
ALPDSLIEAELFGYADGAFTGARSGGAMGLVKEADGGTLFLDEIGDMPVALQGVLLRLLDDWTVRPVGGAAFKVDVFLVS
ATNAALDKAIAEGRFRSDLLYRLNTLEVRLPRLRERSDFDAIARQLLHKIDPGCAITAEALARLAPNHWHGNIRELGNML
ARLTLGVSNGIIDEACVDAMLGQTIGQLIARPSLDTEGSLHDVQRARILMVYAETNGNVSETARRLGVSRNTIYRALGQP
RP
>Mature_642_residues
MDQRDVRAAWQRFVERGTLSGDVRSTVAASWRRSQQHRITVDRAKAPLVAEDELARQRAKHAALRHAARSALQNSKTFLR
DAGSIMILTDPTGLIIDTQGDARVIDAGRTVHLEHGGRWSEADIGTNAIGAALADSCPVQIHGAEHFCTEVQRWTCAAVP
VHDPNDGELLGVVDISGPASTFNPQSLALAVAVGHHVESVLAQLARQDKEQLLCDFIAKRASWATEECILLDRRGAILHA
TERGLRAMKDNGLNTDGDAPTRFLKTVAFEDWPAKLREILPHASFELVKNGNTGVGAIVVMHARRRAAGERSAAGMRGRD
AAPPRSAQAPPPARSAGNKTPRFVAEDPNVLAIVRRVEGAAARKMPILIRGETGTGKEQLARHAHAASGRAGAFIAVNCA
ALPDSLIEAELFGYADGAFTGARSGGAMGLVKEADGGTLFLDEIGDMPVALQGVLLRLLDDWTVRPVGGAAFKVDVFLVS
ATNAALDKAIAEGRFRSDLLYRLNTLEVRLPRLRERSDFDAIARQLLHKIDPGCAITAEALARLAPNHWHGNIRELGNML
ARLTLGVSNGIIDEACVDAMLGQTIGQLIARPSLDTEGSLHDVQRARILMVYAETNGNVSETARRLGVSRNTIYRALGQP
RP

Specific function: Acts as a transcriptional activator of the acoABCL operon encoding the acetoin dehydrogenase complex [H]

COG id: COG3284

COG function: function code QK; Transcriptional activator of acetoin/glycerol metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1789233, Length=312, Percent_Identity=38.7820512820513, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI1788905, Length=307, Percent_Identity=40.0651465798046, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1788550, Length=310, Percent_Identity=38.0645161290323, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI1786524, Length=293, Percent_Identity=42.320819112628, Blast_Score=178, Evalue=9e-46,
Organism=Escherichia coli, GI1790299, Length=349, Percent_Identity=36.1031518624642, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789087, Length=299, Percent_Identity=39.4648829431438, Blast_Score=172, Evalue=8e-44,
Organism=Escherichia coli, GI87082117, Length=306, Percent_Identity=39.5424836601307, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1790437, Length=325, Percent_Identity=36.9230769230769, Blast_Score=167, Evalue=3e-42,
Organism=Escherichia coli, GI87081872, Length=316, Percent_Identity=36.0759493670886, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87082152, Length=237, Percent_Identity=40.5063291139241, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787583, Length=308, Percent_Identity=32.7922077922078, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081858, Length=604, Percent_Identity=24.3377483443709, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI1789828, Length=245, Percent_Identity=33.8775510204082, Blast_Score=122, Evalue=9e-29,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078 [H]

Pfam domain/function: PF02954 HTH_8; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 69138; Mature: 69138

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQRDVRAAWQRFVERGTLSGDVRSTVAASWRRSQQHRITVDRAKAPLVAEDELARQRAK
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHH
HAALRHAARSALQNSKTFLRDAGSIMILTDPTGLIIDTQGDARVIDAGRTVHLEHGGRWS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCEEEECCCEEEECCCCCCC
EADIGTNAIGAALADSCPVQIHGAEHFCTEVQRWTCAAVPVHDPNDGELLGVVDISGPAS
CCCCCCHHHHHHHHCCCCEEEECHHHHHHHHHHCEEEEECCCCCCCCCEEEEEEECCCCC
TFNPQSLALAVAVGHHVESVLAQLARQDKEQLLCDFIAKRASWATEECILLDRRGAILHA
CCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEH
TERGLRAMKDNGLNTDGDAPTRFLKTVAFEDWPAKLREILPHASFELVKNGNTGVGAIVV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCCCEEE
MHARRRAAGERSAAGMRGRDAAPPRSAQAPPPARSAGNKTPRFVAEDPNVLAIVRRVEGA
EEHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEHHHHHHCH
AARKMPILIRGETGTGKEQLARHAHAASGRAGAFIAVNCAALPDSLIEAELFGYADGAFT
HHCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEEHHCCHHHHHHHHHCCCCCCCC
GARSGGAMGLVKEADGGTLFLDEIGDMPVALQGVLLRLLDDWTVRPVGGAAFKVDVFLVS
CCCCCCCEEEEEECCCCEEEHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEE
ATNAALDKAIAEGRFRSDLLYRLNTLEVRLPRLRERSDFDAIARQLLHKIDPGCAITAEA
CCHHHHHHHHHCCCHHHHHHHHHHHHEEECCHHHCCCCHHHHHHHHHHHCCCCCEEHHHH
LARLAPNHWHGNIRELGNMLARLTLGVSNGIIDEACVDAMLGQTIGQLIARPSLDTEGSL
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
HDVQRARILMVYAETNGNVSETARRLGVSRNTIYRALGQPRP
HHHCCEEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MDQRDVRAAWQRFVERGTLSGDVRSTVAASWRRSQQHRITVDRAKAPLVAEDELARQRAK
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHH
HAALRHAARSALQNSKTFLRDAGSIMILTDPTGLIIDTQGDARVIDAGRTVHLEHGGRWS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCEEEECCCEEEECCCCCCC
EADIGTNAIGAALADSCPVQIHGAEHFCTEVQRWTCAAVPVHDPNDGELLGVVDISGPAS
CCCCCCHHHHHHHHCCCCEEEECHHHHHHHHHHCEEEEECCCCCCCCCEEEEEEECCCCC
TFNPQSLALAVAVGHHVESVLAQLARQDKEQLLCDFIAKRASWATEECILLDRRGAILHA
CCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEH
TERGLRAMKDNGLNTDGDAPTRFLKTVAFEDWPAKLREILPHASFELVKNGNTGVGAIVV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCCCEEE
MHARRRAAGERSAAGMRGRDAAPPRSAQAPPPARSAGNKTPRFVAEDPNVLAIVRRVEGA
EEHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEHHHHHHCH
AARKMPILIRGETGTGKEQLARHAHAASGRAGAFIAVNCAALPDSLIEAELFGYADGAFT
HHCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEEHHCCHHHHHHHHHCCCCCCCC
GARSGGAMGLVKEADGGTLFLDEIGDMPVALQGVLLRLLDDWTVRPVGGAAFKVDVFLVS
CCCCCCCEEEEEECCCCEEEHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEE
ATNAALDKAIAEGRFRSDLLYRLNTLEVRLPRLRERSDFDAIARQLLHKIDPGCAITAEA
CCHHHHHHHHHCCCHHHHHHHHHHHHEEECCHHHCCCCHHHHHHHHHHHCCCCCEEHHHH
LARLAPNHWHGNIRELGNMLARLTLGVSNGIIDEACVDAMLGQTIGQLIARPSLDTEGSL
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
HDVQRARILMVYAETNGNVSETARRLGVSRNTIYRALGQPRP
HHHCCEEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377; 10368162 [H]