Click here to switch to the map view.

The map label for this gene is hbdA [H]

Identifier: 146340411

GI number: 146340411

Start: 3629294

End: 3630145

Strand: Direct

Name: hbdA [H]

Synonym: BRADO3444

Alternate gene names: 146340411

Gene position: 3629294-3630145 (Clockwise)

Preceding gene: 146340409

Following gene: 146340412

Centisome position: 48.67

GC content: 62.79

Gene sequence:

>852_bases
ATGATTCAGACGGTTGGCATCATCGGAGCAGGCACCATGGGCAACGGTATCGCGCAGGTGTGCGCGGCCGCCGGCGTGCC
GATCGTCATGGTGGATATTTCCGAGCAGGCGGTCGCGCGCGGGCTCGCCACCGTCGGCTCGAGCCTCGATCGCCTCGTCA
AGAAGGACAAGATGACGACGGCCGACAAGGACAAGGCGCTGTCGCTGATCACCGGCACCACTGACAAGACCAAGCTGTCG
GCCTGCGATCTGGTGATCGAGGCGGCGACCGAGAATGAAGCCCTGAAGCTCAAGATCCTCGGGGATCTCTGTGCCGGGCT
GAAGCCGGAAGCCCTGATCGCGACCAACACCTCGTCGATTTCGATCACCAAGCTCGCGACCGCCACCGACCGTCCGGACC
GCTTCATCGGCATGCACTTCTTCAATCCGGTGCCGATGATGGCGTTGCTCGAGCTGATCCGCGGCCTGCAGACTTCCGAT
GCGACTCACGCTGCGGCAGTGGACTTCGCCAAGCGGATCGGCAAGGTCGCGATCACTGCCAAGAACAGCCCGGGCTTCGC
GGTGAACCGCATCCTGTGCCCGATGATCAACGAGGCGATCTTCGCGTATTCCGAAGGCATCGCTACCGCTGCCGACATTG
ACGAGGGCATGAAGCTCGGCTGCAACCACCCGATCGGGCCGCTGGCGCTCGCGGACCTGATCGGGCTCGACACGATGCTG
TCGGTGATGGAGGTGTTCTACAACGGCTTCAACGATCCGAAGTATCGTCCGGCGCCGCTGTTGAAGGAAATGGTCGCAGC
GGGACAGCTCGGCCGCAAGACCGGCAAGGGCTTCTACGACTACAGCAAGTAG

Upstream 100 bases:

>100_bases
GCTCCGTCAAACAACGCGGGGCTACCGGCGAAGGCGATAGCCTGTTAAGCAACCGCGGACAGCGGGCCGCGGGCCCATAT
CAGCGAAAGAGGCAACGGCA

Downstream 100 bases:

>100_bases
TTGGCGGCGGCGGGCAACCGCTTGAGAACGAGCGCGCGGCGGATCTCAGGTATCTGCCGCGCATTCATGGGCGACCGGTG
GACGACCCACACTCAGCGTT

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MIQTVGIIGAGTMGNGIAQVCAAAGVPIVMVDISEQAVARGLATVGSSLDRLVKKDKMTTADKDKALSLITGTTDKTKLS
ACDLVIEAATENEALKLKILGDLCAGLKPEALIATNTSSISITKLATATDRPDRFIGMHFFNPVPMMALLELIRGLQTSD
ATHAAAVDFAKRIGKVAITAKNSPGFAVNRILCPMINEAIFAYSEGIATAADIDEGMKLGCNHPIGPLALADLIGLDTML
SVMEVFYNGFNDPKYRPAPLLKEMVAAGQLGRKTGKGFYDYSK

Sequences:

>Translated_283_residues
MIQTVGIIGAGTMGNGIAQVCAAAGVPIVMVDISEQAVARGLATVGSSLDRLVKKDKMTTADKDKALSLITGTTDKTKLS
ACDLVIEAATENEALKLKILGDLCAGLKPEALIATNTSSISITKLATATDRPDRFIGMHFFNPVPMMALLELIRGLQTSD
ATHAAAVDFAKRIGKVAITAKNSPGFAVNRILCPMINEAIFAYSEGIATAADIDEGMKLGCNHPIGPLALADLIGLDTML
SVMEVFYNGFNDPKYRPAPLLKEMVAAGQLGRKTGKGFYDYSK
>Mature_283_residues
MIQTVGIIGAGTMGNGIAQVCAAAGVPIVMVDISEQAVARGLATVGSSLDRLVKKDKMTTADKDKALSLITGTTDKTKLS
ACDLVIEAATENEALKLKILGDLCAGLKPEALIATNTSSISITKLATATDRPDRFIGMHFFNPVPMMALLELIRGLQTSD
ATHAAAVDFAKRIGKVAITAKNSPGFAVNRILCPMINEAIFAYSEGIATAADIDEGMKLGCNHPIGPLALADLIGLDTML
SVMEVFYNGFNDPKYRPAPLLKEMVAAGQLGRKTGKGFYDYSK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=41.3194444444444, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=39.0163934426229, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI20127408, Length=288, Percent_Identity=37.1527777777778, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI261878539, Length=294, Percent_Identity=32.6530612244898, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI68989263, Length=294, Percent_Identity=32.6530612244898, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI115430219, Length=257, Percent_Identity=26.8482490272374, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1787661, Length=281, Percent_Identity=38.0782918149466, Blast_Score=205, Evalue=2e-54,
Organism=Escherichia coli, GI1788682, Length=261, Percent_Identity=36.0153256704981, Blast_Score=167, Evalue=5e-43,
Organism=Escherichia coli, GI1790281, Length=269, Percent_Identity=34.5724907063197, Blast_Score=161, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=42.3611111111111, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=41.522491349481, Blast_Score=226, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=37.2822299651568, Blast_Score=194, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17508953, Length=282, Percent_Identity=35.8156028368794, Blast_Score=170, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI25144276, Length=282, Percent_Identity=35.8156028368794, Blast_Score=170, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17508951, Length=282, Percent_Identity=35.8156028368794, Blast_Score=170, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=35.1063829787234, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71985923, Length=281, Percent_Identity=30.6049822064057, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71985930, Length=284, Percent_Identity=30.2816901408451, Blast_Score=130, Evalue=8e-31,
Organism=Drosophila melanogaster, GI19921000, Length=284, Percent_Identity=37.3239436619718, Blast_Score=180, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24583077, Length=284, Percent_Identity=37.3239436619718, Blast_Score=180, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24583079, Length=284, Percent_Identity=37.3239436619718, Blast_Score=180, Evalue=8e-46,
Organism=Drosophila melanogaster, GI20129993, Length=221, Percent_Identity=26.6968325791855, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45549573, Length=255, Percent_Identity=26.2745098039216, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 29808; Mature: 29808

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQTVGIIGAGTMGNGIAQVCAAAGVPIVMVDISEQAVARGLATVGSSLDRLVKKDKMTT
CCEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
ADKDKALSLITGTTDKTKLSACDLVIEAATENEALKLKILGDLCAGLKPEALIATNTSSI
CCCHHEEEEEECCCCCHHHHHHHHEEEECCCCCEEEEEEEHHHHCCCCCCEEEEECCCCE
SITKLATATDRPDRFIGMHFFNPVPMMALLELIRGLQTSDATHAAAVDFAKRIGKVAITA
EEEEEECCCCCCCCEEEHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEE
KNSPGFAVNRILCPMINEAIFAYSEGIATAADIDEGMKLGCNHPIGPLALADLIGLDTML
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
SVMEVFYNGFNDPKYRPAPLLKEMVAAGQLGRKTGKGFYDYSK
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIQTVGIIGAGTMGNGIAQVCAAAGVPIVMVDISEQAVARGLATVGSSLDRLVKKDKMTT
CCEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
ADKDKALSLITGTTDKTKLSACDLVIEAATENEALKLKILGDLCAGLKPEALIATNTSSI
CCCHHEEEEEECCCCCHHHHHHHHEEEECCCCCEEEEEEEHHHHCCCCCCEEEEECCCCE
SITKLATATDRPDRFIGMHFFNPVPMMALLELIRGLQTSDATHAAAVDFAKRIGKVAITA
EEEEEECCCCCCCCEEEHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEE
KNSPGFAVNRILCPMINEAIFAYSEGIATAADIDEGMKLGCNHPIGPLALADLIGLDTML
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
SVMEVFYNGFNDPKYRPAPLLKEMVAAGQLGRKTGKGFYDYSK
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]