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The map label for this gene is algC [H]

Identifier: 146337872

GI number: 146337872

Start: 802600

End: 804099

Strand: Direct

Name: algC [H]

Synonym: BRADO0757

Alternate gene names: 146337872

Gene position: 802600-804099 (Clockwise)

Preceding gene: 146337871

Following gene: 146337878

Centisome position: 10.76

GC content: 63.13

Gene sequence:

>1500_bases
ATGTTCCCCAAGCCGAAACCCATCTTGGTCCCCAATACCTACGCCTTTGAATCCGAGCCGATGGTGAAGCCGACGGGCTT
CCGCGAATATGACGCGCGCTGGCTGTTCAACAAGGAAATCAACCTGATGGGGGTGCAGGCGCTCGGCATGGGGCTGGGCG
CGCTGATCGCGGAGCGCGGCGTGAGCCGAGAAATCGTGACCGGTCACGATTTCCGTGGCTACTCCGCCTCGATCAAATAC
GCGCTGATCTCGGGCCTGATGGCCGCCGGCTGCAAGGTGCACGACATCGGTCTTGCGGTGACACCCATGGCCTATTTCGC
GCAGTTCGAGCTCGATGTGCCCTGCGTCGCGATGGTGACCGCCTCGCATAATGACAACGGCTGGACCGGCGTTAAGATGG
GCGCCAATCGTCCGCTGACCTTTGGGCCGGAGGAAATGACACGGTTGAAAGAGATCGTGCTCAACGCCGAGTTCAAGAAC
ACGGGCGGCGGCTCGTATCAGTTCCACGAGAATTTCCCGGCGCGCTACATCGCCGATCTGACTAACCGTCCGAAACTGAA
GCGCAAGCTCAAGGTCGTCGCCGCCTGCGGCAACGGCACCGCGGGCGCGTTCGCGCCACAGGTGCTGGAGGCGATTGGCT
GCGAGGTGATCCCGCTCGACACCGAGCTCGATCACACCTTCCCGAAATACAATCCCAATCCCGAAGACATGGAGATGCTG
CACGCCATTCGCGACGCCGTACTCGCCCACAAGGCCGATGTCGGCCTCGGCTTCGACGGCGACGGCGACCGCTGTGGCGT
GGTCGACAACACCGGCGAGGAGATCTTCGCCGACAAGGTCGGCGTCATGCTGGCGCGCGACATGTCCGCGATCCACAAGG
ACGCGCAGTTCGTCGTCGACGTGAAATCAACCGGCCTGTTCATGACCGATCCGGTGCTGCAGGCGCAGGGCGCCAAGACC
GAATATTGGAAGACCGGCCATTCCTACATGAAGCGCCGGACCAACGAGCTCGGTGCGCTCGCGGGCTTCGAGAAGTCCGG
CCATTTCTTCTTCAACAAGCCGTTCGGTCGCGGCTATGATGACGGCCTCGTCTCGGCGATCGCGATCTGCGAGATGCTCG
ACCGCGCGCCGGGCAAGTCGATGGCCGACCTCAAGGAGGCCCTGCCCAAGACGTGGTCGTCGCCGACGATGTCGCCGCAT
TGCGGCGACGAGGTCAAATACGGCGTCGTCGACGCGGTGGTGAAGCATTTCCAGACGCTGCAGCAGCAGGGCGGCAAGGT
CGCCGGTCAATCGATCCGCGATCTCGTCACCGTCAACGGCGTGCGTGTCACGGTGGAGGACGGCAGCTGGGGCCTGGTGC
GCGCGTCATCCAACAAGCCGGAGCTCGTCGTCGTCGTCGAAAGCCCCGTGTCGGAGCAGCGCATGCACGACATGTTCGAG
GCGGTCAACGTCGTGCTGCGGACGCACCCCGAAGTGGGCGCCTATAATCAGACGATCTGA

Upstream 100 bases:

>100_bases
GCCTGCTTTCCTCTGCCTTTGTTGTATGACGTCTTTGTATGAAGCCGCGCGCCGCGCGACTGCACTGTTCCATTGATGTG
ATTTCCCGAGGCCCCTCCTT

Downstream 100 bases:

>100_bases
TACGCCAGGGCGAGCATGCCTCGCACGAGGCGCGCTCGCCTTTGTCCAGGCAATTCGGCGAACTAAGCGACCCGCAGCGA
TTTCAGGAACTGATCGACCT

Product: putative phosphomannomutase/phosphoglucomutase (PMM / PGM)

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MFPKPKPILVPNTYAFESEPMVKPTGFREYDARWLFNKEINLMGVQALGMGLGALIAERGVSREIVTGHDFRGYSASIKY
ALISGLMAAGCKVHDIGLAVTPMAYFAQFELDVPCVAMVTASHNDNGWTGVKMGANRPLTFGPEEMTRLKEIVLNAEFKN
TGGGSYQFHENFPARYIADLTNRPKLKRKLKVVAACGNGTAGAFAPQVLEAIGCEVIPLDTELDHTFPKYNPNPEDMEML
HAIRDAVLAHKADVGLGFDGDGDRCGVVDNTGEEIFADKVGVMLARDMSAIHKDAQFVVDVKSTGLFMTDPVLQAQGAKT
EYWKTGHSYMKRRTNELGALAGFEKSGHFFFNKPFGRGYDDGLVSAIAICEMLDRAPGKSMADLKEALPKTWSSPTMSPH
CGDEVKYGVVDAVVKHFQTLQQQGGKVAGQSIRDLVTVNGVRVTVEDGSWGLVRASSNKPELVVVVESPVSEQRMHDMFE
AVNVVLRTHPEVGAYNQTI

Sequences:

>Translated_499_residues
MFPKPKPILVPNTYAFESEPMVKPTGFREYDARWLFNKEINLMGVQALGMGLGALIAERGVSREIVTGHDFRGYSASIKY
ALISGLMAAGCKVHDIGLAVTPMAYFAQFELDVPCVAMVTASHNDNGWTGVKMGANRPLTFGPEEMTRLKEIVLNAEFKN
TGGGSYQFHENFPARYIADLTNRPKLKRKLKVVAACGNGTAGAFAPQVLEAIGCEVIPLDTELDHTFPKYNPNPEDMEML
HAIRDAVLAHKADVGLGFDGDGDRCGVVDNTGEEIFADKVGVMLARDMSAIHKDAQFVVDVKSTGLFMTDPVLQAQGAKT
EYWKTGHSYMKRRTNELGALAGFEKSGHFFFNKPFGRGYDDGLVSAIAICEMLDRAPGKSMADLKEALPKTWSSPTMSPH
CGDEVKYGVVDAVVKHFQTLQQQGGKVAGQSIRDLVTVNGVRVTVEDGSWGLVRASSNKPELVVVVESPVSEQRMHDMFE
AVNVVLRTHPEVGAYNQTI
>Mature_499_residues
MFPKPKPILVPNTYAFESEPMVKPTGFREYDARWLFNKEINLMGVQALGMGLGALIAERGVSREIVTGHDFRGYSASIKY
ALISGLMAAGCKVHDIGLAVTPMAYFAQFELDVPCVAMVTASHNDNGWTGVKMGANRPLTFGPEEMTRLKEIVLNAEFKN
TGGGSYQFHENFPARYIADLTNRPKLKRKLKVVAACGNGTAGAFAPQVLEAIGCEVIPLDTELDHTFPKYNPNPEDMEML
HAIRDAVLAHKADVGLGFDGDGDRCGVVDNTGEEIFADKVGVMLARDMSAIHKDAQFVVDVKSTGLFMTDPVLQAQGAKT
EYWKTGHSYMKRRTNELGALAGFEKSGHFFFNKPFGRGYDDGLVSAIAICEMLDRAPGKSMADLKEALPKTWSSPTMSPH
CGDEVKYGVVDAVVKHFQTLQQQGGKVAGQSIRDLVTVNGVRVTVEDGSWGLVRASSNKPELVVVVESPVSEQRMHDMFE
AVNVVLRTHPEVGAYNQTI

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=485, Percent_Identity=29.8969072164948, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1789566, Length=420, Percent_Identity=27.6190476190476, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 54513; Mature: 54513

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPKPKPILVPNTYAFESEPMVKPTGFREYDARWLFNKEINLMGVQALGMGLGALIAERG
CCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHCC
VSREIVTGHDFRGYSASIKYALISGLMAAGCKVHDIGLAVTPMAYFAQFELDVPCVAMVT
CCCEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCEEHHHHHHHHEECCCCCEEEEEE
ASHNDNGWTGVKMGANRPLTFGPEEMTRLKEIVLNAEFKNTGGGSYQFHENFPARYIADL
ECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHH
TNRPKLKRKLKVVAACGNGTAGAFAPQVLEAIGCEVIPLDTELDHTFPKYNPNPEDMEML
CCCHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHH
HAIRDAVLAHKADVGLGFDGDGDRCGVVDNTGEEIFADKVGVMLARDMSAIHKDAQFVVD
HHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
VKSTGLFMTDPVLQAQGAKTEYWKTGHSYMKRRTNELGALAGFEKSGHFFFNKPFGRGYD
ECCCCEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
DGLVSAIAICEMLDRAPGKSMADLKEALPKTWSSPTMSPHCGDEVKYGVVDAVVKHFQTL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QQQGGKVAGQSIRDLVTVNGVRVTVEDGSWGLVRASSNKPELVVVVESPVSEQRMHDMFE
HHCCCCCHHHHHHHHEEECCEEEEEECCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHH
AVNVVLRTHPEVGAYNQTI
HHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MFPKPKPILVPNTYAFESEPMVKPTGFREYDARWLFNKEINLMGVQALGMGLGALIAERG
CCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHCC
VSREIVTGHDFRGYSASIKYALISGLMAAGCKVHDIGLAVTPMAYFAQFELDVPCVAMVT
CCCEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCEEHHHHHHHHEECCCCCEEEEEE
ASHNDNGWTGVKMGANRPLTFGPEEMTRLKEIVLNAEFKNTGGGSYQFHENFPARYIADL
ECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHH
TNRPKLKRKLKVVAACGNGTAGAFAPQVLEAIGCEVIPLDTELDHTFPKYNPNPEDMEML
CCCHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHH
HAIRDAVLAHKADVGLGFDGDGDRCGVVDNTGEEIFADKVGVMLARDMSAIHKDAQFVVD
HHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
VKSTGLFMTDPVLQAQGAKTEYWKTGHSYMKRRTNELGALAGFEKSGHFFFNKPFGRGYD
ECCCCEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
DGLVSAIAICEMLDRAPGKSMADLKEALPKTWSSPTMSPHCGDEVKYGVVDAVVKHFQTL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QQQGGKVAGQSIRDLVTVNGVRVTVEDGSWGLVRASSNKPELVVVVESPVSEQRMHDMFE
HHCCCCCHHHHHHHHEEECCEEEEEECCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHH
AVNVVLRTHPEVGAYNQTI
HHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]