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The map label for this gene is ilvD [H]

Identifier: 146341009

GI number: 146341009

Start: 4268147

End: 4269871

Strand: Reverse

Name: ilvD [H]

Synonym: BRADO4080

Alternate gene names: 146341009

Gene position: 4269871-4268147 (Counterclockwise)

Preceding gene: 146341010

Following gene: 146341008

Centisome position: 57.26

GC content: 63.94

Gene sequence:

>1725_bases
ATGGACGCGAAGACCGACATCAAGCGCAGGCTGCCCAGCCGTCATGTGACGGAAGGGCCGGAGCGTGCGCCTCATCGGTC
GTATCTCTACGCGATGGGCCTGACCACGGCCCAAATCCATCAGCCCTTCGTCGGCGTCGCCTCGTGCTGGAACGAGGCCG
CGCCCTGCAACATCGCGCTGATGCGGCAGGCGCAAGCCGTGAAGAAGGGCGTGGCCCACGCCGGCGGCACGCCGCGCGAA
TTCTGCACCATCACCGTGACCGACGGCATCGCCATGGGCCATGACGGCATGCGCTCGTCGCTGCCGTCGCGCGAGGCGAT
TGCCGATTCGGTCGAGCTGACGATTCGCGGTCATGCCTACGACGCGCTGGTTGGCCTCGCCGGCTGCGATAAATCGCTGC
CGGGCATGATGATGGCGATGGTCCGGCTCAACGTGCCGTCGATCTTCATTTATGGAGGCTCGATCCTGCCCGGCAATTTC
CGCGGCCAGCAGGTCACCGTGCAGGACATGTTCGAGGCGGTCGGCAAGCATTCGGTCGGCGCGATGTCGGATGAGGATCT
CGACGAGCTCGAGCGCGTCGCCTGTCCGTCGGCCGGTGCGTGCGGTGCTCAGTTCACGGCCAACACGATGGCGACCGTCT
CCGAGGCGATCGGCCTGGCGCTGCCGTACTCGGCTGGCGCGCCCGCACCTTACGAGATCCGCGATTCCTTCTGCATGACC
GCCGGCGAGAAGGTCATGGAGCTGATATCAGCCAACATCCGGCCGCGCGACATCGTGACGCGAGCAGCACTCGAGAATGC
CGCTGCGGTTGTGGCGGCCTCCGGCGGCTCGACCAACGCGGCCCTGCATCTACCAGCGATTGCACACGAGGCCGGCATCA
AGTTCGACTTATTCGATGTCGCCGAAATCTTCAAAAAGACACCTTATATCGCGGATTTGAAGCCGGGTGGCCGCTATGTC
GCCAAAGACATGTTCGAGGCTGGTGGCATTCCGCTCTTGATGAAGACGTTGCTCGACCATGGCTATTTGAACGGCGACTG
CCTCACAGTCACCGGCCGGACGATCGCCGAAAACCTCAAAGGCGTGAAGTGGAATCCGCACCAGGACGTGGTGAGGCCGG
CCGACCAGCCGATCACTGCAACCGGAGGTGTCGTTGGTTTGAAAGGCAATCTCGCGCCAGAGGGTGCGATCGTGAAAGTC
GCGGGCATGTCGAACTTGAAATTCACTGGGCCGGCCCGCTGCTTCGATCGGGAAGAGGATGCCTTTGAAGCCGTTCAGAA
GCGGTCCTATCGCGAGGGCGAGGTCATCGTCATCCGCTATGAGGGCCCGCGCGGCGGTCCCGGCATGCGGGAAATGCTGC
AGACCACGGCGGCGCTGACGGGGCAGGGCATGGGCGGCAAGATCGCGCTCATCACCGATGGCCGGTTCTCGGGCGCGACG
CGCGGCTTCTGCATCGGCCATATCGGGCCGGAGGCGGCGGTCGGCGGACCGATCGCGCTGGTCGAGGATGGCGACATCAT
CGAGATCGACGCCGAGGCGGGCATCCTGAACGTCAAGTTGAGCGATGCCGAACTGACACAACGCAAGACCAAGTGGACGC
CGCGTGAAACGCATCACACGTCAGGTGCACTTTGGAAATATGCCCAGCAGGTGGGACCCGCCGTGGCGGGGGCCGTCACC
CACCCAGGTGGTGCGCAAGAGAAGTATTGCTATGCGGACATCTGA

Upstream 100 bases:

>100_bases
GAAATAGTTTGAACAGAAGAGTACCAGTGCGTGTGAGGTTGCCAGGAATCCACTTTCAGGATTTTAGCGTTCTCCGCAGC
ACCGGGAGGCCAGAACAGCG

Downstream 100 bases:

>100_bases
TCGGATCATTTTCGCACTGTTGCTGGGGGTTGCCCCGCTCGCGCTGCCGACGCCGTCGTTCGCGTTCGATGGCGCGCCGG
TCAACCAGGAGCCGGCGATC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 2 [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MDAKTDIKRRLPSRHVTEGPERAPHRSYLYAMGLTTAQIHQPFVGVASCWNEAAPCNIALMRQAQAVKKGVAHAGGTPRE
FCTITVTDGIAMGHDGMRSSLPSREAIADSVELTIRGHAYDALVGLAGCDKSLPGMMMAMVRLNVPSIFIYGGSILPGNF
RGQQVTVQDMFEAVGKHSVGAMSDEDLDELERVACPSAGACGAQFTANTMATVSEAIGLALPYSAGAPAPYEIRDSFCMT
AGEKVMELISANIRPRDIVTRAALENAAAVVAASGGSTNAALHLPAIAHEAGIKFDLFDVAEIFKKTPYIADLKPGGRYV
AKDMFEAGGIPLLMKTLLDHGYLNGDCLTVTGRTIAENLKGVKWNPHQDVVRPADQPITATGGVVGLKGNLAPEGAIVKV
AGMSNLKFTGPARCFDREEDAFEAVQKRSYREGEVIVIRYEGPRGGPGMREMLQTTAALTGQGMGGKIALITDGRFSGAT
RGFCIGHIGPEAAVGGPIALVEDGDIIEIDAEAGILNVKLSDAELTQRKTKWTPRETHHTSGALWKYAQQVGPAVAGAVT
HPGGAQEKYCYADI

Sequences:

>Translated_574_residues
MDAKTDIKRRLPSRHVTEGPERAPHRSYLYAMGLTTAQIHQPFVGVASCWNEAAPCNIALMRQAQAVKKGVAHAGGTPRE
FCTITVTDGIAMGHDGMRSSLPSREAIADSVELTIRGHAYDALVGLAGCDKSLPGMMMAMVRLNVPSIFIYGGSILPGNF
RGQQVTVQDMFEAVGKHSVGAMSDEDLDELERVACPSAGACGAQFTANTMATVSEAIGLALPYSAGAPAPYEIRDSFCMT
AGEKVMELISANIRPRDIVTRAALENAAAVVAASGGSTNAALHLPAIAHEAGIKFDLFDVAEIFKKTPYIADLKPGGRYV
AKDMFEAGGIPLLMKTLLDHGYLNGDCLTVTGRTIAENLKGVKWNPHQDVVRPADQPITATGGVVGLKGNLAPEGAIVKV
AGMSNLKFTGPARCFDREEDAFEAVQKRSYREGEVIVIRYEGPRGGPGMREMLQTTAALTGQGMGGKIALITDGRFSGAT
RGFCIGHIGPEAAVGGPIALVEDGDIIEIDAEAGILNVKLSDAELTQRKTKWTPRETHHTSGALWKYAQQVGPAVAGAVT
HPGGAQEKYCYADI
>Mature_574_residues
MDAKTDIKRRLPSRHVTEGPERAPHRSYLYAMGLTTAQIHQPFVGVASCWNEAAPCNIALMRQAQAVKKGVAHAGGTPRE
FCTITVTDGIAMGHDGMRSSLPSREAIADSVELTIRGHAYDALVGLAGCDKSLPGMMMAMVRLNVPSIFIYGGSILPGNF
RGQQVTVQDMFEAVGKHSVGAMSDEDLDELERVACPSAGACGAQFTANTMATVSEAIGLALPYSAGAPAPYEIRDSFCMT
AGEKVMELISANIRPRDIVTRAALENAAAVVAASGGSTNAALHLPAIAHEAGIKFDLFDVAEIFKKTPYIADLKPGGRYV
AKDMFEAGGIPLLMKTLLDHGYLNGDCLTVTGRTIAENLKGVKWNPHQDVVRPADQPITATGGVVGLKGNLAPEGAIVKV
AGMSNLKFTGPARCFDREEDAFEAVQKRSYREGEVIVIRYEGPRGGPGMREMLQTTAALTGQGMGGKIALITDGRFSGAT
RGFCIGHIGPEAAVGGPIALVEDGDIIEIDAEAGILNVKLSDAELTQRKTKWTPRETHHTSGALWKYAQQVGPAVAGAVT
HPGGAQEKYCYADI

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=603, Percent_Identity=37.9767827529022, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1786464, Length=480, Percent_Identity=36.875, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI2367371, Length=461, Percent_Identity=34.9240780911063, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1788157, Length=476, Percent_Identity=29.6218487394958, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=553, Percent_Identity=43.2188065099458, Blast_Score=451, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 60757; Mature: 60757

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAKTDIKRRLPSRHVTEGPERAPHRSYLYAMGLTTAQIHQPFVGVASCWNEAAPCNIAL
CCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHCCHHHHHHHCCCCCCCCHHH
MRQAQAVKKGVAHAGGTPREFCTITVTDGIAMGHDGMRSSLPSREAIADSVELTIRGHAY
HHHHHHHHHHHHHCCCCCCCEEEEEEECCEEECCCCHHHCCCCHHHHCCCEEEEEECCHH
DALVGLAGCDKSLPGMMMAMVRLNVPSIFIYGGSILPGNFRGQQVTVQDMFEAVGKHSVG
HHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCEECCCCCCCCEEEHHHHHHHHCCCCCC
AMSDEDLDELERVACPSAGACGAQFTANTMATVSEAIGLALPYSAGAPAPYEIRDSFCMT
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCEECCCCCCCCCCHHHHHHHHHH
AGEKVMELISANIRPRDIVTRAALENAAAVVAASGGSTNAALHLPAIAHEAGIKFDLFDV
HHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEECCCCCCCEEECCHHHHHCCCEEEHHHH
AEIFKKTPYIADLKPGGRYVAKDMFEAGGIPLLMKTLLDHGYLNGDCLTVTGRTIAENLK
HHHHHCCCCEEECCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHCC
GVKWNPHQDVVRPADQPITATGGVVGLKGNLAPEGAIVKVAGMSNLKFTGPARCFDREED
CCCCCCCHHHHCCCCCCEEECCCEEEECCCCCCCCCEEEEECCCCCEECCCHHHCCCCHH
AFEAVQKRSYREGEVIVIRYEGPRGGPGMREMLQTTAALTGQGMGGKIALITDGRFSGAT
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
RGFCIGHIGPEAAVGGPIALVEDGDIIEIDAEAGILNVKLSDAELTQRKTKWTPRETHHT
CCEEEECCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCCCCC
SGALWKYAQQVGPAVAGAVTHPGGAQEKYCYADI
CHHHHHHHHHHCCHHCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MDAKTDIKRRLPSRHVTEGPERAPHRSYLYAMGLTTAQIHQPFVGVASCWNEAAPCNIAL
CCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHCCHHHHHHHCCCCCCCCHHH
MRQAQAVKKGVAHAGGTPREFCTITVTDGIAMGHDGMRSSLPSREAIADSVELTIRGHAY
HHHHHHHHHHHHHCCCCCCCEEEEEEECCEEECCCCHHHCCCCHHHHCCCEEEEEECCHH
DALVGLAGCDKSLPGMMMAMVRLNVPSIFIYGGSILPGNFRGQQVTVQDMFEAVGKHSVG
HHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCEECCCCCCCCEEEHHHHHHHHCCCCCC
AMSDEDLDELERVACPSAGACGAQFTANTMATVSEAIGLALPYSAGAPAPYEIRDSFCMT
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCEECCCCCCCCCCHHHHHHHHHH
AGEKVMELISANIRPRDIVTRAALENAAAVVAASGGSTNAALHLPAIAHEAGIKFDLFDV
HHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEECCCCCCCEEECCHHHHHCCCEEEHHHH
AEIFKKTPYIADLKPGGRYVAKDMFEAGGIPLLMKTLLDHGYLNGDCLTVTGRTIAENLK
HHHHHCCCCEEECCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHCC
GVKWNPHQDVVRPADQPITATGGVVGLKGNLAPEGAIVKVAGMSNLKFTGPARCFDREED
CCCCCCCHHHHCCCCCCEEECCCEEEECCCCCCCCCEEEEECCCCCEECCCHHHCCCCHH
AFEAVQKRSYREGEVIVIRYEGPRGGPGMREMLQTTAALTGQGMGGKIALITDGRFSGAT
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
RGFCIGHIGPEAAVGGPIALVEDGDIIEIDAEAGILNVKLSDAELTQRKTKWTPRETHHT
CCEEEECCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCCCCC
SGALWKYAQQVGPAVAGAVTHPGGAQEKYCYADI
CHHHHHHHHHHCCHHCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]