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The map label for this gene is dnaX [H]

Identifier: 146337878

GI number: 146337878

Start: 808492

End: 810339

Strand: Direct

Name: dnaX [H]

Synonym: BRADO0763

Alternate gene names: 146337878

Gene position: 808492-810339 (Clockwise)

Preceding gene: 146337872

Following gene: 146337879

Centisome position: 10.84

GC content: 68.13

Gene sequence:

>1848_bases
ATGACTGACGTTGGCGCCCCACCTGTTCCGCCCGACAGCGCCGACGCTCCCCCCAAGCCCTACCGGGTTCTGGCGCGCAA
ATACCGCCCCTCCAGCTTCGCGGATCTGATCGGCCAGGAGGCCGTGGTGCGCACCGTCTCGAACGCGTTCGAGACCGGCC
GGATTCCGCAGGCCTGGATCCTCACCGGCGTCCGCGGGGTCGGCAAGACGACCACCGCCCGCATCCTTGCCCGCGCCCTG
AATTACGAGCTGCCCGACGGCTCGGTGAAGGGGCCGACCATCCACATGCCGGTGCTCGGCACCCATTGCCAGGCGATCAT
GGAAAGCCGGCACATGGACATCCTGGAGATGGATGCGGCGTCGCATACCGGCGTCGACGACGTTCGCCAGATCAATGACA
GCGTGCGCTACGCCCCGGCCAGCGCGCGCTACAAAGTCTACATCATCGACGAAGTCCACATGCTGTCGACGGCGGCGTTC
AACGCCTTCCTGAAGACGCTCGAGGAGCCGCCGGAGCACGCCAAATTCGTGTTCGCGACGACAGAAATCCGCAAGGTGCC
GGTGACGGTGTTGTCGCGCTGCCAGCGCTTCGATCTGCGCCGTGTCGAGGCCGACGTGCTGATGAAGCATCTCGCCGGCA
TCGCGACCAAGGAGGGCGTGACGATCGAGCCGGAGGCGCTCGGCATCATCGCGCGCGCCGCCGAGGGCTCCGTGCGCGAC
TCGCTGTCGCTGCTCGACCAGGCCATCGCGCATAGCGCAGGCGAGGTGCGTGCCGACGACGTCCGGCAGATGCTGGGCTT
GGCCGACCGGACCCGCGTGATCGATCTGTTTCATTATCTCGCGAGCGGCGACATCGCGGCCGCCTTCAAGGAATTCCGCG
AGCAATACGACGTCGGCGCCGATCCGGTCGTCGTGCTGTCGGATCTCGCCGAGTTCGTGAACTTCGTGACCCGCGTGAAG
GTCGTGCCGGCCACCGCCGACAACGTCGCGTTCAGCGAGACCGAGCGGCTGCGCGCGCGCGATTTCGCGACCAAGCTGTC
GATGCGCGTGCTGTCGCGGATGTGGCAGATGCTGCTCAAGGGCATCGCCGAGACGCAAGGCGCGACGCGTCCCGCGGCCG
CCGCGGAGATGGTGCTGGTGCGCATTGCCTATGCGGCCGATCTGCCGACGCCCGACGAAGCCATCCGCATGATCGACCAG
AACGGCGGTGGATCGCCTGTGGTCACGAATGGCGGCGGCGGACGCTCTGCGCCGGCGCCCAGCATGAGCACTGCGGCGCA
GCCGGTGATGAGTGCGGCGCCGATGCAGGCGCCGCGCATGCAGGGTCCGACGCTGGCCGCGGTCGGTGGCGGCATGAGGC
CGCAGGCGATGTCCTCGCAGCCGGCGTCGGCGTCGCACGAGCAGCCGGCCTTGCGGCTCGGCAGCTTCCAGGAGCTTGTC
GCCCTCGCAGCTAAGAATCGCGACCTCATCACCAAGAGCGCGCTCGAGATGGACGTCAGGCTCGTCCGTTTCGAGGACGG
CCGGCTGGAGATCGCGCTGGAACGGACGGCGCAGCGCGCGCTTGTGTCAGACCTCGGCCGCAAGCTGGAGGACTGGACCG
GCCGGCGCTGGACCGTGATCGTTTCCAACGAGCAGGGGCAGGCGACCCTCCGCGAGCAAAACCTGCGCGCCAAGAGCGAG
CGCGAGGCGGCGGCGGAAGCGGATCCGCGGGTGCAGGAGATCCTGGCGCGGTTTCCCGGCACGAAGGTGATCGAAGTGCG
CCGGCTCGCCCCCGAGCCGCCCGAATCGGACGCCAGTGCTGTCGAGCCGCCGGACGAGTTCGACTCCGACAATGATGATG
ACCTTTAA

Upstream 100 bases:

>100_bases
GCGGGCGCTCGACCGCACTCCGGCTGATTGCGTCGAGGCTGATGGCGTCGACGACCGCGATCGAAGGCCGGCCTGGAATG
TTTCACTTGCGGATCGCTCG

Downstream 100 bases:

>100_bases
GCTGATGACGAGGTGCTCCGATGGCTGACTTTCTCGGCATGATGAAACAGGCGGCGCAGCTGCAATCGAAGATGCAAGAG
ATGCAGGCCGAGCTCGGCAA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MTDVGAPPVPPDSADAPPKPYRVLARKYRPSSFADLIGQEAVVRTVSNAFETGRIPQAWILTGVRGVGKTTTARILARAL
NYELPDGSVKGPTIHMPVLGTHCQAIMESRHMDILEMDAASHTGVDDVRQINDSVRYAPASARYKVYIIDEVHMLSTAAF
NAFLKTLEEPPEHAKFVFATTEIRKVPVTVLSRCQRFDLRRVEADVLMKHLAGIATKEGVTIEPEALGIIARAAEGSVRD
SLSLLDQAIAHSAGEVRADDVRQMLGLADRTRVIDLFHYLASGDIAAAFKEFREQYDVGADPVVVLSDLAEFVNFVTRVK
VVPATADNVAFSETERLRARDFATKLSMRVLSRMWQMLLKGIAETQGATRPAAAAEMVLVRIAYAADLPTPDEAIRMIDQ
NGGGSPVVTNGGGGRSAPAPSMSTAAQPVMSAAPMQAPRMQGPTLAAVGGGMRPQAMSSQPASASHEQPALRLGSFQELV
ALAAKNRDLITKSALEMDVRLVRFEDGRLEIALERTAQRALVSDLGRKLEDWTGRRWTVIVSNEQGQATLREQNLRAKSE
REAAAEADPRVQEILARFPGTKVIEVRRLAPEPPESDASAVEPPDEFDSDNDDDL

Sequences:

>Translated_615_residues
MTDVGAPPVPPDSADAPPKPYRVLARKYRPSSFADLIGQEAVVRTVSNAFETGRIPQAWILTGVRGVGKTTTARILARAL
NYELPDGSVKGPTIHMPVLGTHCQAIMESRHMDILEMDAASHTGVDDVRQINDSVRYAPASARYKVYIIDEVHMLSTAAF
NAFLKTLEEPPEHAKFVFATTEIRKVPVTVLSRCQRFDLRRVEADVLMKHLAGIATKEGVTIEPEALGIIARAAEGSVRD
SLSLLDQAIAHSAGEVRADDVRQMLGLADRTRVIDLFHYLASGDIAAAFKEFREQYDVGADPVVVLSDLAEFVNFVTRVK
VVPATADNVAFSETERLRARDFATKLSMRVLSRMWQMLLKGIAETQGATRPAAAAEMVLVRIAYAADLPTPDEAIRMIDQ
NGGGSPVVTNGGGGRSAPAPSMSTAAQPVMSAAPMQAPRMQGPTLAAVGGGMRPQAMSSQPASASHEQPALRLGSFQELV
ALAAKNRDLITKSALEMDVRLVRFEDGRLEIALERTAQRALVSDLGRKLEDWTGRRWTVIVSNEQGQATLREQNLRAKSE
REAAAEADPRVQEILARFPGTKVIEVRRLAPEPPESDASAVEPPDEFDSDNDDDL
>Mature_614_residues
TDVGAPPVPPDSADAPPKPYRVLARKYRPSSFADLIGQEAVVRTVSNAFETGRIPQAWILTGVRGVGKTTTARILARALN
YELPDGSVKGPTIHMPVLGTHCQAIMESRHMDILEMDAASHTGVDDVRQINDSVRYAPASARYKVYIIDEVHMLSTAAFN
AFLKTLEEPPEHAKFVFATTEIRKVPVTVLSRCQRFDLRRVEADVLMKHLAGIATKEGVTIEPEALGIIARAAEGSVRDS
LSLLDQAIAHSAGEVRADDVRQMLGLADRTRVIDLFHYLASGDIAAAFKEFREQYDVGADPVVVLSDLAEFVNFVTRVKV
VPATADNVAFSETERLRARDFATKLSMRVLSRMWQMLLKGIAETQGATRPAAAAEMVLVRIAYAADLPTPDEAIRMIDQN
GGGSPVVTNGGGGRSAPAPSMSTAAQPVMSAAPMQAPRMQGPTLAAVGGGMRPQAMSSQPASASHEQPALRLGSFQELVA
LAAKNRDLITKSALEMDVRLVRFEDGRLEIALERTAQRALVSDLGRKLEDWTGRRWTVIVSNEQGQATLREQNLRAKSER
EAAAEADPRVQEILARFPGTKVIEVRRLAPEPPESDASAVEPPDEFDSDNDDDL

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=282, Percent_Identity=22.6950354609929, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI31881687, Length=282, Percent_Identity=22.6950354609929, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI31563534, Length=302, Percent_Identity=22.8476821192053, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786676, Length=374, Percent_Identity=40.9090909090909, Blast_Score=269, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17541988, Length=293, Percent_Identity=24.9146757679181, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=245, Percent_Identity=25.3061224489796, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322528, Length=315, Percent_Identity=22.5396825396825, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647857, Length=308, Percent_Identity=25.3246753246753, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI18859927, Length=319, Percent_Identity=24.1379310344828, Blast_Score=87, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 66821; Mature: 66690

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVGAPPVPPDSADAPPKPYRVLARKYRPSSFADLIGQEAVVRTVSNAFETGRIPQAWI
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LTGVRGVGKTTTARILARALNYELPDGSVKGPTIHMPVLGTHCQAIMESRHMDILEMDAA
HHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCEEEECCC
SHTGVDDVRQINDSVRYAPASARYKVYIIDEVHMLSTAAFNAFLKTLEEPPEHAKFVFAT
CCCCHHHHHHHHHHHEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
TEIRKVPVTVLSRCQRFDLRRVEADVLMKHLAGIATKEGVTIEPEALGIIARAAEGSVRD
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHCCCCHHH
SLSLLDQAIAHSAGEVRADDVRQMLGLADRTRVIDLFHYLASGDIAAAFKEFREQYDVGA
HHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
DPVVVLSDLAEFVNFVTRVKVVPATADNVAFSETERLRARDFATKLSMRVLSRMWQMLLK
CHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIAETQGATRPAAAAEMVLVRIAYAADLPTPDEAIRMIDQNGGGSPVVTNGGGGRSAPAP
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCC
SMSTAAQPVMSAAPMQAPRMQGPTLAAVGGGMRPQAMSSQPASASHEQPALRLGSFQELV
CHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHH
ALAAKNRDLITKSALEMDVRLVRFEDGRLEIALERTAQRALVSDLGRKLEDWTGRRWTVI
HHHHCCCHHHHHHHHHHCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VSNEQGQATLREQNLRAKSEREAAAEADPRVQEILARFPGTKVIEVRRLAPEPPESDASA
EECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
VEPPDEFDSDNDDDL
CCCCHHCCCCCCCCC
>Mature Secondary Structure 
TDVGAPPVPPDSADAPPKPYRVLARKYRPSSFADLIGQEAVVRTVSNAFETGRIPQAWI
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LTGVRGVGKTTTARILARALNYELPDGSVKGPTIHMPVLGTHCQAIMESRHMDILEMDAA
HHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCEEEECCC
SHTGVDDVRQINDSVRYAPASARYKVYIIDEVHMLSTAAFNAFLKTLEEPPEHAKFVFAT
CCCCHHHHHHHHHHHEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
TEIRKVPVTVLSRCQRFDLRRVEADVLMKHLAGIATKEGVTIEPEALGIIARAAEGSVRD
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHCCCCHHH
SLSLLDQAIAHSAGEVRADDVRQMLGLADRTRVIDLFHYLASGDIAAAFKEFREQYDVGA
HHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
DPVVVLSDLAEFVNFVTRVKVVPATADNVAFSETERLRARDFATKLSMRVLSRMWQMLLK
CHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIAETQGATRPAAAAEMVLVRIAYAADLPTPDEAIRMIDQNGGGSPVVTNGGGGRSAPAP
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCC
SMSTAAQPVMSAAPMQAPRMQGPTLAAVGGGMRPQAMSSQPASASHEQPALRLGSFQELV
CHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHH
ALAAKNRDLITKSALEMDVRLVRFEDGRLEIALERTAQRALVSDLGRKLEDWTGRRWTVI
HHHHCCCHHHHHHHHHHCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VSNEQGQATLREQNLRAKSEREAAAEADPRVQEILARFPGTKVIEVRRLAPEPPESDASA
EECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
VEPPDEFDSDNDDDL
CCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]