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The map label for this gene is trpC [H]

Identifier: 146341039

GI number: 146341039

Start: 4300155

End: 4300973

Strand: Direct

Name: trpC [H]

Synonym: BRADO4110

Alternate gene names: 146341039

Gene position: 4300155-4300973 (Clockwise)

Preceding gene: 146341038

Following gene: 146341040

Centisome position: 57.67

GC content: 67.03

Gene sequence:

>819_bases
ATGTCGGACATCCTGGCCAAGATCGAAGCCTATAAGCGCGAGGAGATCGCGGCTGCCAAGCAGGCTTGTCCGCTGTCGGA
ACTCGAGGCACGCGCACGCGAGGCGTCGGCGCCGCGCGGCTTCGTCAAGGCCCTCCGCAGCAAGCATGCCAGCGGCGACT
ATGCTTTGATCGCCGAGGTGAAGAAGGCGTCGCCGTCGAAGGGCCTGATCCGCGCCGATTTCGATCCGCCCGTTCTTGCC
AGGGCTTATGAGGCCGGCGGCGCCGCCTGTCTGTCGGTGCTGACCGATACGCCCTCGTTCCAGGGCCATCTCGACTTCAT
GGTCGCCGCGCGCGCCGCGACCGCCCTGCCCGTGCTGCGCAAGGACTTCATGTTCGACACCTACCAGGTCATCGAGGCGC
GGGCGCATGGCGCCGATTGCATTCTCATCATCATGGCGGCGCTCGACGACGCGGCTGCTGCTGACATCGAGATGGCGGCG
CTCGATAGCGGGATGGACGTGCTGATCGAGATTCACGACCGCGCCGAACTCGACCGCGCGCTGAAGCTGCGCTCGCCGAT
GATCGGCATCAACAACCGCAACCTGCGCACGTTCGAGACCACCCTCGCCACGTCCGAGTCTTTGGCGCCGTTGGTGCCGA
AGGAGCGTCTGCTGGTCGGCGAGAGCGGCATCTTCACCCCGGCGGATCTGTCGCGCCTGGCGCAAGTCGACATCCAGACC
TTCCTGGTCGGCGAGAGCCTGATGCGCCAAGCCGACGTCACCGCGGCGACGCGCGCCCTGCTCGCGCGCAACGCCGCCTC
GGCAAGCGCGGCTGAGTGA

Upstream 100 bases:

>100_bases
AGGCGTCGCAATCGGCAAGGACTCGCTCGACAGCGGTGCCGCTGCCGGGCGTCTGAAGCAGCTGATCGCCGTCTCCAACA
GCTGACATCAGGAGCGCGCC

Downstream 100 bases:

>100_bases
CCATGGCCGACACCTCCGACACATCGTCTCTTACTCATATCGACGCGCGCGGCGAGGCGCGCATGGTCGACGTGTCCGAC
AAGGCCGCCACCGAGCGCAC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSDILAKIEAYKREEIAAAKQACPLSELEARAREASAPRGFVKALRSKHASGDYALIAEVKKASPSKGLIRADFDPPVLA
RAYEAGGAACLSVLTDTPSFQGHLDFMVAARAATALPVLRKDFMFDTYQVIEARAHGADCILIIMAALDDAAAADIEMAA
LDSGMDVLIEIHDRAELDRALKLRSPMIGINNRNLRTFETTLATSESLAPLVPKERLLVGESGIFTPADLSRLAQVDIQT
FLVGESLMRQADVTAATRALLARNAASASAAE

Sequences:

>Translated_272_residues
MSDILAKIEAYKREEIAAAKQACPLSELEARAREASAPRGFVKALRSKHASGDYALIAEVKKASPSKGLIRADFDPPVLA
RAYEAGGAACLSVLTDTPSFQGHLDFMVAARAATALPVLRKDFMFDTYQVIEARAHGADCILIIMAALDDAAAADIEMAA
LDSGMDVLIEIHDRAELDRALKLRSPMIGINNRNLRTFETTLATSESLAPLVPKERLLVGESGIFTPADLSRLAQVDIQT
FLVGESLMRQADVTAATRALLARNAASASAAE
>Mature_271_residues
SDILAKIEAYKREEIAAAKQACPLSELEARAREASAPRGFVKALRSKHASGDYALIAEVKKASPSKGLIRADFDPPVLAR
AYEAGGAACLSVLTDTPSFQGHLDFMVAARAATALPVLRKDFMFDTYQVIEARAHGADCILIIMAALDDAAAADIEMAAL
DSGMDVLIEIHDRAELDRALKLRSPMIGINNRNLRTFETTLATSESLAPLVPKERLLVGESGIFTPADLSRLAQVDIQTF
LVGESLMRQADVTAATRALLARNAASASAAE

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=265, Percent_Identity=37.7358490566038, Blast_Score=152, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322638, Length=273, Percent_Identity=34.0659340659341, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29081; Mature: 28949

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILAKIEAYKREEIAAAKQACPLSELEARAREASAPRGFVKALRSKHASGDYALIAEV
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEH
KKASPSKGLIRADFDPPVLARAYEAGGAACLSVLTDTPSFQGHLDFMVAARAATALPVLR
HHCCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
KDFMFDTYQVIEARAHGADCILIIMAALDDAAAADIEMAALDSGMDVLIEIHDRAELDRA
HHHHHHHHHHHHHHCCCCCEEHHHHHHHCCHHHHCCHHHHHCCCCEEEEEEHHHHHHHHH
LKLRSPMIGINNRNLRTFETTLATSESLAPLVPKERLLVGESGIFTPADLSRLAQVDIQT
HHHCCCEECCCCCCCEEHHHHHHCCCCCCCCCCCHHEEECCCCCCCHHHHHHHHHHHHHH
FLVGESLMRQADVTAATRALLARNAASASAAE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SDILAKIEAYKREEIAAAKQACPLSELEARAREASAPRGFVKALRSKHASGDYALIAEV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEH
KKASPSKGLIRADFDPPVLARAYEAGGAACLSVLTDTPSFQGHLDFMVAARAATALPVLR
HHCCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
KDFMFDTYQVIEARAHGADCILIIMAALDDAAAADIEMAALDSGMDVLIEIHDRAELDRA
HHHHHHHHHHHHHHCCCCCEEHHHHHHHCCHHHHCCHHHHHCCCCEEEEEEHHHHHHHHH
LKLRSPMIGINNRNLRTFETTLATSESLAPLVPKERLLVGESGIFTPADLSRLAQVDIQT
HHHCCCEECCCCCCCEEHHHHHHCCCCCCCCCCCHHEEECCCCCCCHHHHHHHHHHHHHH
FLVGESLMRQADVTAATRALLARNAASASAAE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA