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The map label for this gene is metC [H]

Identifier: 146341150

GI number: 146341150

Start: 4421330

End: 4422613

Strand: Direct

Name: metC [H]

Synonym: BRADO4221

Alternate gene names: 146341150

Gene position: 4421330-4422613 (Clockwise)

Preceding gene: 146341149

Following gene: 146341151

Centisome position: 59.29

GC content: 66.67

Gene sequence:

>1284_bases
ATGACCGAACGTGCCCCCGGATTTTCCACCCTCGCCATTCACGCCGGCGCCCAGCCCGACCCGACCACCGGCGCGCGGGC
GACACCGATCTACCAGACCACGTCTTTCGTCTTCAACGACGCCGACCACGCCGCCTCGCTGTTCGGGCTGCAGGCGTTCG
GCAACATCTACACCCGCATCGGCAACCCGACCAACGCCGTGCTCGAGGAGCGCGTCGCAGCCCTCGAGGGCGGCACCGCC
GCGCTCGCGGTCGCCTCGGGCCATGCCGCGCAGGTCGTGGCGCTGCAGCAGCTGCTGTCCCCCGGCGACGAATTCATCGC
CGCGCGAAAACTCTATGGCGGTTCGATCAACCAGTTCACGCATTCGTTCAAGAGCTTCGGCTGGAACGTGGTGTGGGCCG
ACACCGATGACGTCGCGAGCTTCGAGGCCGCGGTGAGCCCGCGCACCAAGGCGATCTTCATCGAGTCCATCGCCAATCCC
GGCGGCACCATCACCGACATCGAGGCGATCGCGCAGGTCGCGCGGAAAGCGGGCGTGCCGCTGATCGTCGACAACACCCT
GGCCTCGCCCTATCTGATCCGCCCGATCGATCACGGCGCCGACATCGTGCTGCACTCGCTGACCAAGTTCCTCGGCGGCC
ACGGCAACTCGATCGGCGGCATCATCGTCGACGCCGGCACGTTCGACTGGGCCGGCAGCGGCGACAAATATCCGATGCTG
ACGCAGCCGCGTCCCGAATATCATGGCATTCGCATCCACGAGACCTTCGGCAATTTCGCCTTCGCGATCGCCTGCCGCGT
GCTCGGCCTGCGCGATCTCGGCCCCGCGCTGTCGCCGTTCAACGCGTTCCTGATCCTCACCGGCATCGAGACCCTGCCGC
TGCGCGTGCAGAAGCACAGCGACAACGCCAAGGCCGTCGCCGAATATCTCAGCAAGCACCCGGCGGTCGCCTCGGTCAGC
TATGCCGGCCTGCCCGAGGACAAGTACCACGCGCTCGCCCGCAAATATTCGCCGAAGGGCGCCGGCGCGGTGTTCACCTT
CTCGCTGAAGGGCGGCTACGACGCCGGCGTCAAGCTGGTGTCCAATTTGAAGCTGTTCTCGCATCTCGCCAATGTCGGCG
ACACCCGCTCGCTGGTGATCCACCCGGCCTCGACCACGCACAGCCAGCTCGACGACGCCTCGAAGATCAAGGCGGGCGCC
GGCCCCGACATCGTCCGCATCTCCGTCGGCATCGAGGACAAGGAAGACCTGATCGCCGATCTCGAGCAGGCGCTGAGCGC
GTAA

Upstream 100 bases:

>100_bases
GAGGGAGCCGCGACGAGCGCGCGATCGACACCGTCTTCCCTCATCGATCCCCGTGCCGGCCGGCGCCGCCGCGCGAGGAA
ACAAGCCCACGAGGAAACAC

Downstream 100 bases:

>100_bases
GGCTCGCGCACGAACGCGGTCGATAGCCGCCGCAAGCATCTCTCGCAGTCGCTTGCGGCGTCCTTCGAGACCGCCTTCAG
CGGGCTCCTCAGGACGAGGT

Product: O-acetylhomoserine aminocarboxypropyltransferase

Products: NA

Alternate protein names: L-methioninase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTERAPGFSTLAIHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRIGNPTNAVLEERVAALEGGTA
ALAVASGHAAQVVALQQLLSPGDEFIAARKLYGGSINQFTHSFKSFGWNVVWADTDDVASFEAAVSPRTKAIFIESIANP
GGTITDIEAIAQVARKAGVPLIVDNTLASPYLIRPIDHGADIVLHSLTKFLGGHGNSIGGIIVDAGTFDWAGSGDKYPML
TQPRPEYHGIRIHETFGNFAFAIACRVLGLRDLGPALSPFNAFLILTGIETLPLRVQKHSDNAKAVAEYLSKHPAVASVS
YAGLPEDKYHALARKYSPKGAGAVFTFSLKGGYDAGVKLVSNLKLFSHLANVGDTRSLVIHPASTTHSQLDDASKIKAGA
GPDIVRISVGIEDKEDLIADLEQALSA

Sequences:

>Translated_427_residues
MTERAPGFSTLAIHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRIGNPTNAVLEERVAALEGGTA
ALAVASGHAAQVVALQQLLSPGDEFIAARKLYGGSINQFTHSFKSFGWNVVWADTDDVASFEAAVSPRTKAIFIESIANP
GGTITDIEAIAQVARKAGVPLIVDNTLASPYLIRPIDHGADIVLHSLTKFLGGHGNSIGGIIVDAGTFDWAGSGDKYPML
TQPRPEYHGIRIHETFGNFAFAIACRVLGLRDLGPALSPFNAFLILTGIETLPLRVQKHSDNAKAVAEYLSKHPAVASVS
YAGLPEDKYHALARKYSPKGAGAVFTFSLKGGYDAGVKLVSNLKLFSHLANVGDTRSLVIHPASTTHSQLDDASKIKAGA
GPDIVRISVGIEDKEDLIADLEQALSA
>Mature_426_residues
TERAPGFSTLAIHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRIGNPTNAVLEERVAALEGGTAA
LAVASGHAAQVVALQQLLSPGDEFIAARKLYGGSINQFTHSFKSFGWNVVWADTDDVASFEAAVSPRTKAIFIESIANPG
GTITDIEAIAQVARKAGVPLIVDNTLASPYLIRPIDHGADIVLHSLTKFLGGHGNSIGGIIVDAGTFDWAGSGDKYPMLT
QPRPEYHGIRIHETFGNFAFAIACRVLGLRDLGPALSPFNAFLILTGIETLPLRVQKHSDNAKAVAEYLSKHPAVASVSY
AGLPEDKYHALARKYSPKGAGAVFTFSLKGGYDAGVKLVSNLKLFSHLANVGDTRSLVIHPASTTHSQLDDASKIKAGAG
PDIVRISVGIEDKEDLIADLEQALSA

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG2873

COG function: function code E; O-acetylhomoserine sulfhydrylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=428, Percent_Identity=34.1121495327103, Blast_Score=202, Evalue=7e-52,
Organism=Homo sapiens, GI299473759, Length=428, Percent_Identity=30.3738317757009, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI25453487, Length=427, Percent_Identity=29.9765807962529, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1790375, Length=419, Percent_Identity=30.7875894988067, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1789383, Length=426, Percent_Identity=25.3521126760563, Blast_Score=122, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71980708, Length=426, Percent_Identity=32.3943661971831, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17560056, Length=423, Percent_Identity=32.8605200945626, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17538055, Length=424, Percent_Identity=33.7264150943396, Blast_Score=197, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323333, Length=433, Percent_Identity=47.1131639722864, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6319307, Length=429, Percent_Identity=31.2354312354312, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321254, Length=443, Percent_Identity=26.86230248307, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6321904, Length=427, Percent_Identity=26.9320843091335, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321170, Length=365, Percent_Identity=26.3013698630137, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI19922554, Length=424, Percent_Identity=31.3679245283019, Blast_Score=192, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006237
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.11 [H]

Molecular weight: Translated: 45065; Mature: 44934

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERAPGFSTLAIHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRI
CCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEHHHEECCCHHHHHHHHHHHHHHHHHHC
GNPTNAVLEERVAALEGGTAALAVASGHAAQVVALQQLLSPGDEFIAARKLYGGSINQFT
CCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHH
HSFKSFGWNVVWADTDDVASFEAAVSPRTKAIFIESIANPGGTITDIEAIAQVARKAGVP
HHHHHCCCEEEEECCCCHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCC
LIVDNTLASPYLIRPIDHGADIVLHSLTKFLGGHGNSIGGIIVDAGTFDWAGSGDKYPML
EEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCC
TQPRPEYHGIRIHETFGNFAFAIACRVLGLRDLGPALSPFNAFLILTGIETLPLRVQKHS
CCCCCCCCCEEEEECHHHHHHHHHHHHHCHHHCCCCCCCCCEEEEEECCCCCEEEEEECC
DNAKAVAEYLSKHPAVASVSYAGLPEDKYHALARKYSPKGAGAVFTFSLKGGYDAGVKLV
CCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHH
SNLKLFSHLANVGDTRSLVIHPASTTHSQLDDASKIKAGAGPDIVRISVGIEDKEDLIAD
HHHHHHHHHHCCCCCCEEEEECCCCCHHHCCCHHHHCCCCCCCEEEEEECCCCHHHHHHH
LEQALSA
HHHHHCC
>Mature Secondary Structure 
TERAPGFSTLAIHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRI
CCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEHHHEECCCHHHHHHHHHHHHHHHHHHC
GNPTNAVLEERVAALEGGTAALAVASGHAAQVVALQQLLSPGDEFIAARKLYGGSINQFT
CCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHH
HSFKSFGWNVVWADTDDVASFEAAVSPRTKAIFIESIANPGGTITDIEAIAQVARKAGVP
HHHHHCCCEEEEECCCCHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCC
LIVDNTLASPYLIRPIDHGADIVLHSLTKFLGGHGNSIGGIIVDAGTFDWAGSGDKYPML
EEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCC
TQPRPEYHGIRIHETFGNFAFAIACRVLGLRDLGPALSPFNAFLILTGIETLPLRVQKHS
CCCCCCCCCEEEEECHHHHHHHHHHHHHCHHHCCCCCCCCCEEEEEECCCCCEEEEEECC
DNAKAVAEYLSKHPAVASVSYAGLPEDKYHALARKYSPKGAGAVFTFSLKGGYDAGVKLV
CCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHH
SNLKLFSHLANVGDTRSLVIHPASTTHSQLDDASKIKAGAGPDIVRISVGIEDKEDLIAD
HHHHHHHHHHCCCCCCEEEEECCCCCHHHCCCHHHHCCCCCCCEEEEEECCCCHHHHHHH
LEQALSA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8586629; 9190812; 3365412 [H]