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The map label for this gene is fadE12 [H]

Identifier: 146340111

GI number: 146340111

Start: 3321726

End: 3322892

Strand: Direct

Name: fadE12 [H]

Synonym: BRADO3126

Alternate gene names: 146340111

Gene position: 3321726-3322892 (Clockwise)

Preceding gene: 146340110

Following gene: 146340112

Centisome position: 44.55

GC content: 64.52

Gene sequence:

>1167_bases
ATGGATTTCGCGCTCTCCGCCAATCAGGAATCCATCCGCGATGCCGTCGCGAAAATCTGCGCGCGGTTCGACGACGCCTA
TTGGCTGAAGAAGGACAAGGAGGGCGGCTTTCCGGCCGACTTCCACAAGGCCATGGCCGACGCCGGCTGGCTCGGCATCT
GCATTCCGGAGGAATATGGCGGCTCAGGCCTCGGCATTCTCGATGCCGCGATCATGATGCGCACGATCGCGGAGTCGGGC
GCCGGAATGTCCGGCGCCTCCGCGATCCACATGAATGTGTTCGGGCTTAATCCGGTCGTCGTGTTCGGCACCAAGGAGCA
GCGCGCGCGGATGCTGCCCGGCATCGTCGACGGCAGCGAGAAGGCGTGCTTCGCGGTGACCGAGCCGAACACCGGACTCA
ACACCACGCAATTGAAGACCCGCGCGGTGCGCAAGGGCGACCGCTACGTCGTCAATGGGCAGAAGGTGTGGATCTCCACA
GCGCAGGTCGCCGAAAAAATCCTGCTGCTGGCGCGCACCACGCCGCTCGAGGAGGTGAAGCGCCCGACCCACGGGCTCAG
CCTGTTCTACACCGATTTCGATCGCAGCCGCATCAAGGTGCACGAGATCGAGAAGATGGGCCGCAAGCCGGTCGATTCCA
ACGAGCTGTTCTTCGAGGACTTCGAAATTCCCGTCGAGGATCGACTGGGCGAGGAGGGGCGGGGCTTCGACTACATCCTG
CACGGCATGAACCCCGAGCGGATCCTGATCGCCGCCGAGGCCGTCGGCCTCGGCCATCTCGCGCTGTTGCGCGCCTCGGC
CTATGCGCGGACGCGCAACGTGTTCAACCGCCCGATCGGCCAGAACCAGGGCGTCCAGCATCCCCTGGCCAAGAACTGGA
TGGAGCTCGAGGCAGCCTGGCTCATGGTGCTGCAGGCCGGCTGGCAATACGACCAGGGCATGGCCTGCGGCCCGGCCGCC
AACGCCGCAAAATTTCTCGCGGCAGAGGCCGGCTTCCACGCCTGCGAGCAGGCGGTGATGACCCACGGTGGCTTCGGCTA
TGCGCGCGAGTATCACGTCGAACGTTACCTGCGCGAATCCTTGATCCCCCGCATCGCGCCGATCAGCCCGCAACTGATCC
TGTCCTTCATCGCCGAGAAGGTGCTCGGCCTGCCGAAATCGTATTGA

Upstream 100 bases:

>100_bases
GGTCACGAGATCCTGCGCGAGCTCGGATTTTCGGCCGACGAGATCGCCGCGATGATCCGCGATGGCGCAACGATGCCGTC
GCCTCCCAAGGAGTGATCCA

Downstream 100 bases:

>100_bases
GATGTCGTCGTGAGATGAATTGCGCAGAAATGACGAACCACGCTGTAAGGGACGCACAACACCTGCATTCCCTCCCCCCT
GTGGGGGAGGGGCAGGGAGT

Product: putative acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MDFALSANQESIRDAVAKICARFDDAYWLKKDKEGGFPADFHKAMADAGWLGICIPEEYGGSGLGILDAAIMMRTIAESG
AGMSGASAIHMNVFGLNPVVVFGTKEQRARMLPGIVDGSEKACFAVTEPNTGLNTTQLKTRAVRKGDRYVVNGQKVWIST
AQVAEKILLLARTTPLEEVKRPTHGLSLFYTDFDRSRIKVHEIEKMGRKPVDSNELFFEDFEIPVEDRLGEEGRGFDYIL
HGMNPERILIAAEAVGLGHLALLRASAYARTRNVFNRPIGQNQGVQHPLAKNWMELEAAWLMVLQAGWQYDQGMACGPAA
NAAKFLAAEAGFHACEQAVMTHGGFGYAREYHVERYLRESLIPRIAPISPQLILSFIAEKVLGLPKSY

Sequences:

>Translated_388_residues
MDFALSANQESIRDAVAKICARFDDAYWLKKDKEGGFPADFHKAMADAGWLGICIPEEYGGSGLGILDAAIMMRTIAESG
AGMSGASAIHMNVFGLNPVVVFGTKEQRARMLPGIVDGSEKACFAVTEPNTGLNTTQLKTRAVRKGDRYVVNGQKVWIST
AQVAEKILLLARTTPLEEVKRPTHGLSLFYTDFDRSRIKVHEIEKMGRKPVDSNELFFEDFEIPVEDRLGEEGRGFDYIL
HGMNPERILIAAEAVGLGHLALLRASAYARTRNVFNRPIGQNQGVQHPLAKNWMELEAAWLMVLQAGWQYDQGMACGPAA
NAAKFLAAEAGFHACEQAVMTHGGFGYAREYHVERYLRESLIPRIAPISPQLILSFIAEKVLGLPKSY
>Mature_388_residues
MDFALSANQESIRDAVAKICARFDDAYWLKKDKEGGFPADFHKAMADAGWLGICIPEEYGGSGLGILDAAIMMRTIAESG
AGMSGASAIHMNVFGLNPVVVFGTKEQRARMLPGIVDGSEKACFAVTEPNTGLNTTQLKTRAVRKGDRYVVNGQKVWIST
AQVAEKILLLARTTPLEEVKRPTHGLSLFYTDFDRSRIKVHEIEKMGRKPVDSNELFFEDFEIPVEDRLGEEGRGFDYIL
HGMNPERILIAAEAVGLGHLALLRASAYARTRNVFNRPIGQNQGVQHPLAKNWMELEAAWLMVLQAGWQYDQGMACGPAA
NAAKFLAAEAGFHACEQAVMTHGGFGYAREYHVERYLRESLIPRIAPISPQLILSFIAEKVLGLPKSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI187960098, Length=343, Percent_Identity=31.4868804664723, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI4557231, Length=343, Percent_Identity=31.4868804664723, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI4557233, Length=335, Percent_Identity=34.0298507462687, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI7656849, Length=360, Percent_Identity=29.7222222222222, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI226958412, Length=368, Percent_Identity=27.445652173913, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4501859, Length=336, Percent_Identity=30.952380952381, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI226958414, Length=331, Percent_Identity=28.0966767371601, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI4501857, Length=357, Percent_Identity=29.6918767507003, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI21361497, Length=357, Percent_Identity=28.8515406162465, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI76496475, Length=345, Percent_Identity=28.4057971014493, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI4557235, Length=345, Percent_Identity=28.4057971014493, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=26.2430939226519, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4503943, Length=362, Percent_Identity=26.2430939226519, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI48976061, Length=311, Percent_Identity=24.4372990353698, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI211971008, Length=311, Percent_Identity=24.4372990353698, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI38505218, Length=304, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI87081958, Length=387, Percent_Identity=27.906976744186, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=27.6762402088773, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=32.010582010582, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17569725, Length=389, Percent_Identity=30.5912596401028, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17570075, Length=383, Percent_Identity=30.2872062663185, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17538396, Length=366, Percent_Identity=28.1420765027322, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=27.2486772486773, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17508101, Length=334, Percent_Identity=29.940119760479, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=29.0140845070423, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71990804, Length=284, Percent_Identity=30.6338028169014, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17533517, Length=353, Percent_Identity=25.7790368271955, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17505929, Length=336, Percent_Identity=28.2738095238095, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=26.5415549597855, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=28.5087719298246, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71985192, Length=290, Percent_Identity=27.5862068965517, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17534353, Length=343, Percent_Identity=23.0320699708455, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=23.4432234432234, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562446, Length=301, Percent_Identity=23.2558139534884, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356377, Length=355, Percent_Identity=32.112676056338, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24660351, Length=371, Percent_Identity=30.9973045822102, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=30.5851063829787, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24646207, Length=370, Percent_Identity=29.4594594594595, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI21355753, Length=333, Percent_Identity=28.8288288288288, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI281363737, Length=386, Percent_Identity=28.4974093264249, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI19920834, Length=320, Percent_Identity=25.625, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42791; Mature: 42791

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFALSANQESIRDAVAKICARFDDAYWLKKDKEGGFPADFHKAMADAGWLGICIPEEYG
CCCCCCCCHHHHHHHHHHHHHHCCCHHEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCC
GSGLGILDAAIMMRTIAESGAGMSGASAIHMNVFGLNPVVVFGTKEQRARMLPGIVDGSE
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEECCCHHHHHHCCCCCCCCC
KACFAVTEPNTGLNTTQLKTRAVRKGDRYVVNGQKVWISTAQVAEKILLLARTTPLEEVK
CEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCEEEEEHHHHHHHHHHHHCCCCHHHHC
RPTHGLSLFYTDFDRSRIKVHEIEKMGRKPVDSNELFFEDFEIPVEDRLGEEGRGFDYIL
CCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCCEEEE
HGMNPERILIAAEAVGLGHLALLRASAYARTRNVFNRPIGQNQGVQHPLAKNWMELEAAW
ECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LMVLQAGWQYDQGMACGPAANAAKFLAAEAGFHACEQAVMTHGGFGYAREYHVERYLRES
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LIPRIAPISPQLILSFIAEKVLGLPKSY
HCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDFALSANQESIRDAVAKICARFDDAYWLKKDKEGGFPADFHKAMADAGWLGICIPEEYG
CCCCCCCCHHHHHHHHHHHHHHCCCHHEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCC
GSGLGILDAAIMMRTIAESGAGMSGASAIHMNVFGLNPVVVFGTKEQRARMLPGIVDGSE
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEECCCHHHHHHCCCCCCCCC
KACFAVTEPNTGLNTTQLKTRAVRKGDRYVVNGQKVWISTAQVAEKILLLARTTPLEEVK
CEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCEEEEEHHHHHHHHHHHHCCCCHHHHC
RPTHGLSLFYTDFDRSRIKVHEIEKMGRKPVDSNELFFEDFEIPVEDRLGEEGRGFDYIL
CCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCCEEEE
HGMNPERILIAAEAVGLGHLALLRASAYARTRNVFNRPIGQNQGVQHPLAKNWMELEAAW
ECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LMVLQAGWQYDQGMACGPAANAAKFLAAEAGFHACEQAVMTHGGFGYAREYHVERYLRES
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LIPRIAPISPQLILSFIAEKVLGLPKSY
HCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]