Click here to switch to the map view.

The map label for this gene is lvr [H]

Identifier: 146341169

GI number: 146341169

Start: 4444604

End: 4445521

Strand: Reverse

Name: lvr [H]

Synonym: BRADO4242

Alternate gene names: 146341169

Gene position: 4445521-4444604 (Counterclockwise)

Preceding gene: 146341178

Following gene: 146341164

Centisome position: 59.62

GC content: 66.12

Gene sequence:

>918_bases
ATGGGCCGCGAGCTCGCGCGCCAGCTCGTCGCCGAGGGCTGCAACGTCGCGATGTGCGACGTCTCGACCGAGGCGATGGC
CGAGACCAAGCGGCTGTGCGAGGCGGAAGGACTGCCGCAGGGCCTGCGCGTCACCACCCATGTCGCCGACGTCTCGATCG
AGGCGCAGCTGCAGCGTTTCCGCGATGAGCTTGCCGAGCAGCAGGCCACCGACAGGATTCATCTCCTGTTCAACAATGCC
GGTATCGGCGGCGGCGGAAGCCTGTTCACCAACTCCAGGGAGCAATGGGAGCGCACCTTCAACATCTGCTGGGGCGGCGT
CTATCTCGGCGTCCGCACCTTCCTGCCGATGCTGCTGAAGGCCGACGAGGCGCACATCGTCAATACGTCGAGCGTCAACG
GCTTCTGGGCCTCGGTCGGCATGGGCGTCTCGCACACCGCCTATAGCGCGGCGAAATTCGCGGTGAAGGGTTTCACCGAG
GCACTGATCAACGACCTCCGCCTCAACGCCCCGCACATCAAATGCTCGGTGGTGATGCCCGGTCATATCGGCACCTCGAT
CGTATCGAACTCGCGGAAAGTGCAAAGCGGCGGCGGATCCGATGAGCTCAGCGAGACCGAGATCGCGTTAGCCCGCCAGC
GCATGAAGGGCATGGGCATCGACGTCTCAGCGATGAGCGACCAGGACATCCAGAACGCCGCCCGCGAGCGCGCCCGCAGC
TTCCTCGAGGACGCGCCGACGACGGCGGCGCAGGCGGCGAAGATCATCCTCGACGGCGTCAAGGCCGAGCAATGGCGCAT
CCTCGTCGGCGAAGACGCCAAGCTCCTGGACATGCGCGTGCGCCAGTCGCCGGAGCAGGCCTACGAGCCGGAGTTCTTCC
AGCGCTTCGCGCAGGAGGCGGGGTGGAAGCTGGGGTAG

Upstream 100 bases:

>100_bases
AAGTCGCCGGGGCGGCCTTGGCTGTTCCGCAGCAGGGAAGGATGACCCAATGAAGGATTTTGCCGGCAGGACCGCTGTGA
TCACCGGGGGCGGCACGGGC

Downstream 100 bases:

>100_bases
GGGATTGCTGTTAGTTGGAGCAATCCGCACGCTGCGCGGTGCCAGCGACTGTGCCCTCTCCCCTTGTGGGAGAGGGCTAC
ACCGACATCAGCGTCATACT

Product: putative short-chain dehydrogenase

Products: NA

Alternate protein names: (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MGRELARQLVAEGCNVAMCDVSTEAMAETKRLCEAEGLPQGLRVTTHVADVSIEAQLQRFRDELAEQQATDRIHLLFNNA
GIGGGGSLFTNSREQWERTFNICWGGVYLGVRTFLPMLLKADEAHIVNTSSVNGFWASVGMGVSHTAYSAAKFAVKGFTE
ALINDLRLNAPHIKCSVVMPGHIGTSIVSNSRKVQSGGGSDELSETEIALARQRMKGMGIDVSAMSDQDIQNAARERARS
FLEDAPTTAAQAAKIILDGVKAEQWRILVGEDAKLLDMRVRQSPEQAYEPEFFQRFAQEAGWKLG

Sequences:

>Translated_305_residues
MGRELARQLVAEGCNVAMCDVSTEAMAETKRLCEAEGLPQGLRVTTHVADVSIEAQLQRFRDELAEQQATDRIHLLFNNA
GIGGGGSLFTNSREQWERTFNICWGGVYLGVRTFLPMLLKADEAHIVNTSSVNGFWASVGMGVSHTAYSAAKFAVKGFTE
ALINDLRLNAPHIKCSVVMPGHIGTSIVSNSRKVQSGGGSDELSETEIALARQRMKGMGIDVSAMSDQDIQNAARERARS
FLEDAPTTAAQAAKIILDGVKAEQWRILVGEDAKLLDMRVRQSPEQAYEPEFFQRFAQEAGWKLG
>Mature_304_residues
GRELARQLVAEGCNVAMCDVSTEAMAETKRLCEAEGLPQGLRVTTHVADVSIEAQLQRFRDELAEQQATDRIHLLFNNAG
IGGGGSLFTNSREQWERTFNICWGGVYLGVRTFLPMLLKADEAHIVNTSSVNGFWASVGMGVSHTAYSAAKFAVKGFTEA
LINDLRLNAPHIKCSVVMPGHIGTSIVSNSRKVQSGGGSDELSETEIALARQRMKGMGIDVSAMSDQDIQNAARERARSF
LEDAPTTAAQAAKIILDGVKAEQWRILVGEDAKLLDMRVRQSPEQAYEPEFFQRFAQEAGWKLG

Specific function: Catalyzes the regio- and stereoselective reversible NAD- dependent reduction of (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI66933014, Length=191, Percent_Identity=29.3193717277487, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI310128830, Length=191, Percent_Identity=27.7486910994764, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI310115468, Length=191, Percent_Identity=27.7486910994764, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI109715829, Length=187, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786701, Length=124, Percent_Identity=37.9032258064516, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082100, Length=221, Percent_Identity=27.6018099547511, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=187, Percent_Identity=25.1336898395722, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=187, Percent_Identity=25.1336898395722, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=188, Percent_Identity=26.063829787234, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24581726, Length=178, Percent_Identity=27.5280898876405, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221510726, Length=221, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 33334; Mature: 33203

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRELARQLVAEGCNVAMCDVSTEAMAETKRLCEAEGLPQGLRVTTHVADVSIEAQLQRF
CCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHH
RDELAEQQATDRIHLLFNNAGIGGGGSLFTNSREQWERTFNICWGGVYLGVRTFLPMLLK
HHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADEAHIVNTSSVNGFWASVGMGVSHTAYSAAKFAVKGFTEALINDLRLNAPHIKCSVVMP
CCCCEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
GHIGTSIVSNSRKVQSGGGSDELSETEIALARQRMKGMGIDVSAMSDQDIQNAARERARS
CCCCHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHH
FLEDAPTTAAQAAKIILDGVKAEQWRILVGEDAKLLDMRVRQSPEQAYEPEFFQRFAQEA
HHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHC
GWKLG
CCCCC
>Mature Secondary Structure 
GRELARQLVAEGCNVAMCDVSTEAMAETKRLCEAEGLPQGLRVTTHVADVSIEAQLQRF
CHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHH
RDELAEQQATDRIHLLFNNAGIGGGGSLFTNSREQWERTFNICWGGVYLGVRTFLPMLLK
HHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADEAHIVNTSSVNGFWASVGMGVSHTAYSAAKFAVKGFTEALINDLRLNAPHIKCSVVMP
CCCCEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
GHIGTSIVSNSRKVQSGGGSDELSETEIALARQRMKGMGIDVSAMSDQDIQNAARERARS
CCCCHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHH
FLEDAPTTAAQAAKIILDGVKAEQWRILVGEDAKLLDMRVRQSPEQAYEPEFFQRFAQEA
HHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHC
GWKLG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11388460; 10508066 [H]