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The map label for this gene is cobT [H]

Identifier: 146337745

GI number: 146337745

Start: 642207

End: 644111

Strand: Direct

Name: cobT [H]

Synonym: BRADO0618

Alternate gene names: 146337745

Gene position: 642207-644111 (Clockwise)

Preceding gene: 146337744

Following gene: 146337746

Centisome position: 8.61

GC content: 67.61

Gene sequence:

>1905_bases
ATGACCACATCCAACAGCAAACTCCGTCCCGGTACCAAGGAAGCGCCGACCGAGCCGTTCAAGCGCTCGGTGACGGGGTG
CCTGCGCGCCATTGCGCGATCGCCCGAGCTCGAAGTCTCCTTCGCCGCCGAACGGCCGGGCCTTGCGCCGGGCAAGGCGC
GGCTGCCGGAGCCGGCGCGCAAGATGACGAAGCGTGACGCCGCTGTCGTGCGCGGCCATGCCGATTCGATCGCGCTGAAG
CTCGCCTGTCACGATCCGAAGATTCACCGCAAGCTGATCCCCGGCAATCCGCAGGCCCGCGGCGTGTTCGAGGCGGTCGA
GCAGGCCCGTGTCGAGGCGATCGGCGCCAAGCGCATGGCCGGCGTCGCCAAGAATCTCACCGCGATGCTCGACGATCACT
TCCATCGCGGCAAGTATGACGAGATCACCGACCGTGCCGACGCGCCGCTGTCGGATGCGCTGGCGATGCTGGTGCGCGAG
CGGCTGACCGGCATGGCGCCGCCGAACGCGGCGCGCAAGGTGGTCGATCTCTGGCGCCCGTTCCTGGAGGACCGGATCGG
CTCGCGGCTCGATGAACTCGGCCGCTTCACCGAGGATCAGGCCAAGTTCGGCGATCTCGTCCATGATCTCCTCTCGGCGC
TCGATCTCGGCGACGAGCGCAATGCCGACTCCGAGGAGGACGAGGACAACGACGACAACCGCGACGGTGACAATGACCAG
TCCGGCGCCGAGGGCTCGCCCGAGTCCGATGCCGCGCAGGAGATGAGTGCCGACCAGGCGCAGACGACCTCGGACGAGAT
GTCGGAGAGCGCGATGGAAGCCGCGCAGGCGTCCGCGTCCGACACGCTCGATGATGGCGAGCTCGGCGACGACGAGACGC
CGGGCGAGGCGACGCGGCCAAACCGCAGTGGCGCCAACGAGCCGCGCGGGCCCGAATATCACGCCTTCGCGCCGAAGTTC
GATGAGATCATCGCGGCTGAGGACCTCTGCGATCATGACGAGCTGGAGCGGCTGCGCTCCTATCTCGACAAGCAGCTCGC
GCATCTCCAGGGCATCGTGGCGCGGCTCGCCAACCGGCTGCAGCGGCGCCTGATGGCGCAGCAGAACCGCGCTTGGGAGT
TCGATCTCGAAGAGGGCATTCTCGATCCGGCGCGGCTGTCGCGCGTGGTCATCGATCCCTACCAGCCCCTGTCCTTCATG
CGCGAAAAGGAAGCGACCTTCCGCGACACCGTCGTCACGCTCTTGCTCGACAATTCCGGCTCGATGCGCGGCCGCCCTAT
CACGGTCGCCGCGACCTGCGCCGACATTCTCGCCCGCACGCTCGAGCGCTGCGGCGTCAAGGTCGAGATCCTCGGCTTCA
CGACGCGCGCGTGGAAGGGCGGGCAGTCGCGCGAGGCGTGGCTTGCCGCTGGCAAGCCGGCCAATCCCGGCCGCCTCAAC
GATCTCCGCCACATCATCTACAAGGCGGCCGACGCGCCGTGGCGCCGGGCTCGGAAGAATCTCGGCCTGATGATGCGCGA
GGGGCTGCTGAAGGAGAACATCGACGGCGAGGCGCTGGACTGGGCGCACAAGCGCCTGCTCGGCCGGCCCGAGCAGCGCA
AGATCCTGATGATGATCTCGGACGGCGCGCCGGTGGACGACTCCACGCTGTCGGTCAACCCCGGCAATTATCTGGAACGT
CACCTGCGTCACATCATCGAGGAGATCGAGACCCGCTCGCCGGTCGAGCTGATCGCGATCGGCATCGGTCATGACGTAAC
GCGCTATTATCGTCGCGCGGTGACGATCGTCGACGCCGAGGAGCTTGGCGGCGCGATCACCGAGAAGCTTGCCGAATTGT
TCACGGAGACGCACGCGGCGCCGCAGCAGCCGGCGCGCGCACCGAAGCGCAAGCTGCACTCGTAA

Upstream 100 bases:

>100_bases
ACGTTTCGGCGATGCGCCGGAGTTGGCTTCGACACGATGAGATGACCGCCGGTGGCTATGGGTCCCGGCGTTCGCCGGGA
CGACAGGCCGCAGGGACAAG

Downstream 100 bases:

>100_bases
GCCGGTCGGTCGATCGGACGCGTCCTCCTCCGCCCTTGAGGAGGTGGGGAAGGGGGCCCCGCCGACGATGACGCTGCAGG
CGATCGCCGACCGCAGGCGT

Product: aerobic cobaltochelatase subunit CobT

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobT [H]

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MTTSNSKLRPGTKEAPTEPFKRSVTGCLRAIARSPELEVSFAAERPGLAPGKARLPEPARKMTKRDAAVVRGHADSIALK
LACHDPKIHRKLIPGNPQARGVFEAVEQARVEAIGAKRMAGVAKNLTAMLDDHFHRGKYDEITDRADAPLSDALAMLVRE
RLTGMAPPNAARKVVDLWRPFLEDRIGSRLDELGRFTEDQAKFGDLVHDLLSALDLGDERNADSEEDEDNDDNRDGDNDQ
SGAEGSPESDAAQEMSADQAQTTSDEMSESAMEAAQASASDTLDDGELGDDETPGEATRPNRSGANEPRGPEYHAFAPKF
DEIIAAEDLCDHDELERLRSYLDKQLAHLQGIVARLANRLQRRLMAQQNRAWEFDLEEGILDPARLSRVVIDPYQPLSFM
REKEATFRDTVVTLLLDNSGSMRGRPITVAATCADILARTLERCGVKVEILGFTTRAWKGGQSREAWLAAGKPANPGRLN
DLRHIIYKAADAPWRRARKNLGLMMREGLLKENIDGEALDWAHKRLLGRPEQRKILMMISDGAPVDDSTLSVNPGNYLER
HLRHIIEEIETRSPVELIAIGIGHDVTRYYRRAVTIVDAEELGGAITEKLAELFTETHAAPQQPARAPKRKLHS

Sequences:

>Translated_634_residues
MTTSNSKLRPGTKEAPTEPFKRSVTGCLRAIARSPELEVSFAAERPGLAPGKARLPEPARKMTKRDAAVVRGHADSIALK
LACHDPKIHRKLIPGNPQARGVFEAVEQARVEAIGAKRMAGVAKNLTAMLDDHFHRGKYDEITDRADAPLSDALAMLVRE
RLTGMAPPNAARKVVDLWRPFLEDRIGSRLDELGRFTEDQAKFGDLVHDLLSALDLGDERNADSEEDEDNDDNRDGDNDQ
SGAEGSPESDAAQEMSADQAQTTSDEMSESAMEAAQASASDTLDDGELGDDETPGEATRPNRSGANEPRGPEYHAFAPKF
DEIIAAEDLCDHDELERLRSYLDKQLAHLQGIVARLANRLQRRLMAQQNRAWEFDLEEGILDPARLSRVVIDPYQPLSFM
REKEATFRDTVVTLLLDNSGSMRGRPITVAATCADILARTLERCGVKVEILGFTTRAWKGGQSREAWLAAGKPANPGRLN
DLRHIIYKAADAPWRRARKNLGLMMREGLLKENIDGEALDWAHKRLLGRPEQRKILMMISDGAPVDDSTLSVNPGNYLER
HLRHIIEEIETRSPVELIAIGIGHDVTRYYRRAVTIVDAEELGGAITEKLAELFTETHAAPQQPARAPKRKLHS
>Mature_633_residues
TTSNSKLRPGTKEAPTEPFKRSVTGCLRAIARSPELEVSFAAERPGLAPGKARLPEPARKMTKRDAAVVRGHADSIALKL
ACHDPKIHRKLIPGNPQARGVFEAVEQARVEAIGAKRMAGVAKNLTAMLDDHFHRGKYDEITDRADAPLSDALAMLVRER
LTGMAPPNAARKVVDLWRPFLEDRIGSRLDELGRFTEDQAKFGDLVHDLLSALDLGDERNADSEEDEDNDDNRDGDNDQS
GAEGSPESDAAQEMSADQAQTTSDEMSESAMEAAQASASDTLDDGELGDDETPGEATRPNRSGANEPRGPEYHAFAPKFD
EIIAAEDLCDHDELERLRSYLDKQLAHLQGIVARLANRLQRRLMAQQNRAWEFDLEEGILDPARLSRVVIDPYQPLSFMR
EKEATFRDTVVTLLLDNSGSMRGRPITVAATCADILARTLERCGVKVEILGFTTRAWKGGQSREAWLAAGKPANPGRLND
LRHIIYKAADAPWRRARKNLGLMMREGLLKENIDGEALDWAHKRLLGRPEQRKILMMISDGAPVDDSTLSVNPGNYLERH
LRHIIEEIETRSPVELIAIGIGHDVTRYYRRAVTIVDAEELGGAITEKLAELFTETHAAPQQPARAPKRKLHS

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG4547

COG function: function code H; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 VWFA domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006538
- InterPro:   IPR002035 [H]

Pfam domain/function: PF06213 CobT [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 70178; Mature: 70047

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50234 VWFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSNSKLRPGTKEAPTEPFKRSVTGCLRAIARSPELEVSFAAERPGLAPGKARLPEPAR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHH
KMTKRDAAVVRGHADSIALKLACHDPKIHRKLIPGNPQARGVFEAVEQARVEAIGAKRMA
HHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GVAKNLTAMLDDHFHRGKYDEITDRADAPLSDALAMLVRERLTGMAPPNAARKVVDLWRP
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FLEDRIGSRLDELGRFTEDQAKFGDLVHDLLSALDLGDERNADSEEDEDNDDNRDGDNDQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
SGAEGSPESDAAQEMSADQAQTTSDEMSESAMEAAQASASDTLDDGELGDDETPGEATRP
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NRSGANEPRGPEYHAFAPKFDEIIAAEDLCDHDELERLRSYLDKQLAHLQGIVARLANRL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRRLMAQQNRAWEFDLEEGILDPARLSRVVIDPYQPLSFMREKEATFRDTVVTLLLDNSG
HHHHHHHHCCCEECCHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEECCCC
SMRGRPITVAATCADILARTLERCGVKVEILGFTTRAWKGGQSREAWLAAGKPANPGRLN
CCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCCCHHEECCCCCCCCHHH
DLRHIIYKAADAPWRRARKNLGLMMREGLLKENIDGEALDWAHKRLLGRPEQRKILMMIS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEE
DGAPVDDSTLSVNPGNYLERHLRHIIEEIETRSPVELIAIGIGHDVTRYYRRAVTIVDAE
CCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHEECHH
ELGGAITEKLAELFTETHAAPQQPARAPKRKLHS
HHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
TTSNSKLRPGTKEAPTEPFKRSVTGCLRAIARSPELEVSFAAERPGLAPGKARLPEPAR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHH
KMTKRDAAVVRGHADSIALKLACHDPKIHRKLIPGNPQARGVFEAVEQARVEAIGAKRMA
HHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GVAKNLTAMLDDHFHRGKYDEITDRADAPLSDALAMLVRERLTGMAPPNAARKVVDLWRP
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FLEDRIGSRLDELGRFTEDQAKFGDLVHDLLSALDLGDERNADSEEDEDNDDNRDGDNDQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
SGAEGSPESDAAQEMSADQAQTTSDEMSESAMEAAQASASDTLDDGELGDDETPGEATRP
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NRSGANEPRGPEYHAFAPKFDEIIAAEDLCDHDELERLRSYLDKQLAHLQGIVARLANRL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRRLMAQQNRAWEFDLEEGILDPARLSRVVIDPYQPLSFMREKEATFRDTVVTLLLDNSG
HHHHHHHHCCCEECCHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEECCCC
SMRGRPITVAATCADILARTLERCGVKVEILGFTTRAWKGGQSREAWLAAGKPANPGRLN
CCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCCCHHEECCCCCCCCHHH
DLRHIIYKAADAPWRRARKNLGLMMREGLLKENIDGEALDWAHKRLLGRPEQRKILMMIS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEE
DGAPVDDSTLSVNPGNYLERHLRHIIEEIETRSPVELIAIGIGHDVTRYYRRAVTIVDAE
CCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHEECHH
ELGGAITEKLAELFTETHAAPQQPARAPKRKLHS
HHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]