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The map label for this gene is envZ [H]

Identifier: 146338494

GI number: 146338494

Start: 1511295

End: 1512647

Strand: Reverse

Name: envZ [H]

Synonym: BRADO1412

Alternate gene names: 146338494

Gene position: 1512647-1511295 (Counterclockwise)

Preceding gene: 146338495

Following gene: 146338490

Centisome position: 20.29

GC content: 69.62

Gene sequence:

>1353_bases
GTGCTCGGGCGTCTCGGCTTCGCCGGCCGGCTGATGGCGATCGTGCTGTTCGCGCTGATCGCGCTATGGGCGGCCGGCGT
CGGCTGGCTGTTCCTGAGCGAGTCGCGCCAGGAGATCCTGAGCCGGTTGTTTCCCGTGCCCGAGCAGATCAGCGCCATCG
TCCAGCTGATCGAAGCCGCCGGCCCCGCCGAACGCACGCTGATTCTCAAGGCCGTCAGCAGCGAACGCCTTCACGTGACG
CTGACCCAGGAACGCCCTGAAGCCTCGGCCGAGACCATGCGCCGGCCGCTCGCCGAGCATTTCTTCGCCCTGTATCTGCA
GTCGCTGCAGCCGCGCGACGTGATCGCATTGAGCCCGCGCGGCCGTCTGCCGCGCTGGCGCGACTGGCACCTCGGCGACT
ATTGGCGCAACATCAACCGTTCCGAGCGGTTCGCCGTGTCCTTGCGCGACCACGGCTACGTCGTGTTCGAAACCTTCGGT
GCGACCGGACCGCGGCTGTTCGGGCTGCCGCCGGGCTTCGGCGTCGGCCTGCTCGGCGCGCTGATCGGCATGGCCGCCGT
GATCGCGATCGCGCGCGAGGCGCGGCCGCTGCGCCAGCTCAGTCACTCGCTCGGCCGATTCAGCAGCGATGCCACCGTGG
CGCATGTGAAGCCGGCGGGCGCGCCGGAAATCCGCAAGCTGATCACGGCCGTGAACGACATGCAGACCCGGATCTCCGAG
CTGGTGCGCGGCCGCACCCTGCTGCTCGGCGCCGTCTCGCACGACCTCAAGACCTACATCACCCGGCTGCGGCTGCGCGC
CGAGCGCCTGCCCGAGCCGGAGCAGCGCGACAAGGCGGCGAGCGATCTCGACGAGATGACGCGGCTGCTGGAGGATGCAT
TGGCGGTCTCGCGCGGCGGCTTCGCGGCCATCCAGCGCCAGCCGGTCGATCTCGCCGCGATGCTCAGGGAGATCGTGGAG
GACCGGCGGCAGAGCGGCGCGCACATCAAGACCGAGCTCGGCGGCGAAGCGCTGACCGTTCTCGGCGAGCCGACCGCACT
GCGGCGCCTGTTCATCAATCTGATCGAGAATGCACTGCGCTTCGCGACGCGCTGCACGGTACGCGTGCTGCCTGACAGGG
CCGTCGTGATCGCCATCGACGACGACGGCCCGGGCATTCCGCCGAATGCCCGCAACGCGGTGTTCGAGCCGTTCTTCCGA
TTGGAGAACTCCCGCAGCCGCAGCACCGGTGGCAGCGGGCTCGGCCTCGCCATCGTCAAGCAGATCGCCGACGCGCATGG
TGCGCGCCTCGATCTCTCGACCTCGCCAGAAGGCGGCCTGCGGGTGCGCATCGCGTTTCCGCAGGCCTCCTAG

Upstream 100 bases:

>100_bases
GCTGCGCAAGAAGATCGAGCGCGACGGCGAGGAGGAGCTGATCAAGACGGTGCGCAGCGCCGGCTACATCTTCACCGGCT
CGGTCAAGGAGCTGTGAAAC

Downstream 100 bases:

>100_bases
ATCGGCTCAGCTTCCTTTGCGGTCGCGGAGCTGGGTGACGAACATGTCCTGCCAGCTCGCCGGCTTGACCTTGATCGAGC
CGACGCCGTGCATGAACTCG

Product: putative two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MLGRLGFAGRLMAIVLFALIALWAAGVGWLFLSESRQEILSRLFPVPEQISAIVQLIEAAGPAERTLILKAVSSERLHVT
LTQERPEASAETMRRPLAEHFFALYLQSLQPRDVIALSPRGRLPRWRDWHLGDYWRNINRSERFAVSLRDHGYVVFETFG
ATGPRLFGLPPGFGVGLLGALIGMAAVIAIAREARPLRQLSHSLGRFSSDATVAHVKPAGAPEIRKLITAVNDMQTRISE
LVRGRTLLLGAVSHDLKTYITRLRLRAERLPEPEQRDKAASDLDEMTRLLEDALAVSRGGFAAIQRQPVDLAAMLREIVE
DRRQSGAHIKTELGGEALTVLGEPTALRRLFINLIENALRFATRCTVRVLPDRAVVIAIDDDGPGIPPNARNAVFEPFFR
LENSRSRSTGGSGLGLAIVKQIADAHGARLDLSTSPEGGLRVRIAFPQAS

Sequences:

>Translated_450_residues
MLGRLGFAGRLMAIVLFALIALWAAGVGWLFLSESRQEILSRLFPVPEQISAIVQLIEAAGPAERTLILKAVSSERLHVT
LTQERPEASAETMRRPLAEHFFALYLQSLQPRDVIALSPRGRLPRWRDWHLGDYWRNINRSERFAVSLRDHGYVVFETFG
ATGPRLFGLPPGFGVGLLGALIGMAAVIAIAREARPLRQLSHSLGRFSSDATVAHVKPAGAPEIRKLITAVNDMQTRISE
LVRGRTLLLGAVSHDLKTYITRLRLRAERLPEPEQRDKAASDLDEMTRLLEDALAVSRGGFAAIQRQPVDLAAMLREIVE
DRRQSGAHIKTELGGEALTVLGEPTALRRLFINLIENALRFATRCTVRVLPDRAVVIAIDDDGPGIPPNARNAVFEPFFR
LENSRSRSTGGSGLGLAIVKQIADAHGARLDLSTSPEGGLRVRIAFPQAS
>Mature_450_residues
MLGRLGFAGRLMAIVLFALIALWAAGVGWLFLSESRQEILSRLFPVPEQISAIVQLIEAAGPAERTLILKAVSSERLHVT
LTQERPEASAETMRRPLAEHFFALYLQSLQPRDVIALSPRGRLPRWRDWHLGDYWRNINRSERFAVSLRDHGYVVFETFG
ATGPRLFGLPPGFGVGLLGALIGMAAVIAIAREARPLRQLSHSLGRFSSDATVAHVKPAGAPEIRKLITAVNDMQTRISE
LVRGRTLLLGAVSHDLKTYITRLRLRAERLPEPEQRDKAASDLDEMTRLLEDALAVSRGGFAAIQRQPVDLAAMLREIVE
DRRQSGAHIKTELGGEALTVLGEPTALRRLFINLIENALRFATRCTVRVLPDRAVVIAIDDDGPGIPPNARNAVFEPFFR
LENSRSRSTGGSGLGLAIVKQIADAHGARLDLSTSPEGGLRVRIAFPQAS

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=263, Percent_Identity=33.4600760456274, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=30.7692307692308, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788393, Length=271, Percent_Identity=29.1512915129151, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787894, Length=234, Percent_Identity=32.9059829059829, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1786783, Length=297, Percent_Identity=26.5993265993266, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=31.7460317460317, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790551, Length=271, Percent_Identity=28.7822878228782, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789403, Length=275, Percent_Identity=25.4545454545455, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786912, Length=255, Percent_Identity=29.0196078431373, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=25.3275109170306, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082128, Length=275, Percent_Identity=26.5454545454545, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790861, Length=283, Percent_Identity=28.6219081272085, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788549, Length=252, Percent_Identity=24.6031746031746, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=277, Percent_Identity=26.3537906137184, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49469; Mature: 49469

Theoretical pI: Translated: 10.82; Mature: 10.82

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGRLGFAGRLMAIVLFALIALWAAGVGWLFLSESRQEILSRLFPVPEQISAIVQLIEAA
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHEHHHHHHHHHHHCCCHHHHHHHHHHHHHC
GPAERTLILKAVSSERLHVTLTQERPEASAETMRRPLAEHFFALYLQSLQPRDVIALSPR
CCCHHEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GRLPRWRDWHLGDYWRNINRSERFAVSLRDHGYVVFETFGATGPRLFGLPPGFGVGLLGA
CCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCEEECCCCCCHHHHHHH
LIGMAAVIAIAREARPLRQLSHSLGRFSSDATVAHVKPAGAPEIRKLITAVNDMQTRISE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LVRGRTLLLGAVSHDLKTYITRLRLRAERLPEPEQRDKAASDLDEMTRLLEDALAVSRGG
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FAAIQRQPVDLAAMLREIVEDRRQSGAHIKTELGGEALTVLGEPTALRRLFINLIENALR
HHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHH
FATRCTVRVLPDRAVVIAIDDDGPGIPPNARNAVFEPFFRLENSRSRSTGGSGLGLAIVK
HHHHCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
QIADAHGARLDLSTSPEGGLRVRIAFPQAS
HHHHHCCCEEECCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MLGRLGFAGRLMAIVLFALIALWAAGVGWLFLSESRQEILSRLFPVPEQISAIVQLIEAA
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHEHHHHHHHHHHHCCCHHHHHHHHHHHHHC
GPAERTLILKAVSSERLHVTLTQERPEASAETMRRPLAEHFFALYLQSLQPRDVIALSPR
CCCHHEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GRLPRWRDWHLGDYWRNINRSERFAVSLRDHGYVVFETFGATGPRLFGLPPGFGVGLLGA
CCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCEEECCCCCCHHHHHHH
LIGMAAVIAIAREARPLRQLSHSLGRFSSDATVAHVKPAGAPEIRKLITAVNDMQTRISE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LVRGRTLLLGAVSHDLKTYITRLRLRAERLPEPEQRDKAASDLDEMTRLLEDALAVSRGG
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FAAIQRQPVDLAAMLREIVEDRRQSGAHIKTELGGEALTVLGEPTALRRLFINLIENALR
HHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHH
FATRCTVRVLPDRAVVIAIDDDGPGIPPNARNAVFEPFFRLENSRSRSTGGSGLGLAIVK
HHHHCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
QIADAHGARLDLSTSPEGGLRVRIAFPQAS
HHHHHCCCEEECCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]