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The map label for this gene is ubiB [C]

Identifier: 146337585

GI number: 146337585

Start: 452568

End: 453899

Strand: Direct

Name: ubiB [C]

Synonym: BRADO0441

Alternate gene names: 146337585

Gene position: 452568-453899 (Clockwise)

Preceding gene: 146337584

Following gene: 146337586

Centisome position: 6.07

GC content: 72.37

Gene sequence:

>1332_bases
ATGAGTTCGACCTCCGACCGTCCGTTGCCGCGCTTCTCCGCCGTGCCGTCGTCGCGGCCGGGGCGGCTGTTGCGGCTGGG
CGGGATCGCGGCGGGGATCGCGGGCGGGGTGGTGACGGACGGCTTGCGGCAGCTCGCACAGGGGCGGCGGCCCGGGTTGC
CGGAGCTGCTGCTGGCGCCGGCGCAGGCGATGCGGCTCGCCAGCGGGCTTGCCGGACTACGCGGCGCGGCGATGAAGCTC
GGCCAGATGCTGTCGCTGGATCCGGGACTTGTGCTGCCGAAAGAGGCCGCGGCGCTGCTGGCGCAGCTGCAGGAGGCGGC
GCCGCCGATGCCGCCGCCGCAGCTCGAGCGCGTGCTGGCGCGGGCCTGGGGGAGCGGCTGGCGCGCGCGCTTCAAGAGCT
TCGAGATGCGGCCGTTCGCGGCGGCTTCGATCGGCCAAGTGCACCGTGCCGTGACGTCGGACGGGCGGCGCCTCGCCATC
AAGGTGCAGTATCCCGGCGTCCGCGCCAGCATCGACAGCGACGTCGACAACATCGCCGCGCTGCTGCGCCTGCCCGGCCT
GCTGCCGCGCCAGATGGACATCTCGCCGCTGCTGTCCGCCGCCAAGGCGCAGCTGCACGCGGAGGCGGATTATGCCGCGG
AGGTCGCGCAGCTGCGCGCCTTCGGCGATTTTCTGCGCGACGATCCGCGCTTCGTGGTGCCTTCGCCGGTGACGGCGCTG
TCGACGCCGGAGGTGCTGGCGATGGATTTCGTCGACAGCCGGCCGATCGCGTCGCTGGCGACCGCTGCGCCGAACCAGCG
CGACGGCGCCATGACGGCGCTGATCGACCTGACCATGCGCGAACTGTTCGTGTTCGGCGCGATGCAGACCGATCCCAATC
CCGGCAATTTCCGCGTCACGCCGGACGGCACACGGATCGTACTGCTCGATTTCGGCGCCGTGCGGCCGATCGCGGCGGAG
CTGCAGGCCTCATTCCGCGCTCTGCTGGCGGCCGGGCTCGATGCGGACCGCGCAGCGAGCCGCGCCGCCATGCAGACCAT
CGGCTATTTCGACGCAGCGACGGCGCCGCGCCATCAGGACGCGATCGTCGACATGTTCCTGCGGGCGATGGCGCCGCTGC
GCCAGCGCGCGCCCTTCGATTTCGCGCGCCAGGACCTGCTGGCGGAGCTGCGCGACCGCGGCCTTGCGCTCGGCCTCGAT
CGCGACCTCATGCATGTGCCGCCGGCGGACACGCTGTTCCTCCACCGCAAGATCGGCGGGCTCTATCTGCTCGCGACGCA
GCTGCGCGCGAAGGTGGATTGCGCGGCCTGCGTCGCGCCGTACCGCGCATGA

Upstream 100 bases:

>100_bases
TGCGGGCCGCCCCCAGGGCATCACGCCGGATGGGAGAACTGGACGCAGGTTTCGCTCGTATTCTCTCCATGCACTGCCGC
CCGCCCTGGAGTTTCACCTG

Downstream 100 bases:

>100_bases
CGGGGAAGCTACCGATCGCCACCCGCGCGGCAGGGCTCGCGCGTTTGCAGACGGTGCTGCCGCGGCTCGGCCGCGCCTAT
GCGGCGGGACGCAACCATGA

Product: putative ABC1 protein (chaperonin)

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSSTSDRPLPRFSAVPSSRPGRLLRLGGIAAGIAGGVVTDGLRQLAQGRRPGLPELLLAPAQAMRLASGLAGLRGAAMKL
GQMLSLDPGLVLPKEAAALLAQLQEAAPPMPPPQLERVLARAWGSGWRARFKSFEMRPFAAASIGQVHRAVTSDGRRLAI
KVQYPGVRASIDSDVDNIAALLRLPGLLPRQMDISPLLSAAKAQLHAEADYAAEVAQLRAFGDFLRDDPRFVVPSPVTAL
STPEVLAMDFVDSRPIASLATAAPNQRDGAMTALIDLTMRELFVFGAMQTDPNPGNFRVTPDGTRIVLLDFGAVRPIAAE
LQASFRALLAAGLDADRAASRAAMQTIGYFDAATAPRHQDAIVDMFLRAMAPLRQRAPFDFARQDLLAELRDRGLALGLD
RDLMHVPPADTLFLHRKIGGLYLLATQLRAKVDCAACVAPYRA

Sequences:

>Translated_443_residues
MSSTSDRPLPRFSAVPSSRPGRLLRLGGIAAGIAGGVVTDGLRQLAQGRRPGLPELLLAPAQAMRLASGLAGLRGAAMKL
GQMLSLDPGLVLPKEAAALLAQLQEAAPPMPPPQLERVLARAWGSGWRARFKSFEMRPFAAASIGQVHRAVTSDGRRLAI
KVQYPGVRASIDSDVDNIAALLRLPGLLPRQMDISPLLSAAKAQLHAEADYAAEVAQLRAFGDFLRDDPRFVVPSPVTAL
STPEVLAMDFVDSRPIASLATAAPNQRDGAMTALIDLTMRELFVFGAMQTDPNPGNFRVTPDGTRIVLLDFGAVRPIAAE
LQASFRALLAAGLDADRAASRAAMQTIGYFDAATAPRHQDAIVDMFLRAMAPLRQRAPFDFARQDLLAELRDRGLALGLD
RDLMHVPPADTLFLHRKIGGLYLLATQLRAKVDCAACVAPYRA
>Mature_442_residues
SSTSDRPLPRFSAVPSSRPGRLLRLGGIAAGIAGGVVTDGLRQLAQGRRPGLPELLLAPAQAMRLASGLAGLRGAAMKLG
QMLSLDPGLVLPKEAAALLAQLQEAAPPMPPPQLERVLARAWGSGWRARFKSFEMRPFAAASIGQVHRAVTSDGRRLAIK
VQYPGVRASIDSDVDNIAALLRLPGLLPRQMDISPLLSAAKAQLHAEADYAAEVAQLRAFGDFLRDDPRFVVPSPVTALS
TPEVLAMDFVDSRPIASLATAAPNQRDGAMTALIDLTMRELFVFGAMQTDPNPGNFRVTPDGTRIVLLDFGAVRPIAAEL
QASFRALLAAGLDADRAASRAAMQTIGYFDAATAPRHQDAIVDMFLRAMAPLRQRAPFDFARQDLLAELRDRGLALGLDR
DLMHVPPADTLFLHRKIGGLYLLATQLRAKVDCAACVAPYRA

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=432, Percent_Identity=34.7222222222222, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI27363457, Length=378, Percent_Identity=34.3915343915344, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI217416386, Length=354, Percent_Identity=33.6158192090396, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI40254938, Length=300, Percent_Identity=31.6666666666667, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI217035081, Length=231, Percent_Identity=32.4675324675325, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI41393593, Length=305, Percent_Identity=29.5081967213115, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI2367309, Length=269, Percent_Identity=27.1375464684015, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32565180, Length=433, Percent_Identity=33.9491916859122, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17559152, Length=286, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321319, Length=426, Percent_Identity=35.4460093896714, Blast_Score=277, Evalue=3e-75,
Organism=Drosophila melanogaster, GI18859849, Length=421, Percent_Identity=34.4418052256532, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI22024280, Length=280, Percent_Identity=26.7857142857143, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24662575, Length=301, Percent_Identity=23.2558139534884, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 47418; Mature: 47286

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTSDRPLPRFSAVPSSRPGRLLRLGGIAAGIAGGVVTDGLRQLAQGRRPGLPELLLAP
CCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AQAMRLASGLAGLRGAAMKLGQMLSLDPGLVLPKEAAALLAQLQEAAPPMPPPQLERVLA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
RAWGSGWRARFKSFEMRPFAAASIGQVHRAVTSDGRRLAIKVQYPGVRASIDSDVDNIAA
HHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHH
LLRLPGLLPRQMDISPLLSAAKAQLHAEADYAAEVAQLRAFGDFLRDDPRFVVPSPVTAL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCC
STPEVLAMDFVDSRPIASLATAAPNQRDGAMTALIDLTMRELFVFGAMQTDPNPGNFRVT
CCCCCEEHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEC
PDGTRIVLLDFGAVRPIAAELQASFRALLAAGLDADRAASRAAMQTIGYFDAATAPRHQD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
AIVDMFLRAMAPLRQRAPFDFARQDLLAELRDRGLALGLDRDLMHVPPADTLFLHRKIGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHCC
LYLLATQLRAKVDCAACVAPYRA
HHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSTSDRPLPRFSAVPSSRPGRLLRLGGIAAGIAGGVVTDGLRQLAQGRRPGLPELLLAP
CCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AQAMRLASGLAGLRGAAMKLGQMLSLDPGLVLPKEAAALLAQLQEAAPPMPPPQLERVLA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
RAWGSGWRARFKSFEMRPFAAASIGQVHRAVTSDGRRLAIKVQYPGVRASIDSDVDNIAA
HHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHH
LLRLPGLLPRQMDISPLLSAAKAQLHAEADYAAEVAQLRAFGDFLRDDPRFVVPSPVTAL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCC
STPEVLAMDFVDSRPIASLATAAPNQRDGAMTALIDLTMRELFVFGAMQTDPNPGNFRVT
CCCCCEEHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEC
PDGTRIVLLDFGAVRPIAAELQASFRALLAAGLDADRAASRAAMQTIGYFDAATAPRHQD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
AIVDMFLRAMAPLRQRAPFDFARQDLLAELRDRGLALGLDRDLMHVPPADTLFLHRKIGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHCC
LYLLATQLRAKVDCAACVAPYRA
HHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]