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The map label for this gene is atpA [H]

Identifier: 146337562

GI number: 146337562

Start: 426612

End: 428141

Strand: Direct

Name: atpA [H]

Synonym: BRADO0417

Alternate gene names: 146337562

Gene position: 426612-428141 (Clockwise)

Preceding gene: 146337561

Following gene: 146337563

Centisome position: 5.72

GC content: 65.82

Gene sequence:

>1530_bases
ATGGACATCCGCGCCGCGGAAATTTCCGCGATCCTCAAGGACCAGATCAAGAATTTCGGGCAGGAAGCCGAAGTCACCGA
AGTCGGGCAGGTGCTGTCCGTCGGTGACGGTATCGCCCGCGTCTACGGTCTCGACAACGTCCAGGCCGGTGAAATGGTCG
AGTTCGAGAACGGCACCCGCGGCATGGCGCTGAACCTCGAGACCGACAATGTCGGCGTCGTCATCTTCGGCGCCGACCGC
GAGATCAAGGAAGGCCAGACCGTCAAGCGCACCCGCGCCATCGTCGACGCGCCCGTCGGCAAGGGCCTGCTCGGCCGCGT
CGTCGACGCCCTCGGCAACCCGATCGACGGCAAGGGCCCGATCCAGTTCACCGAGCGCAAGCGCGTCGACGTCAAGGCGC
CCGGCATCATTCCGCGCAAGTCGGTCAACGAGCCGATGGCCACCGGCCTGAAGGCGATCGACGCCCTGATCCCGATCGGC
CGCGGCCAGCGCGAGCTGATCATCGGCGACCGTCAGACCGGCAAGACCGCGATCGCGCTCGACACCATCCTGAACCAGAA
GCCGCTCAACGCCCAGCCTGACGAGAAGATCAAGCTGTACTGCGTCTATGTGGCCGTCGGTCAGAAGCGTTCGACCGTCG
CCCAGTTCGTGAAGGTGCTGGAAGAGCAGGGCGCGCTGGAATACTCGATCGTGGTCGCCGCGACCGCGTCCGATCCGGCC
CCGATGCAGTACCTGGCGCCGTTCACCGGCTGCACCATGGGCGAGTACTTCCGCGACAACGGCATGCACGCCGTCATCAT
CTATGACGACCTCTCCAAGCAGGCCGTCGCCTACCGCCAGATGTCGCTGCTGCTGCGCCGTCCGCCGGGCCGCGAGGCCT
ATCCGGGCGACGTGTTCTACCTGCACTCCCGCCTGCTCGAGCGCGCCGCCAAGCTGAACGAGACCCAGGGTGCGGGCTCG
CTGACCGCTCTGCCAGTCATCGAAACCCAGGCCAACGACGTGTCGGCCTACATCCCGACCAACGTCATCTCGATCACCGA
CGGCCAGATCTTCCTGGAAACCGACCTGTTCTTCCAGGGCATCCGCCCCGCCGTGAACGTCGGTCTGTCGGTGTCGCGCG
TCGGCTCGTCGGCGCAGACCAAGGCGATGAAGAAGGTCGCCGGCAAGATCAAGGGCGAGCTGGCGCAGTACCGCGAAATG
GCGGCCTTCGCCCAGTTCGGCTCCGACCTCGACGCGGCGACCCAGCGCCTGCTGAACCGCGGCTCGCGCCTGACCGAGCT
CCTGAAACAGCCGCAGTTCTCGCCGCTGAAGATGGAAGAGCAGGTGTGCGTGATCTGGGCCGGCACCAACGGCTTCCTCG
ACGGTCTTCCGCTCAACAAGGTCCGCGCCTTCGAGGACGGCCTGCTGTCGCTGCTGCGCGGCAAGCACGCCGACCTCTTG
AACACGATCCGCGACACGCGCGATCTGTCGGATGACAGCGCGGCCAAGCTGAAGGCTGCGGTCGAAGGTTTTGCCAAGAC
CTTCTCCTGA

Upstream 100 bases:

>100_bases
TTATCGGCGGGCTCGTCGTCAAGCTCGGCAGCCGCATGATCGATAGTTCGCTTCGCACCAAACTCAACTCGATCAAGCAC
GCGATGAAAGAGGCAGGCTG

Downstream 100 bases:

>100_bases
TCCGACCGGGAGGCGGTGGCCGGCATGCCAGGCCACCCCACGTCATCAGACGTGGACCAAGACGTCACGCCAGGCGCACG
GCCTGGCGCTTAGGGATTAG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MDIRAAEISAILKDQIKNFGQEAEVTEVGQVLSVGDGIARVYGLDNVQAGEMVEFENGTRGMALNLETDNVGVVIFGADR
EIKEGQTVKRTRAIVDAPVGKGLLGRVVDALGNPIDGKGPIQFTERKRVDVKAPGIIPRKSVNEPMATGLKAIDALIPIG
RGQRELIIGDRQTGKTAIALDTILNQKPLNAQPDEKIKLYCVYVAVGQKRSTVAQFVKVLEEQGALEYSIVVAATASDPA
PMQYLAPFTGCTMGEYFRDNGMHAVIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNETQGAGS
LTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFFQGIRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYREM
AAFAQFGSDLDAATQRLLNRGSRLTELLKQPQFSPLKMEEQVCVIWAGTNGFLDGLPLNKVRAFEDGLLSLLRGKHADLL
NTIRDTRDLSDDSAAKLKAAVEGFAKTFS

Sequences:

>Translated_509_residues
MDIRAAEISAILKDQIKNFGQEAEVTEVGQVLSVGDGIARVYGLDNVQAGEMVEFENGTRGMALNLETDNVGVVIFGADR
EIKEGQTVKRTRAIVDAPVGKGLLGRVVDALGNPIDGKGPIQFTERKRVDVKAPGIIPRKSVNEPMATGLKAIDALIPIG
RGQRELIIGDRQTGKTAIALDTILNQKPLNAQPDEKIKLYCVYVAVGQKRSTVAQFVKVLEEQGALEYSIVVAATASDPA
PMQYLAPFTGCTMGEYFRDNGMHAVIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNETQGAGS
LTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFFQGIRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYREM
AAFAQFGSDLDAATQRLLNRGSRLTELLKQPQFSPLKMEEQVCVIWAGTNGFLDGLPLNKVRAFEDGLLSLLRGKHADLL
NTIRDTRDLSDDSAAKLKAAVEGFAKTFS
>Mature_509_residues
MDIRAAEISAILKDQIKNFGQEAEVTEVGQVLSVGDGIARVYGLDNVQAGEMVEFENGTRGMALNLETDNVGVVIFGADR
EIKEGQTVKRTRAIVDAPVGKGLLGRVVDALGNPIDGKGPIQFTERKRVDVKAPGIIPRKSVNEPMATGLKAIDALIPIG
RGQRELIIGDRQTGKTAIALDTILNQKPLNAQPDEKIKLYCVYVAVGQKRSTVAQFVKVLEEQGALEYSIVVAATASDPA
PMQYLAPFTGCTMGEYFRDNGMHAVIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNETQGAGS
LTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFFQGIRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYREM
AAFAQFGSDLDAATQRLLNRGSRLTELLKQPQFSPLKMEEQVCVIWAGTNGFLDGLPLNKVRAFEDGLLSLLRGKHADLL
NTIRDTRDLSDDSAAKLKAAVEGFAKTFS

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=503, Percent_Identity=71.5705765407555, Blast_Score=731, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=503, Percent_Identity=71.5705765407555, Blast_Score=731, Evalue=0.0,
Organism=Homo sapiens, GI19913428, Length=358, Percent_Identity=27.6536312849162, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI19913426, Length=361, Percent_Identity=28.5318559556787, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI32189394, Length=392, Percent_Identity=25, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI19913424, Length=248, Percent_Identity=26.6129032258064, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790172, Length=520, Percent_Identity=55.7692307692308, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1790170, Length=408, Percent_Identity=25, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788251, Length=340, Percent_Identity=27.0588235294118, Blast_Score=102, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=503, Percent_Identity=70.3777335984095, Blast_Score=725, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=503, Percent_Identity=70.3777335984095, Blast_Score=723, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=503, Percent_Identity=65.2087475149105, Blast_Score=658, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17510931, Length=305, Percent_Identity=30.1639344262295, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17570191, Length=333, Percent_Identity=28.5285285285285, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71988068, Length=76, Percent_Identity=56.578947368421, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25144756, Length=393, Percent_Identity=24.4274809160305, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=64, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565854, Length=271, Percent_Identity=25.4612546125461, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=502, Percent_Identity=70.1195219123506, Blast_Score=729, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=368, Percent_Identity=29.8913043478261, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322581, Length=379, Percent_Identity=25.065963060686, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=70.2970297029703, Blast_Score=719, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=301, Percent_Identity=30.2325581395349, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24646341, Length=301, Percent_Identity=30.2325581395349, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17136796, Length=301, Percent_Identity=30.2325581395349, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24638766, Length=428, Percent_Identity=24.2990654205607, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28574560, Length=427, Percent_Identity=24.824355971897, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24583992, Length=351, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583988, Length=248, Percent_Identity=25.4032258064516, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583986, Length=248, Percent_Identity=25.4032258064516, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583984, Length=248, Percent_Identity=25.4032258064516, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129479, Length=250, Percent_Identity=28, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55196; Mature: 55196

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRAAEISAILKDQIKNFGQEAEVTEVGQVLSVGDGIARVYGLDNVQAGEMVEFENGTR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCEEEECCCCC
GMALNLETDNVGVVIFGADREIKEGQTVKRTRAIVDAPVGKGLLGRVVDALGNPIDGKGP
CEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCC
IQFTERKRVDVKAPGIIPRKSVNEPMATGLKAIDALIPIGRGQRELIIGDRQTGKTAIAL
EEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEH
DTILNQKPLNAQPDEKIKLYCVYVAVGQKRSTVAQFVKVLEEQGALEYSIVVAATASDPA
HHHHCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PMQYLAPFTGCTMGEYFRDNGMHAVIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CHHHHCCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKLNETQGAGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFFQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEEHHHHHC
IRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYREMAAFAQFGSDLDAATQRLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GSRLTELLKQPQFSPLKMEEQVCVIWAGTNGFLDGLPLNKVRAFEDGLLSLLRGKHADLL
CHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
NTIRDTRDLSDDSAAKLKAAVEGFAKTFS
HHHHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIRAAEISAILKDQIKNFGQEAEVTEVGQVLSVGDGIARVYGLDNVQAGEMVEFENGTR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCEEEECCCCC
GMALNLETDNVGVVIFGADREIKEGQTVKRTRAIVDAPVGKGLLGRVVDALGNPIDGKGP
CEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCC
IQFTERKRVDVKAPGIIPRKSVNEPMATGLKAIDALIPIGRGQRELIIGDRQTGKTAIAL
EEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEH
DTILNQKPLNAQPDEKIKLYCVYVAVGQKRSTVAQFVKVLEEQGALEYSIVVAATASDPA
HHHHCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PMQYLAPFTGCTMGEYFRDNGMHAVIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CHHHHCCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKLNETQGAGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETDLFFQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEEHHHHHC
IRPAVNVGLSVSRVGSSAQTKAMKKVAGKIKGELAQYREMAAFAQFGSDLDAATQRLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GSRLTELLKQPQFSPLKMEEQVCVIWAGTNGFLDGLPLNKVRAFEDGLLSLLRGKHADLL
CHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
NTIRDTRDLSDDSAAKLKAAVEGFAKTFS
HHHHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA