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The map label for this gene is zraS [H]

Identifier: 146341232

GI number: 146341232

Start: 4501036

End: 4503717

Strand: Reverse

Name: zraS [H]

Synonym: BRADO4308

Alternate gene names: 146341232

Gene position: 4503717-4501036 (Counterclockwise)

Preceding gene: 146341233

Following gene: 146341231

Centisome position: 60.4

GC content: 66.11

Gene sequence:

>2682_bases
ATGAGTAAAAACGTTGATTTCGGCTTGGCCTGTGATCGTCTCCGATCTCTCACGATCGGGCGGATGATCTTTGGCAGTTT
TTTGCTGCTGCTGGCCGTCATCACCGCGACCAGCATGGCGAGCGTGATCGCCATCCGCCACATCGATTCGACCTTTGCCG
AGCTGCAGCGGCTGCAGGGCGTCGGCGATCTCGCCGAGGAGATCGATCAGCGCATGAACGAGCTGCGGCTCGCGGCGCGC
GATTTCGTCACCGATCCCGCCTCGCGCTCCGATCGTGTGATGGAGGCTGCGACCGAGCTGAGCGCGCTGCTGAAGAAGAC
GCGGCTGCAGCTGGCGCCGGAGCAGCAGGCGACCATCGACGGCGTCTCGCAGCGGTTGACGAACTACCGCGAAGGCATCG
GCCGGATCAGTGCGTTGATCGCACTGCGCGCCGAGCTGCTCTCCGTTCTGCCGGCGGCGCGCGAGGGGTTTGAAGCGGCG
ATCGCCGGTGTCACCGATCGCGGCACTGCGCGGGCCCTGTTCCAGGTGCAGAACCAGGTCGGAGCGGCGCTGCTGGCGCG
TGATCCGGCCGGTGCCGAGCAGGCGGCCCGCAGCATGCGTGCGCTGCCGATCGAGGATGCGACGTTGCGCAAGGCTGTGG
ACCGCTATGCCGAGGCGATCATCGAGATCTCCGGCACCGAGGACGAGATCGGCCGGCTCGACAAGGAGGTGCTCGGCATC
GAGGGCCGGCTGATCGGCCGCGTCACCGAGCTGTTGCGGGCGCTCAGCGCCAGCCAGGGCAAGGTGCTGTCGCGCGACTT
CGCGCGCACGCTCGCGGAAACGAAATGGCAGAGCATCCTCTTCGGCACGTCAGGCGTGCTGATCGGCATCTTTGCCGCGT
GGTTCGTGGTACGCCGGACGGTGAAGCCGCTGGCCTCGATCGCGCGCTCGATCCGCGCGCTGGCCGCCGGCGAGAAGGCG
GCCTCGATCCCGCAGACCGACGTCCAGAACGAGATCGGCGACATCGCGCGCGCCGCCGAAGTGTTCCGGCAGACGCTGCA
GGATGCCGATGCCGCGCGCGAGGCGGCGGTGCGCGCGCTCGCCGAGCAGCGGCTCGCCGAGGAGAGCTATCGCAAGCTGT
TCGAAGCCTCGATTGACGGCATCTATGTGACCACGCCGAGCGGCCTCGTGCTCAATGCCAATCCGGCGTTGGCGCGCATC
ATGGGCTACGAGTCTCCGAGCGAACTGATCCAGAGCGTCAACGACATCGCCGACACGATCTATGTGCATCCGCTGGCGCG
CGAGCGCTACCAGCGGCTGATGCGGCGCGACGGCATGGTCCGCGAGTTCGAATACCAGGTGCGCCGGCGCAATGGCGAGA
TTCGCTGGCTCTCGGACAGCGCCACTGTGGTGCGTGACGAGAGCGGCGAGGTCGTGCGCTACGAAGGCGTCGTTCGCGAC
ATCACCGACCAGAAGCGCGCGGAAGATGCGATCGCCGAAGGACGGCGCCTGCTGCAGCAGGTCATCGACACCGTGCCAGC
CGTGATCAACGTCAAGGATCGCGAGCTGCGCTACGTGCTGATGAACCGCTACATGGCCGGAATCTTCAACGTCGAGCCTG
AGGATGCGCTGGGGCGCACCACGGGCGAGCTGATGTCGCGCTATGGCGCAAGCAAGACCGACGGCAACGACAAGCGCGTG
CTGGCGACCAAGGCCGGCCTCGGCTTCTACGAGGAAGAATACCTGGATTCCTGCAACGTCATGCGCCAGTGGCTCGTCAA
CAAGCTGCCGCTGCTCGATGCCGACGGCGAGGTCGACAAGATCGTCACCGTGGCGCTCGATATCGGCGAGCGCAAGAAGA
GCGAGCACGAGATGCGCAAGGCCAAGGAGGCAGCCGAGACGGCGCTCCGGAACCTGCGCGAGACTCAGGCCTCGTTGATC
GAGGCGGAGAAGCTCGCGGCGCTCGGACGCATGGTCGCGGGCGTTGCGCACGAGGTCAACAACCCCGTCGGCATCAGCCT
GACGGTGGCATCCGCTCTCGAGCGCAAGACCGAGCGCTTCAGCGAAGCGGTCACGCGCGGCGAGCTTCGGAAATCGAGCC
TCAATGAGTTCATCGAGACCAGCCGCAATGCTGCCGCTCAACTGGTCGCCAACCTCAACCGCGCGGCCGAGCTGATCCAG
TCGTTCAAGCAGGTCGCGGCGGACCGCAACTACTCCGACCAGCGCAGCTTCGATCTCGCCGATCTCACCGAGCAGGTGGT
GATGAGTTTGCGCCCGGGCGTGCGCAGACAGAACCTGACGGTCAATGTCGACTGTCAGCCCAATCTGCTGATGAACAGCT
ATCCCGGCCCTTACGGCCAGGTCCTGACCAATCTGTTCCTCAATGCCGTCGCCCATGCGTTTCCGGACGGCCGCGGCGGC
ACGATCGAGATCAAGGCGCGCGAGTCCGGGCGCGACAATGTCGAGATCATCTTTTCCGACAATGGCTGCGGCATGTCGCT
CGATGTCCGCCGCCGCGCTTTCGATCCGTTCTTCACGACGCGGCGCGACCAGGGCGGCACGGGGCTCGGGCTGCACATCG
TCTACAACATCGTCACCAACAGGCTCGGCGGCCGGCTCGATCTCGAGTCGGAGCCCGGCGCGGGCACGCGTGTTCAGATC
ATTCTGCCGCGCACGGCGCCGCTGGAGCAGGCGGCCGAGTAG

Upstream 100 bases:

>100_bases
TTTTTCGTCTGGCCGTGATGCCCAGATGCCCATTGTTCCTGATTTGTTCTAGTTGCCGCGTGGCGGCTCGTATATACTGC
GGTTCCGACAATCGGATCCC

Downstream 100 bases:

>100_bases
TCACGATCGCGCTTTCGCGATCGGCGCGGCGCAACTACGTCGATCCCCGGATTGACTCTCACGAAGCTGCGATCGAATCA
AAATCTGGCCCGGTTGATGC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 893; Mature: 892

Protein sequence:

>893_residues
MSKNVDFGLACDRLRSLTIGRMIFGSFLLLLAVITATSMASVIAIRHIDSTFAELQRLQGVGDLAEEIDQRMNELRLAAR
DFVTDPASRSDRVMEAATELSALLKKTRLQLAPEQQATIDGVSQRLTNYREGIGRISALIALRAELLSVLPAAREGFEAA
IAGVTDRGTARALFQVQNQVGAALLARDPAGAEQAARSMRALPIEDATLRKAVDRYAEAIIEISGTEDEIGRLDKEVLGI
EGRLIGRVTELLRALSASQGKVLSRDFARTLAETKWQSILFGTSGVLIGIFAAWFVVRRTVKPLASIARSIRALAAGEKA
ASIPQTDVQNEIGDIARAAEVFRQTLQDADAAREAAVRALAEQRLAEESYRKLFEASIDGIYVTTPSGLVLNANPALARI
MGYESPSELIQSVNDIADTIYVHPLARERYQRLMRRDGMVREFEYQVRRRNGEIRWLSDSATVVRDESGEVVRYEGVVRD
ITDQKRAEDAIAEGRRLLQQVIDTVPAVINVKDRELRYVLMNRYMAGIFNVEPEDALGRTTGELMSRYGASKTDGNDKRV
LATKAGLGFYEEEYLDSCNVMRQWLVNKLPLLDADGEVDKIVTVALDIGERKKSEHEMRKAKEAAETALRNLRETQASLI
EAEKLAALGRMVAGVAHEVNNPVGISLTVASALERKTERFSEAVTRGELRKSSLNEFIETSRNAAAQLVANLNRAAELIQ
SFKQVAADRNYSDQRSFDLADLTEQVVMSLRPGVRRQNLTVNVDCQPNLLMNSYPGPYGQVLTNLFLNAVAHAFPDGRGG
TIEIKARESGRDNVEIIFSDNGCGMSLDVRRRAFDPFFTTRRDQGGTGLGLHIVYNIVTNRLGGRLDLESEPGAGTRVQI
ILPRTAPLEQAAE

Sequences:

>Translated_893_residues
MSKNVDFGLACDRLRSLTIGRMIFGSFLLLLAVITATSMASVIAIRHIDSTFAELQRLQGVGDLAEEIDQRMNELRLAAR
DFVTDPASRSDRVMEAATELSALLKKTRLQLAPEQQATIDGVSQRLTNYREGIGRISALIALRAELLSVLPAAREGFEAA
IAGVTDRGTARALFQVQNQVGAALLARDPAGAEQAARSMRALPIEDATLRKAVDRYAEAIIEISGTEDEIGRLDKEVLGI
EGRLIGRVTELLRALSASQGKVLSRDFARTLAETKWQSILFGTSGVLIGIFAAWFVVRRTVKPLASIARSIRALAAGEKA
ASIPQTDVQNEIGDIARAAEVFRQTLQDADAAREAAVRALAEQRLAEESYRKLFEASIDGIYVTTPSGLVLNANPALARI
MGYESPSELIQSVNDIADTIYVHPLARERYQRLMRRDGMVREFEYQVRRRNGEIRWLSDSATVVRDESGEVVRYEGVVRD
ITDQKRAEDAIAEGRRLLQQVIDTVPAVINVKDRELRYVLMNRYMAGIFNVEPEDALGRTTGELMSRYGASKTDGNDKRV
LATKAGLGFYEEEYLDSCNVMRQWLVNKLPLLDADGEVDKIVTVALDIGERKKSEHEMRKAKEAAETALRNLRETQASLI
EAEKLAALGRMVAGVAHEVNNPVGISLTVASALERKTERFSEAVTRGELRKSSLNEFIETSRNAAAQLVANLNRAAELIQ
SFKQVAADRNYSDQRSFDLADLTEQVVMSLRPGVRRQNLTVNVDCQPNLLMNSYPGPYGQVLTNLFLNAVAHAFPDGRGG
TIEIKARESGRDNVEIIFSDNGCGMSLDVRRRAFDPFFTTRRDQGGTGLGLHIVYNIVTNRLGGRLDLESEPGAGTRVQI
ILPRTAPLEQAAE
>Mature_892_residues
SKNVDFGLACDRLRSLTIGRMIFGSFLLLLAVITATSMASVIAIRHIDSTFAELQRLQGVGDLAEEIDQRMNELRLAARD
FVTDPASRSDRVMEAATELSALLKKTRLQLAPEQQATIDGVSQRLTNYREGIGRISALIALRAELLSVLPAAREGFEAAI
AGVTDRGTARALFQVQNQVGAALLARDPAGAEQAARSMRALPIEDATLRKAVDRYAEAIIEISGTEDEIGRLDKEVLGIE
GRLIGRVTELLRALSASQGKVLSRDFARTLAETKWQSILFGTSGVLIGIFAAWFVVRRTVKPLASIARSIRALAAGEKAA
SIPQTDVQNEIGDIARAAEVFRQTLQDADAAREAAVRALAEQRLAEESYRKLFEASIDGIYVTTPSGLVLNANPALARIM
GYESPSELIQSVNDIADTIYVHPLARERYQRLMRRDGMVREFEYQVRRRNGEIRWLSDSATVVRDESGEVVRYEGVVRDI
TDQKRAEDAIAEGRRLLQQVIDTVPAVINVKDRELRYVLMNRYMAGIFNVEPEDALGRTTGELMSRYGASKTDGNDKRVL
ATKAGLGFYEEEYLDSCNVMRQWLVNKLPLLDADGEVDKIVTVALDIGERKKSEHEMRKAKEAAETALRNLRETQASLIE
AEKLAALGRMVAGVAHEVNNPVGISLTVASALERKTERFSEAVTRGELRKSSLNEFIETSRNAAAQLVANLNRAAELIQS
FKQVAADRNYSDQRSFDLADLTEQVVMSLRPGVRRQNLTVNVDCQPNLLMNSYPGPYGQVLTNLFLNAVAHAFPDGRGGT
IEIKARESGRDNVEIIFSDNGCGMSLDVRRRAFDPFFTTRRDQGGTGLGLHIVYNIVTNRLGGRLDLESEPGAGTRVQII
LPRTAPLEQAAE

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=262, Percent_Identity=33.206106870229, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1788549, Length=252, Percent_Identity=29.3650793650794, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI145693157, Length=289, Percent_Identity=25.2595155709343, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 98399; Mature: 98268

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKNVDFGLACDRLRSLTIGRMIFGSFLLLLAVITATSMASVIAIRHIDSTFAELQRLQG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VGDLAEEIDQRMNELRLAARDFVTDPASRSDRVMEAATELSALLKKTRLQLAPEQQATID
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GVSQRLTNYREGIGRISALIALRAELLSVLPAAREGFEAAIAGVTDRGTARALFQVQNQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHH
GAALLARDPAGAEQAARSMRALPIEDATLRKAVDRYAEAIIEISGTEDEIGRLDKEVLGI
HHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
EGRLIGRVTELLRALSASQGKVLSRDFARTLAETKWQSILFGTSGVLIGIFAAWFVVRRT
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VKPLASIARSIRALAAGEKAASIPQTDVQNEIGDIARAAEVFRQTLQDADAAREAAVRAL
HHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEQRLAEESYRKLFEASIDGIYVTTPSGLVLNANPALARIMGYESPSELIQSVNDIADTI
HHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHH
YVHPLARERYQRLMRRDGMVREFEYQVRRRNGEIRWLSDSATVVRDESGEVVRYEGVVRD
HHCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCEEEECCCCCEEEECCHHHH
ITDQKRAEDAIAEGRRLLQQVIDTVPAVINVKDRELRYVLMNRYMAGIFNVEPEDALGRT
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHCCCCCHHHHCCC
TGELMSRYGASKTDGNDKRVLATKAGLGFYEEEYLDSCNVMRQWLVNKLPLLDADGEVDK
HHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
IVTVALDIGERKKSEHEMRKAKEAAETALRNLRETQASLIEAEKLAALGRMVAGVAHEVN
HEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NPVGISLTVASALERKTERFSEAVTRGELRKSSLNEFIETSRNAAAQLVANLNRAAELIQ
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFKQVAADRNYSDQRSFDLADLTEQVVMSLRPGVRRQNLTVNVDCQPNLLMNSYPGPYGQ
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHCCCCCCCHHH
VLTNLFLNAVAHAFPDGRGGTIEIKARESGRDNVEIIFSDNGCGMSLDVRRRAFDPFFTT
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHC
RRDQGGTGLGLHIVYNIVTNRLGGRLDLESEPGAGTRVQIILPRTAPLEQAAE
CCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEEECCCCCHHHCCC
>Mature Secondary Structure 
SKNVDFGLACDRLRSLTIGRMIFGSFLLLLAVITATSMASVIAIRHIDSTFAELQRLQG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VGDLAEEIDQRMNELRLAARDFVTDPASRSDRVMEAATELSALLKKTRLQLAPEQQATID
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GVSQRLTNYREGIGRISALIALRAELLSVLPAAREGFEAAIAGVTDRGTARALFQVQNQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHH
GAALLARDPAGAEQAARSMRALPIEDATLRKAVDRYAEAIIEISGTEDEIGRLDKEVLGI
HHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
EGRLIGRVTELLRALSASQGKVLSRDFARTLAETKWQSILFGTSGVLIGIFAAWFVVRRT
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VKPLASIARSIRALAAGEKAASIPQTDVQNEIGDIARAAEVFRQTLQDADAAREAAVRAL
HHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEQRLAEESYRKLFEASIDGIYVTTPSGLVLNANPALARIMGYESPSELIQSVNDIADTI
HHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHH
YVHPLARERYQRLMRRDGMVREFEYQVRRRNGEIRWLSDSATVVRDESGEVVRYEGVVRD
HHCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCEEEECCCCCEEEECCHHHH
ITDQKRAEDAIAEGRRLLQQVIDTVPAVINVKDRELRYVLMNRYMAGIFNVEPEDALGRT
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHCCCCCHHHHCCC
TGELMSRYGASKTDGNDKRVLATKAGLGFYEEEYLDSCNVMRQWLVNKLPLLDADGEVDK
HHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
IVTVALDIGERKKSEHEMRKAKEAAETALRNLRETQASLIEAEKLAALGRMVAGVAHEVN
HEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NPVGISLTVASALERKTERFSEAVTRGELRKSSLNEFIETSRNAAAQLVANLNRAAELIQ
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFKQVAADRNYSDQRSFDLADLTEQVVMSLRPGVRRQNLTVNVDCQPNLLMNSYPGPYGQ
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHCCCCCCCHHH
VLTNLFLNAVAHAFPDGRGGTIEIKARESGRDNVEIIFSDNGCGMSLDVRRRAFDPFFTT
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHC
RRDQGGTGLGLHIVYNIVTNRLGGRLDLESEPGAGTRVQIILPRTAPLEQAAE
CCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEEECCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]