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The map label for this gene is hom [H]

Identifier: 146340529

GI number: 146340529

Start: 3764798

End: 3766114

Strand: Direct

Name: hom [H]

Synonym: BRADO3572

Alternate gene names: 146340529

Gene position: 3764798-3766114 (Clockwise)

Preceding gene: 146340528

Following gene: 146340530

Centisome position: 50.49

GC content: 67.5

Gene sequence:

>1317_bases
ATGGTCGCACCCCTGAGAGTGGGCATCGCGGGCCTCGGCACCGTGGGTGCCGAGGTCGTTCGTCTGATCGAGCGGCAGGG
GCGCGTGCTCACCGAGCGGACGGGGCGTCCCGTGCAGGTCGTGGCGGTCACGGCGCGGTCGAAGAAGAAGCGCGCGATCG
ATCTCTCCGGGATCAAGTGGGCCAAGGATCCGCTGGCGCTCGCCAGCGACCCCGAAGTCGACTGTCTGGTCGAGCTGATG
GGTGGTGCAGGTGATCCCGCGCTGTCGGCAATCGACACCGCGCTCAAGGCCGGCAAGTCGGTGGTGACCGCGAACAAGGC
GCTGATCGCCAGGCACGGTCTGAAGCTCGCCAAGGCGGCCGAGAAGCACGGCGGCGCGCTGAATTTCGAGGCCGCTGTCT
GCGCCGCGATTCCGGTCATCAAGACCCTGCGCGAAGGCCTCGCCGGCACCGGCATCAGCCGCGTCTACGGCATTCTCAAT
GGCACCTGCAACTACATCCTGACCCGGATGGAGCAGGAAGGTCTGTCGTTCGACGAGTGCCTGGCGGACGCGCAGCGTCT
CGGCTACGCCGAGGCCGATCCGTCGTTCGACATCCATGGCCACGACACCGCGCAGAAGCTCGCGATCCTCGCGAGCCTCG
CCTTCGGCACCCAGGTCGCGGAAAAATCCATCTACGTGGAAGGCATCTCCTCGATCGCCCCGGAGGATCTGAAGGCGGCC
GCCGAGCTCGGCTACCGCGTCAAGCTGCTCGGCGTCGCCGTGCGCACGGCCAAGGGCATCGAGCAGCGCGTGCATCCGAC
CATGGTGCCGAAATCGTCGTCGATCGCCCAGGTCATGGGCGTGACCAACGCGGTGACCATCGACGGCGAGGGCATTCCGC
CGATCACTCTGGTCGGACCGGGAGCAGGGGGCGCGGCGACCGCGTCCGCGGTCCTGGCTGATATCGCCGATGTCGCGCGC
GGTATCCGCGCGGCGCCGTTCGGACGACCGGTCGACAAGCTGCAGGCGACCGAGAAGGCGCCGATGGAGCGGCACGAAGG
CGGCTACTACATCCGACTGATGGCCCGCGATCACGCCGGCACTGCCGCGACGATCGCCACGCGCCTCGCCGAGCAGAAGA
TCTCGATCGAGTCGATCGTGCAGCGCCATCCCAACGGCAGCGAGCCGCTGAAGACCGGCGCCAAGGGCGGGCCCGTGCCT
GTGATCCTGATCACCTATGCCACGCATGAGGACGCCGTGTACAAGGCGCTCCAGGCCGTGCAGCGCGACAAGGTGATCAG
CGGCAAGCCGCAGGTGATCCGGATCGAGAAGAATTAA

Upstream 100 bases:

>100_bases
CCGCTTCCTTGAAAGCGGCATCGAAACGTTGCACAACGTGGTTCCTCTCGCCAACCGGCGCTGAGTCTCCCGTTGTCCTT
GCTGCAGGTTCTTTGATTCC

Downstream 100 bases:

>100_bases
TCTGGGATGCCCAGGGAACCGGTTGTCCCTGCTCAAACAAACGCGTGGCGTTTGGGCTAGGTTCATGCTCAAACCGGTGA
AATCGAGTGGCGTGCAGCGG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MVAPLRVGIAGLGTVGAEVVRLIERQGRVLTERTGRPVQVVAVTARSKKKRAIDLSGIKWAKDPLALASDPEVDCLVELM
GGAGDPALSAIDTALKAGKSVVTANKALIARHGLKLAKAAEKHGGALNFEAAVCAAIPVIKTLREGLAGTGISRVYGILN
GTCNYILTRMEQEGLSFDECLADAQRLGYAEADPSFDIHGHDTAQKLAILASLAFGTQVAEKSIYVEGISSIAPEDLKAA
AELGYRVKLLGVAVRTAKGIEQRVHPTMVPKSSSIAQVMGVTNAVTIDGEGIPPITLVGPGAGGAATASAVLADIADVAR
GIRAAPFGRPVDKLQATEKAPMERHEGGYYIRLMARDHAGTAATIATRLAEQKISIESIVQRHPNGSEPLKTGAKGGPVP
VILITYATHEDAVYKALQAVQRDKVISGKPQVIRIEKN

Sequences:

>Translated_438_residues
MVAPLRVGIAGLGTVGAEVVRLIERQGRVLTERTGRPVQVVAVTARSKKKRAIDLSGIKWAKDPLALASDPEVDCLVELM
GGAGDPALSAIDTALKAGKSVVTANKALIARHGLKLAKAAEKHGGALNFEAAVCAAIPVIKTLREGLAGTGISRVYGILN
GTCNYILTRMEQEGLSFDECLADAQRLGYAEADPSFDIHGHDTAQKLAILASLAFGTQVAEKSIYVEGISSIAPEDLKAA
AELGYRVKLLGVAVRTAKGIEQRVHPTMVPKSSSIAQVMGVTNAVTIDGEGIPPITLVGPGAGGAATASAVLADIADVAR
GIRAAPFGRPVDKLQATEKAPMERHEGGYYIRLMARDHAGTAATIATRLAEQKISIESIVQRHPNGSEPLKTGAKGGPVP
VILITYATHEDAVYKALQAVQRDKVISGKPQVIRIEKN
>Mature_438_residues
MVAPLRVGIAGLGTVGAEVVRLIERQGRVLTERTGRPVQVVAVTARSKKKRAIDLSGIKWAKDPLALASDPEVDCLVELM
GGAGDPALSAIDTALKAGKSVVTANKALIARHGLKLAKAAEKHGGALNFEAAVCAAIPVIKTLREGLAGTGISRVYGILN
GTCNYILTRMEQEGLSFDECLADAQRLGYAEADPSFDIHGHDTAQKLAILASLAFGTQVAEKSIYVEGISSIAPEDLKAA
AELGYRVKLLGVAVRTAKGIEQRVHPTMVPKSSSIAQVMGVTNAVTIDGEGIPPITLVGPGAGGAATASAVLADIADVAR
GIRAAPFGRPVDKLQATEKAPMERHEGGYYIRLMARDHAGTAATIATRLAEQKISIESIVQRHPNGSEPLKTGAKGGPVP
VILITYATHEDAVYKALQAVQRDKVISGKPQVIRIEKN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=250, Percent_Identity=30.4, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790376, Length=360, Percent_Identity=25.5555555555556, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45831; Mature: 45831

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAPLRVGIAGLGTVGAEVVRLIERQGRVLTERTGRPVQVVAVTARSKKKRAIDLSGIKW
CCCCCEECHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCCCCCEEECCCCEE
AKDPLALASDPEVDCLVELMGGAGDPALSAIDTALKAGKSVVTANKALIARHGLKLAKAA
CCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHCHHHHHHH
EKHGGALNFEAAVCAAIPVIKTLREGLAGTGISRVYGILNGTCNYILTRMEQEGLSFDEC
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
LADAQRLGYAEADPSFDIHGHDTAQKLAILASLAFGTQVAEKSIYVEGISSIAPEDLKAA
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AELGYRVKLLGVAVRTAKGIEQRVHPTMVPKSSSIAQVMGVTNAVTIDGEGIPPITLVGP
HHCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEECCCCCCCEEEECC
GAGGAATASAVLADIADVARGIRAAPFGRPVDKLQATEKAPMERHEGGYYIRLMARDHAG
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHCCCCEEEEEEEECCCC
TAATIATRLAEQKISIESIVQRHPNGSEPLKTGAKGGPVPVILITYATHEDAVYKALQAV
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHCCCCCCCEEEEEEEEECCHHHHHHHHHHH
QRDKVISGKPQVIRIEKN
HHCCCCCCCCCEEEEECC
>Mature Secondary Structure
MVAPLRVGIAGLGTVGAEVVRLIERQGRVLTERTGRPVQVVAVTARSKKKRAIDLSGIKW
CCCCCEECHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCCCCCEEECCCCEE
AKDPLALASDPEVDCLVELMGGAGDPALSAIDTALKAGKSVVTANKALIARHGLKLAKAA
CCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHCHHHHHHH
EKHGGALNFEAAVCAAIPVIKTLREGLAGTGISRVYGILNGTCNYILTRMEQEGLSFDEC
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
LADAQRLGYAEADPSFDIHGHDTAQKLAILASLAFGTQVAEKSIYVEGISSIAPEDLKAA
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AELGYRVKLLGVAVRTAKGIEQRVHPTMVPKSSSIAQVMGVTNAVTIDGEGIPPITLVGP
HHCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEECCCCCCCEEEECC
GAGGAATASAVLADIADVARGIRAAPFGRPVDKLQATEKAPMERHEGGYYIRLMARDHAG
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHCCCCEEEEEEEECCCC
TAATIATRLAEQKISIESIVQRHPNGSEPLKTGAKGGPVPVILITYATHEDAVYKALQAV
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHCCCCCCCEEEEEEEEECCHHHHHHHHHHH
QRDKVISGKPQVIRIEKN
HHCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]