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The map label for this gene is ilvD [H]

Identifier: 146339500

GI number: 146339500

Start: 2656715

End: 2658433

Strand: Direct

Name: ilvD [H]

Synonym: BRADO2489

Alternate gene names: 146339500

Gene position: 2656715-2658433 (Clockwise)

Preceding gene: 146339499

Following gene: 146339502

Centisome position: 35.63

GC content: 65.62

Gene sequence:

>1719_bases
ATGACCGATGGCCTGCGCAAGGGACTGACCGCTTACGGCGATGCCGGATTCTCGCTGTTCCTGCGCAAGGCGTTCATCAA
GGCGGCGGGCTATTCCGACGACGCGCTCGACCGTCCGATCGTCGGCATCACCAACACCTATAGCGACTACAATCCCTGCC
ACGGCAACGTGCCGCAGATCCTGGAGGCCGTGAAGCGCGGCGTCATGCTGTCGGGCGCGATGCCGTTCGTGTTTCCGACG
ATCTCGATCGCCGAAAGCTTTGCGCATCCGACCTCGATGTATCTGCGCAACCTGATGGCGATGGAAACCGAGGAGATGAT
CCGGGCCCAGCCGATGGACGCGGTGGTCGTCATCGGCGGCTGTGACAAGACCCTGCCCGCGCAGATCATGGCCGCAGTGT
CCGCCGATCTGCCGACAGTTGTTATTCCAGTCGGGCCGATGGTGGTCGGGCATCATAAGGGCGAGGTGCTCGGCGCCTGC
ACCGACTGTCGACGCCTGTGGGCCAAATATCGCGCTGGTGAAATGGACGACAGCGAGATCGAAGCGGTCAACGGCCGGCT
CGCGCCGTCGGTCGGCACCTGCATGGTGATGGGGACGGCCTCGACCATGGCCTGCATCACCGAGGCGCTCGGCCTTTCGC
TGCCGATGAGTGCGACGATTCCCGCACCGCATGCCGAACGCTTCCGCTCGGCCGAGGCCAGCGGCCGGGTCGCCGCGGAA
ATGGCTAAGGCGAAGGGGCCGAAGCCGAGCGAACTGCTGACGCCGGCCGCTTTCAAGAATGCCCAGGTGGTGCTGCAGGC
CATCGGCGGCTCGACCAACGGCCTCGTGCATCTCACCGCGATCGCCGGCCGTACGCCGCACACCATCGATCTCGACGCGT
TCGACCACATCGGGCGCGAGGTGCCGGTGCTGGTCGACCTCAAGCCATCCGGCGATCACTACATGGAGCATTTCCACCAT
GCCGGCGGCGTGCCGAAGCTGATGAAGCAGCTCGGCGATCTCATCGATCTCGACTGCCGCTCGATCACCGGCCAGTCGCT
CCGCGACATCGTTGCTGCAGCCGAGGAGGTGCCGGGCCAGGACGTCATCCGCTCGCGTGCCGACGCAATCAAACCTGAAG
GTGGCCTCGCTGTGTTGCGCGGCAATCTCGCGCCGCGCGGCGCGGTCATCAAGCATTCCGCGGCGAGCCCGAAGCTGCTG
CAGCACACCGGCCGCGCCGTCGTGTTCGAATCGGTCGAGGACATGACCTTGCGGGTCGACGATCCCGGCCTCGACGTTTC
GGCTGACGATGTGCTGGTGCTGCGGAACGCAGGACCGAAGGGTGCGCCGGGGATGCCGGAGGCGGGCTATTTGCCAATTC
CGAAAAAGCTCGCGCGCGGCGGCACCAAGGACATGGTGCGGATCTCCGATGCGCGCATGAGCGGCACGGCGTTCGGCACG
ATCGTGCTGCACATCACGCCGGAATCCGCGGTCGGCGGACCGCTGGCGCTGGTCAGGACCGGGGACATGATCCGGCTCGA
TGTCGCCAAGCGCCGCATCGACCTGCTCGTCGACGATGCCGAGCTCGATCGCCGGCGAGCCGCGCTGAAGCCTGCGACGA
CTCCGGACTGGGCCGAGCGCGGTTATGCGCATCTGTTTCATGAAACGATCCTGCAGGCCGACGACGGCTGCGATTTCGAT
TTCATGCGCCGGAAAGGGAAGGGACAAGGAAAAGGGTGA

Upstream 100 bases:

>100_bases
CGACTGGGGTTGATACGATCTCGCCGTTCCGGGGCCGGCGTGCCCCGGGACGGCGCTTGCGACAGACAAGAACAAGAATA
GAAGAAGAGACGGGACTGAC

Downstream 100 bases:

>100_bases
GCTCAGTCCTACTTTCCTTTGCTGGTGAACCGCTTCACAGCGGCACGGAATCCGTCGGTGTGCATGCAATTGATGATCGC
ATCGCGCTCGGCGCCGAGCT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MTDGLRKGLTAYGDAGFSLFLRKAFIKAAGYSDDALDRPIVGITNTYSDYNPCHGNVPQILEAVKRGVMLSGAMPFVFPT
ISIAESFAHPTSMYLRNLMAMETEEMIRAQPMDAVVVIGGCDKTLPAQIMAAVSADLPTVVIPVGPMVVGHHKGEVLGAC
TDCRRLWAKYRAGEMDDSEIEAVNGRLAPSVGTCMVMGTASTMACITEALGLSLPMSATIPAPHAERFRSAEASGRVAAE
MAKAKGPKPSELLTPAAFKNAQVVLQAIGGSTNGLVHLTAIAGRTPHTIDLDAFDHIGREVPVLVDLKPSGDHYMEHFHH
AGGVPKLMKQLGDLIDLDCRSITGQSLRDIVAAAEEVPGQDVIRSRADAIKPEGGLAVLRGNLAPRGAVIKHSAASPKLL
QHTGRAVVFESVEDMTLRVDDPGLDVSADDVLVLRNAGPKGAPGMPEAGYLPIPKKLARGGTKDMVRISDARMSGTAFGT
IVLHITPESAVGGPLALVRTGDMIRLDVAKRRIDLLVDDAELDRRRAALKPATTPDWAERGYAHLFHETILQADDGCDFD
FMRRKGKGQGKG

Sequences:

>Translated_572_residues
MTDGLRKGLTAYGDAGFSLFLRKAFIKAAGYSDDALDRPIVGITNTYSDYNPCHGNVPQILEAVKRGVMLSGAMPFVFPT
ISIAESFAHPTSMYLRNLMAMETEEMIRAQPMDAVVVIGGCDKTLPAQIMAAVSADLPTVVIPVGPMVVGHHKGEVLGAC
TDCRRLWAKYRAGEMDDSEIEAVNGRLAPSVGTCMVMGTASTMACITEALGLSLPMSATIPAPHAERFRSAEASGRVAAE
MAKAKGPKPSELLTPAAFKNAQVVLQAIGGSTNGLVHLTAIAGRTPHTIDLDAFDHIGREVPVLVDLKPSGDHYMEHFHH
AGGVPKLMKQLGDLIDLDCRSITGQSLRDIVAAAEEVPGQDVIRSRADAIKPEGGLAVLRGNLAPRGAVIKHSAASPKLL
QHTGRAVVFESVEDMTLRVDDPGLDVSADDVLVLRNAGPKGAPGMPEAGYLPIPKKLARGGTKDMVRISDARMSGTAFGT
IVLHITPESAVGGPLALVRTGDMIRLDVAKRRIDLLVDDAELDRRRAALKPATTPDWAERGYAHLFHETILQADDGCDFD
FMRRKGKGQGKG
>Mature_571_residues
TDGLRKGLTAYGDAGFSLFLRKAFIKAAGYSDDALDRPIVGITNTYSDYNPCHGNVPQILEAVKRGVMLSGAMPFVFPTI
SIAESFAHPTSMYLRNLMAMETEEMIRAQPMDAVVVIGGCDKTLPAQIMAAVSADLPTVVIPVGPMVVGHHKGEVLGACT
DCRRLWAKYRAGEMDDSEIEAVNGRLAPSVGTCMVMGTASTMACITEALGLSLPMSATIPAPHAERFRSAEASGRVAAEM
AKAKGPKPSELLTPAAFKNAQVVLQAIGGSTNGLVHLTAIAGRTPHTIDLDAFDHIGREVPVLVDLKPSGDHYMEHFHHA
GGVPKLMKQLGDLIDLDCRSITGQSLRDIVAAAEEVPGQDVIRSRADAIKPEGGLAVLRGNLAPRGAVIKHSAASPKLLQ
HTGRAVVFESVEDMTLRVDDPGLDVSADDVLVLRNAGPKGAPGMPEAGYLPIPKKLARGGTKDMVRISDARMSGTAFGTI
VLHITPESAVGGPLALVRTGDMIRLDVAKRRIDLLVDDAELDRRRAALKPATTPDWAERGYAHLFHETILQADDGCDFDF
MRRKGKGQGKG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=572, Percent_Identity=31.2937062937063, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1786464, Length=499, Percent_Identity=31.4629258517034, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI2367371, Length=460, Percent_Identity=32.6086956521739, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1788157, Length=516, Percent_Identity=31.0077519379845, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322476, Length=554, Percent_Identity=30.14440433213, Blast_Score=249, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 60878; Mature: 60747

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGLRKGLTAYGDAGFSLFLRKAFIKAAGYSDDALDRPIVGITNTYSDYNPCHGNVPQI
CCCHHHHCCHHHCCCHHHHHHHHHHHHHCCCCCCHHCCCCEEEECCCCCCCCCCCCHHHH
LEAVKRGVMLSGAMPFVFPTISIAESFAHPTSMYLRNLMAMETEEMIRAQPMDAVVVIGG
HHHHHCCEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
CDKTLPAQIMAAVSADLPTVVIPVGPMVVGHHKGEVLGACTDCRRLWAKYRAGEMDDSEI
CCCCHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
EAVNGRLAPSVGTCMVMGTASTMACITEALGLSLPMSATIPAPHAERFRSAEASGRVAAE
HHHCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCHHHHH
MAKAKGPKPSELLTPAAFKNAQVVLQAIGGSTNGLVHLTAIAGRTPHTIDLDAFDHIGRE
HHHCCCCCCHHHCCCHHHCCHHHHHHHHCCCCCCEEEEEEECCCCCCEEECHHHHHCCCC
VPVLVDLKPSGDHYMEHFHHAGGVPKLMKQLGDLIDLDCRSITGQSLRDIVAAAEEVPGQ
CCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCH
DVIRSRADAIKPEGGLAVLRGNLAPRGAVIKHSAASPKLLQHTGRAVVFESVEDMTLRVD
HHHHHHHHHCCCCCCEEEEECCCCCCCCEEECCCCCCHHHHHCCCEEEEECCCCCEEEEC
DPGLDVSADDVLVLRNAGPKGAPGMPEAGYLPIPKKLARGGTKDMVRISDARMSGTAFGT
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCEEEE
IVLHITPESAVGGPLALVRTGDMIRLDVAKRRIDLLVDDAELDRRRAALKPATTPDWAER
EEEEECCCCCCCCCEEEEECCCEEEEHHHHHHHHEEECCHHHHHHHHHCCCCCCCCHHHH
GYAHLFHETILQADDGCDFDFMRRKGKGQGKG
HHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDGLRKGLTAYGDAGFSLFLRKAFIKAAGYSDDALDRPIVGITNTYSDYNPCHGNVPQI
CCHHHHCCHHHCCCHHHHHHHHHHHHHCCCCCCHHCCCCEEEECCCCCCCCCCCCHHHH
LEAVKRGVMLSGAMPFVFPTISIAESFAHPTSMYLRNLMAMETEEMIRAQPMDAVVVIGG
HHHHHCCEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
CDKTLPAQIMAAVSADLPTVVIPVGPMVVGHHKGEVLGACTDCRRLWAKYRAGEMDDSEI
CCCCHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
EAVNGRLAPSVGTCMVMGTASTMACITEALGLSLPMSATIPAPHAERFRSAEASGRVAAE
HHHCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCHHHHH
MAKAKGPKPSELLTPAAFKNAQVVLQAIGGSTNGLVHLTAIAGRTPHTIDLDAFDHIGRE
HHHCCCCCCHHHCCCHHHCCHHHHHHHHCCCCCCEEEEEEECCCCCCEEECHHHHHCCCC
VPVLVDLKPSGDHYMEHFHHAGGVPKLMKQLGDLIDLDCRSITGQSLRDIVAAAEEVPGQ
CCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCH
DVIRSRADAIKPEGGLAVLRGNLAPRGAVIKHSAASPKLLQHTGRAVVFESVEDMTLRVD
HHHHHHHHHCCCCCCEEEEECCCCCCCCEEECCCCCCHHHHHCCCEEEEECCCCCEEEEC
DPGLDVSADDVLVLRNAGPKGAPGMPEAGYLPIPKKLARGGTKDMVRISDARMSGTAFGT
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCEEEE
IVLHITPESAVGGPLALVRTGDMIRLDVAKRRIDLLVDDAELDRRRAALKPATTPDWAER
EEEEECCCCCCCCCEEEEECCCEEEEHHHHHHHHEEECCHHHHHHHHHCCCCCCCCHHHH
GYAHLFHETILQADDGCDFDFMRRKGKGQGKG
HHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA