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The map label for this gene is iorA [H]

Identifier: 146337593

GI number: 146337593

Start: 460382

End: 460816

Strand: Direct

Name: iorA [H]

Synonym: BRADO0449

Alternate gene names: 146337593

Gene position: 460382-460816 (Clockwise)

Preceding gene: 146337592

Following gene: 146337594

Centisome position: 6.17

GC content: 67.59

Gene sequence:

>435_bases
GTGAACGGCCGCGACCATGAGGTTGCGGTGGAGGCGGATACGCCGCTGCTCTGGGTGCTCCGGGACACGCTGGGGCTGAC
GGGGACCAAATATGGCTGCGGCATCGCGCAATGCGGCGCCTGCACGGTCATGATCGACGGTCAGGCGACGCGTTCGTGCC
AGGTTCCGATCGAGAGCATCGGCTCCGCCGAGATTCGCACCATCGAGGCGATCGAGCAGGATGCAACCGGCCGCAAGGTC
GTCGAGGCCTGGGTCGCCGACCAGGTGCCGCAATGCGGCTATTGCCAGTCCGGCCAGGTGATGGCCGCGACCGCGCTGCT
GACGCAAAATCCGAAGCCCTCTGACTCCGACATCGCCGACGCGATGACCAATCTCTGCCGTTGCGGCACCTACAACCGCA
TCGCCGCGGCGATCCGCCGCGCGGCGCAGGCCTGA

Upstream 100 bases:

>100_bases
CCATGTCCGAAACTGCCGGACTTTCGTCATCCGGTTGCGACGCAATTGCATGTAGCCTGTGCGCTTCCAATCGAGGTGCT
GTGCCATGACGACAATTCGC

Downstream 100 bases:

>100_bases
GGAGACCGGCTCATGAACGCGCTTCTCAAGACCGACCTCGCAAATGCGCTGCCGCTGCTGCGGCCGCAGGGCATCACCAA
TCTGTCGCGCCGCCGCCTGC

Product: isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MNGRDHEVAVEADTPLLWVLRDTLGLTGTKYGCGIAQCGACTVMIDGQATRSCQVPIESIGSAEIRTIEAIEQDATGRKV
VEAWVADQVPQCGYCQSGQVMAATALLTQNPKPSDSDIADAMTNLCRCGTYNRIAAAIRRAAQA

Sequences:

>Translated_144_residues
MNGRDHEVAVEADTPLLWVLRDTLGLTGTKYGCGIAQCGACTVMIDGQATRSCQVPIESIGSAEIRTIEAIEQDATGRKV
VEAWVADQVPQCGYCQSGQVMAATALLTQNPKPSDSDIADAMTNLCRCGTYNRIAAAIRRAAQA
>Mature_144_residues
MNGRDHEVAVEADTPLLWVLRDTLGLTGTKYGCGIAQCGACTVMIDGQATRSCQVPIESIGSAEIRTIEAIEQDATGRKV
VEAWVADQVPQCGYCQSGQVMAATALLTQNPKPSDSDIADAMTNLCRCGTYNRIAAAIRRAAQA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=156, Percent_Identity=36.5384615384615, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1786480, Length=158, Percent_Identity=35.4430379746835, Blast_Score=92, Evalue=1e-20,
Organism=Escherichia coli, GI1789232, Length=141, Percent_Identity=35.4609929078014, Blast_Score=79, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17540638, Length=149, Percent_Identity=40.2684563758389, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17539860, Length=150, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32566215, Length=150, Percent_Identity=34, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17737937, Length=147, Percent_Identity=36.734693877551, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24647197, Length=158, Percent_Identity=34.8101265822785, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24647195, Length=158, Percent_Identity=34.8101265822785, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15261; Mature: 15261

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
5.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
8.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGRDHEVAVEADTPLLWVLRDTLGLTGTKYGCGIAQCGACTVMIDGQATRSCQVPIESI
CCCCCCEEEEECCCCEEEEEHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHC
GSAEIRTIEAIEQDATGRKVVEAWVADQVPQCGYCQSGQVMAATALLTQNPKPSDSDIAD
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHCCCCCCCHHHHH
AMTNLCRCGTYNRIAAAIRRAAQA
HHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGRDHEVAVEADTPLLWVLRDTLGLTGTKYGCGIAQCGACTVMIDGQATRSCQVPIESI
CCCCCCEEEEECCCCEEEEEHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHC
GSAEIRTIEAIEQDATGRKVVEAWVADQVPQCGYCQSGQVMAATALLTQNPKPSDSDIAD
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHCCCCCCCHHHHH
AMTNLCRCGTYNRIAAAIRRAAQA
HHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]