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The map label for this gene is fabG [C]

Identifier: 146340128

GI number: 146340128

Start: 3341876

End: 3342793

Strand: Direct

Name: fabG [C]

Synonym: BRADO3143

Alternate gene names: 146340128

Gene position: 3341876-3342793 (Clockwise)

Preceding gene: 146340127

Following gene: 146340129

Centisome position: 44.82

GC content: 66.45

Gene sequence:

>918_bases
ATGGCAATCAGATTCGACGGACGTGTCGCCATCGTCACCGGCGCAGGTAATGGGCTCGGGCGCGCGCATGCGCTGGGGCT
GGCGAGCCGCGGCGCCAAGGTCGTAGTCAATGATTTCGGCGGCGCGCGCGACGGCACCGGCGGGTCGATGACCGCGGCCG
AGACCGTGGTCGAGGAGATCCGCAAAGCCGGCGGCACCGCGATGGCCGACGGTGCCGACGTCTCGAACTTCGAGCAGGTC
ACCGCGATGGCCGAGCGCGCCACCAGGGAGTGGGGCAGTGTCGACATCATGTGTGCCAATGCCGGCATCCTCCGCGACAA
GTCGTTCGCCAAGATGGAGGTGGCGGATTTCGCCAAGGTGCTCGACGTGCATCTGGTCGGCAGCTTCTACTGCTGCAAGG
CGGTGTGGAACGGCATGCGCGAGCGCAACTACGGGCGCATCGTGTTGACGACGTCATCGTCGGGCCTGTTCGGCAATTTC
GGCCAGGCCAACTACGGCGCGGCCAAGACCGGCATGGTCGGCCTGATGAACGTGCTGGCGGAGGAAGGGCGCAAGACCAA
CATCCGCGTCAACATCATCTCGCCGACCGCTGCCACCCGCATGACCGAGGAATTGCTGCCGCCGCAGGCGCTGCAGCTGA
TGAAGCCGGAATCGATCACGCCGGCGGTGGAGTATCTGCTCAGCGAGGACGCGCCCACCCGCACCATCATGGGCGCCGGC
GCCGGCTCGTTCGCGGTGATCAGGATCCTGGAGAGCGAGGGCGTCAACCTGCCGCCGGAGGAGTGGACGCCGGACGCAGT
GGCTGCGCATTTCGCCGAGATCAGCGACATGTCGAAGGCGCGGGCGCTGCAGGGTGCGTTCGAGCAGACGCAGAAATATG
TGTCGCAGGCTGCTGCGCGGCTGGGGATCAAGCTGTAA

Upstream 100 bases:

>100_bases
TCATTGCCGGGCTTGACCCGGCGATCCATCCACTTCTGAAAATGGGATGGATGCCGGGTCAAGCCCGGGCATGACGAGTG
CAGAACCGAGGACAAACATC

Downstream 100 bases:

>100_bases
GGCACAGTCGGCATCCCACACTCCACCGTCATGGCCGGGCTTGACCCGGCCATCCATCGTCTTTGGCACCATGGGCGTGG
AAAGGCGTGGATACCCGGGC

Product: putative 3-oxo-(acyl) acyl carrier protein reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MAIRFDGRVAIVTGAGNGLGRAHALGLASRGAKVVVNDFGGARDGTGGSMTAAETVVEEIRKAGGTAMADGADVSNFEQV
TAMAERATREWGSVDIMCANAGILRDKSFAKMEVADFAKVLDVHLVGSFYCCKAVWNGMRERNYGRIVLTTSSSGLFGNF
GQANYGAAKTGMVGLMNVLAEEGRKTNIRVNIISPTAATRMTEELLPPQALQLMKPESITPAVEYLLSEDAPTRTIMGAG
AGSFAVIRILESEGVNLPPEEWTPDAVAAHFAEISDMSKARALQGAFEQTQKYVSQAAARLGIKL

Sequences:

>Translated_305_residues
MAIRFDGRVAIVTGAGNGLGRAHALGLASRGAKVVVNDFGGARDGTGGSMTAAETVVEEIRKAGGTAMADGADVSNFEQV
TAMAERATREWGSVDIMCANAGILRDKSFAKMEVADFAKVLDVHLVGSFYCCKAVWNGMRERNYGRIVLTTSSSGLFGNF
GQANYGAAKTGMVGLMNVLAEEGRKTNIRVNIISPTAATRMTEELLPPQALQLMKPESITPAVEYLLSEDAPTRTIMGAG
AGSFAVIRILESEGVNLPPEEWTPDAVAAHFAEISDMSKARALQGAFEQTQKYVSQAAARLGIKL
>Mature_304_residues
AIRFDGRVAIVTGAGNGLGRAHALGLASRGAKVVVNDFGGARDGTGGSMTAAETVVEEIRKAGGTAMADGADVSNFEQVT
AMAERATREWGSVDIMCANAGILRDKSFAKMEVADFAKVLDVHLVGSFYCCKAVWNGMRERNYGRIVLTTSSSGLFGNFG
QANYGAAKTGMVGLMNVLAEEGRKTNIRVNIISPTAATRMTEELLPPQALQLMKPESITPAVEYLLSEDAPTRTIMGAGA
GSFAVIRILESEGVNLPPEEWTPDAVAAHFAEISDMSKARALQGAFEQTQKYVSQAAARLGIKL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=291, Percent_Identity=45.7044673539519, Blast_Score=241, Evalue=6e-64,
Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=33.969465648855, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI40254992, Length=199, Percent_Identity=33.1658291457286, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4503817, Length=224, Percent_Identity=26.7857142857143, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI210032110, Length=192, Percent_Identity=31.25, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI25282469, Length=262, Percent_Identity=27.4809160305344, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40807363, Length=231, Percent_Identity=30.3030303030303, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI109715829, Length=246, Percent_Identity=30.8943089430894, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI310128830, Length=199, Percent_Identity=28.1407035175879, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI310115468, Length=199, Percent_Identity=28.1407035175879, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4758504, Length=236, Percent_Identity=29.6610169491525, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI142976729, Length=176, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI32483357, Length=239, Percent_Identity=28.4518828451883, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=239, Percent_Identity=35.1464435146443, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787905, Length=235, Percent_Identity=32.7659574468085, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789208, Length=206, Percent_Identity=29.126213592233, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1789057, Length=218, Percent_Identity=32.1100917431193, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI87082100, Length=193, Percent_Identity=32.1243523316062, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790717, Length=206, Percent_Identity=28.1553398058252, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367175, Length=192, Percent_Identity=32.2916666666667, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI87082160, Length=206, Percent_Identity=30.5825242718447, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787526, Length=236, Percent_Identity=27.1186440677966, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788459, Length=200, Percent_Identity=29, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786812, Length=191, Percent_Identity=27.2251308900524, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=299, Percent_Identity=43.1438127090301, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI25147288, Length=241, Percent_Identity=30.7053941908714, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI193203117, Length=280, Percent_Identity=26.7857142857143, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17555706, Length=241, Percent_Identity=31.1203319502075, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193203115, Length=270, Percent_Identity=26.2962962962963, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17564282, Length=193, Percent_Identity=29.5336787564767, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=251, Percent_Identity=29.8804780876494, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17567345, Length=181, Percent_Identity=32.5966850828729, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=188, Percent_Identity=26.5957446808511, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71982365, Length=321, Percent_Identity=27.7258566978193, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=277, Percent_Identity=49.4584837545126, Blast_Score=256, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6324126, Length=193, Percent_Identity=28.4974093264249, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859837, Length=285, Percent_Identity=47.3684210526316, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI281364892, Length=220, Percent_Identity=29.0909090909091, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24639444, Length=235, Percent_Identity=32.3404255319149, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24640492, Length=198, Percent_Identity=28.2828282828283, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24649181, Length=194, Percent_Identity=29.3814432989691, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24581726, Length=222, Percent_Identity=26.1261261261261, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI116007236, Length=240, Percent_Identity=29.5833333333333, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI116007234, Length=241, Percent_Identity=29.045643153527, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21355631, Length=181, Percent_Identity=31.4917127071823, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648693, Length=250, Percent_Identity=29.2, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355889, Length=250, Percent_Identity=29.2, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356301, Length=192, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737361, Length=199, Percent_Identity=29.1457286432161, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21357673, Length=259, Percent_Identity=27.7992277992278, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571387, Length=161, Percent_Identity=29.8136645962733, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32240; Mature: 32109

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRFDGRVAIVTGAGNGLGRAHALGLASRGAKVVVNDFGGARDGTGGSMTAAETVVEEI
CEEEECCEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
RKAGGTAMADGADVSNFEQVTAMAERATREWGSVDIMCANAGILRDKSFAKMEVADFAKV
HHCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCHHHHHHHHHHHH
LDVHLVGSFYCCKAVWNGMRERNYGRIVLTTSSSGLFGNFGQANYGAAKTGMVGLMNVLA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
EEGRKTNIRVNIISPTAATRMTEELLPPQALQLMKPESITPAVEYLLSEDAPTRTIMGAG
HCCCCCEEEEEEECCHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEECC
AGSFAVIRILESEGVNLPPEEWTPDAVAAHFAEISDMSKARALQGAFEQTQKYVSQAAAR
CCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGIKL
HCCCC
>Mature Secondary Structure 
AIRFDGRVAIVTGAGNGLGRAHALGLASRGAKVVVNDFGGARDGTGGSMTAAETVVEEI
EEEECCEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
RKAGGTAMADGADVSNFEQVTAMAERATREWGSVDIMCANAGILRDKSFAKMEVADFAKV
HHCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCHHHHHHHHHHHH
LDVHLVGSFYCCKAVWNGMRERNYGRIVLTTSSSGLFGNFGQANYGAAKTGMVGLMNVLA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
EEGRKTNIRVNIISPTAATRMTEELLPPQALQLMKPESITPAVEYLLSEDAPTRTIMGAG
HCCCCCEEEEEEECCHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEECC
AGSFAVIRILESEGVNLPPEEWTPDAVAAHFAEISDMSKARALQGAFEQTQKYVSQAAAR
CCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGIKL
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]