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The map label for this gene is lolC [H]

Identifier: 146341082

GI number: 146341082

Start: 4352066

End: 4353346

Strand: Reverse

Name: lolC [H]

Synonym: BRADO4153

Alternate gene names: 146341082

Gene position: 4353346-4352066 (Counterclockwise)

Preceding gene: 146341083

Following gene: 146341081

Centisome position: 58.38

GC content: 63.86

Gene sequence:

>1281_bases
ATGGATGACGCCATGACCGAACCCGTGCAGACCGCGCCCTTCGCGCCCTTCGAGTGGATGCTGTCCGGGCGCTATCTGCG
TGCCCGGCGCCGCGAGGGTTTCATCTCCGTGATTGCGGGTTTCTCCTTCCTCGGCATCATGCTCGGCGTCGCGACGCTGA
TCATCGTGATGGCCGTCATGAACGGCTTCCGCAAGGAGCTGCTCGACAAGATCCTCGGCCTCAACGGCCACCTCCTGGTG
CAGCCGCTGGAATCGCCGCTGACCGATTGGAAGGATGTTTCCGAGCGGATCTCGCAGGTGCAGGGCATCCGGCTCGCGGC
GCCCGTGGTCGACGGCCAGGGCCTGGGCTCGTCGCCGTTCAACGCCTCGGGCGTCTTCATCCGCGGCATCCGCTCGCAGG
ATCTGACGAACCTGACGTCGATCGCCAAGAACATCAAGCAGGGCACCCTCGAAGGTTTCGACGAGGGCCAGGGCGTCGCC
ATCGGTCGACGTCTCGCGGATCTGCTCTCGCTGCATGCCGGCGACAGCATCACGCTGGTTGCGCCGAAGGGCGCGGTGAC
GCCGATGGGCACGACACCGCGCATCAAGCCCTACAAGGTGGCCGCGGTGTTCGAGATCGGCATGTCGGAATATGACTCCA
GCTTCGTGTTCATGCCGCTGGCGGAAGCCCAGGCCTATTTCAACCGTAACAACGACGTGACCGCGATCGAAATCTTCACC
AGCAATCCCGACAAGGTGGAGCAGTTTCGCAAGACGGTGACGGAGGCGGCCGGCCGGCCGGTGTTCCTGGTCGACTGGCG
CCAGCGCAACTCCACCTTCTTCAACGCGCTCCAGGTCGAGCGCAATGTGATGTTCCTGATCCTGACCCTGATCGTGCTGG
TGGCGGCGCTGAACATCGTTTCGGGACTGATCATGCTGGTCAAGGACAAGGGCCAGGACATCGCGGTGCTCCGGACGATG
GGTGCCTCGCAGGGGGCGATCATGCGAATCTTCCTGATCACCGGGGCCTCGATCGGCGTGGTGGGCACGCTCACCGGCTT
CTTCGTTGGCCTCCTGATCTGCCTGAACATCGAGACCATCCGGCTGTTCCTGTCGTGGCTGACCAACACCGACCTGTTCG
ATCCGACGCTGTACTTCCTGTCGAAGCTGCCGGCCGAGATCGATGCCGGCGAGACCAGCGCGGTCGTCATCATGGCCCTG
ACCCTGTCCTTTCTGGCCACGCTCTATCCCTCCTGGCGCGCGGCCCGATTAGACCCGGTCGAAGCGCTTCGCTACGAGTG
A

Upstream 100 bases:

>100_bases
GCTGAGCCGTTCGTTCGATCATCGTATTATCCACCGGGGCAGCCAGCCGGCCGACGGCCAATCCGGCCACAATCGGCCCG
AATCATGGGATGATCGCGCA

Downstream 100 bases:

>100_bases
GGCGCTGATGGAAGAGCAGGGGGCAGAAGACGTCCCGGTCGTTTATCTCCACGAGATCAAGCGCCGGTACATGCAGGGCG
AGAAGCAGCTGACCATCCTC

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MDDAMTEPVQTAPFAPFEWMLSGRYLRARRREGFISVIAGFSFLGIMLGVATLIIVMAVMNGFRKELLDKILGLNGHLLV
QPLESPLTDWKDVSERISQVQGIRLAAPVVDGQGLGSSPFNASGVFIRGIRSQDLTNLTSIAKNIKQGTLEGFDEGQGVA
IGRRLADLLSLHAGDSITLVAPKGAVTPMGTTPRIKPYKVAAVFEIGMSEYDSSFVFMPLAEAQAYFNRNNDVTAIEIFT
SNPDKVEQFRKTVTEAAGRPVFLVDWRQRNSTFFNALQVERNVMFLILTLIVLVAALNIVSGLIMLVKDKGQDIAVLRTM
GASQGAIMRIFLITGASIGVVGTLTGFFVGLLICLNIETIRLFLSWLTNTDLFDPTLYFLSKLPAEIDAGETSAVVIMAL
TLSFLATLYPSWRAARLDPVEALRYE

Sequences:

>Translated_426_residues
MDDAMTEPVQTAPFAPFEWMLSGRYLRARRREGFISVIAGFSFLGIMLGVATLIIVMAVMNGFRKELLDKILGLNGHLLV
QPLESPLTDWKDVSERISQVQGIRLAAPVVDGQGLGSSPFNASGVFIRGIRSQDLTNLTSIAKNIKQGTLEGFDEGQGVA
IGRRLADLLSLHAGDSITLVAPKGAVTPMGTTPRIKPYKVAAVFEIGMSEYDSSFVFMPLAEAQAYFNRNNDVTAIEIFT
SNPDKVEQFRKTVTEAAGRPVFLVDWRQRNSTFFNALQVERNVMFLILTLIVLVAALNIVSGLIMLVKDKGQDIAVLRTM
GASQGAIMRIFLITGASIGVVGTLTGFFVGLLICLNIETIRLFLSWLTNTDLFDPTLYFLSKLPAEIDAGETSAVVIMAL
TLSFLATLYPSWRAARLDPVEALRYE
>Mature_426_residues
MDDAMTEPVQTAPFAPFEWMLSGRYLRARRREGFISVIAGFSFLGIMLGVATLIIVMAVMNGFRKELLDKILGLNGHLLV
QPLESPLTDWKDVSERISQVQGIRLAAPVVDGQGLGSSPFNASGVFIRGIRSQDLTNLTSIAKNIKQGTLEGFDEGQGVA
IGRRLADLLSLHAGDSITLVAPKGAVTPMGTTPRIKPYKVAAVFEIGMSEYDSSFVFMPLAEAQAYFNRNNDVTAIEIFT
SNPDKVEQFRKTVTEAAGRPVFLVDWRQRNSTFFNALQVERNVMFLILTLIVLVAALNIVSGLIMLVKDKGQDIAVLRTM
GASQGAIMRIFLITGASIGVVGTLTGFFVGLLICLNIETIRLFLSWLTNTDLFDPTLYFLSKLPAEIDAGETSAVVIMAL
TLSFLATLYPSWRAARLDPVEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=409, Percent_Identity=31.5403422982885, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1787360, Length=416, Percent_Identity=30.7692307692308, Blast_Score=166, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 46623; Mature: 46623

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDAMTEPVQTAPFAPFEWMLSGRYLRARRREGFISVIAGFSFLGIMLGVATLIIVMAVM
CCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGFRKELLDKILGLNGHLLVQPLESPLTDWKDVSERISQVQGIRLAAPVVDGQGLGSSPF
HHHHHHHHHHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHHCCCEEEECEECCCCCCCCCC
NASGVFIRGIRSQDLTNLTSIAKNIKQGTLEGFDEGQGVAIGRRLADLLSLHAGDSITLV
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
APKGAVTPMGTTPRIKPYKVAAVFEIGMSEYDSSFVFMPLAEAQAYFNRNNDVTAIEIFT
ECCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCEEEEEEEE
SNPDKVEQFRKTVTEAAGRPVFLVDWRQRNSTFFNALQVERNVMFLILTLIVLVAALNIV
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLIMLVKDKGQDIAVLRTMGASQGAIMRIFLITGASIGVVGTLTGFFVGLLICLNIETI
HHHHHEEECCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
RLFLSWLTNTDLFDPTLYFLSKLPAEIDAGETSAVVIMALTLSFLATLYPSWRAARLDPV
HHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
EALRYE
HHHCCC
>Mature Secondary Structure
MDDAMTEPVQTAPFAPFEWMLSGRYLRARRREGFISVIAGFSFLGIMLGVATLIIVMAVM
CCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGFRKELLDKILGLNGHLLVQPLESPLTDWKDVSERISQVQGIRLAAPVVDGQGLGSSPF
HHHHHHHHHHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHHCCCEEEECEECCCCCCCCCC
NASGVFIRGIRSQDLTNLTSIAKNIKQGTLEGFDEGQGVAIGRRLADLLSLHAGDSITLV
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
APKGAVTPMGTTPRIKPYKVAAVFEIGMSEYDSSFVFMPLAEAQAYFNRNNDVTAIEIFT
ECCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCEEEEEEEE
SNPDKVEQFRKTVTEAAGRPVFLVDWRQRNSTFFNALQVERNVMFLILTLIVLVAALNIV
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLIMLVKDKGQDIAVLRTMGASQGAIMRIFLITGASIGVVGTLTGFFVGLLICLNIETI
HHHHHEEECCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
RLFLSWLTNTDLFDPTLYFLSKLPAEIDAGETSAVVIMALTLSFLATLYPSWRAARLDPV
HHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
EALRYE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]