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The map label for this gene is ftsJ [H]

Identifier: 146340136

GI number: 146340136

Start: 3353138

End: 3353833

Strand: Direct

Name: ftsJ [H]

Synonym: BRADO3151

Alternate gene names: 146340136

Gene position: 3353138-3353833 (Clockwise)

Preceding gene: 146340135

Following gene: 146340137

Centisome position: 44.97

GC content: 66.52

Gene sequence:

>696_bases
ATGGCAAAAGACACCACCGGCCGCATGCATGTGCAGGTCAAGACCGGGGGCAAGCGCAAGCTGTCCTCGAAGCTCTGGCT
GGAGCGCCAGCTCAACGACCCCTATGTGGCGCAGGCCAAGCGCGACGGCTATCGCTCGCGCGCGACCTACAAGCTGATCG
AAATCGACGACAAATATCACATGCTCAAGCCCGGCATGACCGTGGTCGATCTCGGCGCTGCGCCCGGCGGCTGGAGCCAG
ATCGCCGCGCGCCGCGTCGGCGCCGAGGCCGGCAAGGGCAAGGTGGTCGCGATCGATTTGCTGGAGATGGGCGAGATCCC
CGGCGTGACCTTCGCCCAGCTCGACTTCCACGCCCAGGATGCGCCCGAAAAGCTCCGCACCATGATCGGCGGCCGCGCTG
ACGTGGTCATGTCGGACATGGCTGCCAACACCACGGGACATCGCAAGACCGACCAGCTGCGGATCGTCGGCCTCGTGGAA
CTCGCCGCGCATTTCGCCGGCGAGGTGCTGAAGCCCGGCGGCAGCTTCCTCGCCAAGACGTTCCAGAGCGGCGCCGATGC
CGAGTTGCTGGCGCAGCTGAAGCGCGATTACGCCACAGTCCGCCATGTCAAGCCGGCGGCGAGCCGGCAGGATTCCTCGG
AGCGCTACGTGTTGGCGATGGGCTTCCGCGGCGGAGAGCAGGCCGACCTGTTGTAA

Upstream 100 bases:

>100_bases
AGCTGTTTGCGTCTGGCGCGAACCGGGAAACTCGTTCCGTAACCTCTGGATTCCGGGTCCCGCCCTGACGGGCGGTCCCG
GAATGGCTTCCGAGATCAAG

Downstream 100 bases:

>100_bases
TGGCGTCATTGCGGTGGCCTCGCCCGGGCGATAAAGAGCAGCTGCAACCACAGTCTCGGGAATCGGTTGAAGAGCCGGCG
AGACATCAATTTCGGAGGTC

Product: ribosomal RNA large subunit (23S) methyltransferase

Products: NA

Alternate protein names: 23S rRNA Um2552 methyltransferase; rRNA (uridine-2'-O-)-methyltransferase [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MAKDTTGRMHVQVKTGGKRKLSSKLWLERQLNDPYVAQAKRDGYRSRATYKLIEIDDKYHMLKPGMTVVDLGAAPGGWSQ
IAARRVGAEAGKGKVVAIDLLEMGEIPGVTFAQLDFHAQDAPEKLRTMIGGRADVVMSDMAANTTGHRKTDQLRIVGLVE
LAAHFAGEVLKPGGSFLAKTFQSGADAELLAQLKRDYATVRHVKPAASRQDSSERYVLAMGFRGGEQADLL

Sequences:

>Translated_231_residues
MAKDTTGRMHVQVKTGGKRKLSSKLWLERQLNDPYVAQAKRDGYRSRATYKLIEIDDKYHMLKPGMTVVDLGAAPGGWSQ
IAARRVGAEAGKGKVVAIDLLEMGEIPGVTFAQLDFHAQDAPEKLRTMIGGRADVVMSDMAANTTGHRKTDQLRIVGLVE
LAAHFAGEVLKPGGSFLAKTFQSGADAELLAQLKRDYATVRHVKPAASRQDSSERYVLAMGFRGGEQADLL
>Mature_230_residues
AKDTTGRMHVQVKTGGKRKLSSKLWLERQLNDPYVAQAKRDGYRSRATYKLIEIDDKYHMLKPGMTVVDLGAAPGGWSQI
AARRVGAEAGKGKVVAIDLLEMGEIPGVTFAQLDFHAQDAPEKLRTMIGGRADVVMSDMAANTTGHRKTDQLRIVGLVEL
AAHFAGEVLKPGGSFLAKTFQSGADAELLAQLKRDYATVRHVKPAASRQDSSERYVLAMGFRGGEQADLL

Specific function: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit [H]

COG id: COG0293

COG function: function code J; 23S rRNA methylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmE family [H]

Homologues:

Organism=Homo sapiens, GI7019377, Length=207, Percent_Identity=39.6135265700483, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI29029591, Length=196, Percent_Identity=37.2448979591837, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI29029589, Length=196, Percent_Identity=37.2448979591837, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI7110661, Length=196, Percent_Identity=37.2448979591837, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI194097365, Length=198, Percent_Identity=32.3232323232323, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI1789569, Length=208, Percent_Identity=46.1538461538462, Blast_Score=170, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17554650, Length=199, Percent_Identity=38.6934673366834, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17553474, Length=205, Percent_Identity=34.1463414634146, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71987561, Length=200, Percent_Identity=30, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17553860, Length=200, Percent_Identity=30, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71987550, Length=199, Percent_Identity=30.1507537688442, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319535, Length=200, Percent_Identity=35.5, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319796, Length=216, Percent_Identity=32.8703703703704, Blast_Score=99, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6321302, Length=127, Percent_Identity=34.6456692913386, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356387, Length=214, Percent_Identity=42.0560747663551, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24648639, Length=196, Percent_Identity=34.6938775510204, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24647580, Length=198, Percent_Identity=33.8383838383838, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18859957, Length=198, Percent_Identity=31.3131313131313, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015507
- InterPro:   IPR002877 [H]

Pfam domain/function: PF01728 FtsJ [H]

EC number: =2.1.1.166 [H]

Molecular weight: Translated: 25151; Mature: 25020

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDTTGRMHVQVKTGGKRKLSSKLWLERQLNDPYVAQAKRDGYRSRATYKLIEIDDKYH
CCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEEECCCEE
MLKPGMTVVDLGAAPGGWSQIAARRVGAEAGKGKVVAIDLLEMGEIPGVTFAQLDFHAQD
EECCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCC
APEKLRTMIGGRADVVMSDMAANTTGHRKTDQLRIVGLVELAAHFAGEVLKPGGSFLAKT
CHHHHHHHHCCCHHEEEHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHH
FQSGADAELLAQLKRDYATVRHVKPAASRQDSSERYVLAMGFRGGEQADLL
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
AKDTTGRMHVQVKTGGKRKLSSKLWLERQLNDPYVAQAKRDGYRSRATYKLIEIDDKYH
CCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEEECCCEE
MLKPGMTVVDLGAAPGGWSQIAARRVGAEAGKGKVVAIDLLEMGEIPGVTFAQLDFHAQD
EECCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCC
APEKLRTMIGGRADVVMSDMAANTTGHRKTDQLRIVGLVELAAHFAGEVLKPGGSFLAKT
CHHHHHHHHCCCHHEEEHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHH
FQSGADAELLAQLKRDYATVRHVKPAASRQDSSERYVLAMGFRGGEQADLL
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA