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The map label for this gene is dxr [H]

Identifier: 146341063

GI number: 146341063

Start: 4330581

End: 4331804

Strand: Reverse

Name: dxr [H]

Synonym: BRADO4134

Alternate gene names: 146341063

Gene position: 4331804-4330581 (Counterclockwise)

Preceding gene: 146341064

Following gene: 146341062

Centisome position: 58.09

GC content: 67.97

Gene sequence:

>1224_bases
ATGAGCGCAGTGCCATTGCGAAACAACAAGGCGATCGCGGCTGATGTGCGCAGCATCACCGTGCTCGGCGCCACCGGCTC
GATCGGCGATTCGACCATGGACCTCCTGCGCGGCGCGCCCGAGCGCTACCGGGTCGAGGCGCTGACCGGCAACAGCAACA
TCGAGGGCCTCGCCAAGCTCGCCCGCGAGTTCAATTCCCGCTTCGTGGCGGTCGCAGATCCGGCCCGGCTCGGCGAGTTG
CGCGAGGCACTCGCCGGCACCGGGATCGCCTGCGGGGCCGGGGAGAGCGCGATCATCGAGGCCGCTGCGCGGCCGGCCGA
CTGGGTCATGGCCGCCGTGTCCGGCGCCGCCGGCCTGAAGCCGGCGCTTGCCGCCGTCGACCGCGGGGCCACCGTCGCCC
TCGCCAACAAGGAATGCCTGGTCTGTGCCGGCGATTTCTTCATGCAGCGCGCGGCACAGGCCGGCGCCTGCATCCTGCCG
GCCGATTCGGAGCACAACGCACTGTTCCAGGCGCTGTCCTCGGGCAACCGCGAGGAGCTGGTCCGGGTCATCATCACCGC
GTCAGGCGGTCCGTTCCGGACCTGGGCACCCCAGGACATCGAGCAGGCGACGCTCGAGCAGGCGCTCAAGCATCCGAACT
GGAGCATGGGCCAGAAGATCACGATCGATTCGGCTTCGATGATGAACAAGGGTCTCGAGGTGATCGAGGCGTCGTACCTG
TTCGCGCTGTCGCCGGACGAGATCGACGTGCTGGTGCATCCGCAGTCGATCGTCCACGGCATGGTCGAGTTCTCCGACCG
TTCGGTGGTCGCCCAGCTCGGCGCGCCCGACATGCGGATCCCAATCGCGCACTGCCTGGGCTGGCCGGAGCGCATCAAGG
GACCGTCGGCGCGGCTCGACCTGGCCAAAATCGGCACGCTGACCTTTGAGGCGCCGGACTTCGAGCGGTTCCCCGGCCTG
CGGCTGGCCTACGATTCGCTGCGCGCGGGGCGCGGCGCCACGACCGTCTTCAATGCGGCCAACGAAGTTGCGGTGGCGGC
GTTCATCGGTGGCCATATCCGCTTCGGCGCGATTGCCCGGCTGGTCGAGGCGACGCTCAACGACTGGACGCGATCCGGTA
ATCAGGCACCTCTGTCATCGGCGGACGACGCGATCGCCATTGACCATGATGCCCGAAAAAGGGCCGCGGGGCTCTTGCCT
CAAATCGCCGCAAAAGCATCTTAA

Upstream 100 bases:

>100_bases
GTGGTGGGTTTGCTCCGCGGCGGCCTCGACGGCGTCGGCCGCGGTCTTCTGGTTTGGTGACCGGTGCCTTGGCGACCGGT
CGAGATTGTTTGGTGAGAAC

Downstream 100 bases:

>100_bases
AGGGTTGGACGGGCCGCCGGCCCATCGGGAAGGTTATCGATGTCCGAAATTTTCCACCATATTTTCAATACGTTGAGCCA
CGGCCTGCTCGGCACCATCA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MSAVPLRNNKAIAADVRSITVLGATGSIGDSTMDLLRGAPERYRVEALTGNSNIEGLAKLAREFNSRFVAVADPARLGEL
REALAGTGIACGAGESAIIEAAARPADWVMAAVSGAAGLKPALAAVDRGATVALANKECLVCAGDFFMQRAAQAGACILP
ADSEHNALFQALSSGNREELVRVIITASGGPFRTWAPQDIEQATLEQALKHPNWSMGQKITIDSASMMNKGLEVIEASYL
FALSPDEIDVLVHPQSIVHGMVEFSDRSVVAQLGAPDMRIPIAHCLGWPERIKGPSARLDLAKIGTLTFEAPDFERFPGL
RLAYDSLRAGRGATTVFNAANEVAVAAFIGGHIRFGAIARLVEATLNDWTRSGNQAPLSSADDAIAIDHDARKRAAGLLP
QIAAKAS

Sequences:

>Translated_407_residues
MSAVPLRNNKAIAADVRSITVLGATGSIGDSTMDLLRGAPERYRVEALTGNSNIEGLAKLAREFNSRFVAVADPARLGEL
REALAGTGIACGAGESAIIEAAARPADWVMAAVSGAAGLKPALAAVDRGATVALANKECLVCAGDFFMQRAAQAGACILP
ADSEHNALFQALSSGNREELVRVIITASGGPFRTWAPQDIEQATLEQALKHPNWSMGQKITIDSASMMNKGLEVIEASYL
FALSPDEIDVLVHPQSIVHGMVEFSDRSVVAQLGAPDMRIPIAHCLGWPERIKGPSARLDLAKIGTLTFEAPDFERFPGL
RLAYDSLRAGRGATTVFNAANEVAVAAFIGGHIRFGAIARLVEATLNDWTRSGNQAPLSSADDAIAIDHDARKRAAGLLP
QIAAKAS
>Mature_406_residues
SAVPLRNNKAIAADVRSITVLGATGSIGDSTMDLLRGAPERYRVEALTGNSNIEGLAKLAREFNSRFVAVADPARLGELR
EALAGTGIACGAGESAIIEAAARPADWVMAAVSGAAGLKPALAAVDRGATVALANKECLVCAGDFFMQRAAQAGACILPA
DSEHNALFQALSSGNREELVRVIITASGGPFRTWAPQDIEQATLEQALKHPNWSMGQKITIDSASMMNKGLEVIEASYLF
ALSPDEIDVLVHPQSIVHGMVEFSDRSVVAQLGAPDMRIPIAHCLGWPERIKGPSARLDLAKIGTLTFEAPDFERFPGLR
LAYDSLRAGRGATTVFNAANEVAVAAFIGGHIRFGAIARLVEATLNDWTRSGNQAPLSSADDAIAIDHDARKRAAGLLPQ
IAAKAS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=393, Percent_Identity=44.7837150127226, Blast_Score=321, Evalue=5e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42811; Mature: 42680

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVPLRNNKAIAADVRSITVLGATGSIGDSTMDLLRGAPERYRVEALTGNSNIEGLAKL
CCCCCCCCCCEEEEECEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHH
AREFNSRFVAVADPARLGELREALAGTGIACGAGESAIIEAAARPADWVMAAVSGAAGLK
HHHHCCCEEEEECCHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCHHHHHHHHHCCCCCC
PALAAVDRGATVALANKECLVCAGDFFMQRAAQAGACILPADSEHNALFQALSSGNREEL
HHHHHHCCCCEEEEECCCEEEECHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCHHHE
VRVIITASGGPFRTWAPQDIEQATLEQALKHPNWSMGQKITIDSASMMNKGLEVIEASYL
EEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHCHHHHHHEEE
FALSPDEIDVLVHPQSIVHGMVEFSDRSVVAQLGAPDMRIPIAHCLGWPERIKGPSARLD
EEECCCCEEEEECCHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHCCCHHHHCCCCCCEE
LAKIGTLTFEAPDFERFPGLRLAYDSLRAGRGATTVFNAANEVAVAAFIGGHIRFGAIAR
HHHHCEEEECCCCHHHCCCCEEEHHHHHCCCCCHHHHHCCCCEEEEEHHCCCHHHHHHHH
LVEATLNDWTRSGNQAPLSSADDAIAIDHDARKRAAGLLPQIAAKAS
HHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure 
SAVPLRNNKAIAADVRSITVLGATGSIGDSTMDLLRGAPERYRVEALTGNSNIEGLAKL
CCCCCCCCCEEEEECEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHH
AREFNSRFVAVADPARLGELREALAGTGIACGAGESAIIEAAARPADWVMAAVSGAAGLK
HHHHCCCEEEEECCHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCHHHHHHHHHCCCCCC
PALAAVDRGATVALANKECLVCAGDFFMQRAAQAGACILPADSEHNALFQALSSGNREEL
HHHHHHCCCCEEEEECCCEEEECHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCHHHE
VRVIITASGGPFRTWAPQDIEQATLEQALKHPNWSMGQKITIDSASMMNKGLEVIEASYL
EEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHCHHHHHHEEE
FALSPDEIDVLVHPQSIVHGMVEFSDRSVVAQLGAPDMRIPIAHCLGWPERIKGPSARLD
EEECCCCEEEEECCHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHCCCHHHHCCCCCCEE
LAKIGTLTFEAPDFERFPGLRLAYDSLRAGRGATTVFNAANEVAVAAFIGGHIRFGAIAR
HHHHCEEEECCCCHHHCCCCEEEHHHHHCCCCCHHHHHCCCCEEEEEHHCCCHHHHHHHH
LVEATLNDWTRSGNQAPLSSADDAIAIDHDARKRAAGLLPQIAAKAS
HHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA