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The map label for this gene is cvrA [H]

Identifier: 146337840

GI number: 146337840

Start: 759604

End: 761397

Strand: Direct

Name: cvrA [H]

Synonym: BRADO0721

Alternate gene names: 146337840

Gene position: 759604-761397 (Clockwise)

Preceding gene: 146337836

Following gene: 146337845

Centisome position: 10.19

GC content: 67.39

Gene sequence:

>1794_bases
ATGACATCCCTCGACGCCGTCAGCATTGCCATTCTCCTTGGCGCGGTCCTGGTCATGGCTGGGATCCTGTCCAGCCTGCT
GGCGCTGCGCTTCGGCGCGCCGCTGCTGCTGGTGTTCCTGGTGATCGGCATGCTGGCGGGTGATTCCGGCCCTGGTCATA
TCGAATTTCAGGACGTCCGCACCACCTATCTGGTCGGCTCGGTCGCTCTGGCGCTGATTCTGTTCGACGGCGGCCTGCGC
ACGCGCTTTCAGAGCATCCGCACCGTGCTGGCGCCGTCGATGGTGCTCGCCACCATCGGCGTGCTGTTGACGGCGTTCAT
CACCGCGCCGGTGGCGAAATACGCGCTCGACCTCGACTGGACCGAGGCGATGCTGGTCGGCGCCGTCATCGCCTCGACAG
ACGCGGCCGCCGTGTTTCTGCTGGTGCATGCGCAGGGCCTGCGCCTGCGGCCGCGCGTCGGCGCGACGCTGGAAGCGGAA
TCCGGCAGCAATGATCCGTTCGCGGTGTTCCTGACCCTGATGCTGGTCGAGCTGATCTCGGTCGGCCACGGCAGCATCGG
CCATTTCCTGTTCGAGCTGGTGCGGGAGGCCGTGCTCGGCGCCCTGTTCGGCATCGTCGGCGGCCGTCTCGTGGTGATCG
GTCTCAACAAGGTCGCGCTGCCGCAGGGCCTGCACGCGCCCTTCGTCACGACGGCGGCGCTCGTCATCTTCGGCGCGGCG
CAGATCGCGCATGGCTCCGGCTTCCTCGCCGTCTATCTCGCCGGCATCATCATCGGCAACCGGCCGACGCGCGCACATAA
TTCGGTGGTCGCCTTTCTCGACGCCGCCACCTGGCTTGCGCAGATCGTGATGTTCGTGCTGCTCGGGCTGCTCGTGTCGC
CGCAGCGGCTGCTCGACAGCCTCCTGCCGGCGATTGCGGTGGCGCTGGTGCTGATGCTGGTCGCGCGCCCCGCCGCGGTG
TTTCTCTGCCTGCATCCGTTCCGGTTCAACTGGCGGGAGAAGGCGTTCATCGCCTGGACCGGCCTGCGCGGCGCGGTGGC
GATCTTCCTGGCGTCGATCCCGATGCTGGTCGGATTGTCCAAGGCCTATCTCTATTTCGACGTCGCCTTCGTCGTCGTCA
TCATCTCACTGCTGGCGCAGGGCTGGACGCTCGGCGTCGCCGCCCGCAAGCTGCACGTGGCGCTGCCGCGCACCGACCGC
GGGCCCCGCCGCGTCGAGCTCGATCTGCCCGGCCAGCTCGAGCAGCAGCTGGTCGGCTACTCGGTCCGCTCCAAGAGTCT
GTACTATCGCCGGGGCCTGATCCCGTCATGGTCCAAGCCGACGCTGGTGATCCGCAACCAGCAGATCCTGTCGCCTAACG
AGGCCGAGCCGATCGCGCCGGGGGATTACCTCTATCTGCTGGCGCCGCCTGAAAAGGCCGAGTCGCTCGACCGCTTCTTC
GTCGACATGCCGCCGTCGTCGTCGCCCGATCCGCATCTGCTCGGCGACTTCATGGTGTCGGCCGAGCACACGCTCGACGA
AGTCGCCGGCATCTACGGCGTCAAGCTCGGCGAGGGCGAGGACAAGCTGACCTTGGCGGATTACTTCGACATCCATCTCG
ACAACGCGCCGAAGGAAGGCTCCACCGTCGCGCTCGACACCATCGTGCTGGTCGCCCGCTCGATCTCCGGCGGCCGCGTC
AACGTCGTCGGCCTGCGCCTGCCCGAGGACGAGGAGCCGCAGCCGGTGCTGACACGCAAGGAGCAGGTGAGACGCAAGCT
CGCGGATGTGTGGGCGACGGTGGTAGGGGTGTGA

Upstream 100 bases:

>100_bases
GTGGAAAAATGGGCATATCGCCGCGATATGAGCAAATCCGGTTGGCGTGCAAGTGTGGCGACGATAAGGATGTAAAACTC
GGATCCATCAACGTTTTTTC

Downstream 100 bases:

>100_bases
AGACTGCAGTCTCGAGCTAATTCGCTTTTGGATCTACGTCTGCAAAGATTGCGACGATGTCCTGCCGCGCGTCGATGACA
CGGACGATCTGCGGCCCTTC

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MTSLDAVSIAILLGAVLVMAGILSSLLALRFGAPLLLVFLVIGMLAGDSGPGHIEFQDVRTTYLVGSVALALILFDGGLR
TRFQSIRTVLAPSMVLATIGVLLTAFITAPVAKYALDLDWTEAMLVGAVIASTDAAAVFLLVHAQGLRLRPRVGATLEAE
SGSNDPFAVFLTLMLVELISVGHGSIGHFLFELVREAVLGALFGIVGGRLVVIGLNKVALPQGLHAPFVTTAALVIFGAA
QIAHGSGFLAVYLAGIIIGNRPTRAHNSVVAFLDAATWLAQIVMFVLLGLLVSPQRLLDSLLPAIAVALVLMLVARPAAV
FLCLHPFRFNWREKAFIAWTGLRGAVAIFLASIPMLVGLSKAYLYFDVAFVVVIISLLAQGWTLGVAARKLHVALPRTDR
GPRRVELDLPGQLEQQLVGYSVRSKSLYYRRGLIPSWSKPTLVIRNQQILSPNEAEPIAPGDYLYLLAPPEKAESLDRFF
VDMPPSSSPDPHLLGDFMVSAEHTLDEVAGIYGVKLGEGEDKLTLADYFDIHLDNAPKEGSTVALDTIVLVARSISGGRV
NVVGLRLPEDEEPQPVLTRKEQVRRKLADVWATVVGV

Sequences:

>Translated_597_residues
MTSLDAVSIAILLGAVLVMAGILSSLLALRFGAPLLLVFLVIGMLAGDSGPGHIEFQDVRTTYLVGSVALALILFDGGLR
TRFQSIRTVLAPSMVLATIGVLLTAFITAPVAKYALDLDWTEAMLVGAVIASTDAAAVFLLVHAQGLRLRPRVGATLEAE
SGSNDPFAVFLTLMLVELISVGHGSIGHFLFELVREAVLGALFGIVGGRLVVIGLNKVALPQGLHAPFVTTAALVIFGAA
QIAHGSGFLAVYLAGIIIGNRPTRAHNSVVAFLDAATWLAQIVMFVLLGLLVSPQRLLDSLLPAIAVALVLMLVARPAAV
FLCLHPFRFNWREKAFIAWTGLRGAVAIFLASIPMLVGLSKAYLYFDVAFVVVIISLLAQGWTLGVAARKLHVALPRTDR
GPRRVELDLPGQLEQQLVGYSVRSKSLYYRRGLIPSWSKPTLVIRNQQILSPNEAEPIAPGDYLYLLAPPEKAESLDRFF
VDMPPSSSPDPHLLGDFMVSAEHTLDEVAGIYGVKLGEGEDKLTLADYFDIHLDNAPKEGSTVALDTIVLVARSISGGRV
NVVGLRLPEDEEPQPVLTRKEQVRRKLADVWATVVGV
>Mature_596_residues
TSLDAVSIAILLGAVLVMAGILSSLLALRFGAPLLLVFLVIGMLAGDSGPGHIEFQDVRTTYLVGSVALALILFDGGLRT
RFQSIRTVLAPSMVLATIGVLLTAFITAPVAKYALDLDWTEAMLVGAVIASTDAAAVFLLVHAQGLRLRPRVGATLEAES
GSNDPFAVFLTLMLVELISVGHGSIGHFLFELVREAVLGALFGIVGGRLVVIGLNKVALPQGLHAPFVTTAALVIFGAAQ
IAHGSGFLAVYLAGIIIGNRPTRAHNSVVAFLDAATWLAQIVMFVLLGLLVSPQRLLDSLLPAIAVALVLMLVARPAAVF
LCLHPFRFNWREKAFIAWTGLRGAVAIFLASIPMLVGLSKAYLYFDVAFVVVIISLLAQGWTLGVAARKLHVALPRTDRG
PRRVELDLPGQLEQQLVGYSVRSKSLYYRRGLIPSWSKPTLVIRNQQILSPNEAEPIAPGDYLYLLAPPEKAESLDRFFV
DMPPSSSPDPHLLGDFMVSAEHTLDEVAGIYGVKLGEGEDKLTLADYFDIHLDNAPKEGSTVALDTIVLVARSISGGRVN
VVGLRLPEDEEPQPVLTRKEQVRRKLADVWATVVGV

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=579, Percent_Identity=40.0690846286701, Blast_Score=339, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 63990; Mature: 63859

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLDAVSIAILLGAVLVMAGILSSLLALRFGAPLLLVFLVIGMLAGDSGPGHIEFQDVR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCEEEEHHH
TTYLVGSVALALILFDGGLRTRFQSIRTVLAPSMVLATIGVLLTAFITAPVAKYALDLDW
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TEAMLVGAVIASTDAAAVFLLVHAQGLRLRPRVGATLEAESGSNDPFAVFLTLMLVELIS
HHHHHHHHHHHCCCHHHEEHEEECCCCEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
VGHGSIGHFLFELVREAVLGALFGIVGGRLVVIGLNKVALPQGLHAPFVTTAALVIFGAA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
QIAHGSGFLAVYLAGIIIGNRPTRAHNSVVAFLDAATWLAQIVMFVLLGLLVSPQRLLDS
HHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LLPAIAVALVLMLVARPAAVFLCLHPFRFNWREKAFIAWTGLRGAVAIFLASIPMLVGLS
HHHHHHHHHHHHHHHCHHHEEHEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
KAYLYFDVAFVVVIISLLAQGWTLGVAARKLHVALPRTDRGPRRVELDLPGQLEQQLVGY
HHHHHHHHHHHHHHHHHHHCCCEEEHHHHEEEEECCCCCCCCCEEEECCCCHHHHHHHCH
SVRSKSLYYRRGLIPSWSKPTLVIRNQQILSPNEAEPIAPGDYLYLLAPPEKAESLDRFF
HHHCCCHHHHCCCCCCCCCCEEEEECCEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHE
VDMPPSSSPDPHLLGDFMVSAEHTLDEVAGIYGVKLGEGEDKLTLADYFDIHLDNAPKEG
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEEEEECCCCCCC
STVALDTIVLVARSISGGRVNVVGLRLPEDEEPQPVLTRKEQVRRKLADVWATVVGV
CEEHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSLDAVSIAILLGAVLVMAGILSSLLALRFGAPLLLVFLVIGMLAGDSGPGHIEFQDVR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCEEEEHHH
TTYLVGSVALALILFDGGLRTRFQSIRTVLAPSMVLATIGVLLTAFITAPVAKYALDLDW
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TEAMLVGAVIASTDAAAVFLLVHAQGLRLRPRVGATLEAESGSNDPFAVFLTLMLVELIS
HHHHHHHHHHHCCCHHHEEHEEECCCCEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
VGHGSIGHFLFELVREAVLGALFGIVGGRLVVIGLNKVALPQGLHAPFVTTAALVIFGAA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
QIAHGSGFLAVYLAGIIIGNRPTRAHNSVVAFLDAATWLAQIVMFVLLGLLVSPQRLLDS
HHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LLPAIAVALVLMLVARPAAVFLCLHPFRFNWREKAFIAWTGLRGAVAIFLASIPMLVGLS
HHHHHHHHHHHHHHHCHHHEEHEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
KAYLYFDVAFVVVIISLLAQGWTLGVAARKLHVALPRTDRGPRRVELDLPGQLEQQLVGY
HHHHHHHHHHHHHHHHHHHCCCEEEHHHHEEEEECCCCCCCCCEEEECCCCHHHHHHHCH
SVRSKSLYYRRGLIPSWSKPTLVIRNQQILSPNEAEPIAPGDYLYLLAPPEKAESLDRFF
HHHCCCHHHHCCCCCCCCCCEEEEECCEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHE
VDMPPSSSPDPHLLGDFMVSAEHTLDEVAGIYGVKLGEGEDKLTLADYFDIHLDNAPKEG
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEEEEECCCCCCC
STVALDTIVLVARSISGGRVNVVGLRLPEDEEPQPVLTRKEQVRRKLADVWATVVGV
CEEHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]