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The map label for this gene is ywrD [H]

Identifier: 146338941

GI number: 146338941

Start: 2005862

End: 2007511

Strand: Direct

Name: ywrD [H]

Synonym: BRADO1881

Alternate gene names: 146338941

Gene position: 2005862-2007511 (Clockwise)

Preceding gene: 146338937

Following gene: 146338942

Centisome position: 26.9

GC content: 67.33

Gene sequence:

>1650_bases
ATGTGCCATGTAGCCGGCCAGCACGGGCCGTCCGGCCCCAACGAGAGCACCCAGCGAGCCACGATGAGAAGCTTCCATTT
CCCCGGCAGGTCCACGGTCCACGCCCAGAACGGAATGATTGCCACCTCGCATCCGCAGGCGGCGCTGGCCGGAATCGAGG
TGCTGCGCGCCGGCGGCACCGCGGCCGACGCGGCGGTGGCCGCCTGCGCGCTGCTCGGCGTGATCGAGCCGCAGTCGACC
GGCATCGGCGGCGACTGCTTCGCGCTGGTGCAGCCGAAGGGCGAGGGCCGGATCCTGGCCTATAACGGCTCCGGCCGGGC
GCCGGCCGCGGCGACCGTCGACTGGTACCTCGAGCGCAAGATCCATTCGGTGCCGCTGACCTCGGCGCATGCCGTCTCCG
TGCCCGGCGCGATCGATGCCTGGGCGCGCATCCTGCACGACCATGGCCGCCTCGGCCTCGACCGGCTGCTGCAGCCGGCG
ATCCGCGCCGCCGAGGATGGCTATGTGGTGGCGCCGCGCGTCGCCTTCGACTGGAACAACCAGTTCGAGAAGCTCAAGAA
CGGCACCAATACCGCGCGCTACTTCCTGCCGCACGGCAAGGCCGCCGTCGCGGGCGACGTGATCCGTCAGCCGGAGCTGG
CGCAGACCTTGCGCGTCATCGCCAAGGAAGGTCCGAAGGGCTTTTATACCGGCGCGGTCGCCGAGGACATGGTGCAGACG
CTGCGCAGCATCGGCGGTCTGCATACTTTGGAGGACTTCGCCAACCATCAGACCGAGGTGACCTCGCCGATCGGCACCAC
CTACAAGGACTACGACGTCTGGCAGTGCCCTCCGAACGGCCCGGGCATCACCATGCTGGTCATGCTGAACATCCTCTCGC
GCTTCGATCTGACCCGCATCGCGCCGCTCAGCATCGAGCGCTTTCATCTCGAAGCGGAGGCCGCGCGCATCGCCTACATG
ATGCGCGAGCAGCACATCGGCGATCCCCAGCACATGACCACCGAGGTCGCGAGCATCCTCGCCAAGGAGTTCGCCGACGA
GTACATTTCGCAGATCAGCCTCGACAAGCTGCTGGACCTGCCGAACGTCGCGCCGCCGATGAACCCGGAGACGGTGTACA
TCACGGTGGTGGACCGCGACCGCAACGTCTGCTCCTTCATCAACTCGATCGCGCATTCGTTCGGCTCGGCGATCGTCTCC
AACGAGACCGGCGTGCTGCTGCAGAACCGCGCCGGCGGCTTCCGCATCCAGCCCGGCCATCCGAACTGCATCGGTCCGGG
CAAGCGCCCGCTGCACACCATCATCCCGGCGCTGGCCACCAAGGCTGGCCGCGCACAGATGTCGTTCGGCGTCATGGGCG
GCCAGTATCAGCCGGTCGGACAGACCCATGTGCTGACCAACATCCTCGACTATGGCTGCGACGTGCAGGAAGCGATCGAT
ATGGCGCGCGGTCTGCACTATGAAGGCGTCTATCAGCTCGAGGACGGTGTGCCGGCCGAGGTCGTCGAAGGCCTGCAGAA
GATCGGCCACAAGACCACCAAGGTGGTCTCGCCGCTTGGCGGCGGCCAGGCGATCTGGATCGACTGGGACAAGGGCACGC
TCACCGGCGGCTCCGACCCGCGCAAGGACGGCTGCGCGCTGGGGTATTGA

Upstream 100 bases:

>100_bases
ACTGATAGAGGGCGGCGACCGTCAGGGACATGCGGCCGTTTAGCAGCAGACCTGACCATAGAAAAGCTGGTATCCGCGGG
CATTGCCGAGGCCGGAAGGA

Downstream 100 bases:

>100_bases
GGCGGGCGCGTATGTCGTCACGCGCCGACCCGTACGGTGGGCAAAGGCGCGCCACGATCTATCGGGTGTGGCATGTTCTC
TCCCGCGCCGTGCCCACCGT

Product: putative gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MCHVAGQHGPSGPNESTQRATMRSFHFPGRSTVHAQNGMIATSHPQAALAGIEVLRAGGTAADAAVAACALLGVIEPQST
GIGGDCFALVQPKGEGRILAYNGSGRAPAAATVDWYLERKIHSVPLTSAHAVSVPGAIDAWARILHDHGRLGLDRLLQPA
IRAAEDGYVVAPRVAFDWNNQFEKLKNGTNTARYFLPHGKAAVAGDVIRQPELAQTLRVIAKEGPKGFYTGAVAEDMVQT
LRSIGGLHTLEDFANHQTEVTSPIGTTYKDYDVWQCPPNGPGITMLVMLNILSRFDLTRIAPLSIERFHLEAEAARIAYM
MREQHIGDPQHMTTEVASILAKEFADEYISQISLDKLLDLPNVAPPMNPETVYITVVDRDRNVCSFINSIAHSFGSAIVS
NETGVLLQNRAGGFRIQPGHPNCIGPGKRPLHTIIPALATKAGRAQMSFGVMGGQYQPVGQTHVLTNILDYGCDVQEAID
MARGLHYEGVYQLEDGVPAEVVEGLQKIGHKTTKVVSPLGGGQAIWIDWDKGTLTGGSDPRKDGCALGY

Sequences:

>Translated_549_residues
MCHVAGQHGPSGPNESTQRATMRSFHFPGRSTVHAQNGMIATSHPQAALAGIEVLRAGGTAADAAVAACALLGVIEPQST
GIGGDCFALVQPKGEGRILAYNGSGRAPAAATVDWYLERKIHSVPLTSAHAVSVPGAIDAWARILHDHGRLGLDRLLQPA
IRAAEDGYVVAPRVAFDWNNQFEKLKNGTNTARYFLPHGKAAVAGDVIRQPELAQTLRVIAKEGPKGFYTGAVAEDMVQT
LRSIGGLHTLEDFANHQTEVTSPIGTTYKDYDVWQCPPNGPGITMLVMLNILSRFDLTRIAPLSIERFHLEAEAARIAYM
MREQHIGDPQHMTTEVASILAKEFADEYISQISLDKLLDLPNVAPPMNPETVYITVVDRDRNVCSFINSIAHSFGSAIVS
NETGVLLQNRAGGFRIQPGHPNCIGPGKRPLHTIIPALATKAGRAQMSFGVMGGQYQPVGQTHVLTNILDYGCDVQEAID
MARGLHYEGVYQLEDGVPAEVVEGLQKIGHKTTKVVSPLGGGQAIWIDWDKGTLTGGSDPRKDGCALGY
>Mature_549_residues
MCHVAGQHGPSGPNESTQRATMRSFHFPGRSTVHAQNGMIATSHPQAALAGIEVLRAGGTAADAAVAACALLGVIEPQST
GIGGDCFALVQPKGEGRILAYNGSGRAPAAATVDWYLERKIHSVPLTSAHAVSVPGAIDAWARILHDHGRLGLDRLLQPA
IRAAEDGYVVAPRVAFDWNNQFEKLKNGTNTARYFLPHGKAAVAGDVIRQPELAQTLRVIAKEGPKGFYTGAVAEDMVQT
LRSIGGLHTLEDFANHQTEVTSPIGTTYKDYDVWQCPPNGPGITMLVMLNILSRFDLTRIAPLSIERFHLEAEAARIAYM
MREQHIGDPQHMTTEVASILAKEFADEYISQISLDKLLDLPNVAPPMNPETVYITVVDRDRNVCSFINSIAHSFGSAIVS
NETGVLLQNRAGGFRIQPGHPNCIGPGKRPLHTIIPALATKAGRAQMSFGVMGGQYQPVGQTHVLTNILDYGCDVQEAID
MARGLHYEGVYQLEDGVPAEVVEGLQKIGHKTTKVVSPLGGGQAIWIDWDKGTLTGGSDPRKDGCALGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=536, Percent_Identity=28.1716417910448, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI73915090, Length=536, Percent_Identity=28.1716417910448, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI73915096, Length=536, Percent_Identity=28.1716417910448, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI73915094, Length=536, Percent_Identity=28.1716417910448, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI113429324, Length=534, Percent_Identity=27.5280898876405, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI113429326, Length=539, Percent_Identity=27.0871985157699, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI109148539, Length=511, Percent_Identity=28.1800391389432, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI153266885, Length=535, Percent_Identity=27.1028037383178, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI153266901, Length=539, Percent_Identity=27.0871985157699, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI153266907, Length=534, Percent_Identity=26.2172284644195, Blast_Score=124, Evalue=3e-28,
Organism=Escherichia coli, GI1789856, Length=541, Percent_Identity=31.9778188539741, Blast_Score=265, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI17506189, Length=497, Percent_Identity=27.1629778672032, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI72000294, Length=506, Percent_Identity=25.8893280632411, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI212646519, Length=506, Percent_Identity=25.8893280632411, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17542894, Length=513, Percent_Identity=25.3411306042885, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI193208245, Length=566, Percent_Identity=23.6749116607774, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=566, Percent_Identity=23.6749116607774, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323330, Length=522, Percent_Identity=22.7969348659004, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161077880, Length=543, Percent_Identity=25.414364640884, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45551474, Length=543, Percent_Identity=25.414364640884, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI161077878, Length=543, Percent_Identity=25.414364640884, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24642670, Length=543, Percent_Identity=25.414364640884, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24642666, Length=543, Percent_Identity=25.414364640884, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI18859893, Length=520, Percent_Identity=25.7692307692308, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI18859741, Length=531, Percent_Identity=25.6120527306968, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI161077496, Length=501, Percent_Identity=25.748502994012, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58931; Mature: 58931

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCHVAGQHGPSGPNESTQRATMRSFHFPGRSTVHAQNGMIATSHPQAALAGIEVLRAGGT
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCHHHHHHHHHHHCCCC
AADAAVAACALLGVIEPQSTGIGGDCFALVQPKGEGRILAYNGSGRAPAAATVDWYLERK
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHH
IHSVPLTSAHAVSVPGAIDAWARILHDHGRLGLDRLLQPAIRAAEDGYVVAPRVAFDWNN
HHCCCCCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECEEEECCCH
QFEKLKNGTNTARYFLPHGKAAVAGDVIRQPELAQTLRVIAKEGPKGFYTGAVAEDMVQT
HHHHHHCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LRSIGGLHTLEDFANHQTEVTSPIGTTYKDYDVWQCPPNGPGITMLVMLNILSRFDLTRI
HHHHCCHHHHHHHHCCCCEECCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCHHC
APLSIERFHLEAEAARIAYMMREQHIGDPQHMTTEVASILAKEFADEYISQISLDKLLDL
CCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PNVAPPMNPETVYITVVDRDRNVCSFINSIAHSFGSAIVSNETGVLLQNRAGGFRIQPGH
CCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCC
PNCIGPGKRPLHTIIPALATKAGRAQMSFGVMGGQYQPVGQTHVLTNILDYGCDVQEAID
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHH
MARGLHYEGVYQLEDGVPAEVVEGLQKIGHKTTKVVSPLGGGQAIWIDWDKGTLTGGSDP
HHHCCCCCCEEEECCCCCHHHHHHHHHHCCHHHHHHCCCCCCEEEEEECCCCEECCCCCC
RKDGCALGY
CCCCCCCCC
>Mature Secondary Structure
MCHVAGQHGPSGPNESTQRATMRSFHFPGRSTVHAQNGMIATSHPQAALAGIEVLRAGGT
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCHHHHHHHHHHHCCCC
AADAAVAACALLGVIEPQSTGIGGDCFALVQPKGEGRILAYNGSGRAPAAATVDWYLERK
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHH
IHSVPLTSAHAVSVPGAIDAWARILHDHGRLGLDRLLQPAIRAAEDGYVVAPRVAFDWNN
HHCCCCCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECEEEECCCH
QFEKLKNGTNTARYFLPHGKAAVAGDVIRQPELAQTLRVIAKEGPKGFYTGAVAEDMVQT
HHHHHHCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LRSIGGLHTLEDFANHQTEVTSPIGTTYKDYDVWQCPPNGPGITMLVMLNILSRFDLTRI
HHHHCCHHHHHHHHCCCCEECCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCHHC
APLSIERFHLEAEAARIAYMMREQHIGDPQHMTTEVASILAKEFADEYISQISLDKLLDL
CCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PNVAPPMNPETVYITVVDRDRNVCSFINSIAHSFGSAIVSNETGVLLQNRAGGFRIQPGH
CCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCC
PNCIGPGKRPLHTIIPALATKAGRAQMSFGVMGGQYQPVGQTHVLTNILDYGCDVQEAID
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHH
MARGLHYEGVYQLEDGVPAEVVEGLQKIGHKTTKVVSPLGGGQAIWIDWDKGTLTGGSDP
HHHCCCCCCEEEECCCCCHHHHHHHHHHCCHHHHHHCCCCCCEEEEEECCCCEECCCCCC
RKDGCALGY
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]