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The map label for this gene is guaB [H]

Identifier: 146340150

GI number: 146340150

Start: 3367744

End: 3369231

Strand: Direct

Name: guaB [H]

Synonym: BRADO3165

Alternate gene names: 146340150

Gene position: 3367744-3369231 (Clockwise)

Preceding gene: 146340149

Following gene: 146340151

Centisome position: 45.16

GC content: 67.61

Gene sequence:

>1488_bases
ATGGCGACCGTGCAGACACTTCGCGAAGCCTTCACCTTCGACGACGTGCTCTTGAAGCCGGGCCTGTCCGATGTGCTTCC
CTCCGAGGTCGACATCCGCTCGCGCGTGACGCGCGAAATCCCGCTGAACATTCCGATCATGGCCTCCGCCATGGATACCG
TCACCGAGGCGCGCATGGCGATCGCGATGGCGCAGGCTGGTGGTGTCGGGGTGATCCATCGCAATTTCGATCCCGAGGGC
CAGGCCGCCCAGGTGCGCCAGGTCAAGAAGTTCGAATCCGGCATGGTGGTGAACCCGCTGACCATCGCGCCGGACGCGAC
GCTGGCGGACGCGCTGGCGCTGATGAAGGATTACGGCTTCTCCGGCATTCCCGTCGTCACCGGTGGCGGCAAGGGCATTC
CCGGCAAGCTGGTCGGCATCCTGACCAACCGCGACGTCCGCTTCGCCACCGATCCGCGGCAGAAGATCTCCGAGCTGATG
ACGCATGAGAACCTCGTCACCGTGCGCGAGGGCGTCGGCCAGGACGAGGCCAAGAAGATCCTGCACAAGCACCGCATCGA
AAAGCTGCTCGTCGTCGACGATCAGTACCGCTGCGTGGGCCTGATCACCGTCAAGGACATGGAGAAGGCGGTCGCGCATC
CCCTGGCCTGCAAGGACGCGCAGGGACGGCTCCGCGTCGCCGCCGCGACCACCGTGGGCGAGGGCGGTTTCGAGCGCACC
GAGAAGCTGATCGAGGCCGGCGTCGATCTCGTCGTCGTCGATACCGCGCATGGCCATTCCTCGCGCGTGCTGGAAGCGGT
CAACCGCATCAAGCGCATCTCCAACGCGGTGCAGGTGATCGCCGGCAACATCGCCACCCGCGACGGCGCCCAGGCGCTGA
TCGATGCTGGCGCTGACGCGGTCAAGGTCGGCATCGGCCCGGGCTCGATCTGCACCACCCGCATCGTCGCCGGCGTCGGC
GTGCCGCAGCTCACCGCGATCATGGATGCAGTGGAAGCCGCCAAGAAGGCTGACGTGCCTGTGATCGCCGACGGCGGCAT
CAAGTTCTCCGGCGACCTCGCCAAGGCGCTCGCCGCCGGCGCCGACGTCGCCATGGTCGGCTCGCTGCTCGCCGGCACCG
ACGAGACCCCCGGCGAAGTCTTCCTGTGGCAGGGCCGCTCCTACAAGGCCTATCGCGGCATGGGCTCGGTCGGCGCGATG
GCCCGCGGCTCGGCCGACCGCTACTTCCAGCAGGACATCAAGGACACCTTGAAGCTCGTGCCCGAGGGCATCGAGGGCCA
GGTGCCGTACAAGGGCCCGGTCGGCAACGTCATGCACCAGCTCGCCGGGGGCCTGCGCGCCGCCATGGGCTATGTCGGCG
CCAAGACGCTGGAAGACTTCCACGCCAAGGCCGAGTTCGTCCGCATCACCGGCGCGGGCTTGCGCGAAAGCCACGTCCAC
GACGTGACCATCACCCGCGAGAGCCCGAACTATCCGGGCGGGGCGTAA

Upstream 100 bases:

>100_bases
CGATGGGCTCCGATTCGACGGCGAGGCATGGTCTCGACGGCGGCGCCGCTCATCCTTAGATCCCATCGCGGCCGTTATGG
CTGCAGACAAGGAGTTGACG

Downstream 100 bases:

>100_bases
GACGGGGAGAGAGCAAGCGTGTAGCCCGGATGAGCGAAGCGATATCCGGGTTCTAGTAAACAGCGCGTGCGACCCCGGAT
GTCGCTCCGCTCATCCGGGC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MATVQTLREAFTFDDVLLKPGLSDVLPSEVDIRSRVTREIPLNIPIMASAMDTVTEARMAIAMAQAGGVGVIHRNFDPEG
QAAQVRQVKKFESGMVVNPLTIAPDATLADALALMKDYGFSGIPVVTGGGKGIPGKLVGILTNRDVRFATDPRQKISELM
THENLVTVREGVGQDEAKKILHKHRIEKLLVVDDQYRCVGLITVKDMEKAVAHPLACKDAQGRLRVAAATTVGEGGFERT
EKLIEAGVDLVVVDTAHGHSSRVLEAVNRIKRISNAVQVIAGNIATRDGAQALIDAGADAVKVGIGPGSICTTRIVAGVG
VPQLTAIMDAVEAAKKADVPVIADGGIKFSGDLAKALAAGADVAMVGSLLAGTDETPGEVFLWQGRSYKAYRGMGSVGAM
ARGSADRYFQQDIKDTLKLVPEGIEGQVPYKGPVGNVMHQLAGGLRAAMGYVGAKTLEDFHAKAEFVRITGAGLRESHVH
DVTITRESPNYPGGA

Sequences:

>Translated_495_residues
MATVQTLREAFTFDDVLLKPGLSDVLPSEVDIRSRVTREIPLNIPIMASAMDTVTEARMAIAMAQAGGVGVIHRNFDPEG
QAAQVRQVKKFESGMVVNPLTIAPDATLADALALMKDYGFSGIPVVTGGGKGIPGKLVGILTNRDVRFATDPRQKISELM
THENLVTVREGVGQDEAKKILHKHRIEKLLVVDDQYRCVGLITVKDMEKAVAHPLACKDAQGRLRVAAATTVGEGGFERT
EKLIEAGVDLVVVDTAHGHSSRVLEAVNRIKRISNAVQVIAGNIATRDGAQALIDAGADAVKVGIGPGSICTTRIVAGVG
VPQLTAIMDAVEAAKKADVPVIADGGIKFSGDLAKALAAGADVAMVGSLLAGTDETPGEVFLWQGRSYKAYRGMGSVGAM
ARGSADRYFQQDIKDTLKLVPEGIEGQVPYKGPVGNVMHQLAGGLRAAMGYVGAKTLEDFHAKAEFVRITGAGLRESHVH
DVTITRESPNYPGGA
>Mature_494_residues
ATVQTLREAFTFDDVLLKPGLSDVLPSEVDIRSRVTREIPLNIPIMASAMDTVTEARMAIAMAQAGGVGVIHRNFDPEGQ
AAQVRQVKKFESGMVVNPLTIAPDATLADALALMKDYGFSGIPVVTGGGKGIPGKLVGILTNRDVRFATDPRQKISELMT
HENLVTVREGVGQDEAKKILHKHRIEKLLVVDDQYRCVGLITVKDMEKAVAHPLACKDAQGRLRVAAATTVGEGGFERTE
KLIEAGVDLVVVDTAHGHSSRVLEAVNRIKRISNAVQVIAGNIATRDGAQALIDAGADAVKVGIGPGSICTTRIVAGVGV
PQLTAIMDAVEAAKKADVPVIADGGIKFSGDLAKALAAGADVAMVGSLLAGTDETPGEVFLWQGRSYKAYRGMGSVGAMA
RGSADRYFQQDIKDTLKLVPEGIEGQVPYKGPVGNVMHQLAGGLRAAMGYVGAKTLEDFHAKAEFVRITGAGLRESHVHD
VTITRESPNYPGGA

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=454, Percent_Identity=42.7312775330396, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI156616279, Length=454, Percent_Identity=42.7312775330396, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI34328930, Length=454, Percent_Identity=42.7312775330396, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI34328928, Length=454, Percent_Identity=42.7312775330396, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI217035152, Length=448, Percent_Identity=43.0803571428571, Blast_Score=328, Evalue=9e-90,
Organism=Homo sapiens, GI66933016, Length=484, Percent_Identity=40.0826446280992, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI217035148, Length=454, Percent_Identity=41.8502202643172, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035150, Length=454, Percent_Identity=39.647577092511, Blast_Score=291, Evalue=6e-79,
Organism=Homo sapiens, GI50541956, Length=250, Percent_Identity=38, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI50541954, Length=250, Percent_Identity=38, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI50541952, Length=250, Percent_Identity=38, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI50541948, Length=250, Percent_Identity=38, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI156104880, Length=265, Percent_Identity=36.6037735849057, Blast_Score=166, Evalue=6e-41,
Organism=Escherichia coli, GI1788855, Length=489, Percent_Identity=57.6687116564417, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1786293, Length=249, Percent_Identity=35.3413654618474, Blast_Score=158, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=36.3070539419087, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI71994389, Length=426, Percent_Identity=38.0281690140845, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17560440, Length=247, Percent_Identity=36.8421052631579, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=39.1393442622951, Blast_Score=339, Evalue=8e-94,
Organism=Saccharomyces cerevisiae, GI6323585, Length=489, Percent_Identity=39.2638036809816, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=487, Percent_Identity=40.2464065708419, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=343, Percent_Identity=39.6501457725948, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=111, Percent_Identity=38.7387387387387, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=39.5445134575569, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=39.5445134575569, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.9092970521542, Blast_Score=295, Evalue=5e-80,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52220; Mature: 52089

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVQTLREAFTFDDVLLKPGLSDVLPSEVDIRSRVTREIPLNIPIMASAMDTVTEARMA
CCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
IAMAQAGGVGVIHRNFDPEGQAAQVRQVKKFESGMVVNPLTIAPDATLADALALMKDYGF
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEECCEEECCCCHHHHHHHHHHHCCC
SGIPVVTGGGKGIPGKLVGILTNRDVRFATDPRQKISELMTHENLVTVREGVGQDEAKKI
CCCEEEECCCCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHH
LHKHRIEKLLVVDDQYRCVGLITVKDMEKAVAHPLACKDAQGRLRVAAATTVGEGGFERT
HHHHHHCEEEEECCCCEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHH
EKLIEAGVDLVVVDTAHGHSSRVLEAVNRIKRISNAVQVIAGNIATRDGAQALIDAGADA
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCE
VKVGIGPGSICTTRIVAGVGVPQLTAIMDAVEAAKKADVPVIADGGIKFSGDLAKALAAG
EEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCC
ADVAMVGSLLAGTDETPGEVFLWQGRSYKAYRGMGSVGAMARGSADRYFQQDIKDTLKLV
CCHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHC
PEGIEGQVPYKGPVGNVMHQLAGGLRAAMGYVGAKTLEDFHAKAEFVRITGAGLRESHVH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCE
DVTITRESPNYPGGA
EEEEEECCCCCCCCC
>Mature Secondary Structure 
ATVQTLREAFTFDDVLLKPGLSDVLPSEVDIRSRVTREIPLNIPIMASAMDTVTEARMA
CHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
IAMAQAGGVGVIHRNFDPEGQAAQVRQVKKFESGMVVNPLTIAPDATLADALALMKDYGF
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEECCEEECCCCHHHHHHHHHHHCCC
SGIPVVTGGGKGIPGKLVGILTNRDVRFATDPRQKISELMTHENLVTVREGVGQDEAKKI
CCCEEEECCCCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHH
LHKHRIEKLLVVDDQYRCVGLITVKDMEKAVAHPLACKDAQGRLRVAAATTVGEGGFERT
HHHHHHCEEEEECCCCEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHH
EKLIEAGVDLVVVDTAHGHSSRVLEAVNRIKRISNAVQVIAGNIATRDGAQALIDAGADA
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCE
VKVGIGPGSICTTRIVAGVGVPQLTAIMDAVEAAKKADVPVIADGGIKFSGDLAKALAAG
EEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCC
ADVAMVGSLLAGTDETPGEVFLWQGRSYKAYRGMGSVGAMARGSADRYFQQDIKDTLKLV
CCHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHC
PEGIEGQVPYKGPVGNVMHQLAGGLRAAMGYVGAKTLEDFHAKAEFVRITGAGLRESHVH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCE
DVTITRESPNYPGGA
EEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA